ZA201009085B - Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors - Google Patents

Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors

Info

Publication number
ZA201009085B
ZA201009085B ZA2010/09085A ZA201009085A ZA201009085B ZA 201009085 B ZA201009085 B ZA 201009085B ZA 2010/09085 A ZA2010/09085 A ZA 2010/09085A ZA 201009085 A ZA201009085 A ZA 201009085A ZA 201009085 B ZA201009085 B ZA 201009085B
Authority
ZA
South Africa
Prior art keywords
tumors
treatment
tyrosine kinase
kinase modulators
dihydropyrazole derivatives
Prior art date
Application number
ZA2010/09085A
Other languages
English (en)
Inventor
Dieter Dorsch
Oliver Schadt
Frank Stieber
Andree Blaukat
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA201009085B publication Critical patent/ZA201009085B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA2010/09085A 2008-05-29 2010-12-17 Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors ZA201009085B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008025750A DE102008025750A1 (de) 2008-05-29 2008-05-29 Dihydropyrazolderivate
PCT/EP2009/003030 WO2009143945A1 (de) 2008-05-29 2009-04-24 Dihydropyrazolderivate als tyrosinkinase modulatoren zur behandlung von tumoren

Publications (1)

Publication Number Publication Date
ZA201009085B true ZA201009085B (en) 2011-10-26

Family

ID=40822993

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2010/09085A ZA201009085B (en) 2008-05-29 2010-12-17 Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors

Country Status (16)

Country Link
US (1) US8404685B2 (enExample)
EP (1) EP2300434B1 (enExample)
JP (1) JP5643192B2 (enExample)
KR (1) KR20110010821A (enExample)
CN (1) CN102046605B (enExample)
AR (1) AR071951A1 (enExample)
AU (1) AU2009253432B2 (enExample)
BR (1) BRPI0912970A2 (enExample)
CA (1) CA2726009C (enExample)
DE (1) DE102008025750A1 (enExample)
EA (1) EA018394B1 (enExample)
ES (1) ES2507573T3 (enExample)
IL (1) IL209418A (enExample)
MX (1) MX2010012804A (enExample)
WO (1) WO2009143945A1 (enExample)
ZA (1) ZA201009085B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2726463B1 (en) 2011-07-01 2020-03-11 Merck Patent GmbH Dihydropyrazoles, pharmaceutical compositions thereof and their use for the treatment of fertility disorders
CA2878621C (en) * 2012-07-10 2020-09-15 Ares Trading S.A. Pyrimidine pyrazolyl derivatives
EP3886854A4 (en) 2018-11-30 2022-07-06 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
BR9707495A (pt) 1996-02-13 1999-07-27 Zeneca Ltd Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente
JP4464466B2 (ja) 1996-03-05 2010-05-19 アストラゼネカ・ユーケイ・リミテッド ４―アニリノキナゾリン誘導体
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
IL152682A0 (en) 2000-05-31 2003-06-24 Astrazeneca Ab Indole derivatives with vascular damaging activity
JP2004502766A (ja) 2000-07-07 2004-01-29 アンギオジェン・ファーマシューティカルズ・リミテッド 血管損傷剤としてのコルヒノール誘導体
CA2410562A1 (en) 2000-07-07 2002-01-31 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
AU2003249597B2 (en) 2002-03-08 2007-06-28 Merck Sharp & Dohme Corp. Mitotic kinesin inhibitors
DE102005038537A1 (de) 2005-08-16 2007-02-22 Merck Patent Gmbh 1-Acyldihydropyrazolderivate

Also Published As

Publication number Publication date
JP5643192B2 (ja) 2014-12-17
JP2011520996A (ja) 2011-07-21
US20110071153A1 (en) 2011-03-24
WO2009143945A1 (de) 2009-12-03
EP2300434A1 (de) 2011-03-30
EP2300434B1 (de) 2014-07-23
CN102046605A (zh) 2011-05-04
HK1157345A1 (en) 2012-06-29
CA2726009C (en) 2016-08-23
US8404685B2 (en) 2013-03-26
MX2010012804A (es) 2010-12-07
IL209418A (en) 2015-09-24
CA2726009A1 (en) 2009-12-03
AU2009253432A1 (en) 2009-12-03
CN102046605B (zh) 2013-09-18
AR071951A1 (es) 2010-07-28
KR20110010821A (ko) 2011-02-07
DE102008025750A1 (de) 2009-12-03
ES2507573T3 (es) 2014-10-15
EA018394B1 (ru) 2013-07-30
AU2009253432B2 (en) 2013-08-01
IL209418A0 (en) 2011-01-31
BRPI0912970A2 (pt) 2015-10-13
EA201001831A1 (ru) 2011-06-30

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