JP5680823B2 - スクレロスチンエピトープ - Google Patents

スクレロスチンエピトープ Download PDF

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Publication number
JP5680823B2
JP5680823B2 JP2008510081A JP2008510081A JP5680823B2 JP 5680823 B2 JP5680823 B2 JP 5680823B2 JP 2008510081 A JP2008510081 A JP 2008510081A JP 2008510081 A JP2008510081 A JP 2008510081A JP 5680823 B2 JP5680823 B2 JP 5680823B2
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JP
Japan
Prior art keywords
seq
cdr
sequence
antibody
sclerostin
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Expired - Lifetime
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JP2008510081A
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English (en)
Japanese (ja)
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JP2009500296A (ja
Inventor
セン ル，シェン
セン ル，シェン
パツティー，クリストファー
キム ロビンソン，マーティン
キム ロビンソン，マーティン
ジェイムス ヘンリー，アリステア
ジェイムス ヘンリー，アリステア
スー ホフマン，ケリー
スー ホフマン，ケリー
レイサム，ジョン
ローソン，アラステア
ウィンクラー，デヴィッド
ジョージ ウィンターズ，アーロン
ジョージ ウィンターズ，アーロン
Original Assignee
アムジエン・インコーポレーテツド
ユーシービー ファーマ ソシエテ アノニム
ユーシービー ファーマ ソシエテ アノニム
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36956127&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP5680823(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by アムジエン・インコーポレーテツド, ユーシービー ファーマ ソシエテ アノニム, ユーシービー ファーマ ソシエテ アノニム filed Critical アムジエン・インコーポレーテツド
Publication of JP2009500296A publication Critical patent/JP2009500296A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
JP2008510081A 2005-05-03 2006-04-28 スクレロスチンエピトープ Expired - Lifetime JP5680823B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US67758305P 2005-05-03 2005-05-03
US60/677,583 2005-05-03
US77684706P 2006-02-24 2006-02-24
US60/776,847 2006-02-24
US78224406P 2006-03-13 2006-03-13
US60/782,244 2006-03-13
US79264506P 2006-04-17 2006-04-17
US60/792,645 2006-04-17
US11/410,540 2006-04-25
US11/410,540 US8003108B2 (en) 2005-05-03 2006-04-25 Sclerostin epitopes
PCT/US2006/016345 WO2006119062A2 (en) 2005-05-03 2006-04-28 Sclerostin epitopes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014095921A Division JP2014177470A (ja) 2005-05-03 2014-05-07 スクレロスチンエピトープ

Publications (2)

Publication Number Publication Date
JP2009500296A JP2009500296A (ja) 2009-01-08
JP5680823B2 true JP5680823B2 (ja) 2015-03-04

Family

ID=36956127

Family Applications (7)

Application Number Title Priority Date Filing Date
JP2008510081A Expired - Lifetime JP5680823B2 (ja) 2005-05-03 2006-04-28 スクレロスチンエピトープ
JP2014095921A Pending JP2014177470A (ja) 2005-05-03 2014-05-07 スクレロスチンエピトープ
JP2015192869A Expired - Lifetime JP6158268B2 (ja) 2005-05-03 2015-09-30 スクレロスチンエピトープ
JP2017031654A Pending JP2017128583A (ja) 2005-05-03 2017-02-23 スクレロスチンエピトープ
JP2018147689A Expired - Lifetime JP6858733B2 (ja) 2005-05-03 2018-08-06 スクレロスチンエピトープ
JP2020081948A Expired - Lifetime JP7010994B2 (ja) 2005-05-03 2020-05-07 スクレロスチンエピトープ
JP2021195517A Expired - Lifetime JP7361086B2 (ja) 2005-05-03 2021-12-01 スクレロスチンエピトープ

Family Applications After (6)

Application Number Title Priority Date Filing Date
JP2014095921A Pending JP2014177470A (ja) 2005-05-03 2014-05-07 スクレロスチンエピトープ
JP2015192869A Expired - Lifetime JP6158268B2 (ja) 2005-05-03 2015-09-30 スクレロスチンエピトープ
JP2017031654A Pending JP2017128583A (ja) 2005-05-03 2017-02-23 スクレロスチンエピトープ
JP2018147689A Expired - Lifetime JP6858733B2 (ja) 2005-05-03 2018-08-06 スクレロスチンエピトープ
JP2020081948A Expired - Lifetime JP7010994B2 (ja) 2005-05-03 2020-05-07 スクレロスチンエピトープ
JP2021195517A Expired - Lifetime JP7361086B2 (ja) 2005-05-03 2021-12-01 スクレロスチンエピトープ

Country Status (17)

Country Link
US (3) US8003108B2 (enExample)
EP (6) EP1891100A2 (enExample)
JP (7) JP5680823B2 (enExample)
CA (1) CA2607276C (enExample)
CY (2) CY1118977T1 (enExample)
DK (2) DK2251351T4 (enExample)
ES (5) ES2616985T5 (enExample)
FI (2) FI2251351T4 (enExample)
HR (2) HRP20170679T4 (enExample)
HU (2) HUE033718T2 (enExample)
LT (2) LT2251351T (enExample)
MX (1) MX348432B (enExample)
MY (1) MY174493A (enExample)
PL (2) PL2251351T5 (enExample)
PT (2) PT2301961T (enExample)
SI (2) SI2251351T2 (enExample)
WO (1) WO2006119062A2 (enExample)

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