UY33159A - Compuestos y métodos para la modulación de quinasa e indicaciones de la misma - Google Patents
Compuestos y métodos para la modulación de quinasa e indicaciones de la mismaInfo
- Publication number
- UY33159A UY33159A UY33159A UY33159A UY33159A UY 33159 A UY33159 A UY 33159A UY 33159 A UY33159 A UY 33159A UY 33159 A UY33159 A UY 33159A UY 33159 A UY33159 A UY 33159A
- Authority
- UY
- Uruguay
- Prior art keywords
- kinase
- indications
- modulation
- compounds
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28993009P | 2009-12-23 | 2009-12-23 | |
US38331810P | 2010-09-15 | 2010-09-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY33159A true UY33159A (es) | 2011-07-29 |
Family
ID=44196390
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY33159A UY33159A (es) | 2009-12-23 | 2010-12-23 | Compuestos y métodos para la modulación de quinasa e indicaciones de la misma |
Country Status (14)
Country | Link |
---|---|
US (2) | US20110183988A1 (es) |
EP (1) | EP2516438A4 (es) |
JP (1) | JP5815558B2 (es) |
KR (1) | KR20120112623A (es) |
CN (1) | CN102753549A (es) |
AR (1) | AR079690A1 (es) |
AU (1) | AU2010336524B2 (es) |
BR (1) | BR112012015745A2 (es) |
CA (1) | CA2784393A1 (es) |
MX (1) | MX2012007429A (es) |
RU (1) | RU2012131373A (es) |
TW (1) | TW201132639A (es) |
UY (1) | UY33159A (es) |
WO (1) | WO2011079133A2 (es) |
Families Citing this family (49)
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JP2010533729A (ja) | 2007-07-17 | 2010-10-28 | プレキシコン,インコーポレーテッド | キナーゼ調節のための化合物と方法、及びそのための適応 |
WO2009143018A2 (en) | 2008-05-19 | 2009-11-26 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
AR078033A1 (es) | 2009-04-03 | 2011-10-12 | Plexxikon Inc | Una dispersion solida, que contiene al compuesto {3-[5-(4-(cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico, composiciones y formulaciones que comprenden a dicha dispersion solida; metodos para fabricar dicha dispersion solida, formas 1 y 2 de |
NZ629615A (en) | 2009-11-06 | 2016-01-29 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
WO2011063159A1 (en) | 2009-11-18 | 2011-05-26 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
KR20120112623A (ko) | 2009-12-23 | 2012-10-11 | 플렉시콘, 인코퍼레이티드 | 키나제 조절을 위한 화합물 및 방법, 및 그에 대한 적응증 |
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WO2012138809A1 (en) * | 2011-04-05 | 2012-10-11 | Dawei Zhang | Heterocyclic compounds as kinase inhibitors |
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TWI601725B (zh) | 2012-08-27 | 2017-10-11 | 加拓科學公司 | 取代的氮雜吲哚化合物及其鹽、組合物和用途 |
ES2889757T3 (es) | 2012-09-06 | 2022-01-13 | Plexxikon Inc | Compuestos y procedimientos para la modulación de quinasas e indicaciones para estos |
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US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
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MX2015015966A (es) | 2013-05-30 | 2016-04-13 | Plexxikon Inc | Compuestos para la modulacion de cinasas e indicaciones para los mismos. |
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JP6832846B2 (ja) | 2014-09-15 | 2021-02-24 | プレキシコン インコーポレーテッドPlexxikon Inc. | ヘテロ環化合物およびその用途 |
WO2016164641A1 (en) | 2015-04-08 | 2016-10-13 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
SG10201912355TA (en) | 2015-05-06 | 2020-02-27 | Plexxikon Inc | Solid forms of a compound modulating kinases |
CN107531706A (zh) | 2015-05-06 | 2018-01-02 | 普莱希科公司 | 调节激酶的1H‑吡咯并[2,3‑b]吡啶衍生物的合成 |
CA2986735A1 (en) | 2015-05-22 | 2016-12-01 | Plexxikon Inc. | Solid forms of a compound for modulating kinases |
CA2986739C (en) | 2015-05-22 | 2023-03-14 | Plexxikon Inc. | Plx-8394 or plx-7904 for use in the treatment of braf-v600-related diseases |
US10829484B2 (en) | 2015-07-28 | 2020-11-10 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
RU2744897C2 (ru) | 2015-09-21 | 2021-03-16 | Плексксикон Инк. | Гетероциклические соединения и их применение |
KR20180086247A (ko) | 2015-12-07 | 2018-07-30 | 플렉시콘 인코퍼레이티드 | 키나제 조절을 위한 화합물 및 방법과 이들에 대한 징후 |
ES2904615T3 (es) | 2016-03-16 | 2022-04-05 | Plexxikon Inc | Compuestos y métodos para la modulación de quinasas e indicaciones al respecto |
TW201815766A (zh) | 2016-09-22 | 2018-05-01 | 美商普雷辛肯公司 | 用於ido及tdo調節之化合物及方法以及其適應症 |
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JP7300394B2 (ja) * | 2017-01-17 | 2023-06-29 | ヘパリジェニックス ゲーエムベーハー | 肝再生の促進又は肝細胞死の低減もしくは予防のためのプロテインキナーゼ阻害 |
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CN111217654A (zh) * | 2020-01-02 | 2020-06-02 | 陕西科技大学 | 钯催化的间位芳基化反应及其在维罗非尼类似物合成中的应用 |
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AU2012255275B2 (en) | 2011-05-17 | 2016-01-28 | Plexxikon Inc. | Kinase modulation and indications therefor |
US9358235B2 (en) | 2012-03-19 | 2016-06-07 | Plexxikon Inc. | Kinase modulation, and indications therefor |
US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
ES2889757T3 (es) | 2012-09-06 | 2022-01-13 | Plexxikon Inc | Compuestos y procedimientos para la modulación de quinasas e indicaciones para estos |
WO2014100620A2 (en) | 2012-12-21 | 2014-06-26 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
ES2688575T3 (es) | 2013-03-15 | 2018-11-05 | Plexxikon Inc. | Compuestos heterocíclicos y sus usos |
US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
MX2015015966A (es) | 2013-05-30 | 2016-04-13 | Plexxikon Inc | Compuestos para la modulacion de cinasas e indicaciones para los mismos. |
-
2010
- 2010-12-21 KR KR1020127019219A patent/KR20120112623A/ko not_active Application Discontinuation
- 2010-12-21 EP EP10840075.5A patent/EP2516438A4/en not_active Withdrawn
- 2010-12-21 MX MX2012007429A patent/MX2012007429A/es not_active Application Discontinuation
- 2010-12-21 AU AU2010336524A patent/AU2010336524B2/en not_active Expired - Fee Related
- 2010-12-21 RU RU2012131373/04A patent/RU2012131373A/ru not_active Application Discontinuation
- 2010-12-21 US US12/975,239 patent/US20110183988A1/en not_active Abandoned
- 2010-12-21 CN CN2010800638309A patent/CN102753549A/zh active Pending
- 2010-12-21 CA CA2784393A patent/CA2784393A1/en not_active Abandoned
- 2010-12-21 WO PCT/US2010/061601 patent/WO2011079133A2/en active Application Filing
- 2010-12-21 JP JP2012546158A patent/JP5815558B2/ja not_active Expired - Fee Related
- 2010-12-21 BR BR112012015745A patent/BR112012015745A2/pt not_active IP Right Cessation
- 2010-12-22 TW TW099145373A patent/TW201132639A/zh unknown
- 2010-12-22 AR ARP100104871A patent/AR079690A1/es unknown
- 2010-12-23 UY UY33159A patent/UY33159A/es not_active Application Discontinuation
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2014
- 2014-10-14 US US14/514,232 patent/US9440969B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP5815558B2 (ja) | 2015-11-17 |
AR079690A1 (es) | 2012-02-15 |
TW201132639A (en) | 2011-10-01 |
US20110183988A1 (en) | 2011-07-28 |
JP2013515736A (ja) | 2013-05-09 |
BR112012015745A2 (pt) | 2016-05-17 |
EP2516438A2 (en) | 2012-10-31 |
KR20120112623A (ko) | 2012-10-11 |
CA2784393A1 (en) | 2011-06-30 |
US20150080372A1 (en) | 2015-03-19 |
CN102753549A (zh) | 2012-10-24 |
AU2010336524B2 (en) | 2015-10-08 |
EP2516438A4 (en) | 2013-06-12 |
MX2012007429A (es) | 2012-07-23 |
US9440969B2 (en) | 2016-09-13 |
RU2012131373A (ru) | 2014-01-27 |
WO2011079133A3 (en) | 2011-11-17 |
WO2011079133A2 (en) | 2011-06-30 |
AU2010336524A1 (en) | 2012-07-05 |
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