TWI520730B - 調配物 - Google Patents

調配物 Download PDF

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Publication number
TWI520730B
TWI520730B TW100140230A TW100140230A TWI520730B TW I520730 B TWI520730 B TW I520730B TW 100140230 A TW100140230 A TW 100140230A TW 100140230 A TW100140230 A TW 100140230A TW I520730 B TWI520730 B TW I520730B
Authority
TW
Taiwan
Prior art keywords
solid
peg
solid formulation
mannitol
formulation according
Prior art date
Application number
TW100140230A
Other languages
English (en)
Chinese (zh)
Other versions
TW201223522A (en
Inventor
彼得 史坦
伊恩 寇克斯
山姆爾 史密斯
賴頓 瓊斯
傑克 普拉瑟
Original Assignee
諾金私人有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1018647.6A external-priority patent/GB201018647D0/en
Priority claimed from GBGB1104049.0A external-priority patent/GB201104049D0/en
Priority claimed from GBGB1107626.2A external-priority patent/GB201107626D0/en
Application filed by 諾金私人有限公司 filed Critical 諾金私人有限公司
Publication of TW201223522A publication Critical patent/TW201223522A/zh
Application granted granted Critical
Publication of TWI520730B publication Critical patent/TWI520730B/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/765Polymers containing oxygen
    • A61K31/77Polymers containing oxygen of oxiranes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/075Ethers or acetals
    • A61K31/08Ethers or acetals acyclic, e.g. paraformaldehyde
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/765Polymers containing oxygen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW100140230A 2010-11-04 2011-11-04 調配物 TWI520730B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1018647.6A GB201018647D0 (en) 2010-11-04 2010-11-04 Formulations
US41210910P 2010-11-10 2010-11-10
GBGB1104049.0A GB201104049D0 (en) 2011-03-09 2011-03-09 Formulations
GBGB1107626.2A GB201107626D0 (en) 2011-05-06 2011-05-06 Formulations

Publications (2)

Publication Number Publication Date
TW201223522A TW201223522A (en) 2012-06-16
TWI520730B true TWI520730B (zh) 2016-02-11

Family

ID=44999794

Family Applications (1)

Application Number Title Priority Date Filing Date
TW100140230A TWI520730B (zh) 2010-11-04 2011-11-04 調配物

Country Status (20)

Country Link
US (3) US20130225692A1 (enExample)
EP (1) EP2635264B8 (enExample)
JP (1) JP5872573B2 (enExample)
KR (1) KR20130101102A (enExample)
CN (1) CN103384516B (enExample)
AR (1) AR083769A1 (enExample)
AU (1) AU2011324995B2 (enExample)
BE (1) BE1019493A3 (enExample)
BR (1) BR112013010884A2 (enExample)
CA (1) CA2816835A1 (enExample)
EA (1) EA024566B1 (enExample)
ES (1) ES2405531B1 (enExample)
IL (1) IL225892A0 (enExample)
MX (1) MX342181B (enExample)
MY (1) MY164204A (enExample)
NL (1) NL2007716C2 (enExample)
NZ (1) NZ611148A (enExample)
SG (1) SG190018A1 (enExample)
TW (1) TWI520730B (enExample)
WO (1) WO2012059724A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI535461B (zh) 2011-03-11 2016-06-01 諾金私人有限公司 結腸清潔溶液、用於製備該溶液之組成物、包含該組成物或溶液之套組、與製備該溶液之方法
US20130209522A1 (en) * 2012-02-06 2013-08-15 University Of Utah Research Foundation Drug Release from a Polymer-Controlled Local Antibiotic Delivery System Using a Degradable Bone Graft
SG10201702005VA (en) 2012-09-11 2017-04-27 Norgine Bv Compositions comprising peg and ascorbate
US9889235B2 (en) 2013-02-05 2018-02-13 University Of Utah Research Foundation Implantable devices for bone or joint defects
SI2968174T1 (sl) 2013-03-15 2020-02-28 Braintree Laboratories, Inc. Dvojna uporaba tablet oralnega farmacevtskega sestavka sulfatnih soli in metode njihove uporabe
MX2016014230A (es) * 2014-04-29 2017-05-03 Colonaryconcepts Llc Alimentos, sistemas, metodos y kits para proporcionar reemplazo de electrolitos.
JP2018532702A (ja) * 2015-09-01 2018-11-08 コロナリーコンセプツ エルエルシー 下剤製剤及び製造
CN109328035B (zh) 2016-06-15 2022-05-10 株式会社岛津制作所 放射线摄影装置
FR3056109B1 (fr) 2016-09-21 2019-10-11 Pierre Fabre Medicament Utilisation de formulations solides de polyethylene glycol dans le traitement de la constipation
CN112386577B (zh) * 2019-08-16 2024-01-23 北京天衡药物研究院有限公司 一种治疗便秘的组合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5710183A (en) * 1995-07-14 1998-01-20 Halow; George M. Laxative/antidiarrheal composition comprising polyethylene glycol and fiber bulking agent
CA2516291C (en) * 2003-02-28 2012-02-14 Alk-Abello A/S Dosage form having a saccharide matrix
GB0409104D0 (en) * 2004-04-23 2004-05-26 Norgine Europe Bv Compressed pharmaceutical compositions
WO2006122104A1 (en) * 2005-05-06 2006-11-16 Salix Pharmaceuticals, Inc. Polyethylene glycol colonic purgative composition
CO5790164A1 (es) * 2006-08-10 2007-08-31 Procaps S A Composicion farmaceutica solida que incluye en combinacion un agente regulador de la motilidad intestinal y un agente antiflatulento

Also Published As

Publication number Publication date
MY164204A (en) 2017-11-30
BE1019493A3 (fr) 2012-07-03
AU2011324995A1 (en) 2013-05-02
TW201223522A (en) 2012-06-16
MX342181B (es) 2016-09-20
CA2816835A1 (en) 2012-05-10
WO2012059724A8 (en) 2013-06-06
EP2635264B8 (en) 2018-07-18
ES2405531A2 (es) 2013-05-31
IL225892A0 (en) 2013-06-27
AR083769A1 (es) 2013-03-20
BR112013010884A2 (pt) 2016-08-02
AU2011324995B2 (en) 2015-12-24
MX2013004972A (es) 2013-08-27
ES2405531R1 (es) 2013-06-07
KR20130101102A (ko) 2013-09-12
CN103384516B (zh) 2017-02-15
WO2012059724A1 (en) 2012-05-10
EA024566B1 (ru) 2016-09-30
US20160193245A1 (en) 2016-07-07
EP2635264B1 (en) 2018-05-30
EA201300539A1 (ru) 2013-09-30
US20130225692A1 (en) 2013-08-29
SG190018A1 (en) 2013-06-28
CN103384516A (zh) 2013-11-06
NL2007716A (en) 2012-05-07
ES2405531B1 (es) 2014-06-11
NL2007716C2 (en) 2012-11-13
EP2635264A1 (en) 2013-09-11
JP2014500246A (ja) 2014-01-09
US20170296575A1 (en) 2017-10-19
NZ611148A (en) 2015-09-25
JP5872573B2 (ja) 2016-03-01

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MM4A Annulment or lapse of patent due to non-payment of fees