JP5538356B2 - １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤 - Google Patents

１１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤 Download PDF

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JP5538356B2
JP5538356B2 JP2011500805A JP2011500805A JP5538356B2 JP 5538356 B2 JP5538356 B2 JP 5538356B2 JP 2011500805 A JP2011500805 A JP 2011500805A JP 2011500805 A JP2011500805 A JP 2011500805A JP 5538356 B2 JP5538356 B2 JP 5538356B2
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alkyl
halo
cycloalkyl
alkoxy
hydroxy
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JP2011515398A5 (enExample
JP2011515398A (ja
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クラレモン，デーヴィッド・エイ
ツァン，リンハン
イエ，ユアンジェ
シン，スレシュ・ビー
タイス，コリン・エム
マクギーハン，ジェラルド
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ヴァイティー ファーマシューティカルズ，インコーポレイテッド
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    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
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    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Pharmacology & Pharmacy (AREA)
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  • Diabetes (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
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JP2011500805A 2008-03-18 2009-03-18 １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤 Expired - Fee Related JP5538356B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3764608P 2008-03-18 2008-03-18
US61/037,646 2008-03-18
PCT/US2009/001712 WO2009117109A1 (en) 2008-03-18 2009-03-18 Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1

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Publication Number Publication Date
JP2011515398A JP2011515398A (ja) 2011-05-19
JP2011515398A5 JP2011515398A5 (enExample) 2012-05-10
JP5538356B2 true JP5538356B2 (ja) 2014-07-02

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US (1) US20110105504A1 (enExample)
EP (1) EP2274287B1 (enExample)
JP (1) JP5538356B2 (enExample)
CA (1) CA2718264A1 (enExample)
WO (1) WO2009117109A1 (enExample)

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AR069207A1 (es) 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
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US8440658B2 (en) 2007-12-11 2013-05-14 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
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US8592409B2 (en) * 2008-01-24 2013-11-26 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1
JP5734666B2 (ja) * 2008-02-11 2015-06-17 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の１，３−オキサアゼパン−２−オン及び１，３−ジアゼパン−２−オン阻害剤
CA2715290A1 (en) 2008-02-15 2009-08-20 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2291373B1 (en) * 2008-05-01 2013-09-11 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5301563B2 (ja) * 2008-05-01 2013-09-25 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
EP2291371B1 (en) 2008-05-01 2015-06-10 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
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EP2288596B1 (en) 2008-05-13 2016-11-30 Boehringer Ingelheim International GmbH Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
WO2010010150A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
PL2324018T3 (pl) 2008-07-25 2014-02-28 Boehringer Ingelheim Int Cykliczne inhibitory dehydrogenazy 11 beta-hydroksysteroidowej typu 1
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