JP5553289B2 - 新規核初期化物質 - Google Patents
新規核初期化物質 Download PDFInfo
- Publication number
- JP5553289B2 JP5553289B2 JP2011536662A JP2011536662A JP5553289B2 JP 5553289 B2 JP5553289 B2 JP 5553289B2 JP 2011536662 A JP2011536662 A JP 2011536662A JP 2011536662 A JP2011536662 A JP 2011536662A JP 5553289 B2 JP5553289 B2 JP 5553289B2
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- JP
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- Prior art keywords
- cells
- cell
- ips
- oct3
- myc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/602—Sox-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/603—Oct-3/4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/606—Transcription factors c-Myc
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Developmental Biology & Embryology (AREA)
- Microbiology (AREA)
- Transplantation (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20885309P | 2009-02-27 | 2009-02-27 | |
| US61/208,853 | 2009-02-27 | ||
| US27612309P | 2009-09-08 | 2009-09-08 | |
| US61/276,123 | 2009-09-08 | ||
| PCT/JP2010/053024 WO2010098419A1 (en) | 2009-02-27 | 2010-02-19 | Novel nuclear reprogramming substance |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012518988A JP2012518988A (ja) | 2012-08-23 |
| JP2012518988A5 JP2012518988A5 (OSRAM) | 2013-02-21 |
| JP5553289B2 true JP5553289B2 (ja) | 2014-07-16 |
Family
ID=42665623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011536662A Active JP5553289B2 (ja) | 2009-02-27 | 2010-02-19 | 新規核初期化物質 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8951801B2 (OSRAM) |
| EP (2) | EP2401372A4 (OSRAM) |
| JP (1) | JP5553289B2 (OSRAM) |
| KR (1) | KR101764100B1 (OSRAM) |
| CN (1) | CN102388136B (OSRAM) |
| CA (1) | CA2753845C (OSRAM) |
| IL (1) | IL214833A (OSRAM) |
| SG (1) | SG173876A1 (OSRAM) |
| WO (1) | WO2010098419A1 (OSRAM) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2753845C (en) | 2009-02-27 | 2019-10-29 | Kyoto University | Nuclear reprogramming substance comprising glis1 |
| KR101857302B1 (ko) | 2010-02-16 | 2018-05-11 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 유도된 다능성 줄기 세포의 효율적 확립 방법 |
| EP2647699B1 (en) * | 2010-12-03 | 2020-04-01 | Kyoto University | Efficient method for establishing induced pluripotent stem cells |
| US9404082B2 (en) | 2010-12-03 | 2016-08-02 | Kyoto University | Method for production of eosinophil from pluripotent stem cell |
| WO2012137970A1 (ja) | 2011-04-08 | 2012-10-11 | 国立大学法人大阪大学 | 改変ラミニンおよびその利用 |
| WO2012141181A1 (ja) * | 2011-04-11 | 2012-10-18 | 国立大学法人京都大学 | 核初期化物質 |
| KR101334404B1 (ko) * | 2011-04-28 | 2013-12-12 | 포항공과대학교 산학협력단 | 배아줄기세포 유래의 인공 마이크로베시클을 이용한 역분화 유도만능줄기세포의 제조방법 |
| KR101791926B1 (ko) | 2011-07-25 | 2017-11-20 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 유도 만능 줄기 세포 스크리닝 방법 |
| WO2013058403A1 (ja) | 2011-10-21 | 2013-04-25 | 国立大学法人京都大学 | 層流による多能性維持単一分散細胞培養法 |
| WO2013077423A1 (ja) | 2011-11-25 | 2013-05-30 | 国立大学法人京都大学 | 多能性幹細胞の培養方法 |
| PT2852671T (pt) | 2012-05-21 | 2018-11-29 | Univ California | Produção de células ips humanas através de um rna autorreplicativo sintético |
| JP6495658B2 (ja) | 2013-02-08 | 2019-04-03 | 国立大学法人京都大学 | 巨核球及び血小板の製造方法 |
| WO2014136581A1 (ja) | 2013-03-06 | 2014-09-12 | 国立大学法人京都大学 | 多能性幹細胞の培養システム及び多能性幹細胞の継代方法 |
| JP6473077B2 (ja) | 2013-03-21 | 2019-02-20 | 国立大学法人京都大学 | 神経分化誘導用の多能性幹細胞 |
| WO2014157257A1 (ja) | 2013-03-25 | 2014-10-02 | 公益財団法人先端医療振興財団 | 細胞の選別方法 |
| EP2985344B1 (en) | 2013-04-12 | 2018-07-18 | Kyoto University | Method for inducing alveolar epithelium progenitor cells |
| EP2998391B1 (en) | 2013-05-14 | 2020-02-19 | Kyoto University | Efficient myocardial cell induction method |
| KR101870174B1 (ko) | 2013-05-31 | 2018-06-22 | 아이하트 재팬 가부시키가이샤 | 하이드로겔을 포함하는 적층화된 세포 시트 |
| BR112015030918A2 (pt) | 2013-06-11 | 2017-12-05 | Astellas Pharma Inc | método para produção de células progenitoras renais, e fármacos contendo células progenitoras renais |
| JP6516672B2 (ja) | 2013-07-26 | 2019-05-22 | 京都府公立大学法人 | 骨芽細胞及びその調製方法 |
| EP3031905A4 (en) | 2013-08-07 | 2017-04-26 | Kyoto University | Method for producing pancreatic hormone-producing cell |
| MY184219A (en) | 2013-09-05 | 2021-03-26 | Univ Kyoto | New method for inducing dopamine-producing neural precursor cells |
| WO2015064754A1 (ja) | 2013-11-01 | 2015-05-07 | 国立大学法人京都大学 | 新規軟骨細胞誘導方法 |
| JP7012432B2 (ja) | 2014-07-14 | 2022-01-28 | 中外製薬株式会社 | タンパク質のエピトープを同定するための方法 |
| SG11201701191WA (en) | 2014-07-18 | 2017-03-30 | Univ Kyoto | Method for inducing t cells for cell-based immunotherapy from pluripotent stem cells |
| US10711249B2 (en) | 2014-12-26 | 2020-07-14 | Kyoto University | Method for inducing hepatocytes |
| JP2016202172A (ja) | 2015-04-16 | 2016-12-08 | 国立大学法人京都大学 | 疑似膵島の製造方法 |
| EP3356520B1 (en) | 2015-10-02 | 2022-03-23 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Lentiviral protein delivery system for rna-guided genome editing |
| HUE056387T2 (hu) | 2016-04-15 | 2022-02-28 | Univ Kyoto | Eljárás antigénspecifikus CD8-pozitív T-sejtek indukálására |
| WO2017183736A1 (ja) | 2016-04-22 | 2017-10-26 | 国立大学法人京都大学 | ドーパミン産生神経前駆細胞の製造方法 |
| CN110114470A (zh) | 2016-12-27 | 2019-08-09 | 住友化学株式会社 | 诱导的多能性干细胞的评价方法及选择方法、以及诱导的多能性干细胞的制备方法 |
| EP3572502B1 (en) | 2017-01-20 | 2023-01-11 | Kyoto University | Method for producing cd8alpha +beta + cytotoxic t cells |
| WO2018139548A1 (ja) | 2017-01-26 | 2018-08-02 | 国立大学法人大阪大学 | 幹細胞の中胚葉系細胞への分化誘導用培地および中胚葉系細胞の製造方法 |
| EP3597734A4 (en) | 2017-03-14 | 2021-03-03 | Kyoto University | METHOD FOR PRODUCING HELPER T-CELLS FROM PLURIPOTENT STEM CELLS |
| KR102594102B1 (ko) | 2017-05-25 | 2023-10-25 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 중간 중배엽 세포로부터 신장 전구 세포로의 분화 유도 방법 및 다능성 줄기세포로부터 신장 전구 세포로의 분화 유도 방법 |
| CN111164209A (zh) | 2017-06-19 | 2020-05-15 | 公益财团法人神户医疗产业都市推进机构 | 多能干细胞的分化能力的预测方法和用于该预测方法的试剂 |
| US20210363496A1 (en) | 2017-10-17 | 2021-11-25 | Kyoto University | Method for obtaining artificial neuromuscular junction from pluripotent stem cells |
| SG11202100260QA (en) | 2018-07-13 | 2021-02-25 | Univ Kyoto | METHOD FOR PRODUCING γδ T CELLS |
| US20210299331A1 (en) | 2018-07-19 | 2021-09-30 | Kyoto University | Pluripotent stem cell-derived plate-shaped cartilage and method for producing the same |
| WO2020022261A1 (ja) | 2018-07-23 | 2020-01-30 | 国立大学法人京都大学 | 新規腎前駆細胞マーカーおよびそれを利用した腎前駆細胞の濃縮方法 |
| US12168781B2 (en) | 2018-12-06 | 2024-12-17 | Kirin Holdings Kabushiki Kaisha | Production method for T cells or NK cells, medium for culturing T cells or NK cells, method for culturing T cells or NK cells, method for maintaining undifferentiated state of undifferentiated T cells, and growth-accelerating agent for T cells or NK cells |
| WO2020130147A1 (ja) | 2018-12-21 | 2020-06-25 | 国立大学法人京都大学 | ルブリシン局在軟骨様組織、その製造方法及びそれを含む関節軟骨損傷治療用組成物 |
| WO2020138371A1 (ja) | 2018-12-26 | 2020-07-02 | キリンホールディングス株式会社 | 改変tcr及びその製造方法 |
| EP3933033A4 (en) | 2019-02-26 | 2022-11-23 | Tohoku University | METHOD FOR PRODUCING AN AGGREGATE OF OSTEOBLASTS USING HUMAN IPS CELLS |
| CN113811316A (zh) | 2019-05-15 | 2021-12-17 | 味之素株式会社 | 神经嵴细胞或角膜上皮细胞的纯化方法 |
| CA3141455A1 (en) | 2019-05-20 | 2020-11-26 | Ajinomoto Co., Inc. | Expansion culture method for cartilage or bone precursor cells |
| US20230030814A1 (en) | 2019-12-12 | 2023-02-02 | National University Corporation Chiba University | Freeze-Dried Preparations Comprising Megakaryocytes and Platelets |
| TWI886220B (zh) | 2020-02-28 | 2025-06-11 | 美商千禧製藥公司 | 用於自富潛能幹細胞生產自然殺手細胞之方法 |
| EP4170020A4 (en) | 2020-06-17 | 2025-01-22 | Kyoto University | IMMUNOCOMPETENT CELLS WITH CHIMERIC ANTIGEN RECEPTOR EXPRESSION |
| EP4180516A4 (en) | 2020-07-13 | 2024-01-17 | Kyoto University | SKELETON MUSCLE PRECURSOR CELLS AND METHOD FOR PURIFICATION THEREOF, COMPOSITION FOR THE TREATMENT OF MYOGENIC DISEASES AND METHOD FOR PRODUCING SKELETON MUSCLE PRECURSOR CELLS CONTAINING CELL GROUPS |
| JPWO2022019152A1 (OSRAM) | 2020-07-20 | 2022-01-27 | ||
| CN116323917A (zh) | 2020-08-18 | 2023-06-23 | 国立大学法人京都大学 | 人原始生殖细胞/人原始生殖细胞样细胞的维持扩增方法 |
| EP4310176A4 (en) | 2021-03-17 | 2025-03-26 | Astellas Pharma Inc. | Pericyte with basic fibroblast growth factor (BFGF) gene inserted into it |
| CA3214490A1 (en) | 2021-03-25 | 2022-09-29 | Bluerock Therapeutics Lp | Methods for obtaining induced pluripotent stem cells |
| JPWO2022230977A1 (OSRAM) | 2021-04-30 | 2022-11-03 | ||
| US20240254441A1 (en) | 2021-06-04 | 2024-08-01 | Kirin Holdings Kabushiki Kaisha | Cell composition, method for producing cell composition, and pharmaceutical composition containing cell composition |
| WO2022259721A1 (ja) | 2021-06-10 | 2022-12-15 | 味の素株式会社 | 間葉系幹細胞の製造方法 |
| KR20240021878A (ko) | 2021-06-15 | 2024-02-19 | 다케다 야쿠힌 고교 가부시키가이샤 | 다능성 줄기 세포로부터 자연 살해 세포를 생산하기 위한 방법 |
| US20240316115A1 (en) | 2021-07-15 | 2024-09-26 | Astellas Pharma Inc. | Method for producing vascular endothelial growth factor (vegf)- highly expressing pericyte-like cell |
| JPWO2023286834A1 (OSRAM) | 2021-07-15 | 2023-01-19 | ||
| WO2023017848A1 (ja) | 2021-08-11 | 2023-02-16 | 国立大学法人京都大学 | 腎間質前駆細胞の製造方法並びにエリスロポエチン産生細胞、およびレニン産生細胞の製造方法 |
| EP4431605A4 (en) | 2021-11-11 | 2025-12-10 | Healios Kk | Genetically modified pluripotent stem cell, derived immunocompetent cell, method for producing these cells and associated uses |
| WO2023153464A1 (ja) | 2022-02-09 | 2023-08-17 | 住友ファーマ株式会社 | 多能性幹細胞から中脳底板領域の神経系細胞への分化における、培養液中の細胞の分化能を判定する方法 |
| JPWO2023210713A1 (OSRAM) | 2022-04-27 | 2023-11-02 | ||
| EP4538384A1 (en) | 2022-06-10 | 2025-04-16 | Kyoto University | Detection method and detection reagent for undifferentiated pluripotent stem cells |
| WO2024248017A1 (ja) | 2023-05-29 | 2024-12-05 | 国立研究開発法人理化学研究所 | 心筋細胞を成熟させる方法及び成熟した心筋細胞の製造方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4937190A (en) | 1987-10-15 | 1990-06-26 | Wisconsin Alumni Research Foundation | Translation enhancer |
| WO2000070070A1 (en) | 1999-05-18 | 2000-11-23 | Dnavec Research Inc. | Paramyxoviridae virus vector defective in envelope gene |
| EP4223769A3 (en) * | 2005-12-13 | 2023-11-01 | Kyoto University | Nuclear reprogramming factor |
| CN101743306A (zh) * | 2007-03-23 | 2010-06-16 | 威斯康星校友研究基金会 | 体细胞重编程 |
| EP3878949B1 (en) * | 2007-04-07 | 2025-06-04 | Whitehead Institute for Biomedical Research | Reprogramming of somatic cells |
| WO2008151058A2 (en) * | 2007-05-30 | 2008-12-11 | The General Hospital Corporation | Methods of generating pluripotent cells from somatic cells |
| JP2008307007A (ja) * | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| AU2008297024B2 (en) | 2007-10-31 | 2014-08-28 | Kyoto University | Nuclear reprogramming method |
| US20110231944A1 (en) | 2008-09-04 | 2011-09-22 | Riken | B cell-derived ips cells and application thereof |
| EP2336303B1 (en) | 2008-09-08 | 2015-07-15 | Riken | NKT CELL-DERIVED iPS CELLS AND NKT CELLS DERIVED THEREFROM |
| CA2753845C (en) | 2009-02-27 | 2019-10-29 | Kyoto University | Nuclear reprogramming substance comprising glis1 |
| CN101613717B (zh) | 2009-04-17 | 2012-01-11 | 中国科学院广州生物医药与健康研究院 | 用猪成纤维细胞生成诱导的多能性干细胞的方法 |
| SG10201608797WA (en) | 2009-08-07 | 2016-12-29 | Univ Kyoto | Method of efficiently establishing induced pluripotent stem cells |
| KR101857302B1 (ko) | 2010-02-16 | 2018-05-11 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 유도된 다능성 줄기 세포의 효율적 확립 방법 |
-
2010
- 2010-02-19 CA CA2753845A patent/CA2753845C/en active Active
- 2010-02-19 CN CN201080011401.7A patent/CN102388136B/zh active Active
- 2010-02-19 SG SG2011061959A patent/SG173876A1/en unknown
- 2010-02-19 WO PCT/JP2010/053024 patent/WO2010098419A1/en not_active Ceased
- 2010-02-19 JP JP2011536662A patent/JP5553289B2/ja active Active
- 2010-02-19 US US13/203,735 patent/US8951801B2/en active Active
- 2010-02-19 KR KR1020117022584A patent/KR101764100B1/ko active Active
- 2010-02-19 EP EP10746298A patent/EP2401372A4/en not_active Withdrawn
- 2010-02-19 EP EP13158495.5A patent/EP2607476B1/en active Active
-
2011
- 2011-08-25 IL IL214833A patent/IL214833A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010098419A1 (en) | 2010-09-02 |
| US20120052583A1 (en) | 2012-03-01 |
| CA2753845A1 (en) | 2010-09-02 |
| IL214833A0 (en) | 2011-11-30 |
| KR101764100B1 (ko) | 2017-08-02 |
| CA2753845C (en) | 2019-10-29 |
| EP2401372A1 (en) | 2012-01-04 |
| CN102388136B (zh) | 2014-10-01 |
| EP2607476A1 (en) | 2013-06-26 |
| KR20120003867A (ko) | 2012-01-11 |
| EP2401372A4 (en) | 2012-09-19 |
| CN102388136A (zh) | 2012-03-21 |
| EP2607476B1 (en) | 2015-04-08 |
| JP2012518988A (ja) | 2012-08-23 |
| US8951801B2 (en) | 2015-02-10 |
| SG173876A1 (en) | 2011-09-29 |
| IL214833A (en) | 2016-07-31 |
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