KR20110051243A - 종양 치료용 비시클릭 트리아졸 유도체 - Google Patents
종양 치료용 비시클릭 트리아졸 유도체 Download PDFInfo
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- KR20110051243A KR20110051243A KR1020117005525A KR20117005525A KR20110051243A KR 20110051243 A KR20110051243 A KR 20110051243A KR 1020117005525 A KR1020117005525 A KR 1020117005525A KR 20117005525 A KR20117005525 A KR 20117005525A KR 20110051243 A KR20110051243 A KR 20110051243A
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008037790.2 | 2008-08-14 | ||
| DE102008037790A DE102008037790A1 (de) | 2008-08-14 | 2008-08-14 | Bicyclische Triazolderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20110051243A true KR20110051243A (ko) | 2011-05-17 |
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Family Applications (1)
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|---|---|---|---|
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| Country | Link |
|---|---|
| US (1) | US8435986B2 (enExample) |
| EP (1) | EP2310013B1 (enExample) |
| JP (1) | JP5475778B2 (enExample) |
| KR (1) | KR20110051243A (enExample) |
| CN (1) | CN102123710B (enExample) |
| AR (1) | AR073055A1 (enExample) |
| AU (1) | AU2009281491B2 (enExample) |
| BR (1) | BRPI0914555A2 (enExample) |
| CA (1) | CA2733941C (enExample) |
| DE (1) | DE102008037790A1 (enExample) |
| EA (1) | EA201100334A1 (enExample) |
| ES (1) | ES2648233T3 (enExample) |
| IL (1) | IL211193A0 (enExample) |
| MX (1) | MX2011001511A (enExample) |
| WO (1) | WO2010017870A1 (enExample) |
| ZA (1) | ZA201101899B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018147575A1 (ko) * | 2017-02-08 | 2018-08-16 | 에이비온 주식회사 | 트리아졸로 피라진 유도체의 신규한 다형체 및 이의 제조 방법 |
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| JP2011515343A (ja) * | 2008-03-03 | 2011-05-19 | タイガー ファーマテック | チロシンキナーゼ阻害薬 |
| BR112012016129B1 (pt) | 2009-12-31 | 2020-11-03 | Hutchison Medipharma Limited | composto, composição e uso dos ditos compostos |
| JP5960688B2 (ja) * | 2010-05-17 | 2016-08-02 | インコゼン セラピューティクス プライベート リミテッド | プロテインキナーゼ調節物質としての新規３，５−二置換−３ｈ−［１，２，３］トリアゾロ［４，５−ｂ］ピリジン化合物 |
| AU2011305667A1 (en) * | 2010-09-23 | 2013-03-21 | Boehringer Ingelheim International Gmbh | Oxadiazole inhibitors of leukotriene production |
| MX368311B (es) * | 2013-09-30 | 2019-09-27 | Korea Res Inst Chemical Tech | Nuevos derivados de triazolopirazina y usos de los mismos. |
| JP6546161B2 (ja) | 2013-10-04 | 2019-07-17 | ノバルティス アーゲー | Ｂ型肝炎ウイルスを治療するための有機化合物 |
| KR102298475B1 (ko) * | 2013-10-04 | 2021-09-06 | 노파르티스 아게 | ＲＮＡ 간섭에 사용하기 위한 ＲＮＡｉ 작용제를 위한 3' 말단 캡 |
| GB201321740D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| CA2934679C (en) * | 2013-12-30 | 2023-02-28 | Genentech, Inc. | Serine/threonine kinase inhibitors |
| AU2017213628B2 (en) | 2016-02-05 | 2021-07-29 | Denali Therapeutics Inc. | Inhibitors of receptor-interacting protein kinase 1 |
| WO2018107060A1 (en) | 2016-12-09 | 2018-06-14 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| CN108570053A (zh) * | 2017-03-13 | 2018-09-25 | 中国科学院上海药物研究所 | 五元并六元杂环化合物、制备方法、中间体、组合和应用 |
| SI3752501T1 (sl) | 2018-02-13 | 2023-08-31 | Gilead Sciences, Inc. | Inhibitorji pd-1/pd-l1 |
| CA3093130C (en) | 2018-04-19 | 2023-10-17 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| SI3820572T1 (sl) | 2018-07-13 | 2023-12-29 | Gilead Sciences, Inc. | Inhibitorji pd-1/pd-l1 |
| JP7158577B2 (ja) | 2018-10-24 | 2022-10-21 | ギリアード サイエンシーズ， インコーポレイテッド | Ｐｄ－１／ｐｄ－ｌ１阻害剤 |
| EP4463229A1 (en) | 2022-01-12 | 2024-11-20 | Denali Therapeutics Inc. | Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide |
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| TWI241295B (en) | 1998-03-02 | 2005-10-11 | Kowa Co | Pyridazine derivative and medicine containing the same as effect component |
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| DE102008019907A1 (de) * | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
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| WO2010010150A1 (en) * | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
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- 2009-07-16 BR BRPI0914555A patent/BRPI0914555A2/pt not_active IP Right Cessation
- 2009-07-16 EA EA201100334A patent/EA201100334A1/ru unknown
- 2009-08-14 AR ARP090103142A patent/AR073055A1/es unknown
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- 2011-03-11 ZA ZA2011/01899A patent/ZA201101899B/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018147575A1 (ko) * | 2017-02-08 | 2018-08-16 | 에이비온 주식회사 | 트리아졸로 피라진 유도체의 신규한 다형체 및 이의 제조 방법 |
| US10538529B2 (en) | 2017-02-08 | 2020-01-21 | Abion Inc | Polymorphic forms of triazolopyrazine derivatives and method of preparing the same |
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0914555A2 (pt) | 2015-12-15 |
| CA2733941A1 (en) | 2010-02-18 |
| CN102123710B (zh) | 2012-11-07 |
| EA201100334A1 (ru) | 2011-08-30 |
| JP2011530545A (ja) | 2011-12-22 |
| CN102123710A (zh) | 2011-07-13 |
| AU2009281491B2 (en) | 2014-02-20 |
| US20110135600A1 (en) | 2011-06-09 |
| HK1159989A1 (en) | 2012-08-10 |
| DE102008037790A1 (de) | 2010-02-18 |
| ES2648233T3 (es) | 2017-12-29 |
| ZA201101899B (en) | 2011-11-30 |
| AR073055A1 (es) | 2010-10-13 |
| JP5475778B2 (ja) | 2014-04-16 |
| CA2733941C (en) | 2016-10-04 |
| EP2310013B1 (de) | 2017-08-23 |
| AU2009281491A1 (en) | 2010-02-18 |
| MX2011001511A (es) | 2011-03-15 |
| EP2310013A1 (de) | 2011-04-20 |
| US8435986B2 (en) | 2013-05-07 |
| IL211193A0 (en) | 2011-04-28 |
| WO2010017870A1 (de) | 2010-02-18 |
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