JP5756428B2 - 新規なスタフィロコッカス・アウレウス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓ）プロテインＡベースのリガンドを含むクロマトグラフィーマトリックス - Google Patents

新規なスタフィロコッカス・アウレウス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓ）プロテインＡベースのリガンドを含むクロマトグラフィーマトリックス Download PDF

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JP5756428B2
JP5756428B2 JP2012124067A JP2012124067A JP5756428B2 JP 5756428 B2 JP5756428 B2 JP 5756428B2 JP 2012124067 A JP2012124067 A JP 2012124067A JP 2012124067 A JP2012124067 A JP 2012124067A JP 5756428 B2 JP5756428 B2 JP 5756428B2
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affinity chromatography
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JP2012254981A (ja
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シヤリー・スペクター
ロバート・スミス
ジヨー・オーランド
ナンイン・ビエン
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イー・エム・デイー・ミリポア・コーポレイシヨン
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
JP2012124067A 2011-06-08 2012-05-31 新規なスタフィロコッカス・アウレウス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓ）プロテインＡベースのリガンドを含むクロマトグラフィーマトリックス Active JP5756428B2 (ja)

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US201161494701P 2011-06-08 2011-06-08
US61/494,701 2011-06-08

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JP2014101360A Division JP6018120B2 (ja) 2011-06-08 2014-05-15 新規なスタフィロコッカス・アウレウス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓ）プロテインＡベースのリガンドを含むクロマトグラフィーマトリックス

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JP2012254981A JP2012254981A (ja) 2012-12-27
JP5756428B2 true JP5756428B2 (ja) 2015-07-29

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JP2012124067A Active JP5756428B2 (ja) 2011-06-08 2012-05-31 新規なスタフィロコッカス・アウレウス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓ）プロテインＡベースのリガンドを含むクロマトグラフィーマトリックス
JP2014101360A Active JP6018120B2 (ja) 2011-06-08 2014-05-15 新規なスタフィロコッカス・アウレウス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓ）プロテインＡベースのリガンドを含むクロマトグラフィーマトリックス
JP2016140214A Active JP6189493B2 (ja) 2011-06-08 2016-07-15 新規なスタフィロコッカス・アウレウス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）プロテインＡベースのリガンドを含むクロマトグラフィーマトリックス
JP2017148843A Active JP6586131B2 (ja) 2011-06-08 2017-08-01 新規なスタフィロコッカス・アウレウス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）プロテインＡベースのリガンドを含むクロマトグラフィーマトリックス

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JP2016140214A Active JP6189493B2 (ja) 2011-06-08 2016-07-15 新規なスタフィロコッカス・アウレウス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）プロテインＡベースのリガンドを含むクロマトグラフィーマトリックス
JP2017148843A Active JP6586131B2 (ja) 2011-06-08 2017-08-01 新規なスタフィロコッカス・アウレウス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）プロテインＡベースのリガンドを含むクロマトグラフィーマトリックス

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US (5) US8754196B2 (enExample)
EP (2) EP3053931B1 (enExample)
JP (4) JP5756428B2 (enExample)
KR (3) KR101464040B1 (enExample)
CN (2) CN102895960B (enExample)
AU (3) AU2012366229C1 (enExample)
DK (2) DK2532672T3 (enExample)
ES (2) ES2671722T3 (enExample)
IL (2) IL229774A (enExample)
RU (2) RU2595430C2 (enExample)
SG (3) SG10201604559TA (enExample)
TW (3) TWI638828B (enExample)
WO (1) WO2013109302A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014193892A (ja) * 2011-06-08 2014-10-09 E M D Millipore Corp 新規なスタフィロコッカス・アウレウス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓ）プロテインＡベースのリガンドを含むクロマトグラフィーマトリックス

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040067532A1 (en) 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
EP3124497B1 (en) 2007-09-14 2020-04-15 Adimab, LLC Rationally designed, synthetic antibody libraries and uses therefor
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
US8592555B2 (en) 2008-08-11 2013-11-26 Emd Millipore Corporation Immunoglobulin-binding proteins with improved specificity
SG162687A1 (en) 2008-12-24 2010-07-29 Millipore Corp Caustic stable chromatography ligands
WO2013081540A1 (en) * 2011-11-30 2013-06-06 Ge Healthcare Bio-Sciences Ab Affinity chromatography matrix
WO2014004103A1 (en) 2012-06-29 2014-01-03 Emd Millipore Corporation Methods for inactivating viruses during a protein purification process
EP2682168A1 (en) 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
CA2885263C (en) 2012-09-17 2021-11-16 W. R. Grace & Co.-Conn. Chromatography media and devices
SG11201404684RA (en) 2012-09-17 2014-10-30 Grace W R & Co Functionalized particulate support material and methods of making and using the same
ES2735354T3 (es) * 2013-03-14 2019-12-18 Emd Millipore Corp Métodos para aumentar la pureza de proteínas utilizando la cromatografía basada en proteína A
US9896486B2 (en) * 2013-07-10 2018-02-20 Ge Healthcare Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
KR102058067B1 (ko) * 2013-09-04 2019-12-20 이엠디 밀리포어 코포레이션 단백질 a 기반 친화성 크로마토그래피 컬럼의 세정 방법
SG11201605712SA (en) * 2014-01-16 2016-08-30 Grace W R & Co Affinity chromatography media and chromatography devices
CN107847907A (zh) 2014-05-02 2018-03-27 格雷斯公司 官能化载体材料以及制备和使用官能化载体材料的方法
EP2985076B1 (en) * 2014-08-15 2022-03-30 Merck Patent GmbH Purification of immunoglobulins from plasma
US11566082B2 (en) * 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
CN104399283B (zh) * 2014-12-04 2016-02-17 江西省农业科学院农产品质量安全与标准研究所 黄曲霉毒素b1适配体亲和柱的制备方法
CN104645949B (zh) * 2015-02-04 2017-01-25 浙江大学 一种以四肽为功能配基的亲和层析介质及其制备方法
JP6805831B2 (ja) 2015-02-05 2020-12-23 三菱ケミカル株式会社 免疫グロブリンに親和性を有するタンパク質、およびそれを用いたアフィニティ分離剤、液体クロマトグラフィー用カラム
JP6738340B2 (ja) 2015-02-06 2020-08-12 ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ 新規なｅｇｆｒ結合タンパク質
GB201503578D0 (en) 2015-03-03 2015-04-15 Ge Healthcare Bio Sciences Ab Sanitization method for affinity chromatography matrices
EP3276002B1 (en) * 2015-03-26 2020-04-29 JSR Corporation Immunoglobulin-binding protein and affinity carrier using same
WO2016167143A1 (ja) * 2015-04-13 2016-10-20 富士フイルム株式会社 短鎖ペプチド固定化担体の製造方法および短鎖ペプチド固定化担体
BR112017026193B1 (pt) 2015-06-05 2021-09-14 W.R. Grace & Co-Conn Adsorventes, método de produção dos adsorventes e uso dos adsorventes
CA2991812C (en) * 2015-07-16 2024-02-13 Navigo Proteins Gmbh Immunoglobulin-binding proteins and their use in affinity purification
JP2018520675A (ja) 2015-07-20 2018-08-02 ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ ジユビキチン変異タンパク質をベースとした新規結合タンパク質及びその生成方法
GB201515339D0 (en) * 2015-08-28 2015-10-14 Ge Healthcare Bio Sciences Ab A seperation matrix and a method of seperating antibodies
US20170066839A1 (en) 2015-09-08 2017-03-09 Merck Patent Gmbh Novel affinity chromatography media for removal of anti-a and/or anti-b antibodies
US10697982B2 (en) * 2015-09-08 2020-06-30 Merck Patent Gmbh Methods of evaluating quality of a chromatography media which binds anti-A or anti-B antibodies
US10697983B2 (en) * 2015-09-08 2020-06-30 Merck Patent Gmbh Methods of evaluating quality of media suitable for removing anti-A or anti-B antibodies
CN105413644A (zh) * 2015-12-02 2016-03-23 南昌大学 基于特异结合黄曲霉毒素单域重链抗体的亲和吸附材料
KR101993845B1 (ko) * 2016-02-18 2019-06-28 (주)에이피테크놀로지 알칼리 저항성이 증대된 항체 친화성 리간드
CA3022751A1 (en) 2016-05-04 2017-11-09 Navigo Proteins Gmbh Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker
CN109311949B (zh) 2016-05-11 2022-09-16 思拓凡生物工艺研发有限公司 储存分离基质的方法
US10889615B2 (en) 2016-05-11 2021-01-12 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
JP6987424B2 (ja) 2016-05-11 2022-01-05 サイティバ・バイオプロセス・アールアンドディ・アクチボラグ 分離マトリックスを洗浄および／または消毒する方法
US10703774B2 (en) 2016-09-30 2020-07-07 Ge Healthcare Bioprocess R&D Ab Separation method
US10730908B2 (en) 2016-05-11 2020-08-04 Ge Healthcare Bioprocess R&D Ab Separation method
WO2017194597A1 (en) 2016-05-11 2017-11-16 Ge Healthcare Bioprocess R&D Ab Separation matrix
DK3455244T3 (da) * 2016-05-11 2022-06-07 Cytiva Bioprocess R & D Ab Muterede immunoglobulin-bindende polypeptider
US10654887B2 (en) 2016-05-11 2020-05-19 Ge Healthcare Bio-Process R&D Ab Separation matrix
JP7031934B2 (ja) 2016-05-11 2022-03-08 サイティバ・バイオプロセス・アールアンドディ・アクチボラグ 分離マトリックス
KR101857953B1 (ko) * 2016-07-06 2018-05-16 아미코젠주식회사 알칼리 내성이 증가된 변이 면역글로불린 결합 단백질
CN109963864B (zh) 2016-08-11 2024-01-02 瑞普利金公司 用于亲和色谱的碱性稳定性fc结合蛋白
US12448411B2 (en) 2016-09-30 2025-10-21 Cytiva Bioprocess R&D Ab Separation method
EP3551646A1 (en) 2016-12-12 2019-10-16 HurraH S.à r.l. Compositions and methods for increasing the immunoglobulin binding capacities of immunoglobulin-binding polypeptides and oligopeptides
CN106596822B (zh) * 2016-12-16 2018-01-19 南京市产品质量监督检验院 一种食品中金黄色葡萄球菌苯酚可溶性调控蛋白的检测方法
GB201708277D0 (en) * 2017-05-24 2017-07-05 Ge Healthcare A Recombinant protein
EP4491268A3 (en) 2017-08-07 2025-04-09 Repligen Corporation Fc binding proteins with cysteine in the c-terminal helical region
WO2019091918A1 (en) 2017-11-07 2019-05-16 Navigo Proteins Gmbh Fusion proteins with specificity for ed-b and long serum half-life for diagnosis or treatment of cancer
EP3708667B1 (en) 2017-11-09 2025-01-01 Tosoh Corporation Immunoglobulin-binding protein
EP4249097A3 (en) 2018-02-01 2024-01-10 Repligen Corporation Fc binding proteins with cysteine in the c-terminal helical region
US20210130395A1 (en) * 2018-05-11 2021-05-06 William Marsh Rice University Proximity induced site-specific antibody conjugation
KR102055708B1 (ko) 2018-06-26 2019-12-13 동일플랜트 주식회사 스팀 배기관에 삽입된 히트파이프를 이용한 드래프트 방식 복수기
WO2020040307A1 (ja) 2018-08-24 2020-02-27 Jsr株式会社 イムノグロブリン結合タンパク質、及びそれを用いたアフィニティー担体
GB201904125D0 (en) 2019-03-26 2019-05-08 Ge Healthcare Bio Sciences Ab Method for sanitization of a chromatography column
CN112210013A (zh) * 2019-07-03 2021-01-12 拜奥普罗塞亚科技有限责任公司 碱耐受性亲和色谱配体
IL317159A (en) * 2019-09-24 2025-01-01 Regeneron Pharma Systems and methods for use in chromatography and regeneration
EP3875472A1 (en) * 2020-03-06 2021-09-08 Navigo Proteins Gmbh Novel immunoglobulin binding polypeptides
GB202113626D0 (en) 2021-09-24 2021-11-10 Cytiva Bioprocess R & D Ab FC binding polypeptides
GB202203478D0 (en) 2022-03-14 2022-04-27 Cytiva Bioprocess R & D Ab Vh3 binding polypeptides
CN115850408A (zh) * 2022-09-01 2023-03-28 西安蓝晓科技新材料股份有限公司 一种多肽、融合型多聚体蛋白质及其用途

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8204810L (sv) 1982-08-23 1984-02-24 Pharmacia Fine Chemicals Ab Hybrid-dna-molekyl, transformerad mikroorganism och sett att framstella protein a
US5151350A (en) 1982-10-27 1992-09-29 Repligen Corporation Cloned genes encoding recombinant protein a
US4617266A (en) 1983-04-28 1986-10-14 Genex Corporation Production of Protein A
NZ218050A (en) 1985-11-13 1989-05-29 Wistar Inst Test for the presence of htlv-1v
SE8505922D0 (sv) 1985-12-13 1985-12-13 Kabigen Ab Construction of an igg binding protein to facilitate downstream processing using protein engineering
US5260373A (en) 1987-03-13 1993-11-09 Repligen Corporation Immobilized immunoglobulin-binding proteins
US5084559A (en) 1987-03-27 1992-01-28 Repligen Corporation Protein a domain mutants
US5089473A (en) 1988-08-29 1992-02-18 Monsanto Company Somatotropin variants and their use
GB8902770D0 (en) 1989-02-08 1989-03-30 Bioprocessing Ltd Improvements in or relating to supports for immunoaffinity separations
US4879378A (en) 1989-03-30 1989-11-07 Union Carbide Chemicals And Plastics Company Inc. Polysiloxanes with pendant sterically hindered phenol moiety connected to the silicon atom via a carbonylyoxy-containing link
US5401650A (en) 1990-10-24 1995-03-28 The Mount Sinai School Of Medicine Of The City University Of New York Cloning and expression of biologically active α-galactosidase A
US5198531A (en) 1991-06-14 1993-03-30 Research Diagnostic Antibodies Polymeric resin for peptide synthesis
EP0863210A3 (en) 1991-07-25 1999-09-22 Oriental Yeast Co., Ltd. Immunoglobulin-binding artificial protein
US5240680A (en) 1991-12-19 1993-08-31 Chiron Corporation Automated apparatus for use in peptide synthesis
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
SE9400088D0 (sv) 1994-01-14 1994-01-14 Kabi Pharmacia Ab Bacterial receptor structures
SE9503925D0 (sv) 1995-11-07 1995-11-07 Pharmacia Biotech Ab Separationsmedium för IgG
AU2429397A (en) 1996-03-29 1997-10-22 David S. Terman Polymerized staphylococcal protein a for treatment of diseases
US6013763A (en) 1996-06-04 2000-01-11 Genentech, Inc. Peptide variants of protein A
US5856452A (en) 1996-12-16 1999-01-05 Sembiosys Genetics Inc. Oil bodies and associated proteins as affinity matrices
CA2315944A1 (en) 1997-12-24 1999-07-08 Diatech Pty. Ltd. Bifunctional molecules
GB9823071D0 (en) 1998-10-21 1998-12-16 Affibody Technology Ab A method
US6589529B1 (en) 1998-10-30 2003-07-08 Children's Hospital Medical Center Rotavirus subunit vaccine
SE9901379D0 (sv) 1999-04-19 1999-04-19 Pharmacia & Upjohn Ab Receptor structures
US6602977B1 (en) 1999-04-19 2003-08-05 Biovitrum Ab Receptor structures
WO2000069457A1 (en) 1999-05-15 2000-11-23 University Of California, San Diego Protein a based binding domains with desirable activities
US7163686B1 (en) 1999-05-15 2007-01-16 The Regents Of The University Of California Protein A based binding domains with desirable activities
EP3960855A1 (en) 2001-12-28 2022-03-02 Chugai Seiyaku Kabushiki Kaisha Method for stabilizing proteins
US7709209B2 (en) 2002-03-25 2010-05-04 Ge Healthcare Bio-Sciences Ab Protein ligands
SE0200943D0 (sv) * 2002-03-25 2002-03-25 Amersham Biosciences Ab Mutant protein
US7083948B1 (en) 2002-12-24 2006-08-01 Immunex Corporation Polypeptide purification reagents and methods for their use
PT1601697E (pt) 2003-02-28 2007-09-04 Lonza Biologics Plc Purificação de anticorpos através de proteína a e cromatografia de troca iónica.
GB0304576D0 (en) 2003-02-28 2003-04-02 Lonza Biologics Plc Protein a chromatography
US7993650B2 (en) 2003-07-04 2011-08-09 Affibody Ab Polypeptides having binding affinity for HER2
US7956165B2 (en) 2003-07-24 2011-06-07 Affisink Biotechnology Ltd. Compositions and methods for purifying and crystallizing molecules of interest
CA2541015A1 (en) 2003-10-03 2005-04-14 Genentech, Inc. Igf binding proteins
EP1564286A1 (en) * 2004-02-11 2005-08-17 Université de Liège Hybrid proteins of beta-lactamase class A
EP2251425B1 (en) 2004-07-06 2016-04-20 Kaneka Corporation Process for producing protein A-like protein with use of Brevibacillus genus bacterium
US8728828B2 (en) 2004-12-22 2014-05-20 Ge Healthcare Bio-Sciences Ab Purification of immunoglobulins
US20080254551A1 (en) 2004-12-30 2008-10-16 Achsel Tilmann Immunoprecipitaion-Based Method to Purify and Characterise Biological Macromolecular Complexes
EP1869071B1 (en) 2005-03-01 2010-12-01 Affibody AB Tnf-alpha binding polypeptide, uses thereof and methods employing it
JP2006304633A (ja) 2005-04-26 2006-11-09 Apro Life Science Institute Inc イムノグロブリン結合タンパク質
ES2402650T3 (es) * 2005-06-17 2013-05-07 Janssen Alzheimer Immunotherapy Métodos de purificación de anticuerpos anti A beta
US20100015044A1 (en) 2005-08-03 2010-01-21 Robert Qiu Methods and compositions for diagnosis of iga-and igm-mediated kidney diseases
CN102417557B (zh) 2005-08-03 2015-03-11 默克专利股份公司 亲水交联聚合物
WO2007061936A2 (en) 2005-11-18 2007-05-31 New England Medical Center Hospitals, Inc. Clearance of abnormal iga1 in iga1 deposition diseases
JP5530633B2 (ja) 2006-01-06 2014-06-25 イー・エム・デイー・ミリポア・コーポレイシヨン アフィニティークロマトグラフィーマトリックスおよびその作成および使用法。
US8674073B2 (en) 2006-02-21 2014-03-18 Protenova Co., Ltd. Immunoglobulin affinity ligand
US20080096819A1 (en) 2006-05-02 2008-04-24 Allozyne, Inc. Amino acid substituted molecules
GB0610776D0 (en) 2006-05-31 2006-07-12 Univ Bath Novel applications for staphylococcus aureus Sbi protein
CN101522278B (zh) * 2006-09-29 2016-08-10 通用电气健康护理生物科学股份公司 用于抗体分离的包含来自金黄色葡萄球菌a蛋白的结构域c的层析配体
JP5004165B2 (ja) 2006-10-10 2012-08-22 独立行政法人産業技術総合研究所 タンパク質の配向制御固定化に適したタンパク質
US7691608B2 (en) 2006-12-06 2010-04-06 Repligen Corporation Nucleic acids encoding recombinant protein A
US8362217B2 (en) 2006-12-21 2013-01-29 Emd Millipore Corporation Purification of proteins
KR101431856B1 (ko) 2007-01-22 2014-08-27 제넨테크, 인크. 항체의 고분자전해질 침전 및 정제
JP2008266221A (ja) 2007-04-20 2008-11-06 National Institute Of Advanced Industrial & Technology アミノ末端１箇所で配向制御固定化された固定化タンパク質
WO2008143199A1 (ja) 2007-05-21 2008-11-27 Nomadic Bioscience Co., Ltd. 新規ポリペプチド，アフィニティークロマトグラフィー用材，及びイムノグロブリンの分離及び／又は精製方法
SG149759A1 (en) 2007-07-10 2009-02-27 Millipore Corp Media for affinity chromatography
JP2009071766A (ja) 2007-09-18 2009-04-02 Panasonic Corp 受信端末装置
CN103396480A (zh) 2008-05-15 2013-11-20 诺沃—诺迪斯克有限公司 抗体纯化方法
US9238810B2 (en) 2008-06-05 2016-01-19 Affibody Ab Polypeptide
US8592555B2 (en) * 2008-08-11 2013-11-26 Emd Millipore Corporation Immunoglobulin-binding proteins with improved specificity
SG162687A1 (en) 2008-12-24 2010-07-29 Millipore Corp Caustic stable chromatography ligands
US20120149875A1 (en) 2009-01-12 2012-06-14 Ge Healthcare Bio-Sciences Ab Affinity chromatography matrix
CN102365361B (zh) 2009-03-24 2015-09-02 株式会社钟化 对免疫球蛋白具有亲和性的蛋白质和免疫球蛋白结合性亲和配体
JP2014502272A (ja) * 2010-11-29 2014-01-30 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ アフィニティークロマトグラフィーマトリックス
US9683013B2 (en) 2010-12-20 2017-06-20 Ge Healthcare Bioprocess R&D Ab Affinity chromatography matrix
WO2012133349A1 (ja) * 2011-03-25 2012-10-04 株式会社カネカ アフィニティー分離マトリックス用タンパク質
SG10201604559TA (en) 2011-06-08 2016-07-28 Emd Millipore Corp Chromatography matrices including novel staphylococcus aureus protein a based ligands

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014193892A (ja) * 2011-06-08 2014-10-09 E M D Millipore Corp 新規なスタフィロコッカス・アウレウス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓ）プロテインＡベースのリガンドを含むクロマトグラフィーマトリックス
JP2017019792A (ja) * 2011-06-08 2017-01-26 イー・エム・デイー・ミリポア・コーポレイシヨン 新規なスタフィロコッカス・アウレウス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）プロテインＡベースのリガンドを含むクロマトグラフィーマトリックス
JP2018021038A (ja) * 2011-06-08 2018-02-08 イー・エム・デイー・ミリポア・コーポレイシヨン 新規なスタフィロコッカス・アウレウス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）プロテインＡベースのリガンドを含むクロマトグラフィーマトリックス

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