BRPI0912970A2 - derivados de di-hidropirazol como moduladores de tirosina quinase para o tratamento de tumores - Google Patents

derivados de di-hidropirazol como moduladores de tirosina quinase para o tratamento de tumores

Info

Publication number
BRPI0912970A2
BRPI0912970A2 BRPI0912970A BRPI0912970A BRPI0912970A2 BR PI0912970 A2 BRPI0912970 A2 BR PI0912970A2 BR PI0912970 A BRPI0912970 A BR PI0912970A BR PI0912970 A BRPI0912970 A BR PI0912970A BR PI0912970 A2 BRPI0912970 A2 BR PI0912970A2
Authority
BR
Brazil
Prior art keywords
tumors
treatment
tyrosine kinase
kinase modulators
dihydropyrazole derivatives
Prior art date
Application number
BRPI0912970A
Other languages
English (en)
Inventor
Andree Blaukat
Dieter Dorsch
Frank Stieber
Oliver Schadt
Original Assignee
Merck Patent Ges Mit Beschränkter Haftung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Ges Mit Beschränkter Haftung filed Critical Merck Patent Ges Mit Beschränkter Haftung
Publication of BRPI0912970A2 publication Critical patent/BRPI0912970A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BRPI0912970A 2008-05-29 2009-04-24 derivados de di-hidropirazol como moduladores de tirosina quinase para o tratamento de tumores BRPI0912970A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008025750A DE102008025750A1 (de) 2008-05-29 2008-05-29 Dihydropyrazolderivate
PCT/EP2009/003030 WO2009143945A1 (de) 2008-05-29 2009-04-24 Dihydropyrazolderivate als tyrosinkinase modulatoren zur behandlung von tumoren

Publications (1)

Publication Number Publication Date
BRPI0912970A2 true BRPI0912970A2 (pt) 2015-10-13

Family

ID=40822993

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0912970A BRPI0912970A2 (pt) 2008-05-29 2009-04-24 derivados de di-hidropirazol como moduladores de tirosina quinase para o tratamento de tumores

Country Status (17)

Country Link
US (1) US8404685B2 (pt)
EP (1) EP2300434B1 (pt)
JP (1) JP5643192B2 (pt)
KR (1) KR20110010821A (pt)
CN (1) CN102046605B (pt)
AR (1) AR071951A1 (pt)
AU (1) AU2009253432B2 (pt)
BR (1) BRPI0912970A2 (pt)
CA (1) CA2726009C (pt)
DE (1) DE102008025750A1 (pt)
EA (1) EA018394B1 (pt)
ES (1) ES2507573T3 (pt)
HK (1) HK1157345A1 (pt)
IL (1) IL209418A (pt)
MX (1) MX2010012804A (pt)
WO (1) WO2009143945A1 (pt)
ZA (1) ZA201009085B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6170043B2 (ja) 2011-07-01 2017-07-26 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ジヒドロピラゾール
PT2872501T (pt) * 2012-07-10 2016-09-06 Ares Trading Sa Derivados de pirazolil pirimidina
WO2020113094A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
KR19990082463A (ko) 1996-02-13 1999-11-25 돈 리사 로얄 혈관 내피 성장 인자 억제제로서의 퀴나졸린유도체
CN1116286C (zh) 1996-03-05 2003-07-30 曾尼卡有限公司 4－苯胺基喹唑啉衍生物
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
IL152682A0 (en) 2000-05-31 2003-06-24 Astrazeneca Ab Indole derivatives with vascular damaging activity
CN1255391C (zh) 2000-07-07 2006-05-10 安吉奥金尼药品有限公司 作为血管破坏剂的colchinol衍生物
PL359181A1 (en) 2000-07-07 2004-08-23 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
DE60329990D1 (de) 2002-03-08 2009-12-24 Merck & Co Inc Mitotische kinesin-hemmer
DE102005038537A1 (de) * 2005-08-16 2007-02-22 Merck Patent Gmbh 1-Acyldihydropyrazolderivate

Also Published As

Publication number Publication date
AR071951A1 (es) 2010-07-28
AU2009253432A1 (en) 2009-12-03
DE102008025750A1 (de) 2009-12-03
ES2507573T3 (es) 2014-10-15
MX2010012804A (es) 2010-12-07
EP2300434A1 (de) 2011-03-30
US8404685B2 (en) 2013-03-26
WO2009143945A1 (de) 2009-12-03
JP2011520996A (ja) 2011-07-21
JP5643192B2 (ja) 2014-12-17
KR20110010821A (ko) 2011-02-07
IL209418A (en) 2015-09-24
HK1157345A1 (en) 2012-06-29
AU2009253432B2 (en) 2013-08-01
EA018394B1 (ru) 2013-07-30
CN102046605B (zh) 2013-09-18
CN102046605A (zh) 2011-05-04
ZA201009085B (en) 2011-10-26
CA2726009C (en) 2016-08-23
US20110071153A1 (en) 2011-03-24
CA2726009A1 (en) 2009-12-03
EP2300434B1 (de) 2014-07-23
EA201001831A1 (ru) 2011-06-30
IL209418A0 (en) 2011-01-31

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.