JP5755884B2 - 第一級アルコールを産生する生物 - Google Patents

第一級アルコールを産生する生物 Download PDF

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JP5755884B2
JP5755884B2 JP2010549897A JP2010549897A JP5755884B2 JP 5755884 B2 JP5755884 B2 JP 5755884B2 JP 2010549897 A JP2010549897 A JP 2010549897A JP 2010549897 A JP2010549897 A JP 2010549897A JP 5755884 B2 JP5755884 B2 JP 5755884B2
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coa
production
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naturally occurring
gene
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JP2011512848A (ja
JP2011512848A5 (enExample
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ジュン サン，
ジュン サン，
プリティ ファルキヤ，
プリティ ファルキヤ，
アンソニー ピー． バーガード，
アンソニー ピー． バーガード，
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ジェノマティカ， インコーポレイテッド
ジェノマティカ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01001—Alcohol dehydrogenase (1.1.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01035—3-Hydroxyacyl-CoA dehydrogenase (1.1.1.35)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/0105—Long-chain-fatty-acyl-CoA reductase (1.2.1.50)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01009—Acetyl-CoA C-acetyltransferase (2.3.1.9)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01016—Acetyl-CoA C-acyltransferase (2.3.1.16)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01017—Enoyl-CoA hydratase (4.2.1.17), i.e. crotonase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
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  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2010549897A 2008-03-05 2009-03-05 第一級アルコールを産生する生物 Expired - Fee Related JP5755884B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US3414608P 2008-03-05 2008-03-05
US61/034,146 2008-03-05
US9017108P 2008-08-19 2008-08-19
US61/090,171 2008-08-19
US11050008P 2008-10-31 2008-10-31
US61/110,500 2008-10-31
PCT/US2009/036242 WO2009111672A1 (en) 2008-03-05 2009-03-05 Primary alcohol producing organisms

Related Child Applications (1)

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JP2014042892A Division JP2014100147A (ja) 2008-03-05 2014-03-05 第一級アルコールを産生する生物

Publications (3)

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JP2011512848A JP2011512848A (ja) 2011-04-28
JP2011512848A5 JP2011512848A5 (enExample) 2012-04-05
JP5755884B2 true JP5755884B2 (ja) 2015-07-29

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JP2014042892A Withdrawn JP2014100147A (ja) 2008-03-05 2014-03-05 第一級アルコールを産生する生物

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US (5) US7977084B2 (enExample)
EP (2) EP2262901B1 (enExample)
JP (2) JP5755884B2 (enExample)
BR (1) BRPI0909690A2 (enExample)
CA (2) CA3081506A1 (enExample)
DK (1) DK2262901T3 (enExample)
ES (1) ES2703775T3 (enExample)
PL (1) PL2262901T3 (enExample)
SI (1) SI2262901T1 (enExample)
WO (1) WO2009111672A1 (enExample)
ZA (1) ZA201007065B (enExample)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8110670B2 (en) 2006-05-19 2012-02-07 Ls9, Inc. Enhanced production of fatty acid derivatives
US20100242345A1 (en) 2006-05-19 2010-09-30 LS9, Inc Production of fatty acids & derivatives thereof
US9080187B2 (en) * 2007-05-17 2015-07-14 The Board Of Trustees Of The University Of Illinois Methods and compositions for producing solvents
CA2712779C (en) 2008-01-22 2021-03-16 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
CA3081506A1 (en) 2008-03-05 2009-09-11 Genomatica, Inc. Long chain alcohol-producing organisms
MX350285B (es) 2008-05-16 2017-09-04 Reg Life Sciences Llc Métodos y composiciones para producir hidrocarburos.
US8129154B2 (en) 2008-06-17 2012-03-06 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
ES2550467T3 (es) 2008-10-07 2015-11-10 REG Life Sciences, LLC Métodos y composiciones para producir aldehídos grasos
ES2505115T3 (es) * 2008-10-28 2014-10-09 Ls9, Inc. Métodos para producir alcoholes grasos
WO2010057022A1 (en) * 2008-11-14 2010-05-20 Genomatica, Inc. Microorganisms for the production of methyl ethyl ketone and 2-butanol
EP2376619A4 (en) * 2008-12-15 2012-07-04 Greenlight Biosciences Inc METHODS FOR CONTROLLING FLOWS IN METABOLIC PATHWAYS
WO2010071697A1 (en) 2008-12-16 2010-06-24 Genomatica, Inc. Microorganisms and methods for conversion of syngas and other carbon sources to useful products
CN102459622B (zh) 2009-04-27 2020-08-18 基因组股份公司 脂肪酸酯的产生
BRPI1015461A2 (pt) * 2009-04-29 2015-09-01 Eudes De Crecy Organismo evolucionariamente modificado, método de produção do organismo e de produto final, fábrica de biocombustível, método para produzir um produto de biocombustível.
WO2010144746A2 (en) * 2009-06-10 2010-12-16 Genomatica, Inc. Microorganisms and methods for carbon-efficient biosynthesis of mek and 2-butanol
EP2277989A1 (en) 2009-07-24 2011-01-26 Technische Universiteit Delft Fermentative glycerol-free ethanol production
CN109136161A (zh) 2009-12-10 2019-01-04 基因组股份公司 合成气或其他气态碳源和甲醇转化为1,3-丁二醇的方法和有机体
US8637286B2 (en) 2010-02-23 2014-01-28 Genomatica, Inc. Methods for increasing product yields
EP2546331B1 (en) 2010-03-09 2019-07-03 Mitsui Chemicals, Inc. Highly productive isopropyl alcohol-producing bacterium
US20110250663A1 (en) 2010-04-08 2011-10-13 Ls9, Inc. Methods and compositions related to fatty alcohol biosynthetic enzymes
US20110269201A1 (en) * 2010-04-30 2011-11-03 Qteros, Inc. Redirected bioenergetics in recombinant cellulolytic clostridium microorganisms
BR112012028290B1 (pt) 2010-05-05 2021-02-02 Lallemand Hungary Liquidity Management Llc. levedura recombinante, processo para converter biomassa em etanol e meio de fermentação compreendendo dita levedura
CA2797786C (en) 2010-05-07 2020-09-22 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways through enzyme relocation
JP5852648B2 (ja) 2010-07-15 2016-02-03 ザ プロクター アンド ギャンブルカンパニー 鎖端付近分枝型化合物（ｎｅａｒｔｅｒｍｉｎａｌ−ｂｒａｎｃｈｅｄｃｏｍｐｏｕｎｄ）を含む組成物及びその製造方法
CA2807561C (en) 2010-08-06 2022-04-12 Mascoma Corporation Production of malonyl-coa derived products via anaerobic pathways
ES2839424T3 (es) 2010-08-31 2021-07-05 Greenlight Biosciences Inc Métodos para control de flujo en vías metabólicas mediante manipulación de proteasas
EP2655612B1 (en) * 2010-12-23 2017-07-19 Shell Internationale Research Maatschappij B.V. Gene disruptants producing fatty acyl-coa derivatives
EP2673369B1 (en) 2011-02-07 2017-04-05 William Marsh Rice University Reverse beta oxidation pathway
CA2827658A1 (en) 2011-02-17 2012-08-23 The Procter & Gamble Company Bio-based linear alkylphenyl sulfonates
JP5815750B2 (ja) 2011-02-17 2015-11-17 ザ プロクター アンド ギャンブルカンパニー Ｃ１０〜ｃ１３アルキルフェニルスルホネートの混合物を含む組成物
WO2012118933A1 (en) * 2011-03-01 2012-09-07 Rutgers, The State University Of New Jersey Genetically engineered microbes and uses thereof
CN102174419B (zh) * 2011-03-24 2013-04-03 南京工业大学 一株米根霉菌株及其诱变筛选方法和发酵生产富马酸的方法
AU2012273005A1 (en) * 2011-06-22 2013-05-09 Genomatica, Inc. Microorganism for producing primary alcohols and related compounds and methods related thereto
WO2013003432A1 (en) * 2011-06-29 2013-01-03 Genomatica, Inc. Microorganisms for producing succinate and methods related thereto
MX348706B (es) 2011-07-12 2017-06-26 Scientist Of Fortune Sa Microorganismo recombinante para la produccion de metabolitos utiles.
CA2880785A1 (en) 2011-08-03 2013-02-07 REG Life Sciences, LLC Production of fatty acids and derivatives thereof having improved aliphatic chain length and saturation characteristics
CN103998600A (zh) 2011-09-07 2014-08-20 威廉马什莱斯大学 通过反向脂肪酸氧化的官能化羧酸和醇
WO2013036787A2 (en) 2011-09-09 2013-03-14 Greenlight Biosciences, Inc. Cell-free preparation of carbapenems
DE102012207921A1 (de) 2012-05-11 2013-11-14 Evonik Industries Ag Mehrstufiges Syntheseverfahren mit Synthesegas
KR101464656B1 (ko) 2012-06-15 2014-12-02 한국생명공학연구원 발효산물 고생성능을 가지는 변이 미생물 및 이를 이용한 발효산물의 제조방법
WO2014004616A2 (en) * 2012-06-26 2014-01-03 Gevo, Inc. Engineered yeast with improved growth under low aeration
WO2014016328A1 (en) * 2012-07-25 2014-01-30 Total Marketing Services Genetically engineered micro-organisms for production of fatty acids
US20140051136A1 (en) 2012-08-10 2014-02-20 Opx Biotechnologies, Inc. Micoorganisms and Methods for the Production of Fatty Acids and Fatty Acid Derived Products
EP2906705A4 (en) * 2012-10-15 2016-09-07 Genomatica Inc MICRO-ORGANISMS AND METHOD FOR PRODUCING FAT-ALCOHOLS OF SPECIFIC LENGTH AND RELATED COMPOUNDS
JP2016504034A (ja) 2012-12-21 2016-02-12 グリーンライト バイオサイエンシーズ インコーポレーテッドＧｒｅｅｎｌｉｇｈｔ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． メタンを燃料、ピルビン酸またはイソブタノールに変換する無細胞システム
JP2014193153A (ja) * 2013-02-28 2014-10-09 Euglena Co Ltd ユーグレナへの遺伝子導入方法
BR112015020827A2 (pt) * 2013-02-28 2017-10-10 Euglena Co Ltd método para a introdução de gene em euglena, e transformante do mesmo
US9267158B2 (en) 2013-03-14 2016-02-23 Intrexon Corporation Biological production of multi-carbon compounds from methane
WO2014146026A1 (en) 2013-03-15 2014-09-18 Opx Biotechnologies, Inc. Bioproduction of chemicals
EP2971021A4 (en) 2013-03-15 2016-12-21 Genomatica Inc MICROORGANISMS AND METHOD FOR THE PRODUCTION OF BUTADIENE AND RELATED COMPOUNDS BY FORMATASSIMILATION
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
WO2015010103A2 (en) 2013-07-19 2015-01-22 Opx Biotechnologies, Inc. Microorganisms and methods for the production of fatty acids and fatty acid derived products
SG11201600898YA (en) 2013-08-05 2016-03-30 Greenlight Biosciences Inc Engineered proteins with a protease cleavage site
CN103571764B (zh) * 2013-08-26 2015-06-10 天津科技大学 一种高产中链脂肪酸乙酯的酿酒酵母工程菌及其构建方法
WO2015057154A2 (en) * 2013-10-18 2015-04-23 Biopetrolia Ab ENGINEERING OF ACETYL-CoA METABOLISM IN YEAST
EP4296364B1 (en) 2013-12-03 2025-12-03 Genomatica, Inc. Microorganisms and methods for improving product yields on methanol using acetyl-coa synthesis
EP3087174B1 (en) 2013-12-27 2020-05-13 Genomatica, Inc. Methods and organisms with increased carbon flux efficiencies
JP6034332B2 (ja) 2014-05-30 2016-11-30 トヨタ自動車株式会社 組換え微生物及び当該組換え微生物を用いた物質製造方法
JP6189793B2 (ja) 2014-05-30 2017-08-30 トヨタ自動車株式会社 組換え微生物及び当該組換え微生物を用いた物質製造方法
EP3470840B1 (en) 2014-06-12 2021-03-03 Hyglos Invest GmbH Unmasking endotoxins in solution
ES2942896T3 (es) 2014-06-12 2023-06-07 Biomerieux Deutschland Gmbh Desenmascaramiento de endotoxinas en disolución
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
CN120624582A (zh) 2014-09-18 2025-09-12 基因组股份公司 具有提高的能源效率的非天然微生物
EP3277808A4 (en) 2015-03-30 2019-05-22 Greenlight Biosciences, Inc. ACELLULAR PRODUCTION OF RIBONUCLEIC ACID
EP3283615A4 (en) * 2015-04-15 2018-09-05 William Marsh Rice University Iterative platform for the synthesis of alpha functionalized products
US11319562B2 (en) 2015-04-15 2022-05-03 Ramon Gonzalez Modified fatty acid biosynthesis with ACP-dependent thiolases
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CN105331647B (zh) * 2015-07-03 2019-02-22 赣南师范大学 一种微生物体内合成脂肪醇乙酸酯的方法
US10301653B2 (en) * 2015-07-06 2019-05-28 Wisconsin Alumni Research Foundation Microorganisms that co-consume glucose with non-glucose carbohydrates and methods of use
CN115322261A (zh) 2015-10-30 2022-11-11 基因组股份公司 甲醇脱氢酶融合蛋白
RU2018138975A (ru) 2016-04-06 2020-05-12 Гринлайт Байосайенсис, Инк. Бесклеточная продукция рибонуклеиновой кислоты
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
WO2018129275A1 (en) 2017-01-06 2018-07-12 Greenlight Biosciences, Inc. Cell-free production of sugars
CN110494566A (zh) 2017-02-02 2019-11-22 嘉吉公司 产生c6-c10脂肪酸衍生物的经遗传修饰的细胞
WO2019075167A1 (en) 2017-10-11 2019-04-18 Greenlight Biosciences, Inc. METHODS AND COMPOSITIONS FOR THE PRODUCTION OF NUCLEOSIDE TRIPHOSPHATE AND RIBONUCLEIC ACID
US20210079334A1 (en) 2018-01-30 2021-03-18 Genomatica, Inc. Fermentation systems and methods with substantially uniform volumetric uptake rate of a reactive gaseous component
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
CA3103377A1 (en) 2018-06-26 2020-01-02 Genomatica, Inc. Engineered microorganisms with g3p---> 3pg enzyme and/or fructose-1,6-bisphosphatase including those having synthetic or enhanced methylotrophy
WO2023178261A1 (en) * 2022-03-16 2023-09-21 Genomatica, Inc. Microbial production of z3-hexenol, z3-hexenal and z3-hexenyl acetate

Family Cites Families (180)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3513209A (en) * 1968-08-19 1970-05-19 Du Pont Method of making 1,4-cyclohexadiene
US4076948A (en) * 1968-10-10 1978-02-28 El Paso Products Company Process for treatment of adipic acid mother liquor
GB1230276A (enExample) 1968-12-09 1971-04-28
US3965182A (en) * 1969-10-02 1976-06-22 Ethyl Corporation Preparation of aniline from phenol and ammonia
JPS506776Y1 (enExample) 1969-12-27 1975-02-26
JPS4831084B1 (enExample) 1970-09-04 1973-09-26
GB1344557A (en) 1972-06-23 1974-01-23 Mitsubishi Petrochemical Co Process for preparing 1,4-butanediol
JPS506776A (enExample) 1973-05-28 1975-01-23
DE2455617C3 (de) * 1974-11-23 1982-03-18 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von Butandiol und/oder Tetrahydrofuran über die Zwischenstufe des γ-Butyrolactons
DE2501499A1 (de) 1975-01-16 1976-07-22 Hoechst Ag Verfahren zur herstellung von butandiol-(1.4)
US4344002A (en) 1978-02-22 1982-08-10 Supertex, Inc. Detection circuit and structure therefor
US4301077A (en) * 1980-12-22 1981-11-17 Standard Oil Company Process for the manufacture of 1-4-butanediol and tetrahydrofuran
IT1190783B (it) 1981-04-29 1988-02-24 Davy Mckee Oil & Chem Processo per l'idrogenolisi di esteri di acidi carbossilici
US4652685A (en) * 1985-11-15 1987-03-24 General Electric Company Hydrogenation of lactones to glycols
US5143834A (en) * 1986-06-11 1992-09-01 Glassner David A Process for the production and purification of succinic acid
US5168055A (en) * 1986-06-11 1992-12-01 Rathin Datta Fermentation and purification process for succinic acid
ES2036188T3 (es) * 1986-06-11 1993-05-16 Michigan Biotechnology Institute Un procedimiento para la produccion de acido succinico por fermentacion anaerobia.
US5182199A (en) * 1987-05-27 1993-01-26 Hartley Brian S Thermophilic ethanol production in a two-stage closed system
WO1989010410A1 (fr) * 1988-04-27 1989-11-02 Daicel Chemical Industries, Ltd. Procede de preparation de 1,3-butanediol optiquement actif
DE69020555T2 (de) * 1989-04-27 1995-11-02 Biocontrol Systems Inc Fällungstest für mikroorganismen.
US5192673A (en) * 1990-04-30 1993-03-09 Michigan Biotechnology Institute Mutant strain of C. acetobutylicum and process for making butanol
US5079143A (en) * 1990-05-02 1992-01-07 The Upjohn Company Method of indentifying compounds useful as antiparasitic drugs
DE69132472T2 (de) 1990-10-15 2001-03-15 Daicel Chemical Industries, Ltd. Verfahren zur Herstellung von optisch aktivem 1,3-Butandiol
US5173429A (en) * 1990-11-09 1992-12-22 The Board Of Trustees Of The University Of Arkansas Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism
IL100572A (en) 1991-01-03 1997-01-10 Lepetit Spa Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them
US5416020A (en) * 1992-09-29 1995-05-16 Bio-Technical Resources Lactobacillus delbrueckii ssp. bulgaricus strain and fermentation process for producing L-(+)-lactic acid
US5807722A (en) * 1992-10-30 1998-09-15 Bioengineering Resources, Inc. Biological production of acetic acid from waste gases with Clostridium ljungdahlii
US6136577A (en) * 1992-10-30 2000-10-24 Bioengineering Resources, Inc. Biological production of ethanol from waste gases with Clostridium ljungdahlii
FR2702492B1 (fr) * 1993-03-12 1995-05-24 Rhone Poulenc Chimie Procédé de production par fermentation d'acide itaconique.
US5487987A (en) * 1993-09-16 1996-01-30 Purdue Research Foundation Synthesis of adipic acid from biomass-derived carbon sources
US5521075A (en) 1994-12-19 1996-05-28 Michigan Biotechnology Institute Method for making succinic acid, anaerobiospirillum succiniciproducens variants for use in process and methods for obtaining variants
US5504004A (en) * 1994-12-20 1996-04-02 Michigan Biotechnology Institute Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms
US5700934A (en) * 1995-03-01 1997-12-23 Dsm N.V. Process for the preparation of epsilon-caprolactam and epsilon-caprolactam precursors
US5478952A (en) * 1995-03-03 1995-12-26 E. I. Du Pont De Nemours And Company Ru,Re/carbon catalyst for hydrogenation in aqueous solution
US5863782A (en) 1995-04-19 1999-01-26 Women's And Children's Hospital Synthetic mammalian sulphamidase and genetic sequences encoding same
US5686276A (en) * 1995-05-12 1997-11-11 E. I. Du Pont De Nemours And Company Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
FR2736927B1 (fr) * 1995-07-18 1997-10-17 Rhone Poulenc Fibres & Polymer Enzymes a activite amidase, outils genetiques et microorganismes hotes permettant leur obtention et procede d'hydrolyse mettant en oeuvre lesdites enzymes
US5573931A (en) * 1995-08-28 1996-11-12 Michigan Biotechnology Institute Method for making succinic acid, bacterial variants for use in the process, and methods for obtaining variants
US5869301A (en) * 1995-11-02 1999-02-09 Lockhead Martin Energy Research Corporation Method for the production of dicarboxylic acids
US5770435A (en) * 1995-11-02 1998-06-23 University Of Chicago Mutant E. coli strain with increased succinic acid production
IL125910A0 (en) * 1996-02-27 1999-04-11 Univ Michigan State Cloning and expression of the gene encoding thermoanaerobacter ethanolicus 39e secondary-alcohol dehydrogenase and enzyme biochemical characterization
US5958745A (en) * 1996-03-13 1999-09-28 Monsanto Company Methods of optimizing substrate pools and biosynthesis of poly-β-hydroxybutyrate-co-poly-β-hydroxyvalerate in bacteria and plants
JP4101295B2 (ja) 1996-07-01 2008-06-18 バイオエンジニアリング・リソーシズ・インコーポレーテツド 廃ガスからの酢酸の生物学的生産
KR100459818B1 (ko) * 1996-09-02 2004-12-03 이. 아이. 두퐁 드 느무르 앤드 컴퍼니 ε-카프로락탐의 제조방법
WO1998036078A1 (en) * 1997-02-13 1998-08-20 James Madison University Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units
US6274790B1 (en) * 1997-04-14 2001-08-14 The University Of British Columbia Nucleic acids encoding a plant enzyme involved in very long chain fatty acid synthesis
KR19990013007A (ko) * 1997-07-31 1999-02-25 박원훈 형질전환된 대장균 ｓｓ373(ｋｃｔｃ 8818ｐ)과 이를 이용한숙신산의 생산방법
JPH11103863A (ja) * 1997-10-08 1999-04-20 Nippon Shokubai Co Ltd マレイン酸異性化酵素遺伝子
US6280986B1 (en) * 1997-12-01 2001-08-28 The United States Of America As Represented By The Secretary Of Agriculture Stabilization of pet operon plasmids and ethanol production in bacterial strains lacking lactate dehydrogenase and pyruvate formate lyase activities
US20030087381A1 (en) * 1998-04-13 2003-05-08 University Of Georgia Research Foundation, Inc. Metabolically engineered organisms for enhanced production of oxaloacetate-derived biochemicals
EP2194122B1 (en) * 1998-04-13 2015-12-02 The University Of Georgia Research Foundation, Inc. Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells
US6159738A (en) * 1998-04-28 2000-12-12 University Of Chicago Method for construction of bacterial strains with increased succinic acid production
DE19820652A1 (de) 1998-05-08 1999-11-11 Basf Ag Kationische Rutheniumkomplexe, Verfahren zu ihrer Herstellung und ihre Verwendung
US6432686B1 (en) 1998-05-12 2002-08-13 E. I. Du Pont De Nemours And Company Method for the production of 1,3-propanediol by recombinant organisms comprising genes for vitamin B12 transport
US6444784B1 (en) * 1998-05-29 2002-09-03 Exxonmobil Research & Engineering Company Wax crystal modifiers (LAW657)
US6187569B1 (en) 1998-07-02 2001-02-13 E. I. Du Pont De Nemours And Company Microbial production of terephthalic acid and isophthalic acid
DE19856136C2 (de) * 1998-12-04 2002-10-24 Pasteur Institut Verfahren und Vorrichtung zur Selektion beschleunigter Proliferation lebender Zellen in Suspension
EP1147229A2 (en) * 1999-02-02 2001-10-24 Bernhard O. Palsson Methods for identifying drug targets based on genomic sequence data
US6686310B1 (en) * 1999-02-09 2004-02-03 E. I. Du Pont De Nemours And Company High surface area sol-gel route prepared hydrogenation catalysts
US6365376B1 (en) * 1999-02-19 2002-04-02 E. I. Du Pont De Nemours And Company Genes and enzymes for the production of adipic acid intermediates
EP1159435A1 (en) * 1999-03-05 2001-12-05 Monsanto Technology LLC Multigene expression vectors for the biosynthesis of products via multienzyme biological pathways
DE60030403D1 (de) 1999-08-30 2006-10-12 Wisconsin Alumni Res Found Herstellung von 3-hydroxypropionsäure in rekombinanten organismen
US6852517B1 (en) * 1999-08-30 2005-02-08 Wisconsin Alumni Research Foundation Production of 3-hydroxypropionic acid in recombinant organisms
US6660857B2 (en) * 2000-02-03 2003-12-09 Dsm N.V. Process for the preparation of ε-caprolactam
US6878861B2 (en) 2000-07-21 2005-04-12 Washington State University Research Foundation Acyl coenzyme A thioesterases
PT1303629E (pt) * 2000-07-25 2006-10-31 Emmaus Foundation Inc Metodos para aumentar a producao de etanol a partir da fermantacao microbiana
US7233567B1 (en) * 2000-09-22 2007-06-19 Nortel Networks Limited Apparatus and method for supporting multiple traffic redundancy mechanisms
WO2002042418A2 (en) 2000-11-20 2002-05-30 Cargill, Incorporated 3-hydroxypropionic acid and other organic compounds
CN1249239C (zh) * 2000-11-22 2006-04-05 加吉尔·道聚合物公司 合成有机产物的方法和材料
CN1358841A (zh) 2000-12-11 2002-07-17 云南省微生物研究所 云南链霉菌
CN1491282A (zh) * 2000-12-28 2004-04-21 丰田自动车株式会社 异戊二烯醇的制备方法
US7711490B2 (en) 2001-01-10 2010-05-04 The Penn State Research Foundation Method and system for modeling cellular metabolism
US7127379B2 (en) 2001-01-31 2006-10-24 The Regents Of The University Of California Method for the evolutionary design of biochemical reaction networks
US20030059792A1 (en) * 2001-03-01 2003-03-27 Palsson Bernhard O. Models and methods for determining systemic properties of regulated reaction networks
US6743610B2 (en) * 2001-03-30 2004-06-01 The University Of Chicago Method to produce succinic acid from raw hydrolysates
WO2002090312A1 (en) 2001-05-07 2002-11-14 Cargill, Incorporated Process for preparing carboxylic acids and derivatives thereof
JP4630486B2 (ja) 2001-05-28 2011-02-09 ダイセル化学工業株式会社 新規な（ｒ）−２，３−ブタンジオール脱水素酵素、その製造方法、及びこれを利用した光学活性アルコールの製造方法
WO2003010322A1 (en) 2001-07-20 2003-02-06 Youming Zhang Improved rect or recet cloning and subcloning method
CA2356540A1 (en) 2001-08-30 2003-02-28 Emory University Expressed dna sequences involved in mitochondrial functions
CA2466133A1 (en) * 2001-11-02 2003-05-15 Rice University Recycling system for manipulation of intracellular nadh availability
BR0307010A (pt) * 2002-01-18 2006-04-11 Cargill Inc alanina 2,3-aminomutase
JPWO2003066863A1 (ja) 2002-02-06 2005-06-02 昭和電工株式会社 α−置換−α，β−不飽和カルボニル化合物の還元酵素遺伝子
JP2005520517A (ja) 2002-03-18 2005-07-14 チバ　スペシャルティ　ケミカルズ　ホールディング　インコーポレーテッド 高い溶媒および温度安定性を有するアルコールデヒドロゲナーゼ
US20030224363A1 (en) 2002-03-19 2003-12-04 Park Sung M. Compositions and methods for modeling bacillus subtilis metabolism
EP1495321A4 (en) 2002-03-29 2006-10-25 Genomatica Inc HUMAN METABOLISM MODELS AND ASSOCIATED METHODS
US20050287655A1 (en) * 2002-05-10 2005-12-29 Kyowa Hakko Kogyo Co., Ltd. Process for producing mevalonic acid
US7856317B2 (en) * 2002-06-14 2010-12-21 Genomatica, Inc. Systems and methods for constructing genomic-based phenotypic models
JP4402587B2 (ja) 2002-06-14 2010-01-20 ディーエスエム アイピー アセッツ ビー．ブイ． α−Ｈ−α−アミノ酸アミドラセマーゼ活性を有するポリペプチドおよびそれをコードする核酸
US7826975B2 (en) 2002-07-10 2010-11-02 The Penn State Research Foundation Method for redesign of microbial production systems
WO2004018621A2 (en) 2002-07-10 2004-03-04 The Penn State Research Foundation Method for determining gene knockout strategies
US7413878B2 (en) * 2002-07-15 2008-08-19 Kosan Biosciences, Inc. Recombinant host cells expressing atoAD and capable of making a polyketide using a starter unit
CN100471946C (zh) * 2002-10-04 2009-03-25 纳幕尔杜邦公司 高产量生物生产1,3-丙二醇的方法
WO2004035009A2 (en) 2002-10-15 2004-04-29 The Regents Of The University Of California Methods and systems to identify operational reaction pathways
WO2004044210A2 (en) * 2002-11-06 2004-05-27 University Of Florida Materials and methods for the efficient production of acetate and other products
BRPI0406756A (pt) 2003-01-13 2005-12-20 Cargill Inc Método para fabricação de agentes quìmicos industriais
US7432091B2 (en) * 2003-02-24 2008-10-07 Research Institute Of Innovative Technology For The Earth Highly efficient hydrogen production method using microorganism
RU2268300C2 (ru) 2003-04-07 2006-01-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ, ОБЛАДАЮЩИХ ПОВЫШЕННОЙ ЭКСПРЕССИЕЙ ГЕНА pckA
JP4451393B2 (ja) 2003-07-29 2010-04-14 財団法人地球環境産業技術研究機構 コリネ型細菌形質転換体及びそれを用いるジカルボン酸の製造方法
US7927859B2 (en) * 2003-08-22 2011-04-19 Rice University High molar succinate yield bacteria by increasing the intracellular NADH availability
WO2005026349A1 (ja) * 2003-09-17 2005-03-24 Mitsubishi Chemical Corporation 非アミノ有機酸の製造方法
WO2005026338A1 (en) 2003-09-18 2005-03-24 Ciba Specialty Chemicals Holding Inc. Alcohol dehydrogenases with increased solvent and temperature stability
FR2862068B1 (fr) 2003-11-06 2007-10-12 Metabolic Explorer Sa Souches de microorganismes optimisees pour des voies de biosyntheses consommatrices de nadph
US7244610B2 (en) * 2003-11-14 2007-07-17 Rice University Aerobic succinate production in bacteria
FR2864967B1 (fr) * 2004-01-12 2006-05-19 Metabolic Explorer Sa Microorganisme evolue pour la production de 1,2-propanediol
BRPI0506942B1 (pt) 2004-01-19 2015-07-28 Dsm Ip Assets B.V. Síntese bioquímica de ácido 6-amino capróico
US7608700B2 (en) 2004-03-08 2009-10-27 North Carolina State University Lactobacillus acidophilus nucleic acid sequences encoding stress-related proteins and uses therefor
DE102004029112B4 (de) 2004-06-11 2007-06-21 Julich Chiral Solutions Gmbh Alkoholdehydrogenase zur stereoselektiven Gewinnung von Hydroxyverbindungen
DE102004031177A1 (de) 2004-06-29 2006-01-19 Henkel Kgaa Neue Geruchsstoffe bildende Genprodukte von Bacillus licheniformis und darauf aufbauende verbesserte biotechnologische Produktionsverfahren
US7262046B2 (en) * 2004-08-09 2007-08-28 Rice University Aerobic succinate production in bacteria
BRPI0514734B1 (pt) 2004-08-27 2018-02-06 Rice University VARIEDADE BACTERIANA DE E. Coli MODIFICADA
ES2444785T3 (es) * 2004-09-09 2014-02-26 Research Institute Of Innovative Technology For The Earth Fragmento de ADN que tiene función promotora
US20060073577A1 (en) * 2004-09-17 2006-04-06 San Ka-Yiu High succinate producing bacteria
US20070022497A1 (en) * 2004-10-08 2007-01-25 Basf Plant Science Gmbh Trans-2-enoyl-coa reductase gene of euglena gracilis
US7569380B2 (en) * 2004-12-22 2009-08-04 Rice University Simultaneous anaerobic production of isoamyl acetate and succinic acid
JP2006204255A (ja) 2005-01-31 2006-08-10 Canon Inc アセチル−ＣｏＡアシルトランスフェラーゼ遺伝子破壊ポリヒドロキシアルカノエート生産菌、またこれを利用したポリヒドロキシアルカノエート生産方法
WO2006109312A2 (en) 2005-04-15 2006-10-19 Vascular Biogenics Ltd. Compositions containing beta 2-glycoprotein i-derived peptides for the prevention and/or treatment of vascular disease
US8187842B2 (en) 2005-06-20 2012-05-29 Archer Daniels Midland Company Altered glyoxylate shunt for improved production of aspartate-derived amino acids and chemicals
KR100676160B1 (ko) * 2005-08-19 2007-02-01 한국과학기술원 말릭효소를 코딩하는 유전자로 형질전환된 재조합 미생물 및 이를 이용한 숙신산의 제조방법
KR100679638B1 (ko) * 2005-08-19 2007-02-06 한국과학기술원 포메이트 디하이드로게나제 ｄ 또는 ｅ를 코딩하는 유전자로 형질전환된 미생물 및 이를 이용한 숙신산의 제조방법
AU2006287257A1 (en) 2005-09-09 2007-03-15 Genomatica, Inc. Methods and organisms for the growth-coupled production of succinate
EP1926822B1 (en) 2005-09-19 2010-06-30 Basf Se Biocatalytic manufacturing of (meth)acrylic esters
US9297028B2 (en) * 2005-09-29 2016-03-29 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
NZ566406A (en) * 2005-10-26 2012-04-27 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
DE102006017760A1 (de) 2006-03-24 2007-09-27 Ufz-Umweltforschungszentrum Leipzig-Halle Gmbh Verfahren zur enzymatischen Herstellung von 2-Hydroxy-2-methylcarbonsäuren
MY157798A (en) 2006-05-01 2016-07-29 Univ Florida Ethanol production in non-recombination hosts
US8206970B2 (en) * 2006-05-02 2012-06-26 Butamax(Tm) Advanced Biofuels Llc Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase
EP2157170B1 (en) * 2006-05-19 2014-01-15 LS9, Inc. Production of fatty acids and derivatives thereof
US8110670B2 (en) 2006-05-19 2012-02-07 Ls9, Inc. Enhanced production of fatty acid derivatives
US20100242345A1 (en) 2006-05-19 2010-09-30 LS9, Inc Production of fatty acids & derivatives thereof
DE102006025821A1 (de) 2006-06-02 2007-12-06 Degussa Gmbh Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd
WO2008013996A2 (en) * 2006-07-27 2008-01-31 Gevo Inc. Engineered microorganisms for increasing product yield in biotransformations, related methods and systems
RU2311231C1 (ru) 2006-08-15 2007-11-27 ООО "Объединенный центр исследований и разработок" Катализатор для получения эфиров акриловой кислоты по реакции метатезиса диалкилмалеатов (варианты) и каталитическая композиция на его основе
US8030045B2 (en) 2006-08-30 2011-10-04 Cargill, Incorporated Beta-alanine/alpha-ketoglutarate aminotransferase for 3-hydroxypropionic acid production
US20100036174A1 (en) * 2006-10-31 2010-02-11 Lourina Madeleine Raamsdonk Butanol production in a eukaryotic cell
WO2008143704A2 (en) * 2006-12-01 2008-11-27 Gevo, Inc. Engineered microorganisms for producing n-butanol and related methods
US8017364B2 (en) 2006-12-12 2011-09-13 Butamax(Tm) Advanced Biofuels Llc Solvent tolerant microorganisms
CA2715092A1 (en) * 2006-12-21 2008-07-03 Gevo, Inc. Butanol production by metabolically engineered yeast
CN101903513B (zh) 2007-01-12 2013-08-21 科罗拉多大学董事会法人 增强微生物对产生的有机化学物质的耐受性的组合物和方法
PL389665A1 (pl) * 2007-02-09 2010-07-05 The Regents of the University of CaliforniaThe Regents of the University of California Wytwarzanie biopaliwa przez rekombinowane mikroorganizmy
WO2008113041A2 (en) 2007-03-14 2008-09-18 Ls9, Inc. Process for producing low molecular weight hydrocarbons from renewable resources
TWI568847B (zh) * 2007-03-16 2017-02-01 奇諾麥提卡公司 用於１，４-丁二醇及其前驅物之生物合成的組合物及方法
BRPI0809345A2 (pt) 2007-03-28 2014-10-07 Ls9 Inc Células recombinantes, composições produzidas por estas, métodos para produzir derivados de ácidos graxos em uma célula recombinante, para aumentar a produção de derivados de ácidos graxos em uma célula recombinante, construto recombinante, vetores, métodos para aumentar a produção de derivados de ácidos graxos em uma célula hospedeira de produção, para produzir derivados de ácidos graxos, derivados de ácidos graxos, composições de biocombustível.
US20100159546A1 (en) * 2007-03-30 2010-06-24 Aristos Aristidou Metabolic engineering of yeasts for the production of 1-butanol
WO2008130995A2 (en) 2007-04-18 2008-10-30 E. I. Du Pont De Nemours And Company Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes
US20080293125A1 (en) * 2007-04-18 2008-11-27 Gevo, Inc. Engineered microorganisms for producing isopropanol
US20080293060A1 (en) 2007-04-23 2008-11-27 Ls9, Inc. Methods and Compositions for Identification of Hydrocarbon Response, Transport and Biosynthesis Genes
US20080274522A1 (en) * 2007-05-02 2008-11-06 Bramucci Michael G Method for the production of 2-butanone
US8426174B2 (en) 2007-05-02 2013-04-23 Butamax(Tm) Advanced Biofuels Llc Method for the production of 2-butanol
US9080187B2 (en) 2007-05-17 2015-07-14 The Board Of Trustees Of The University Of Illinois Methods and compositions for producing solvents
US9200299B2 (en) 2007-05-22 2015-12-01 REG Life Sciences, LLC Genetically engineered cell encoding ole amino acid motifs in a carbon source producing aliphatic ketones or olefins
KR101504618B1 (ko) 2007-06-01 2015-03-23 솔라짐, 인코포레이티드 미생물에서 오일의 생성
KR20100049012A (ko) 2007-06-15 2010-05-11 에보니크 데구사 게엠베하 비타민 ｂ１２ 시스템이 탈조절된 미생물
US20100199548A1 (en) 2007-07-06 2010-08-12 Ls9, Inc. Systems and methods for the production of fatty esters
EP2017344A1 (en) 2007-07-20 2009-01-21 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Production of itaconic acid
US20100205857A1 (en) 2007-07-23 2010-08-19 Einte-Karst Dijk Butanol production in a eukaryotic cell
WO2009013158A1 (en) * 2007-07-23 2009-01-29 Dsm Ip Assets B.V. Butanol production in a eukaryotic cell
PL2173881T3 (pl) * 2007-07-23 2017-05-31 Dsm Ip Assets B.V. Acetylo-coa wytwarzający enzymy w drożdżach
US8285554B2 (en) * 2007-07-27 2012-10-09 Dsp Group Limited Method and system for dynamic aliasing suppression
US7947483B2 (en) * 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
KR101042242B1 (ko) 2007-09-07 2011-06-17 한국과학기술원 1,4-부탄디올 생성능을 가지는 변이체 및 이를 이용한1,4-부탄디올의 제조방법
CN101903530A (zh) 2007-10-12 2010-12-01 加利福尼亚大学董事会 被改造以产生异丙醇的微生物
WO2009085278A1 (en) 2007-12-21 2009-07-09 Ls9, Inc. Methods and compositions for producing olefins
CA2712779C (en) 2008-01-22 2021-03-16 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
WO2009103026A1 (en) 2008-02-15 2009-08-20 Gevo, Inc. Engineered microorganisms for producing isopropanol
US20090246842A1 (en) 2008-02-15 2009-10-01 Gevo, Inc. Engineered microorganisms for producing propanol
US7981647B2 (en) 2008-03-03 2011-07-19 Joule Unlimited, Inc. Engineered CO2 fixing microorganisms producing carbon-based products of interest
CA3081506A1 (en) * 2008-03-05 2009-09-11 Genomatica, Inc. Long chain alcohol-producing organisms
SI2252698T1 (en) 2008-03-11 2018-04-30 Genomatica, Inc. SYNTHESIS ADIPAT ESTRA OR TIOESTRA
TW200951103A (en) 2008-03-11 2009-12-16 Dsm Ip Assets Bv Preparation of 6-aminocaproic acid from α-ketopimelic acid
US7799545B2 (en) 2008-03-27 2010-09-21 Genomatica, Inc. Microorganisms for the production of adipic acid and other compounds
WO2009131040A1 (ja) 2008-04-25 2009-10-29 財団法人地球環境産業技術研究機構 イソプロパノール生産能を有するコリネ型細菌の形質転換体
MX350285B (es) 2008-05-16 2017-09-04 Reg Life Sciences Llc Métodos y composiciones para producir hidrocarburos.
US8129154B2 (en) * 2008-06-17 2012-03-06 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
WO2010022090A1 (en) 2008-08-18 2010-02-25 Ls9, Inc. Systems and methods for the production of mixed fatty esters
WO2010022763A1 (en) 2008-08-25 2010-03-04 Metabolic Explorer Method for the preparation of 2-hydroxy-isobutyrate
US8357826B2 (en) * 2008-10-16 2013-01-22 Karl Kharas Methods and apparatus for synthesis of alcohols from syngas
ES2505115T3 (es) * 2008-10-28 2014-10-09 Ls9, Inc. Métodos para producir alcoholes grasos
US9090898B2 (en) 2008-12-12 2015-07-28 Metabolix, Inc. Green process and compositions for producing poly(5HV) and 5 carbon chemicals
CN102459622B (zh) 2009-04-27 2020-08-18 基因组股份公司 脂肪酸酯的产生
US9101598B2 (en) 2011-11-30 2015-08-11 Merial, Inc. Recombinant Gallid herpesvirus 3 (MDV serotype 2) vectors expressing antigens of avian pathogens and uses thereof

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