JP5783720B2 - 植物での糖タンパク質生成の改変 - Google Patents

植物での糖タンパク質生成の改変 Download PDF

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JP5783720B2
JP5783720B2 JP2010511461A JP2010511461A JP5783720B2 JP 5783720 B2 JP5783720 B2 JP 5783720B2 JP 2010511461 A JP2010511461 A JP 2010511461A JP 2010511461 A JP2010511461 A JP 2010511461A JP 5783720 B2 JP5783720 B2 JP 5783720B2
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protein
plant
nucleotide sequence
interest
seq
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JP2010531136A5 (enExample
JP2010531136A (ja
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マルク アンドレ ダオース
マルク アンドレ ダオース
ルイ フィリップ ヴェジナ
ルイ フィリップ ヴェジナ
ステファニー アーキン
ステファニー アーキン
ブルーアン エステル マルケ
ブルーアン エステル マルケ
ミュリエル バルドール
ミュリエル バルドール
カロル ビュレル
カロル ビュレル
ロイク ファイユ
ロイク ファイユ
パトリス ルルージュ
パトリス ルルージュ
ヴェロニク ゴモル
ヴェロニク ゴモル
クリストフ リフーエイ
クリストフ リフーエイ
トーマス パカレ
トーマス パカレ
クリストフ スルイユ
クリストフ スルイユ
Original Assignee
メディカゴ インコーポレイテッド
メディカゴ インコーポレイテッド
センター ナショナル ド ラ ルシェルシュ サイエンティフィーク
センター ナショナル ド ラ ルシェルシュ サイエンティフィーク
ユニヴェルシテ ド ルーアン
ユニヴェルシテ ド ルーアン
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
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    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8245—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified carbohydrate or sugar alcohol metabolism, e.g. starch biosynthesis
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
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    • C12N9/1051—Hexosyltransferases (2.4.1)

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  • Nutrition Science (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Cultivation Of Plants (AREA)
JP2010511461A 2007-06-15 2008-06-13 植物での糖タンパク質生成の改変 Expired - Fee Related JP5783720B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94434407P 2007-06-15 2007-06-15
US60/944,344 2007-06-15
PCT/CA2008/001139 WO2008151440A1 (en) 2007-06-15 2008-06-13 Modifying glycoprotein production in plants

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JP2010531136A JP2010531136A (ja) 2010-09-24
JP2010531136A5 JP2010531136A5 (enExample) 2011-07-28
JP5783720B2 true JP5783720B2 (ja) 2015-09-24

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US (1) US20110008837A1 (enExample)
EP (1) EP2155880B1 (enExample)
JP (1) JP5783720B2 (enExample)
KR (2) KR101385050B1 (enExample)
CN (3) CN103382487A (enExample)
AU (1) AU2008261527C1 (enExample)
BR (1) BRPI0812538B1 (enExample)
CA (2) CA2700180C (enExample)
DK (1) DK2155880T3 (enExample)
EG (1) EG26600A (enExample)
ES (1) ES2624776T3 (enExample)
HU (1) HUE031698T2 (enExample)
IL (1) IL202568A (enExample)
MA (1) MA31516B1 (enExample)
MX (1) MX2009013665A (enExample)
NZ (2) NZ598417A (enExample)
PL (1) PL2155880T3 (enExample)
PT (1) PT2155880T (enExample)
RU (2) RU2499053C2 (enExample)
SG (1) SG185249A1 (enExample)
SI (1) SI2155880T1 (enExample)
TN (1) TN2009000512A1 (enExample)
WO (1) WO2008151440A1 (enExample)
ZA (1) ZA201000207B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2615372A1 (en) 2007-07-13 2009-01-13 Marc-Andre D'aoust Influenza virus-like particles (vlps) comprising hemagglutinin
CN103122354B (zh) 2007-11-27 2018-03-23 麦迪卡格公司 表达血凝素之转基因植物中生产的重组流感病毒样颗粒(vlp)
US8771703B2 (en) 2008-07-08 2014-07-08 Medicago Inc. Soluble recombinant influenza antigens
AU2009270404B2 (en) 2008-07-18 2015-01-29 Medicago Inc. New influenza virus immunizing epitope
CA2762042C (en) 2009-06-24 2012-11-20 Medicago Inc. Chimeric influenza virus-like particles comprising hemagglutinin
HRP20171564T1 (hr) 2009-09-22 2017-11-17 Medicago Inc. Postupak za pripremu biljnih čestica sličnih virusu (vlp)
TWI620816B (zh) 2011-03-23 2018-04-11 苜蓿股份有限公司 植物衍生蛋白回收方法
CA2839932C (en) * 2011-06-07 2022-07-05 Ibio, Inc. In vivo de-glycosylation of recombinant proteins by co-expression with pngase f
EP2551348B1 (en) 2011-07-29 2014-09-24 Icon Genetics GmbH Production of galactosylated N-glycans in plants
SI2760882T1 (sl) 2011-09-30 2023-10-30 Medicago Inc. Povečanje količine virusom podobnih delcev v rastlinah
WO2013169009A1 (ko) * 2012-05-08 2013-11-14 경상대학교 산학협력단 고-만노오스형 n-글라이칸을 생산하는 식물체 및 이를 이용한 고-만노오스형 n-글라이칸의 생산방법
JP2016516415A (ja) 2013-03-28 2016-06-09 メディカゴ インコーポレイテッド 植物におけるインフルエンザウイルス様粒子の生成
US12467058B2 (en) 2013-03-28 2025-11-11 Aramis Biotechnologies Inc. Influenza virus-like particle production in plants
JP6788582B2 (ja) 2014-07-11 2020-11-25 メディカゴ インコーポレイテッド 植物におけるタンパク質生産の改変
EA038931B9 (ru) 2014-11-20 2022-02-18 Йиссум Рисерч Дивелопмент Компани Оф Зе Хебрю Юниверсити Оф Иерусалим Лтд. Композиции и способы получения полипептидов с модифицированным профилем гликозилирования в клетках растений
CA3045173A1 (en) 2016-12-01 2018-06-07 Plantform Corporation Transgenic plant with reduced fucosyltransferase and xylosyltransferase activity
WO2019049111A1 (en) * 2017-09-11 2019-03-14 R. J. Reynolds Tobacco Company METHODS AND COMPOSITIONS FOR INCREASING THE EXPRESSION OF GENES OF INTEREST IN A PLANT BY CO-EXPRESSION WITH P21
JP7566045B2 (ja) * 2021-01-15 2024-10-11 デンカ株式会社 栽培条件を決定する方法、及び目的タンパク質又は目的ペプチドの製造方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5312746A (en) * 1993-01-08 1994-05-17 Life Technologies, Inc. Cloning and expressing restriction endonucleases and modification methylases from caryophanon
GB9524350D0 (en) * 1995-11-29 1996-01-31 Lynxvale Ltd Enhancer-increased gene expression in plants
US5945326A (en) * 1997-03-20 1999-08-31 New England Biolabs, Inc. Method for cloning and producing the Spel restriction endonuclease
ATE475714T1 (de) * 1998-12-09 2010-08-15 Phyton Holdings Llc Verfahren zur herstellung von glycoprotein mit menschlichem glycosylierungsbild
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
DE60024658T2 (de) * 1999-10-04 2006-08-24 Medicago Inc., Sainte Foy Promotor zur regulierung von fremdgenexpression
WO2001029242A2 (en) * 1999-10-21 2001-04-26 Monsanto Company Post-translational modification of recombinant proteins produced in plants
ES2349427T3 (es) * 1999-10-26 2011-01-03 Stichting Dienst Landbouwkundig Onderzoek Glicosilación de tipo mamífero en plantas.
WO2001031045A1 (en) * 1999-10-26 2001-05-03 Plant Research International B.V. Mammalian-type glycosylation in plants
CN100385006C (zh) * 2001-01-19 2008-04-30 陶氏化学公司 利用植物细胞分泌性生产具有人型糖链的糖蛋白的方法
US20030035774A1 (en) 2001-07-18 2003-02-20 Adjei Akwete L. Salt/ion pair medicinal aerosol formulation
CA2455365C (en) * 2001-08-03 2014-07-29 Glycart Biotechnology Ag Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
HUE050222T2 (hu) * 2002-02-13 2020-11-30 Wisconsin Alumni Res Found Szignál influenzavírus-vektorok pakolására
JP4532118B2 (ja) * 2002-03-19 2010-08-25 スティヒティング ディーンスト ランドバウクンディフ オンデルズーク 植物体内のグリカンプロセシングの最適化
EP1485492B1 (en) * 2002-03-19 2011-12-21 Stichting Dienst Landbouwkundig Onderzoek Gntiii (udp-n-acetylglucosamine:beta-d mannoside beta(1,4)-n-acetylglucosaminyltransferase iii) expression in plants
PL224786B1 (pl) * 2003-01-22 2017-01-31 Glycart Biotechnology Ag Wyizolowany kwas nukleinowy, ssaczy wektor ekspresyjny, komórki gospodarza, fuzja polipeptydowa i sposób jej wytwarzania, sposoby in vitro i ex vivo modyfikowania profilu glikozylacji polipeptydu wytwarzanego przez komórki gospodarza
CN1761746B (zh) * 2003-01-22 2016-03-23 罗氏格黎卡特股份公司 融合构建体及其用来生产Fc受体结合亲和性和效应子功能提高的抗体的用途
DE602004028004D1 (de) * 2003-05-05 2010-08-19 Thompson Boyce Plant Res Vektoren und zellen zur herstellung von aus transgenen pflanzen gewonnenen immunprotektiven zusammensetzungen
JP2006212019A (ja) * 2004-04-30 2006-08-17 National Institute Of Agrobiological Sciences 植物を用いたユビキノン−１０の製造方法

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IL202568A (en) 2015-02-26
WO2008151440A1 (en) 2008-12-18
EG26600A (en) 2014-03-23
EP2155880A4 (en) 2010-08-04
WO2008151440A4 (en) 2009-02-26
RU2499053C2 (ru) 2013-11-20
KR101385050B1 (ko) 2014-05-13
MA31516B1 (fr) 2010-07-01
ZA201000207B (en) 2013-09-25
WO2008151440A8 (en) 2010-03-04
BRPI0812538A2 (pt) 2014-09-30
AU2008261527C1 (en) 2014-09-04
CA2700180C (en) 2013-01-29
EP2155880B1 (en) 2016-08-10
US20110008837A1 (en) 2011-01-13
NZ598417A (en) 2013-06-28
SG185249A1 (en) 2012-11-29
KR20100037602A (ko) 2010-04-09
RU2013137208A (ru) 2015-02-20
IL202568A0 (en) 2011-08-01
CN103382487A (zh) 2013-11-06
CN101918559A (zh) 2010-12-15
PL2155880T3 (pl) 2017-06-30
AU2008261527A1 (en) 2008-12-18
CN104962579A (zh) 2015-10-07
JP2010531136A (ja) 2010-09-24
AU2008261527B8 (en) 2014-04-24
HUE031698T2 (en) 2017-07-28
RU2010101024A (ru) 2011-07-20
KR20130075787A (ko) 2013-07-05
DK2155880T3 (en) 2016-12-05
CA2795379A1 (en) 2008-12-18
MX2009013665A (es) 2010-06-02
BRPI0812538B1 (pt) 2021-03-16
ES2624776T3 (es) 2017-07-17
SI2155880T1 (sl) 2017-03-31
TN2009000512A1 (en) 2011-03-31
CA2700180A1 (en) 2008-12-18
NZ581944A (en) 2012-03-30
AU2008261527B2 (en) 2014-04-10
PT2155880T (pt) 2016-11-18
EP2155880A1 (en) 2010-02-24

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