JP5643192B2 - 腫瘍を処置するためのチロシンキナーゼモジュレーターとしてのジヒドロピラゾール誘導体 - Google Patents
腫瘍を処置するためのチロシンキナーゼモジュレーターとしてのジヒドロピラゾール誘導体 Download PDFInfo
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- JP5643192B2 JP5643192B2 JP2011510855A JP2011510855A JP5643192B2 JP 5643192 B2 JP5643192 B2 JP 5643192B2 JP 2011510855 A JP2011510855 A JP 2011510855A JP 2011510855 A JP2011510855 A JP 2011510855A JP 5643192 B2 JP5643192 B2 JP 5643192B2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008025750.8 | 2008-05-29 | ||
| DE102008025750A DE102008025750A1 (de) | 2008-05-29 | 2008-05-29 | Dihydropyrazolderivate |
| PCT/EP2009/003030 WO2009143945A1 (de) | 2008-05-29 | 2009-04-24 | Dihydropyrazolderivate als tyrosinkinase modulatoren zur behandlung von tumoren |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011520996A JP2011520996A (ja) | 2011-07-21 |
| JP2011520996A5 JP2011520996A5 (enExample) | 2014-05-08 |
| JP5643192B2 true JP5643192B2 (ja) | 2014-12-17 |
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| JP2011510855A Expired - Fee Related JP5643192B2 (ja) | 2008-05-29 | 2009-04-24 | 腫瘍を処置するためのチロシンキナーゼモジュレーターとしてのジヒドロピラゾール誘導体 |
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| ZA (1) | ZA201009085B (enExample) |
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| EP2726463B1 (en) | 2011-07-01 | 2020-03-11 | Merck Patent GmbH | Dihydropyrazoles, pharmaceutical compositions thereof and their use for the treatment of fertility disorders |
| CA2878621C (en) * | 2012-07-10 | 2020-09-15 | Ares Trading S.A. | Pyrimidine pyrazolyl derivatives |
| EP3886854A4 (en) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
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| BR9707495A (pt) | 1996-02-13 | 1999-07-27 | Zeneca Ltd | Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente |
| JP4464466B2 (ja) | 1996-03-05 | 2010-05-19 | アストラゼネカ・ユーケイ・リミテッド | ４―アニリノキナゾリン誘導体 |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| IL152682A0 (en) | 2000-05-31 | 2003-06-24 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| JP2004502766A (ja) | 2000-07-07 | 2004-01-29 | アンギオジェン・ファーマシューティカルズ・リミテッド | 血管損傷剤としてのコルヒノール誘導体 |
| CA2410562A1 (en) | 2000-07-07 | 2002-01-31 | Angiogene Pharmaceuticals Limited | Colchinol derivatives as angiogenesis inhibitors |
| AU2003249597B2 (en) | 2002-03-08 | 2007-06-28 | Merck Sharp & Dohme Corp. | Mitotic kinesin inhibitors |
| DE102005038537A1 (de) | 2005-08-16 | 2007-02-22 | Merck Patent Gmbh | 1-Acyldihydropyrazolderivate |
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- 2009-04-24 EP EP09753600.7A patent/EP2300434B1/de not_active Not-in-force
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2011520996A (ja) | 2011-07-21 |
| US20110071153A1 (en) | 2011-03-24 |
| WO2009143945A1 (de) | 2009-12-03 |
| EP2300434A1 (de) | 2011-03-30 |
| EP2300434B1 (de) | 2014-07-23 |
| CN102046605A (zh) | 2011-05-04 |
| HK1157345A1 (en) | 2012-06-29 |
| CA2726009C (en) | 2016-08-23 |
| US8404685B2 (en) | 2013-03-26 |
| MX2010012804A (es) | 2010-12-07 |
| IL209418A (en) | 2015-09-24 |
| CA2726009A1 (en) | 2009-12-03 |
| AU2009253432A1 (en) | 2009-12-03 |
| CN102046605B (zh) | 2013-09-18 |
| AR071951A1 (es) | 2010-07-28 |
| KR20110010821A (ko) | 2011-02-07 |
| DE102008025750A1 (de) | 2009-12-03 |
| ES2507573T3 (es) | 2014-10-15 |
| EA018394B1 (ru) | 2013-07-30 |
| ZA201009085B (en) | 2011-10-26 |
| AU2009253432B2 (en) | 2013-08-01 |
| IL209418A0 (en) | 2011-01-31 |
| BRPI0912970A2 (pt) | 2015-10-13 |
| EA201001831A1 (ru) | 2011-06-30 |
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