JP5820821B2 - 第四級アンモニウム塩の製造法 - Google Patents

第四級アンモニウム塩の製造法 Download PDF

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Publication number
JP5820821B2
JP5820821B2 JP2012549043A JP2012549043A JP5820821B2 JP 5820821 B2 JP5820821 B2 JP 5820821B2 JP 2012549043 A JP2012549043 A JP 2012549043A JP 2012549043 A JP2012549043 A JP 2012549043A JP 5820821 B2 JP5820821 B2 JP 5820821B2
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Japanese (ja)
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JP2013525264A5 (enExample
JP2013525264A (ja
Inventor
申行 阿江
申行 阿江
雄二 藤原
雄二 藤原
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Sumitomo Pharma Co Ltd
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Sumitomo Dainippon Pharma Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2012549043A 2010-04-26 2011-04-25 第四級アンモニウム塩の製造法 Active JP5820821B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32780910P 2010-04-26 2010-04-26
US61/327,809 2010-04-26
PCT/JP2011/060570 WO2011136383A1 (en) 2010-04-26 2011-04-25 A process of a quaternary ammonium salt

Publications (3)

Publication Number Publication Date
JP2013525264A JP2013525264A (ja) 2013-06-20
JP2013525264A5 JP2013525264A5 (enExample) 2014-05-22
JP5820821B2 true JP5820821B2 (ja) 2015-11-24

Family

ID=44816340

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012549043A Active JP5820821B2 (ja) 2010-04-26 2011-04-25 第四級アンモニウム塩の製造法

Country Status (7)

Country Link
US (2) US8921551B2 (enExample)
EP (1) EP2563790B1 (enExample)
JP (1) JP5820821B2 (enExample)
DK (1) DK2563790T3 (enExample)
ES (1) ES2594709T3 (enExample)
HU (1) HUE030294T2 (enExample)
WO (1) WO2011136383A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2527545T3 (es) 2010-04-26 2015-01-26 Sumitomo Dainippon Pharma Co., Ltd. Un procedimiento de preparación de una sal de amonio cuaternario utilizando fosfato
WO2013121440A1 (en) 2012-02-13 2013-08-22 Cadila Healthcare Limited Process for preparing benzisothiazol-3-yl-peperazin-l-yl-methyl-cyclo hexyl-methanisoindol-1,3-dione and its intermediates
CN103450172A (zh) * 2012-05-30 2013-12-18 广州药源生物医药科技有限公司 一种抗精神病药物鲁拉西酮的制备方法
CN102863437A (zh) * 2012-09-04 2013-01-09 济南百诺医药科技开发有限公司 一种鲁拉西酮的制备方法
CN102827157A (zh) * 2012-09-20 2012-12-19 北京哈三联科技股份有限公司 一种制备鲁拉西酮的方法
CN102936243B (zh) * 2012-11-16 2015-08-05 上海伯倚化工科技有限公司 一种鲁拉西酮的合成方法
CN103864774B (zh) * 2012-12-14 2016-09-28 成都弘达药业有限公司 一种鲁拉西酮的制备方法
ITMI20130262A1 (it) * 2013-02-22 2014-08-23 Edmond Pharma Srl Procedimento per la preparazione di lurasidone cloridrato
ITMI20131737A1 (it) 2013-10-17 2015-04-18 Procos Spa Processo per la sintesi industriale di lurasidone
JP6594351B2 (ja) 2014-06-16 2019-10-23 ジョンソン、マッセイ、パブリック、リミテッド、カンパニー 新規中間体を含むアルキル化アリールピペラジン及びアルキル化アリールピペリジン化合物の製造方法
EP3207041B1 (en) 2014-10-14 2019-12-04 Jubilant Generics Limited (Formerly Jubilant Life Sciences Division) An improved process for the preparation of lurasidone hydrochloride
WO2016110798A1 (en) 2015-01-08 2016-07-14 Piramal Enterprises Limited An improved process for the preparation of lurasidone and its intermediate
CN106146486A (zh) * 2015-04-21 2016-11-23 上海医药集团股份有限公司 一种制备高纯度高收率鲁拉西酮的方法
CN106946872A (zh) * 2017-03-20 2017-07-14 常州工程职业技术学院 一种制备鲁拉西酮关键中间体的方法
CN107936007B (zh) * 2017-11-28 2021-05-25 常州寅盛药业有限公司 一种盐酸鲁拉西酮的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4351939A (en) * 1980-10-16 1982-09-28 Mead Johnson & Company Spiro-quaternary ammonium halides and N-(2-pyrimidinyl)piperazinylalkylazaspiroalkanedione process
JP2800953B2 (ja) * 1990-07-06 1998-09-21 住友製薬株式会社 新規なイミド誘導体
JP3775823B2 (ja) * 1995-06-09 2006-05-17 大日本住友製薬株式会社 新規なイミド誘導体
JP4175800B2 (ja) * 2001-11-27 2008-11-05 住友化学株式会社 イミド誘導体の製造方法
CN100422178C (zh) 2003-07-29 2008-10-01 大日本住友制药株式会社 生产酰亚胺化合物的方法
JP4708012B2 (ja) * 2004-12-15 2011-06-22 大日本住友製薬株式会社 第四級アンモニウム塩の製造法
JP2006169154A (ja) * 2004-12-15 2006-06-29 Sumitomo Chemical Co Ltd 第四級アンモニウム塩の製造方法
DE602006021437D1 (de) 2005-08-30 2011-06-01 Honeywell Int Inc Verfahren zur synthese von quaternären ammonium-spirosystemen
US20110003994A1 (en) * 2009-07-02 2011-01-06 Dainippon Sumitomo Pharma Co., Ltd. Cycloalkane derivative
ES2527545T3 (es) * 2010-04-26 2015-01-26 Sumitomo Dainippon Pharma Co., Ltd. Un procedimiento de preparación de una sal de amonio cuaternario utilizando fosfato

Also Published As

Publication number Publication date
EP2563790A4 (en) 2014-02-19
US20150087830A1 (en) 2015-03-26
EP2563790B1 (en) 2016-09-14
ES2594709T3 (es) 2016-12-22
DK2563790T3 (en) 2016-10-24
EP2563790A1 (en) 2013-03-06
US20110263847A1 (en) 2011-10-27
US8921551B2 (en) 2014-12-30
WO2011136383A1 (en) 2011-11-03
US9309255B2 (en) 2016-04-12
HUE030294T2 (en) 2017-04-28
JP2013525264A (ja) 2013-06-20

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