DK2155880T3 - Modification of glycoproteinproduktion i plants - Google Patents

Modification of glycoproteinproduktion i plants Download PDF

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Publication number
DK2155880T3
DK2155880T3 DK08772802.8T DK08772802T DK2155880T3 DK 2155880 T3 DK2155880 T3 DK 2155880T3 DK 08772802 T DK08772802 T DK 08772802T DK 2155880 T3 DK2155880 T3 DK 2155880T3
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DK
Denmark
Prior art keywords
plant
protein
interest
nucleotide sequence
seq
Prior art date
Application number
DK08772802.8T
Other languages
Danish (da)
English (en)
Inventor
Marc-Andre D'aoust
Estelle Marquet-Blouin
Carole Burel
Loic Faye
Patrice Lerouge
Véronique Gomord
Stéphanie Aquin
Christophe Rihouey
Thomas Paccalet
Christophe Sourrouille
Muriel Bardor
Louis-Philippe Vezina
Original Assignee
Medicago Inc
Centre Nat Rech Scient
Univ Rouen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medicago Inc, Centre Nat Rech Scient, Univ Rouen filed Critical Medicago Inc
Application granted granted Critical
Publication of DK2155880T3 publication Critical patent/DK2155880T3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8245—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified carbohydrate or sugar alcohol metabolism, e.g. starch biosynthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Cultivation Of Plants (AREA)
DK08772802.8T 2007-06-15 2008-06-13 Modification of glycoproteinproduktion i plants DK2155880T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94434407P 2007-06-15 2007-06-15
PCT/CA2008/001139 WO2008151440A1 (en) 2007-06-15 2008-06-13 Modifying glycoprotein production in plants

Publications (1)

Publication Number Publication Date
DK2155880T3 true DK2155880T3 (en) 2016-12-05

Family

ID=40129187

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08772802.8T DK2155880T3 (en) 2007-06-15 2008-06-13 Modification of glycoproteinproduktion i plants

Country Status (24)

Country Link
US (1) US20110008837A1 (enExample)
EP (1) EP2155880B1 (enExample)
JP (1) JP5783720B2 (enExample)
KR (2) KR101385050B1 (enExample)
CN (3) CN104962579A (enExample)
AU (1) AU2008261527C1 (enExample)
BR (1) BRPI0812538B1 (enExample)
CA (2) CA2700180C (enExample)
DK (1) DK2155880T3 (enExample)
EG (1) EG26600A (enExample)
ES (1) ES2624776T3 (enExample)
HU (1) HUE031698T2 (enExample)
IL (1) IL202568A (enExample)
MA (1) MA31516B1 (enExample)
MX (1) MX2009013665A (enExample)
NZ (2) NZ598417A (enExample)
PL (1) PL2155880T3 (enExample)
PT (1) PT2155880T (enExample)
RU (2) RU2499053C2 (enExample)
SG (1) SG185249A1 (enExample)
SI (1) SI2155880T1 (enExample)
TN (1) TN2009000512A1 (enExample)
WO (1) WO2008151440A1 (enExample)
ZA (1) ZA201000207B (enExample)

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CA2615372A1 (en) 2007-07-13 2009-01-13 Marc-Andre D'aoust Influenza virus-like particles (vlps) comprising hemagglutinin
WO2009076778A1 (en) 2007-11-27 2009-06-25 Medicago Inc. Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin
WO2010003235A1 (en) 2008-07-08 2010-01-14 Medicago Inc. Soluble recombinant influenza antigens
DK2318530T3 (en) 2008-07-18 2016-10-03 Medicago Inc Ny epitope to immunization against influenza
BRPI1015053A2 (pt) 2009-06-24 2019-07-09 Medicago Inc partículas similares a vírus da influenza quiméricas compreendendo hemaglutinina
SI3354657T1 (sl) 2009-09-22 2022-05-31 Medicago Inc. Postopek za pripravo iz rastlin izpeljanih beljakovin
TWI620816B (zh) 2011-03-23 2018-04-11 苜蓿股份有限公司 植物衍生蛋白回收方法
CA2839932C (en) * 2011-06-07 2022-07-05 Ibio, Inc. In vivo de-glycosylation of recombinant proteins by co-expression with pngase f
EP2551348B1 (en) 2011-07-29 2014-09-24 Icon Genetics GmbH Production of galactosylated N-glycans in plants
RU2682752C2 (ru) 2011-09-30 2019-03-21 Медикаго Инк. Повышение выхода вирусоподобных частиц в растениях
KR20130125337A (ko) * 2012-05-08 2013-11-18 경상대학교산학협력단 고-만노오스형 n-글라이칸을 생산하는 식물체 및 이를 이용한 고-만노오스형 n-글라이칸의 생산방법
KR102199018B1 (ko) 2013-03-28 2021-01-07 메디카고 인코포레이티드 식물에서 인플루엔자 바이러스-유사 입자 생산
US12467058B2 (en) 2013-03-28 2025-11-11 Aramis Biotechnologies Inc. Influenza virus-like particle production in plants
AU2015286165B2 (en) 2014-07-11 2021-03-11 Medicago Inc. Modifying protein production in plants
WO2016079739A2 (en) 2014-11-20 2016-05-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions and methods for producing polypeptides with a modified glycosylation pattern in plant cells
EP3548612A4 (en) 2016-12-01 2020-04-15 Plantform Corporation TRANSGENIC PLANT WITH REDUCED FUCOSYL TRANSFERASE AND XYLOSYL TRANSFERASE ACTIVITY
WO2019049111A1 (en) * 2017-09-11 2019-03-14 R. J. Reynolds Tobacco Company METHODS AND COMPOSITIONS FOR INCREASING THE EXPRESSION OF GENES OF INTEREST IN A PLANT BY CO-EXPRESSION WITH P21
WO2022153973A1 (ja) * 2021-01-15 2022-07-21 デンカ株式会社 栽培条件を決定する方法、及び目的タンパク質又は目的ペプチドの製造方法

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US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
MXPA02003455A (es) * 1999-10-04 2002-10-23 Medicago Inc Promotor para regular la expresion de genes foraneos.
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CN1761746B (zh) * 2003-01-22 2016-03-23 罗氏格黎卡特股份公司 融合构建体及其用来生产Fc受体结合亲和性和效应子功能提高的抗体的用途
KR101498588B1 (ko) * 2003-01-22 2015-03-05 로슈 글리카트 아게 융합 구성체와 Fc 수용체 결합 친화도 및 이펙터 기능이 증가된 항체를 생성하기 위한 이의 용도
KR20060035596A (ko) * 2003-05-05 2006-04-26 보이스 톰슨 인스터튜트 포 플랜트 리서치 외래유전자도입 식물로부터 유래된 면역보호성 조성물을제조하기 위한 벡터와 세포
JP2006212019A (ja) * 2004-04-30 2006-08-17 National Institute Of Agrobiological Sciences 植物を用いたユビキノン−10の製造方法

Also Published As

Publication number Publication date
MX2009013665A (es) 2010-06-02
CA2795379A1 (en) 2008-12-18
US20110008837A1 (en) 2011-01-13
CA2700180C (en) 2013-01-29
CA2700180A1 (en) 2008-12-18
SG185249A1 (en) 2012-11-29
PT2155880T (pt) 2016-11-18
NZ581944A (en) 2012-03-30
EP2155880A4 (en) 2010-08-04
AU2008261527A8 (en) 2010-01-21
JP2010531136A (ja) 2010-09-24
EG26600A (en) 2014-03-23
ES2624776T3 (es) 2017-07-17
RU2010101024A (ru) 2011-07-20
AU2008261527A1 (en) 2008-12-18
AU2008261527C1 (en) 2014-09-04
CN103382487A (zh) 2013-11-06
AU2008261527B2 (en) 2014-04-10
KR20130075787A (ko) 2013-07-05
EP2155880B1 (en) 2016-08-10
TN2009000512A1 (en) 2011-03-31
PL2155880T3 (pl) 2017-06-30
CN101918559A (zh) 2010-12-15
BRPI0812538B1 (pt) 2021-03-16
KR20100037602A (ko) 2010-04-09
IL202568A (en) 2015-02-26
ZA201000207B (en) 2013-09-25
HUE031698T2 (en) 2017-07-28
BRPI0812538A2 (pt) 2014-09-30
IL202568A0 (en) 2011-08-01
WO2008151440A4 (en) 2009-02-26
MA31516B1 (fr) 2010-07-01
SI2155880T1 (sl) 2017-03-31
EP2155880A1 (en) 2010-02-24
CN104962579A (zh) 2015-10-07
AU2008261527B8 (en) 2014-04-24
KR101385050B1 (ko) 2014-05-13
WO2008151440A8 (en) 2010-03-04
RU2013137208A (ru) 2015-02-20
JP5783720B2 (ja) 2015-09-24
RU2499053C2 (ru) 2013-11-20
NZ598417A (en) 2013-06-28
WO2008151440A1 (en) 2008-12-18

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