JP5688877B2 - 癌疾患の治療用キナゾリン誘導体 - Google Patents
癌疾患の治療用キナゾリン誘導体 Download PDFInfo
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- JP5688877B2 JP5688877B2 JP2008539440A JP2008539440A JP5688877B2 JP 5688877 B2 JP5688877 B2 JP 5688877B2 JP 2008539440 A JP2008539440 A JP 2008539440A JP 2008539440 A JP2008539440 A JP 2008539440A JP 5688877 B2 JP5688877 B2 JP 5688877B2
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Inorganic Chemistry (AREA)
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| EP05110656.5 | 2005-11-11 | ||
| EP05110656 | 2005-11-11 | ||
| PCT/EP2006/068313 WO2007054550A1 (en) | 2005-11-11 | 2006-11-09 | Quinazoline derivatives for the treatment of cancer diseases |
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| JP2009515851A JP2009515851A (ja) | 2009-04-16 |
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| EP (2) | EP1948179A1 (OSRAM) |
| JP (2) | JP5688877B2 (OSRAM) |
| CA (3) | CA2833852C (OSRAM) |
| WO (1) | WO2007054550A1 (OSRAM) |
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| CA2375259C (en) | 1999-06-21 | 2009-04-28 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them |
| US7019012B2 (en) | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
| DE10221018A1 (de) * | 2002-05-11 | 2003-11-27 | Boehringer Ingelheim Pharma | Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie |
| US20050043233A1 (en) * | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| DE10349113A1 (de) | 2003-10-17 | 2005-05-12 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Aminocrotonylverbindungen |
| PL1948180T3 (pl) * | 2005-11-11 | 2013-09-30 | Boehringer Ingelheim Int | Terapia skojarzona raka polegająca na podawaniu inhibitorów EGFR/HER2 |
| CA2833852C (en) | 2005-11-11 | 2014-10-21 | Boehringer Ingelheim International Gmbh | Quinazoline derivatives for the treatment of cancer diseases |
| JP5241513B2 (ja) | 2006-01-26 | 2013-07-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アミノクロトニルアミノ置換キナゾリン誘導体の合成方法 |
| US8877764B2 (en) | 2006-09-18 | 2014-11-04 | Boehringer Ingelheim International Gmbh | Method for treating cancer harboring EGFR mutations |
| UY31867A (es) * | 2008-06-06 | 2010-01-29 | Boehringer Ingelheim Int | Nuevas formulaciones farmacéuticas sólidas que comprenden bibw 2992 |
| JP2012515184A (ja) * | 2009-01-14 | 2012-07-05 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 大腸がんの治療方法 |
| WO2010130757A1 (en) | 2009-05-14 | 2010-11-18 | Boehringer Ingelheim International Gmbh | New combination therapy in treatment of oncological and fibrotic diseases |
| EP2451445B1 (en) | 2009-07-06 | 2019-04-03 | Boehringer Ingelheim International GmbH | Process for drying of bibw2992, of its salts and of solid pharmaceutical formulations comprising this active ingredient |
| US20130012465A1 (en) | 2009-12-07 | 2013-01-10 | Boehringer Ingelheim International Gmbh | Bibw 2992 for use in the treatment of triple negative breast cancer |
| CN102146059A (zh) * | 2010-02-08 | 2011-08-10 | 上海艾力斯医药科技有限公司 | 喹唑啉衍生物、制备方法及其应用 |
| US20120107304A1 (en) * | 2010-04-27 | 2012-05-03 | Boehringer Ingelheim International Gmbh | Combination therapy in treatment of oncological and fibrotic diseases |
| RS56682B1 (sr) * | 2010-08-26 | 2018-03-30 | Boehringer Ingelheim Int | Postupci primene egfr inhibitora |
| CN102382065B (zh) * | 2010-08-30 | 2014-05-28 | 山东轩竹医药科技有限公司 | 苯胺取代的喹唑啉衍生物 |
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| WO2013173254A1 (en) | 2012-05-14 | 2013-11-21 | Dawei Zhang | Bicyclic compounds as kinases inhibitors |
| CN103755688B (zh) | 2013-12-24 | 2015-11-18 | 江苏奥赛康药业股份有限公司 | 一种阿法替尼化合物的制备方法 |
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- 2006-11-09 EP EP16201715.6A patent/EP3173084B1/en active Active
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- 2006-11-09 WO PCT/EP2006/068313 patent/WO2007054550A1/en not_active Ceased
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Also Published As
| Publication number | Publication date |
|---|---|
| EP3173084B1 (en) | 2019-10-23 |
| US20090306044A1 (en) | 2009-12-10 |
| JP2009515851A (ja) | 2009-04-16 |
| US20130178487A1 (en) | 2013-07-11 |
| CA2833706C (en) | 2014-10-21 |
| US20180360834A1 (en) | 2018-12-20 |
| EP1948179A1 (en) | 2008-07-30 |
| US9089571B2 (en) | 2015-07-28 |
| CA2629244A1 (en) | 2007-05-18 |
| CA2833852A1 (en) | 2007-05-18 |
| US20170112835A1 (en) | 2017-04-27 |
| CA2833706A1 (en) | 2007-05-18 |
| WO2007054550A1 (en) | 2007-05-18 |
| US20150272954A1 (en) | 2015-10-01 |
| JP5695680B2 (ja) | 2015-04-08 |
| US9539258B2 (en) | 2017-01-10 |
| CA2833852C (en) | 2014-10-21 |
| US8404697B2 (en) | 2013-03-26 |
| JP2013064024A (ja) | 2013-04-11 |
| CA2629244C (en) | 2014-08-05 |
| EP3173084A1 (en) | 2017-05-31 |
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