JP2014500246A5 - - Google Patents
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- Publication number
- JP2014500246A5 JP2014500246A5 JP2013537196A JP2013537196A JP2014500246A5 JP 2014500246 A5 JP2014500246 A5 JP 2014500246A5 JP 2013537196 A JP2013537196 A JP 2013537196A JP 2013537196 A JP2013537196 A JP 2013537196A JP 2014500246 A5 JP2014500246 A5 JP 2014500246A5
- Authority
- JP
- Japan
- Prior art keywords
- solid
- preparation according
- mannitol
- solid preparation
- peg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000009472 formulation Methods 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 12
- 206010010774 Constipation Diseases 0.000 claims description 7
- 230000013872 defecation Effects 0.000 claims description 5
- 208000024891 symptom Diseases 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims 33
- 239000002202 Polyethylene glycol Substances 0.000 claims 15
- 229920001223 polyethylene glycol Polymers 0.000 claims 15
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 11
- 229930195725 Mannitol Natural products 0.000 claims 11
- 239000000594 mannitol Substances 0.000 claims 11
- 235000010355 mannitol Nutrition 0.000 claims 11
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 6
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 4
- -1 dextrates Substances 0.000 claims 4
- 239000008101 lactose Substances 0.000 claims 4
- 229960001375 lactose Drugs 0.000 claims 4
- 239000000314 lubricant Substances 0.000 claims 4
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 3
- 239000000796 flavoring agent Substances 0.000 claims 3
- 230000002496 gastric effect Effects 0.000 claims 3
- 235000019359 magnesium stearate Nutrition 0.000 claims 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 239000000600 sorbitol Substances 0.000 claims 3
- 239000000811 xylitol Substances 0.000 claims 3
- 235000010447 xylitol Nutrition 0.000 claims 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 3
- 229960002675 xylitol Drugs 0.000 claims 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 229920002472 Starch Polymers 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 230000018044 dehydration Effects 0.000 claims 2
- 238000006297 dehydration reaction Methods 0.000 claims 2
- 235000013355 food flavoring agent Nutrition 0.000 claims 2
- 239000000845 maltitol Substances 0.000 claims 2
- 235000010449 maltitol Nutrition 0.000 claims 2
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims 2
- 229940035436 maltitol Drugs 0.000 claims 2
- 229960002920 sorbitol Drugs 0.000 claims 2
- 239000008107 starch Substances 0.000 claims 2
- 235000019698 starch Nutrition 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 1
- 235000005979 Citrus limon Nutrition 0.000 claims 1
- 244000131522 Citrus pyriformis Species 0.000 claims 1
- 229920002261 Corn starch Polymers 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 244000246386 Mentha pulegium Species 0.000 claims 1
- 235000016257 Mentha pulegium Nutrition 0.000 claims 1
- 235000004357 Mentha x piperita Nutrition 0.000 claims 1
- 240000007651 Rubus glaucus Species 0.000 claims 1
- 235000011034 Rubus glaucus Nutrition 0.000 claims 1
- 235000009122 Rubus idaeus Nutrition 0.000 claims 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims 1
- 235000010980 cellulose Nutrition 0.000 claims 1
- 239000008120 corn starch Substances 0.000 claims 1
- 229940096516 dextrates Drugs 0.000 claims 1
- 239000003792 electrolyte Substances 0.000 claims 1
- 235000019634 flavors Nutrition 0.000 claims 1
- 235000001050 hortel pimenta Nutrition 0.000 claims 1
- 229960001021 lactose monohydrate Drugs 0.000 claims 1
- 229960001855 mannitol Drugs 0.000 claims 1
- 125000002467 phosphate group Chemical class [H]OP(=O)(O[H])O[*] 0.000 claims 1
- 239000001103 potassium chloride Substances 0.000 claims 1
- 235000011164 potassium chloride Nutrition 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 229910052938 sodium sulfate Inorganic materials 0.000 claims 1
- 235000011152 sodium sulphate Nutrition 0.000 claims 1
- 229940032147 starch Drugs 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000001631 hypertensive effect Effects 0.000 description 1
- 239000008141 laxative Substances 0.000 description 1
- 229940125722 laxative agent Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1018647.6 | 2010-11-04 | ||
| GBGB1018647.6A GB201018647D0 (en) | 2010-11-04 | 2010-11-04 | Formulations |
| US41210910P | 2010-11-10 | 2010-11-10 | |
| US61/412,109 | 2010-11-10 | ||
| GB1104049.0 | 2011-03-09 | ||
| GBGB1104049.0A GB201104049D0 (en) | 2011-03-09 | 2011-03-09 | Formulations |
| GBGB1107626.2A GB201107626D0 (en) | 2011-05-06 | 2011-05-06 | Formulations |
| GB1107626.2 | 2011-05-06 | ||
| PCT/GB2011/001560 WO2012059724A1 (en) | 2010-11-04 | 2011-11-04 | Formulations comprising polyethylene glycol |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014500246A JP2014500246A (ja) | 2014-01-09 |
| JP2014500246A5 true JP2014500246A5 (enExample) | 2014-12-11 |
| JP5872573B2 JP5872573B2 (ja) | 2016-03-01 |
Family
ID=44999794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013537196A Active JP5872573B2 (ja) | 2010-11-04 | 2011-11-04 | ポリエチレングリコール含有製剤 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US20130225692A1 (enExample) |
| EP (1) | EP2635264B8 (enExample) |
| JP (1) | JP5872573B2 (enExample) |
| KR (1) | KR20130101102A (enExample) |
| CN (1) | CN103384516B (enExample) |
| AR (1) | AR083769A1 (enExample) |
| AU (1) | AU2011324995B2 (enExample) |
| BE (1) | BE1019493A3 (enExample) |
| BR (1) | BR112013010884A2 (enExample) |
| CA (1) | CA2816835A1 (enExample) |
| EA (1) | EA024566B1 (enExample) |
| ES (1) | ES2405531B1 (enExample) |
| IL (1) | IL225892A0 (enExample) |
| MX (1) | MX342181B (enExample) |
| MY (1) | MY164204A (enExample) |
| NL (1) | NL2007716C2 (enExample) |
| NZ (1) | NZ611148A (enExample) |
| SG (1) | SG190018A1 (enExample) |
| TW (1) | TWI520730B (enExample) |
| WO (1) | WO2012059724A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI535461B (zh) | 2011-03-11 | 2016-06-01 | 諾金私人有限公司 | 結腸清潔溶液、用於製備該溶液之組成物、包含該組成物或溶液之套組、與製備該溶液之方法 |
| EP2811940A4 (en) * | 2012-02-06 | 2015-10-07 | Univ Utah Res Found | ACTIVE COMPOSITION FROM A LOCAL POLYMER-CONTROLLED ANTIBIOTIC ACTIVATION SYSTEM WITH A DEGRADABLE BONE IMPLANT |
| NZ743984A (en) | 2012-09-11 | 2019-10-25 | Norgine Bv | Compositions comprising polyethylene glycol, alkali metal or alkaline earth metal sulphates and electrolytes for use as colon cleansing compositions |
| WO2014123978A2 (en) | 2013-02-05 | 2014-08-14 | University Of Utah Research Foundation | Implantable devices for bone or joint defects |
| JP6441890B2 (ja) | 2013-03-15 | 2018-12-19 | ブレインツリー・ラボラトリーズ，インコーポレイテッド | 硫酸塩の両用経口薬学的組成物錠剤およびその使用の方法 |
| EP3137167A4 (en) * | 2014-04-29 | 2017-12-20 | Colonaryconcepts LLC | Foods, systems, methods, and kits for providing electrolyte replacement |
| CN108024975A (zh) * | 2015-09-01 | 2018-05-11 | 科罗纳里康赛普茨有限责任公司 | 通便药制剂及其制备 |
| US10859512B2 (en) | 2016-06-15 | 2020-12-08 | Shimadzu Corporation | X-ray phase contrast imaging apparatus |
| FR3056109B1 (fr) | 2016-09-21 | 2019-10-11 | Pierre Fabre Medicament | Utilisation de formulations solides de polyethylene glycol dans le traitement de la constipation |
| CN112386577B (zh) * | 2019-08-16 | 2024-01-23 | 北京天衡药物研究院有限公司 | 一种治疗便秘的组合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5710183A (en) * | 1995-07-14 | 1998-01-20 | Halow; George M. | Laxative/antidiarrheal composition comprising polyethylene glycol and fiber bulking agent |
| WO2004075875A1 (en) * | 2003-02-28 | 2004-09-10 | Alk-Abello A/S | Dosage form having a saccharide matrix |
| GB0409104D0 (en) * | 2004-04-23 | 2004-05-26 | Norgine Europe Bv | Compressed pharmaceutical compositions |
| WO2006122104A1 (en) * | 2005-05-06 | 2006-11-16 | Salix Pharmaceuticals, Inc. | Polyethylene glycol colonic purgative composition |
| CO5790164A1 (es) * | 2006-08-10 | 2007-08-31 | Procaps S A | Composicion farmaceutica solida que incluye en combinacion un agente regulador de la motilidad intestinal y un agente antiflatulento |
-
2011
- 2011-11-04 TW TW100140230A patent/TWI520730B/zh not_active IP Right Cessation
- 2011-11-04 JP JP2013537196A patent/JP5872573B2/ja active Active
- 2011-11-04 WO PCT/GB2011/001560 patent/WO2012059724A1/en not_active Ceased
- 2011-11-04 EA EA201300539A patent/EA024566B1/ru not_active IP Right Cessation
- 2011-11-04 NZ NZ611148A patent/NZ611148A/en not_active IP Right Cessation
- 2011-11-04 MY MYPI2013001599A patent/MY164204A/en unknown
- 2011-11-04 CA CA2816835A patent/CA2816835A1/en not_active Abandoned
- 2011-11-04 AU AU2011324995A patent/AU2011324995B2/en active Active
- 2011-11-04 MX MX2013004972A patent/MX342181B/es active IP Right Grant
- 2011-11-04 BE BE2011/0644A patent/BE1019493A3/fr active
- 2011-11-04 US US13/883,153 patent/US20130225692A1/en not_active Abandoned
- 2011-11-04 NL NL2007716A patent/NL2007716C2/en active
- 2011-11-04 ES ES201131774A patent/ES2405531B1/es active Active
- 2011-11-04 SG SG2013031984A patent/SG190018A1/en unknown
- 2011-11-04 AR ARP110104128A patent/AR083769A1/es unknown
- 2011-11-04 BR BR112013010884A patent/BR112013010884A2/pt not_active IP Right Cessation
- 2011-11-04 KR KR1020137013975A patent/KR20130101102A/ko not_active Ceased
- 2011-11-04 CN CN201180063942.9A patent/CN103384516B/zh not_active Expired - Fee Related
- 2011-11-04 EP EP11785049.5A patent/EP2635264B8/en active Active
-
2013
- 2013-04-22 IL IL225892A patent/IL225892A0/en unknown
-
2016
- 2016-01-14 US US14/995,537 patent/US20160193245A1/en not_active Abandoned
-
2017
- 2017-06-28 US US15/635,897 patent/US20170296575A1/en not_active Abandoned
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