JP5663743B2 - モチリン受容体作動活性を有するオキシインドール誘導体 - Google Patents
モチリン受容体作動活性を有するオキシインドール誘導体 Download PDFInfo
- Publication number
- JP5663743B2 JP5663743B2 JP2011536661A JP2011536661A JP5663743B2 JP 5663743 B2 JP5663743 B2 JP 5663743B2 JP 2011536661 A JP2011536661 A JP 2011536661A JP 2011536661 A JP2011536661 A JP 2011536661A JP 5663743 B2 JP5663743 B2 JP 5663743B2
- Authority
- JP
- Japan
- Prior art keywords
- piperidin
- dimethyl
- oxoindolin
- oxo
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20243009P | 2009-02-27 | 2009-02-27 | |
| US61/202,430 | 2009-02-27 | ||
| US28217309P | 2009-12-24 | 2009-12-24 | |
| US61/282,173 | 2009-12-24 | ||
| PCT/JP2010/001368 WO2010098145A1 (en) | 2009-02-27 | 2010-03-01 | Oxyindole derivatives with motilin receptor agonistic activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012519153A JP2012519153A (ja) | 2012-08-23 |
| JP2012519153A5 JP2012519153A5 (enExample) | 2013-05-02 |
| JP5663743B2 true JP5663743B2 (ja) | 2015-02-04 |
Family
ID=42665356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011536661A Active JP5663743B2 (ja) | 2009-02-27 | 2010-03-01 | モチリン受容体作動活性を有するオキシインドール誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8697877B2 (enExample) |
| EP (1) | EP2401268B1 (enExample) |
| JP (1) | JP5663743B2 (enExample) |
| KR (1) | KR101575703B1 (enExample) |
| CN (1) | CN102317280B (enExample) |
| BR (1) | BRPI1007962A2 (enExample) |
| CA (1) | CA2750699C (enExample) |
| ES (1) | ES2547415T3 (enExample) |
| MX (1) | MX2011008857A (enExample) |
| RU (1) | RU2533116C2 (enExample) |
| WO (1) | WO2010098145A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013369649B2 (en) * | 2012-12-31 | 2018-07-26 | Sunovion Pharmaceuticals Inc. | Heterocyclic compounds and methods of use thereof |
| CN105849102B (zh) * | 2013-10-29 | 2020-10-16 | 生物马林药物股份有限公司 | 作为葡萄糖基神经酰胺合酶抑制剂的n-(1-羟基-3(吡咯烷基)丙烷-2-基)吡咯烷-3-甲酰胺衍生物 |
| JP6836502B2 (ja) * | 2014-05-30 | 2021-03-03 | スプハエラ ファーマ ピーヴィーティー リミテッド | 抗結核薬としての新規な化合物 |
| KR20240042400A (ko) * | 2021-07-30 | 2024-04-02 | 라퀄리아 파마 인코포레이티드 | 결정질 형태 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW355711B (en) | 1992-11-04 | 1999-04-11 | Chugai Pharmaceutical Co Ltd | Erythromycin derivatives |
| JP3449766B2 (ja) | 1993-11-19 | 2003-09-22 | 中外製薬株式会社 | モチリンアンタゴニスト |
| US5767118A (en) * | 1994-10-26 | 1998-06-16 | Merck & Co., Inc. | 4-Heterocyclic peperidines promote release of growth hormone |
| JP3901239B2 (ja) | 1996-03-13 | 2007-04-04 | 大正製薬株式会社 | アリールアルカン誘導体 |
| US5734012A (en) | 1996-05-16 | 1998-03-31 | Ohmeda Pharmaceutical Products Division Inc. | Cyclic motilin-like polypeptides with gastrointestinal motor stimulating activity |
| DE19644195A1 (de) | 1996-10-24 | 1998-04-30 | Solvay Pharm Gmbh | 10,13,15-Trioxatricyclo[9.2.1.1.·9·.·6·]-pentadecanon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| AU4968997A (en) | 1996-11-26 | 1998-06-22 | Chugai Seiyaku Kabushiki Kaisha | 13-membered ring macrolide compounds, medicine containing the same, and process for producing the same |
| TWI242011B (en) * | 1997-03-31 | 2005-10-21 | Eisai Co Ltd | 1,4-substituted cyclic amine derivatives |
| US5972939A (en) | 1997-10-28 | 1999-10-26 | Ortho-Mcneil Pharmaceutical, Inc. | Cyclopentene derivatives useful as antagonists of the motilin receptor |
| DE19805822B4 (de) | 1998-02-13 | 2009-02-05 | Solvay Pharmaceuticals Gmbh | 11-Acetyl-12,13-dioxabicyclo[8.2.1]tridecenon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US6165985A (en) | 1998-02-13 | 2000-12-26 | Solvay Pharmaceuticals Gmbh | 11-acetyl-12,13-dioxabicyclo[8.2.1]-tridecenone derivatives, processes for their preparation and pharmaceutical compositions comprising them |
| AU2001247357A1 (en) | 2000-03-13 | 2001-09-24 | Ortho-Mcneil Pharmaceutical, Inc. | Novel cyclobutene derivatives useful as antagonists of the motilin receptor |
| US6392040B2 (en) | 2000-03-13 | 2002-05-21 | Ortho-Mcneil Pharmaceutical, Inc. | Cyclopentene compounds useful as antagonists of the motilin receptor |
| AU2001250820A1 (en) | 2000-03-13 | 2001-09-24 | Ortho-Mcneil Pharmaceutical, Inc. | Novel cyclohexene derivatives useful as antagonists of the motilin receptor |
| US6511980B2 (en) | 2000-05-05 | 2003-01-28 | Ortho Mcneil Pharmaceutical, Inc. | Substituted diamine derivatives useful as motilin antagonists |
| DE50204789D1 (de) * | 2001-05-10 | 2005-12-08 | Solvay Pharm Gmbh | Neue 1-amidomethylcarbonyl-piperidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE602004030344D1 (de) | 2003-07-31 | 2011-01-13 | Tranzyme Pharma Inc | Räumlich definierte makrocyclische verbindungen, die sich für die entdeckung von arzneimittel eignen |
| WO2005012332A1 (en) | 2003-07-31 | 2005-02-10 | Tranzyme Pharma | Spatially-defined macrocycles incorporating peptide bond surrogates |
| US7338954B2 (en) | 2003-09-17 | 2008-03-04 | Bristol-Myers Squibb Company | Compounds useful as motilin agonists and method |
| US7262195B2 (en) | 2003-09-17 | 2007-08-28 | Bristol-Myers Squibb Company | Compounds useful as motilin agonists and method |
| WO2006011035A1 (en) | 2004-07-23 | 2006-02-02 | Glenmark Pharmaceuticals Ltd. | Novel dipeptidyl peptidase iv inhibitors; process for their preparation and compositions containing them |
| NZ556627A (en) * | 2005-02-22 | 2010-09-30 | Pfizer | Oxyindole derivatives as 5HT4 receptor agonists |
| US7582611B2 (en) | 2005-05-24 | 2009-09-01 | Pfizer Inc. | Motilide compounds |
| EP1902022A1 (en) | 2005-07-12 | 2008-03-26 | Glaxo Group Limited | Piperazine heteroaryl derivates as gpr38 agonists |
| MY150098A (en) | 2005-07-26 | 2013-11-29 | Glaxo Group Ltd | Benzylpiperazine derivates and their medical use |
| EP1757290A1 (en) * | 2005-08-16 | 2007-02-28 | Zentaris GmbH | Novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors |
| PL2041093T3 (pl) * | 2006-06-28 | 2010-09-30 | Glaxo Group Ltd | Pochodne piperazynylowe użyteczne w leczeniu zaburzeń, którym pośredniczy receptor GPR38 |
-
2010
- 2010-03-01 EP EP10746028.9A patent/EP2401268B1/en active Active
- 2010-03-01 JP JP2011536661A patent/JP5663743B2/ja active Active
- 2010-03-01 CN CN201080007432.5A patent/CN102317280B/zh active Active
- 2010-03-01 RU RU2011139287/04A patent/RU2533116C2/ru active IP Right Revival
- 2010-03-01 MX MX2011008857A patent/MX2011008857A/es active IP Right Grant
- 2010-03-01 WO PCT/JP2010/001368 patent/WO2010098145A1/en not_active Ceased
- 2010-03-01 KR KR1020117021833A patent/KR101575703B1/ko active Active
- 2010-03-01 CA CA2750699A patent/CA2750699C/en not_active Expired - Fee Related
- 2010-03-01 ES ES10746028.9T patent/ES2547415T3/es active Active
- 2010-03-01 BR BRPI1007962A patent/BRPI1007962A2/pt not_active IP Right Cessation
- 2010-03-01 US US13/203,301 patent/US8697877B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2401268A1 (en) | 2012-01-04 |
| US8697877B2 (en) | 2014-04-15 |
| CN102317280B (zh) | 2014-07-23 |
| CA2750699C (en) | 2015-12-29 |
| RU2533116C2 (ru) | 2014-11-20 |
| CN102317280A (zh) | 2012-01-11 |
| EP2401268B1 (en) | 2015-07-29 |
| EP2401268A4 (en) | 2013-01-02 |
| KR20110133033A (ko) | 2011-12-09 |
| KR101575703B1 (ko) | 2015-12-10 |
| MX2011008857A (es) | 2011-09-30 |
| BRPI1007962A2 (pt) | 2016-02-23 |
| WO2010098145A1 (en) | 2010-09-02 |
| HK1164318A1 (en) | 2012-09-21 |
| ES2547415T3 (es) | 2015-10-06 |
| RU2011139287A (ru) | 2013-04-10 |
| US20110312933A1 (en) | 2011-12-22 |
| JP2012519153A (ja) | 2012-08-23 |
| CA2750699A1 (en) | 2010-09-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2019204244B2 (en) | Cyclopropylamines as lsd1 inhibitors | |
| ES3037650T3 (en) | Heterocyclic compounds and use thereof | |
| AU2019210624A1 (en) | Cyclopropylamines as lsd1 inhibitors | |
| CN102164920B (zh) | 烷基噻唑氨基甲酸酯衍生物、其制备方法和其作为faah酶抑制剂的用途 | |
| WO2010087399A1 (ja) | ウロテンシンｉｉ受容体拮抗薬 | |
| TW202134229A (zh) | 環烷基尿素衍生物 | |
| CN107098899A (zh) | 作为毒蕈碱的m1受体激动剂的二环氮杂化合物 | |
| US20240239744A1 (en) | 2-(3-ethynylbenzyl)-substituted heterocycle derivatives and related uses | |
| WO2013147160A1 (ja) | 環状アミン誘導体及びその医薬用途 | |
| JP2006527758A (ja) | セロトニン及びノルアドレナリン再取り込み阻害薬としてのｎ−ピロリジン−３−イル−アミド誘導体 | |
| EP3303331B1 (en) | Muscarinic m1 receptor positive allosteric modulators | |
| CN101602741A (zh) | 作为γ-分泌酶抑制剂的取代的N-芳基磺酰基杂环胺 | |
| RU2533116C2 (ru) | Оксииндольные производные, обладающие агонистической активностью в отношении мотилинового рецептора | |
| JP2012519153A5 (enExample) | ||
| US20120122950A1 (en) | Libraries of 1-(sulfonyl)-n-phenylpyrrolidine-2-carboxamides for drug discovery | |
| CN102844301A (zh) | 新苯甲酰胺衍生物 | |
| CN110753690A (zh) | 吡啶衍生物 | |
| US6645971B1 (en) | Quinazolinone derivatives | |
| AU2006236622A1 (en) | Compositions of novel opioid compounds and method of use thereof | |
| CN102112451A (zh) | 用作趋化因子受体调节剂的二氮杂环庚烷和哌嗪衍生物 | |
| JP2017505797A (ja) | Ｇｐｒ１４２アゴニスト化合物 | |
| CN106336387A (zh) | 酰胺类衍生物、其制备方法及其在医药上的用途 | |
| JP6500201B2 (ja) | 置換トロパン誘導体 | |
| HK1164318B (en) | Oxyindole derivatives with motilin receptor agonistic activity | |
| CN101137646A (zh) | Ccr5受体拮抗剂的合成 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130227 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20130227 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140520 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140716 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140812 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140929 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20141021 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20141106 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5663743 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |