JP5749009B2 - ＥｐｈＢ４に結合するヒト化抗体を利用する癌治療剤 - Google Patents

ＥｐｈＢ４に結合するヒト化抗体を利用する癌治療剤 Download PDF

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Publication number
JP5749009B2
JP5749009B2 JP2010521005A JP2010521005A JP5749009B2 JP 5749009 B2 JP5749009 B2 JP 5749009B2 JP 2010521005 A JP2010521005 A JP 2010521005A JP 2010521005 A JP2010521005 A JP 2010521005A JP 5749009 B2 JP5749009 B2 JP 5749009B2
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antibody
antigen
binding fragment
seq
ephb4
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Japanese (ja)
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JP2010536751A5 (OSRAM
JP2010536751A (ja
Inventor
ジョセフ・フランシス・カー
パルカシュ・ギル
ティモシー・デイビッド・ジョーンズ
シモン・ウィリアム・キーン
バレリー・クラスノペロフ
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Vasgene Therapeutics Inc
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Vasgene Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2010521005A 2007-08-13 2008-08-11 ＥｐｈＢ４に結合するヒト化抗体を利用する癌治療剤 Expired - Fee Related JP5749009B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96449607P 2007-08-13 2007-08-13
US60/964,496 2007-08-13
PCT/US2008/009619 WO2009023185A1 (en) 2007-08-13 2008-08-11 Cancer treatment using humanized antibodies that bind to ephb4

Publications (3)

Publication Number Publication Date
JP2010536751A JP2010536751A (ja) 2010-12-02
JP2010536751A5 JP2010536751A5 (OSRAM) 2012-09-27
JP5749009B2 true JP5749009B2 (ja) 2015-07-15

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JP2010521005A Expired - Fee Related JP5749009B2 (ja) 2007-08-13 2008-08-11 ＥｐｈＢ４に結合するヒト化抗体を利用する癌治療剤

Country Status (8)

Country Link
US (1) US8975377B2 (OSRAM)
EP (1) EP2185594B1 (OSRAM)
JP (1) JP5749009B2 (OSRAM)
CN (1) CN102083861B (OSRAM)
AU (1) AU2008287427B2 (OSRAM)
BR (1) BRPI0815399A2 (OSRAM)
CA (1) CA2696164C (OSRAM)
WO (1) WO2009023185A1 (OSRAM)

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WO2012054438A1 (en) * 2010-10-22 2012-04-26 Schering Corporation Anti-pcsk9
JOP20200043A1 (ar) 2011-05-10 2017-06-16 Amgen Inc طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول
EA039663B1 (ru) 2012-05-03 2022-02-24 Амген Инк. Применение антитела против pcsk9 для снижения сывороточного холестерина лпнп и лечения связанных с холестерином расстройств
WO2016005466A2 (en) * 2014-07-10 2016-01-14 Bioarctic Neuroscience Ab IMPROVED Aß PROTOFIBRIL BINDING ANTIBODIES
JP6542383B2 (ja) * 2015-04-14 2019-07-10 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ 抗血管新生及び標的がん療法のための抗ｖｅｇｆｒ２ヒト抗体
AU2019265888B2 (en) * 2018-05-10 2026-04-09 Neuracle Science Co., Ltd. Anti-family with sequence similarity 19, member A5 antibodies and method of use thereof
CN114409792B (zh) * 2021-12-01 2022-08-12 中山大学附属第五医院 抗EphB4纳米抗体
JP2025511146A (ja) * 2022-03-28 2025-04-15 コーヘラス・バイオサイエンシーズ・インコーポレイテッド 抗ｉｌｔ４組成物および方法

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Also Published As

Publication number Publication date
BRPI0815399A2 (pt) 2019-09-24
CN102083861A (zh) 2011-06-01
EP2185594A1 (en) 2010-05-19
CN102083861B (zh) 2016-04-13
CA2696164A1 (en) 2009-02-19
WO2009023185A1 (en) 2009-02-19
AU2008287427A1 (en) 2009-02-19
HK1157798A1 (zh) 2012-07-06
EP2185594B1 (en) 2016-04-06
US8975377B2 (en) 2015-03-10
CA2696164C (en) 2018-06-12
JP2010536751A (ja) 2010-12-02
US20090196880A1 (en) 2009-08-06
AU2008287427B2 (en) 2014-10-09

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