JP5475778B2 - 腫瘍の治療のための二環式トリアゾール誘導体 - Google Patents

腫瘍の治療のための二環式トリアゾール誘導体 Download PDF

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Publication number
JP5475778B2
JP5475778B2 JP2011522392A JP2011522392A JP5475778B2 JP 5475778 B2 JP5475778 B2 JP 5475778B2 JP 2011522392 A JP2011522392 A JP 2011522392A JP 2011522392 A JP2011522392 A JP 2011522392A JP 5475778 B2 JP5475778 B2 JP 5475778B2
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het
hal
atoms
mmol
proportions
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JP2011522392A
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Japanese (ja)
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JP2011530545A (ja
JP2011530545A5 (enExample
Inventor
スティーバー，フランク
シャット，オリバー
ドルシュ，ディーター
ブラウカット，アンドレ
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Merck Patent GmbH
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Merck Patent GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011522392A 2008-08-14 2009-07-16 腫瘍の治療のための二環式トリアゾール誘導体 Expired - Fee Related JP5475778B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102008037790.2 2008-08-14
DE102008037790A DE102008037790A1 (de) 2008-08-14 2008-08-14 Bicyclische Triazolderivate
PCT/EP2009/005172 WO2010017870A1 (de) 2008-08-14 2009-07-16 Bicyclische triazolderivate zur behandlung von tumoren

Publications (3)

Publication Number Publication Date
JP2011530545A JP2011530545A (ja) 2011-12-22
JP2011530545A5 JP2011530545A5 (enExample) 2012-08-30
JP5475778B2 true JP5475778B2 (ja) 2014-04-16

Family

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Application Number Title Priority Date Filing Date
JP2011522392A Expired - Fee Related JP5475778B2 (ja) 2008-08-14 2009-07-16 腫瘍の治療のための二環式トリアゾール誘導体

Country Status (16)

Country Link
US (1) US8435986B2 (enExample)
EP (1) EP2310013B1 (enExample)
JP (1) JP5475778B2 (enExample)
KR (1) KR20110051243A (enExample)
CN (1) CN102123710B (enExample)
AR (1) AR073055A1 (enExample)
AU (1) AU2009281491B2 (enExample)
BR (1) BRPI0914555A2 (enExample)
CA (1) CA2733941C (enExample)
DE (1) DE102008037790A1 (enExample)
EA (1) EA201100334A1 (enExample)
ES (1) ES2648233T3 (enExample)
IL (1) IL211193A0 (enExample)
MX (1) MX2011001511A (enExample)
WO (1) WO2010017870A1 (enExample)
ZA (1) ZA201101899B (enExample)

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AU2011305667A1 (en) * 2010-09-23 2013-03-21 Boehringer Ingelheim International Gmbh Oxadiazole inhibitors of leukotriene production
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JP6546161B2 (ja) 2013-10-04 2019-07-17 ノバルティス アーゲー Ｂ型肝炎ウイルスを治療するための有機化合物
KR102298475B1 (ko) * 2013-10-04 2021-09-06 노파르티스 아게 ＲＮＡ 간섭에 사용하기 위한 ＲＮＡｉ 작용제를 위한 3' 말단 캡
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SI3752501T1 (sl) 2018-02-13 2023-08-31 Gilead Sciences, Inc. Inhibitorji pd-1/pd-l1
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Also Published As

Publication number Publication date
BRPI0914555A2 (pt) 2015-12-15
CA2733941A1 (en) 2010-02-18
CN102123710B (zh) 2012-11-07
EA201100334A1 (ru) 2011-08-30
JP2011530545A (ja) 2011-12-22
CN102123710A (zh) 2011-07-13
AU2009281491B2 (en) 2014-02-20
US20110135600A1 (en) 2011-06-09
HK1159989A1 (en) 2012-08-10
DE102008037790A1 (de) 2010-02-18
ES2648233T3 (es) 2017-12-29
ZA201101899B (en) 2011-11-30
AR073055A1 (es) 2010-10-13
CA2733941C (en) 2016-10-04
EP2310013B1 (de) 2017-08-23
AU2009281491A1 (en) 2010-02-18
KR20110051243A (ko) 2011-05-17
MX2011001511A (es) 2011-03-15
EP2310013A1 (de) 2011-04-20
US8435986B2 (en) 2013-05-07
IL211193A0 (en) 2011-04-28
WO2010017870A1 (de) 2010-02-18

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