JP5718897B2 - 治療用途のためのｆｇｆｒキナーゼ阻害薬としての二環式へテロシクリル誘導体 - Google Patents
治療用途のためのｆｇｆｒキナーゼ阻害薬としての二環式へテロシクリル誘導体 Download PDFInfo
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- JP5718897B2 JP5718897B2 JP2012505238A JP2012505238A JP5718897B2 JP 5718897 B2 JP5718897 B2 JP 5718897B2 JP 2012505238 A JP2012505238 A JP 2012505238A JP 2012505238 A JP2012505238 A JP 2012505238A JP 5718897 B2 JP5718897 B2 JP 5718897B2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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| US61/169,487 | 2009-04-15 | ||
| GBGB0906472.6A GB0906472D0 (en) | 2009-04-15 | 2009-04-15 | New compounds |
| GB0906472.6 | 2009-04-15 | ||
| PCT/GB2010/050617 WO2010119284A1 (en) | 2009-04-15 | 2010-04-15 | Bicyclic heterocyclyl derivatives as fgfr kinase inhibitors for therapeutic use |
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| JP2012524055A JP2012524055A (ja) | 2012-10-11 |
| JP2012524055A5 JP2012524055A5 (https=) | 2013-05-16 |
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| JP (1) | JP5718897B2 (https=) |
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| CY (1) | CY1118061T1 (https=) |
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| ES (1) | ES2580781T3 (https=) |
| GB (1) | GB0906472D0 (https=) |
| HR (1) | HRP20160725T1 (https=) |
| HU (1) | HUE028138T2 (https=) |
| ME (1) | ME02463B (https=) |
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| PT (1) | PT2419427T (https=) |
| RS (1) | RS55038B1 (https=) |
| SI (1) | SI2419427T1 (https=) |
| SM (1) | SMT201600220B (https=) |
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| US8513276B2 (en) | 2006-12-22 | 2013-08-20 | Astex Therapeutics Limited | Imidazo[1,2-a]pyridine compounds for use in treating cancer |
| HRP20150642T1 (hr) | 2006-12-22 | 2015-08-14 | Astex Therapeutics Limited | BICIKLIÄŚKE HETEROCIKLIÄŚKE TVARI KAO INHIBITORI FGFR-a |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| BR112014007622A2 (pt) | 2011-09-30 | 2017-04-04 | Oncodesign Sa | inibidores de flt3 cinase macrocíclicos |
| UA111382C2 (uk) | 2011-10-10 | 2016-04-25 | Оріон Корпорейшн | Інгібітори протеїнкінази |
| RS58514B1 (sr) | 2012-06-13 | 2019-04-30 | Incyte Holdings Corp | Supstituisana triciklična jedinjenja kao inhibitori fgfr |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| AR094812A1 (es) | 2013-02-20 | 2015-08-26 | Eisai R&D Man Co Ltd | Derivado de piridina monocíclico como inhibidor del fgfr |
| EP2975031A4 (en) | 2013-03-14 | 2017-04-19 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| TWI628176B (zh) * | 2013-04-04 | 2018-07-01 | 奧利安公司 | 蛋白質激酶抑制劑 |
| PH12015502383B1 (en) | 2013-04-19 | 2023-02-03 | Incyte Holdings Corp | Bicyclic heterocycles as fgfr inhibitors |
| TN2016000115A1 (en) | 2013-10-25 | 2017-07-05 | Novartis Ag | Ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors. |
| AR098145A1 (es) * | 2013-10-25 | 2016-05-04 | Novartis Ag | Compuestos derivados de piridilo bicíclicos fusionados como inhibidores de fgfr4 |
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| GB0906472D0 (en) | 2009-05-20 |
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| CA2757592A1 (en) | 2010-10-21 |
| AU2010238289A1 (en) | 2011-12-08 |
| ME02463B (me) | 2017-02-20 |
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| EP2419427B1 (en) | 2016-04-06 |
| JP2012524055A (ja) | 2012-10-11 |
| WO2010119284A1 (en) | 2010-10-21 |
| ES2580781T3 (es) | 2016-08-26 |
| AU2010238289B2 (en) | 2015-12-03 |
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| US8481531B2 (en) | 2013-07-09 |
| CA2757592C (en) | 2018-08-21 |
| US20120035171A1 (en) | 2012-02-09 |
| PL2419427T3 (pl) | 2016-12-30 |
| HRP20160725T1 (hr) | 2016-09-23 |
| HUE028138T2 (en) | 2016-12-28 |
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