JP5651275B2 - テノホビルアラフェナミドヘミフマレート - Google Patents

テノホビルアラフェナミドヘミフマレート Download PDF

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JP5651275B2
JP5651275B2 JP2014526164A JP2014526164A JP5651275B2 JP 5651275 B2 JP5651275 B2 JP 5651275B2 JP 2014526164 A JP2014526164 A JP 2014526164A JP 2014526164 A JP2014526164 A JP 2014526164A JP 5651275 B2 JP5651275 B2 JP 5651275B2
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hemifumarate
composition
tenofovir arafenamide
hiv
tenofovir
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JP2014528924A (ja
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ダザン リュー
ダザン リュー
ビン シー
ビン シー
ファン ワン
ファン ワン
リチャード フン チウ ユー
リチャード フン チウ ユー
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ギリアード サイエンシス インコーポレーテッド
ギリアード サイエンシス インコーポレーテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
JP2014526164A 2011-08-16 2012-08-15 テノホビルアラフェナミドヘミフマレート Active JP5651275B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161524224P 2011-08-16 2011-08-16
US61/524,224 2011-08-16
PCT/US2012/050920 WO2013025788A1 (en) 2011-08-16 2012-08-15 Tenofovir alafenamide hemifumarate

Related Child Applications (1)

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JP2014231819A Division JP5956537B2 (ja) 2011-08-16 2014-11-14 テノホビルアラフェナミドヘミフマレート

Publications (2)

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JP2014528924A JP2014528924A (ja) 2014-10-30
JP5651275B2 true JP5651275B2 (ja) 2015-01-07

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JP2014526164A Active JP5651275B2 (ja) 2011-08-16 2012-08-15 テノホビルアラフェナミドヘミフマレート
JP2014231819A Active JP5956537B2 (ja) 2011-08-16 2014-11-14 テノホビルアラフェナミドヘミフマレート
JP2016120153A Active JP6280162B2 (ja) 2011-08-16 2016-06-16 テノホビルアラフェナミドヘミフマレート
JP2018006107A Withdrawn JP2018065870A (ja) 2011-08-16 2018-01-18 テノホビルアラフェナミドヘミフマレート
JP2019210196A Pending JP2020040972A (ja) 2011-08-16 2019-11-21 テノホビルアラフェナミドヘミフマレート

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JP2014231819A Active JP5956537B2 (ja) 2011-08-16 2014-11-14 テノホビルアラフェナミドヘミフマレート
JP2016120153A Active JP6280162B2 (ja) 2011-08-16 2016-06-16 テノホビルアラフェナミドヘミフマレート
JP2018006107A Withdrawn JP2018065870A (ja) 2011-08-16 2018-01-18 テノホビルアラフェナミドヘミフマレート
JP2019210196A Pending JP2020040972A (ja) 2011-08-16 2019-11-21 テノホビルアラフェナミドヘミフマレート

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US (2) US8754065B2 (enExample)
EP (3) EP3070088A1 (enExample)
JP (5) JP5651275B2 (enExample)
KR (1) KR101612642B1 (enExample)
CN (2) CN110343135A (enExample)
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AR (1) AR087546A1 (enExample)
AU (1) AU2012296622C1 (enExample)
BR (1) BR112014003420B1 (enExample)
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CR (1) CR20140072A (enExample)
CY (1) CY1118385T1 (enExample)
DK (1) DK2744810T4 (enExample)
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UA (1) UA115311C2 (enExample)
UY (1) UY34262A (enExample)
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ZA (1) ZA201400582B (enExample)

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