JP5775871B2 - ヘテロ環式オキシム化合物 - Google Patents
ヘテロ環式オキシム化合物 Download PDFInfo
- Publication number
- JP5775871B2 JP5775871B2 JP2012525167A JP2012525167A JP5775871B2 JP 5775871 B2 JP5775871 B2 JP 5775871B2 JP 2012525167 A JP2012525167 A JP 2012525167A JP 2012525167 A JP2012525167 A JP 2012525167A JP 5775871 B2 JP5775871 B2 JP 5775871B2
- Authority
- JP
- Japan
- Prior art keywords
- triazolo
- ethanone
- pyridazin
- mmol
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 Cc1ncc(*)[n]1C Chemical compound Cc1ncc(*)[n]1C 0.000 description 6
- IIOMIXQUKPORSZ-UHFFFAOYSA-N Brc(cn1)c[n]2c1ncc2Cc1cc2cccnc2cc1 Chemical compound Brc(cn1)c[n]2c1ncc2Cc1cc2cccnc2cc1 IIOMIXQUKPORSZ-UHFFFAOYSA-N 0.000 description 1
- SXXYIJSASWDISL-BRJLIKDPSA-N C/C(/c(cc1)n[n]2c1nnc2Cc(ccc1c2cccn1)c2F)=N\OCCO Chemical compound C/C(/c(cc1)n[n]2c1nnc2Cc(ccc1c2cccn1)c2F)=N\OCCO SXXYIJSASWDISL-BRJLIKDPSA-N 0.000 description 1
- COYUFXXHJWERLC-MXVWEQJVSA-N C/C(/c(cc1)n[n]2c1nnc2Cc1ccc(C)c(/C=C\C=C)c1)=N\OC(CO)CO Chemical compound C/C(/c(cc1)n[n]2c1nnc2Cc1ccc(C)c(/C=C\C=C)c1)=N\OC(CO)CO COYUFXXHJWERLC-MXVWEQJVSA-N 0.000 description 1
- FKDCFTCWGQQZSP-WYMPLXKRSA-N C/C(/c1cnc2nn[n](Cc(cc3)cc4c3nccc4)c2n1)=N\OCCN Chemical compound C/C(/c1cnc2nn[n](Cc(cc3)cc4c3nccc4)c2n1)=N\OCCN FKDCFTCWGQQZSP-WYMPLXKRSA-N 0.000 description 1
- MLJLRCOGNFZSIE-LGJNPRDNSA-N C/C(/c1cnc2nn[n](Cc(cc3)cc4c3nccc4)c2n1)=N\OCCNC(OC)=O Chemical compound C/C(/c1cnc2nn[n](Cc(cc3)cc4c3nccc4)c2n1)=N\OCCNC(OC)=O MLJLRCOGNFZSIE-LGJNPRDNSA-N 0.000 description 1
- QEWBLEMJAWTJOO-UHFFFAOYSA-N CC(c(cc1)n[n]2c1nnc2Cc1ccc2ncccc2c1)=O Chemical compound CC(c(cc1)n[n]2c1nnc2Cc1ccc2ncccc2c1)=O QEWBLEMJAWTJOO-UHFFFAOYSA-N 0.000 description 1
- XJXRUPHLZNDKCG-UHFFFAOYSA-N CC(c(cn1)c[n]2c1ncc2Cc1cc2cccnc2cc1)=O Chemical compound CC(c(cn1)c[n]2c1ncc2Cc1cc2cccnc2cc1)=O XJXRUPHLZNDKCG-UHFFFAOYSA-N 0.000 description 1
- UWYBIAQHEVKYNM-ZVHZXABRSA-N CCO/N=C(\C)/c(cc1)n[n]2c1ncc2Cc(cc1)cc2c1nccc2 Chemical compound CCO/N=C(\C)/c(cc1)n[n]2c1ncc2Cc(cc1)cc2c1nccc2 UWYBIAQHEVKYNM-ZVHZXABRSA-N 0.000 description 1
- IIPNTNDPIZNFRU-UHFFFAOYSA-N CNCc1cc2cccnc2cc1 Chemical compound CNCc1cc2cccnc2cc1 IIPNTNDPIZNFRU-UHFFFAOYSA-N 0.000 description 1
- XMWHCMCQRPNWQC-CKAVNCISSA-N C[C@H](C(N(C(C=C1)=N)N=C1/C(/C)=N/OC(N)=O)=N)c(c(F)c(cccn1)c1c1)c1F Chemical compound C[C@H](C(N(C(C=C1)=N)N=C1/C(/C)=N/OC(N)=O)=N)c(c(F)c(cccn1)c1c1)c1F XMWHCMCQRPNWQC-CKAVNCISSA-N 0.000 description 1
- NRIGLLCJLQQTGB-UHFFFAOYSA-N O=C(c1c2cccc1)N(Cc1cc3cccnc3cc1)C2=O Chemical compound O=C(c1c2cccc1)N(Cc1cc3cccnc3cc1)C2=O NRIGLLCJLQQTGB-UHFFFAOYSA-N 0.000 description 1
- XKJCHHZQLQNZHY-UHFFFAOYSA-N O=C(c1c2cccc1)NC2=O Chemical compound O=C(c1c2cccc1)NC2=O XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 description 1
- KRKHRJAAILLRNE-UHFFFAOYSA-N O=CC(Cc1cc2cccnc2cc1)Cl Chemical compound O=CC(Cc1cc2cccnc2cc1)Cl KRKHRJAAILLRNE-UHFFFAOYSA-N 0.000 description 1
- BEVHZNIJSVHOFS-UHFFFAOYSA-N OCC(CO)ON(C(c1c2cccc1)=O)C2=O Chemical compound OCC(CO)ON(C(c1c2cccc1)=O)C2=O BEVHZNIJSVHOFS-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23544009P | 2009-08-20 | 2009-08-20 | |
US61/235,440 | 2009-08-20 | ||
CNPCT/CN2010/071978 | 2010-04-21 | ||
CN2010071978 | 2010-04-21 | ||
CN2010074089 | 2010-06-18 | ||
CNPCT/CN2010/074089 | 2010-06-18 | ||
PCT/EP2010/062057 WO2011020861A1 (en) | 2009-08-20 | 2010-08-18 | Heterocyclic oxime compounds |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2013502396A JP2013502396A (ja) | 2013-01-24 |
JP2013502396A5 JP2013502396A5 (US07122547-20061017-C00224.png) | 2013-09-19 |
JP5775871B2 true JP5775871B2 (ja) | 2015-09-09 |
Family
ID=43243152
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012525167A Expired - Fee Related JP5775871B2 (ja) | 2009-08-20 | 2010-08-18 | ヘテロ環式オキシム化合物 |
Country Status (14)
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA201200260A1 (ru) | 2009-08-12 | 2012-09-28 | Новартис Аг | Гетероциклические гидразоны и их применение для лечения рака и воспаления |
HRP20221090T1 (hr) | 2009-12-31 | 2022-11-25 | Hutchison Medipharma Limited | Određeni triazolopirazini, njihovi pripravci i postupci njihove upotrebe |
DK2571878T3 (en) * | 2010-05-17 | 2019-02-11 | Indian Incozen Therapeutics Pvt Ltd | Hitherto unknown 3,5-DISUBSTITUTED-3H-IMIDAZO [4,5-B] PYRIDINE AND 3,5- DISUBSTITUTED -3H- [1,2,3] TRIAZOL [4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF PROTEIN CHINES |
EP2673277A1 (en) * | 2011-02-10 | 2013-12-18 | Novartis AG | [1, 2, 4]triazolo [4, 3 -b]pyridazine compounds as inhibitors of the c-met tyrosine kinase |
CN103459396B (zh) * | 2011-02-10 | 2015-08-19 | 诺瓦提斯公司 | 作为c-Met酪氨酸激酶抑制剂的[1,2,4]三唑并[4,3-b]哒嗪化合物 |
CN103958509B (zh) * | 2011-09-15 | 2015-12-23 | 诺华股份有限公司 | 作为酪氨酸激酶抑制剂的6-取代的3-(喹啉-6-基硫代)-[1,2,4]三唑并[4,3-a]吡啶化合物 |
WO2013038362A1 (en) | 2011-09-15 | 2013-03-21 | Novartis Ag | 6 - substituted 3 - (quinolin- 6 - ylthio) - [1,2,4] triazolo [4, 3 -a] pyradines as tyrosine kinase |
KR102015968B1 (ko) | 2011-12-27 | 2019-08-29 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | 살진균제로서의 헤테로아릴피페리딘 및 피페라진 유도체 |
MX358508B (es) | 2012-10-16 | 2018-08-22 | Janssen Pharmaceutica Nv | Moduladores de quinolinilo unidos a metileno de receptor nuclear de acido retinoico-gamma-t. |
US9303015B2 (en) | 2012-10-16 | 2016-04-05 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORγt |
ES2628365T3 (es) | 2012-10-16 | 2017-08-02 | Janssen Pharmaceutica N.V. | Moduladores de quinolinilo unidos a fenilo de ROR-GAMA-T |
EP2917210B1 (en) | 2012-11-06 | 2019-02-27 | Shanghai Fochon Pharmaceutical Co. Ltd | Alk kinase inhibitors |
CA2927182A1 (en) | 2013-10-15 | 2015-04-23 | Janssen Pharmaceutica Nv | Quinolinyl modulators of ror.gamma.t |
US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
EP3057421B1 (en) | 2013-10-15 | 2019-11-20 | Janssen Pharmaceutica NV | Alkyl linked quinolinyl modulators of ror(gamma)t |
US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
GB201321736D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
EP3241830A1 (de) | 2016-05-04 | 2017-11-08 | Bayer CropScience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
CN116903624A (zh) * | 2016-11-29 | 2023-10-20 | Ptc医疗Mp公司 | 墨蝶呤及其盐的多晶型物 |
MX2020002271A (es) | 2017-09-01 | 2020-10-05 | Ptc Therapeutics Mp Inc | Composiciones farmaceuticas que comprenden sepiapterina y sus usos de las mismas. |
GB201908511D0 (en) | 2019-06-13 | 2019-07-31 | Adorx Therapeutics Ltd | Hydroxamate compounds |
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KR20120089463A (ko) | 2012-08-10 |
US20120302570A1 (en) | 2012-11-29 |
BR112012008061A2 (pt) | 2016-03-01 |
US8410264B2 (en) | 2013-04-02 |
AR079486A1 (es) | 2012-02-01 |
EA201200318A1 (ru) | 2012-09-28 |
EP2467383A1 (en) | 2012-06-27 |
MX2012002179A (es) | 2012-03-16 |
WO2011020861A1 (en) | 2011-02-24 |
US20110065708A1 (en) | 2011-03-17 |
TW201113284A (en) | 2011-04-16 |
US8507676B2 (en) | 2013-08-13 |
IN2012DN01453A (US07122547-20061017-C00224.png) | 2015-06-05 |
AU2010284972A1 (en) | 2012-03-08 |
CA2771432A1 (en) | 2011-02-24 |
UY32848A (es) | 2011-03-31 |
JP2013502396A (ja) | 2013-01-24 |
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