AU2009253432B2 - Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors - Google Patents

Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors Download PDF

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Publication number
AU2009253432B2
AU2009253432B2 AU2009253432A AU2009253432A AU2009253432B2 AU 2009253432 B2 AU2009253432 B2 AU 2009253432B2 AU 2009253432 A AU2009253432 A AU 2009253432A AU 2009253432 A AU2009253432 A AU 2009253432A AU 2009253432 B2 AU2009253432 B2 AU 2009253432B2
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AU
Australia
Prior art keywords
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compound
nhet
formula
het
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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AU2009253432A
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English (en)
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AU2009253432A1 (en
Inventor
Andree Blaukat
Dieter Dorsch
Oliver Schadt
Frank Stieber
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Merck Patent GmbH
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Merck Patent GmbH
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Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU2009253432A1 publication Critical patent/AU2009253432A1/en
Application granted granted Critical
Publication of AU2009253432B2 publication Critical patent/AU2009253432B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2009253432A 2008-05-29 2009-04-24 Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors Ceased AU2009253432B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102008025750.8 2008-05-29
DE102008025750A DE102008025750A1 (de) 2008-05-29 2008-05-29 Dihydropyrazolderivate
PCT/EP2009/003030 WO2009143945A1 (de) 2008-05-29 2009-04-24 Dihydropyrazolderivate als tyrosinkinase modulatoren zur behandlung von tumoren

Publications (2)

Publication Number Publication Date
AU2009253432A1 AU2009253432A1 (en) 2009-12-03
AU2009253432B2 true AU2009253432B2 (en) 2013-08-01

Family

ID=40822993

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009253432A Ceased AU2009253432B2 (en) 2008-05-29 2009-04-24 Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors

Country Status (16)

Country Link
US (1) US8404685B2 (enExample)
EP (1) EP2300434B1 (enExample)
JP (1) JP5643192B2 (enExample)
KR (1) KR20110010821A (enExample)
CN (1) CN102046605B (enExample)
AR (1) AR071951A1 (enExample)
AU (1) AU2009253432B2 (enExample)
BR (1) BRPI0912970A2 (enExample)
CA (1) CA2726009C (enExample)
DE (1) DE102008025750A1 (enExample)
EA (1) EA018394B1 (enExample)
ES (1) ES2507573T3 (enExample)
IL (1) IL209418A (enExample)
MX (1) MX2010012804A (enExample)
WO (1) WO2009143945A1 (enExample)
ZA (1) ZA201009085B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2796774T3 (es) 2011-07-01 2020-11-30 Merck Patent Gmbh Dihidropirazoles, composiciones farmacéuticas de los mismos y su uso para el tratamiento de trastornos de fertilidad
US9216991B2 (en) * 2012-07-10 2015-12-22 Ares Trading S.A. Pyrimidine pyrazolyl derivatives
AU2019387370A1 (en) 2018-11-30 2021-06-10 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006281700A1 (en) * 2005-08-16 2007-02-22 Merck Patent Gmbh 1-acyldihydropyrazol derivatives

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
PL194689B1 (pl) 1996-02-13 2007-06-29 Astrazeneca Uk Ltd Pochodne chinazoliny, ich kompozycje farmaceutyczne oraz ich zastosowania
EP0885198B1 (en) 1996-03-05 2001-12-19 AstraZeneca AB 4-anilinoquinazoline derivatives
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
EP1289952A1 (en) 2000-05-31 2003-03-12 AstraZeneca AB Indole derivatives with vascular damaging activity
WO2002008213A1 (en) 2000-07-07 2002-01-31 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
CN1255391C (zh) 2000-07-07 2006-05-10 安吉奥金尼药品有限公司 作为血管破坏剂的colchinol衍生物
DE60329990D1 (de) * 2002-03-08 2009-12-24 Merck & Co Inc Mitotische kinesin-hemmer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006281700A1 (en) * 2005-08-16 2007-02-22 Merck Patent Gmbh 1-acyldihydropyrazol derivatives

Also Published As

Publication number Publication date
IL209418A0 (en) 2011-01-31
US8404685B2 (en) 2013-03-26
CN102046605B (zh) 2013-09-18
US20110071153A1 (en) 2011-03-24
CA2726009C (en) 2016-08-23
AU2009253432A1 (en) 2009-12-03
ES2507573T3 (es) 2014-10-15
EP2300434A1 (de) 2011-03-30
KR20110010821A (ko) 2011-02-07
MX2010012804A (es) 2010-12-07
ZA201009085B (en) 2011-10-26
JP2011520996A (ja) 2011-07-21
EA018394B1 (ru) 2013-07-30
EP2300434B1 (de) 2014-07-23
HK1157345A1 (en) 2012-06-29
EA201001831A1 (ru) 2011-06-30
BRPI0912970A2 (pt) 2015-10-13
AR071951A1 (es) 2010-07-28
WO2009143945A1 (de) 2009-12-03
DE102008025750A1 (de) 2009-12-03
IL209418A (en) 2015-09-24
JP5643192B2 (ja) 2014-12-17
CN102046605A (zh) 2011-05-04
CA2726009A1 (en) 2009-12-03

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired