JP5512655B2 - Ｃ型肝炎ウイルス阻害剤 - Google Patents

Ｃ型肝炎ウイルス阻害剤 Download PDF

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Publication number
JP5512655B2
JP5512655B2 JP2011505096A JP2011505096A JP5512655B2 JP 5512655 B2 JP5512655 B2 JP 5512655B2 JP 2011505096 A JP2011505096 A JP 2011505096A JP 2011505096 A JP2011505096 A JP 2011505096A JP 5512655 B2 JP5512655 B2 JP 5512655B2
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JP
Japan
Prior art keywords
compound
hcv
alkyl
nmr
mmol
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Expired - Fee Related
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JP2011505096A
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Japanese (ja)
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JP2011518163A5 (https=
JP2011518163A (ja
Inventor
ニ・シン
ブライアン・リー・ベナブルズ
ポール・マイケル・スコーラ
アラン・シャンドン・ワン
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
JP2011505096A 2008-04-16 2009-04-09 Ｃ型肝炎ウイルス阻害剤 Expired - Fee Related JP5512655B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4543408P 2008-04-16 2008-04-16
US61/045,434 2008-04-16
US12/418,677 2009-04-06
US12/418,677 US8163921B2 (en) 2008-04-16 2009-04-06 Hepatitis C virus inhibitors
PCT/US2009/039993 WO2009129109A1 (en) 2008-04-16 2009-04-09 Hepatitis c virus inhibitors

Publications (3)

Publication Number Publication Date
JP2011518163A JP2011518163A (ja) 2011-06-23
JP2011518163A5 JP2011518163A5 (https=) 2012-05-17
JP5512655B2 true JP5512655B2 (ja) 2014-06-04

Family

ID=40666703

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011505096A Expired - Fee Related JP5512655B2 (ja) 2008-04-16 2009-04-09 Ｃ型肝炎ウイルス阻害剤

Country Status (11)

Country Link
US (1) US8163921B2 (https=)
EP (2) EP2813500B1 (https=)
JP (1) JP5512655B2 (https=)
KR (1) KR101610418B1 (https=)
CN (2) CN103936819B (https=)
AR (1) AR071370A1 (https=)
CL (1) CL2009000923A1 (https=)
MX (1) MX2010010974A (https=)
PE (1) PE20091841A1 (https=)
TW (1) TW200946523A (https=)
WO (1) WO2009129109A1 (https=)

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EP2265606A1 (en) 2010-12-29
US8163921B2 (en) 2012-04-24
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CN102083821A (zh) 2011-06-01
CN102083821B (zh) 2014-09-17
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TW200946523A (en) 2009-11-16
PE20091841A1 (es) 2009-12-04
KR20100132078A (ko) 2010-12-16
CN103936819A (zh) 2014-07-23
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