BRPI0912970A2 - derivados de di-hidropirazol como moduladores de tirosina quinase para o tratamento de tumores - Google Patents

derivados de di-hidropirazol como moduladores de tirosina quinase para o tratamento de tumores

Info

Publication number
BRPI0912970A2
BRPI0912970A2 BRPI0912970A BRPI0912970A BRPI0912970A2 BR PI0912970 A2 BRPI0912970 A2 BR PI0912970A2 BR PI0912970 A BRPI0912970 A BR PI0912970A BR PI0912970 A BRPI0912970 A BR PI0912970A BR PI0912970 A2 BRPI0912970 A2 BR PI0912970A2
Authority
BR
Brazil
Prior art keywords
tumors
treatment
tyrosine kinase
kinase modulators
dihydropyrazole derivatives
Prior art date
Application number
BRPI0912970A
Other languages
English (en)
Portuguese (pt)
Inventor
Andree Blaukat
Dieter Dorsch
Frank Stieber
Oliver Schadt
Original Assignee
Merck Patent Ges Mit Beschränkter Haftung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Ges Mit Beschränkter Haftung filed Critical Merck Patent Ges Mit Beschränkter Haftung
Publication of BRPI0912970A2 publication Critical patent/BRPI0912970A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BRPI0912970A 2008-05-29 2009-04-24 derivados de di-hidropirazol como moduladores de tirosina quinase para o tratamento de tumores BRPI0912970A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008025750A DE102008025750A1 (de) 2008-05-29 2008-05-29 Dihydropyrazolderivate
PCT/EP2009/003030 WO2009143945A1 (de) 2008-05-29 2009-04-24 Dihydropyrazolderivate als tyrosinkinase modulatoren zur behandlung von tumoren

Publications (1)

Publication Number Publication Date
BRPI0912970A2 true BRPI0912970A2 (pt) 2015-10-13

Family

ID=40822993

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0912970A BRPI0912970A2 (pt) 2008-05-29 2009-04-24 derivados de di-hidropirazol como moduladores de tirosina quinase para o tratamento de tumores

Country Status (16)

Country Link
US (1) US8404685B2 (enExample)
EP (1) EP2300434B1 (enExample)
JP (1) JP5643192B2 (enExample)
KR (1) KR20110010821A (enExample)
CN (1) CN102046605B (enExample)
AR (1) AR071951A1 (enExample)
AU (1) AU2009253432B2 (enExample)
BR (1) BRPI0912970A2 (enExample)
CA (1) CA2726009C (enExample)
DE (1) DE102008025750A1 (enExample)
EA (1) EA018394B1 (enExample)
ES (1) ES2507573T3 (enExample)
IL (1) IL209418A (enExample)
MX (1) MX2010012804A (enExample)
WO (1) WO2009143945A1 (enExample)
ZA (1) ZA201009085B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2726463B1 (en) 2011-07-01 2020-03-11 Merck Patent GmbH Dihydropyrazoles, pharmaceutical compositions thereof and their use for the treatment of fertility disorders
CA2878621C (en) * 2012-07-10 2020-09-15 Ares Trading S.A. Pyrimidine pyrazolyl derivatives
EP3886854A4 (en) 2018-11-30 2022-07-06 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
BR9707495A (pt) 1996-02-13 1999-07-27 Zeneca Ltd Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente
JP4464466B2 (ja) 1996-03-05 2010-05-19 アストラゼネカ・ユーケイ・リミテッド ４―アニリノキナゾリン誘導体
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
IL152682A0 (en) 2000-05-31 2003-06-24 Astrazeneca Ab Indole derivatives with vascular damaging activity
JP2004502766A (ja) 2000-07-07 2004-01-29 アンギオジェン・ファーマシューティカルズ・リミテッド 血管損傷剤としてのコルヒノール誘導体
CA2410562A1 (en) 2000-07-07 2002-01-31 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
AU2003249597B2 (en) 2002-03-08 2007-06-28 Merck Sharp & Dohme Corp. Mitotic kinesin inhibitors
DE102005038537A1 (de) 2005-08-16 2007-02-22 Merck Patent Gmbh 1-Acyldihydropyrazolderivate

Also Published As

Publication number Publication date
JP5643192B2 (ja) 2014-12-17
JP2011520996A (ja) 2011-07-21
US20110071153A1 (en) 2011-03-24
WO2009143945A1 (de) 2009-12-03
EP2300434A1 (de) 2011-03-30
EP2300434B1 (de) 2014-07-23
CN102046605A (zh) 2011-05-04
HK1157345A1 (en) 2012-06-29
CA2726009C (en) 2016-08-23
US8404685B2 (en) 2013-03-26
MX2010012804A (es) 2010-12-07
IL209418A (en) 2015-09-24
CA2726009A1 (en) 2009-12-03
AU2009253432A1 (en) 2009-12-03
CN102046605B (zh) 2013-09-18
AR071951A1 (es) 2010-07-28
KR20110010821A (ko) 2011-02-07
DE102008025750A1 (de) 2009-12-03
ES2507573T3 (es) 2014-10-15
EA018394B1 (ru) 2013-07-30
ZA201009085B (en) 2011-10-26
AU2009253432B2 (en) 2013-08-01
IL209418A0 (en) 2011-01-31
EA201001831A1 (ru) 2011-06-30

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.