AU2009281491B2 - Bicyclic triazole derivatives for treating tumors - Google Patents

Bicyclic triazole derivatives for treating tumors Download PDF

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Publication number
AU2009281491B2
AU2009281491B2 AU2009281491A AU2009281491A AU2009281491B2 AU 2009281491 B2 AU2009281491 B2 AU 2009281491B2 AU 2009281491 A AU2009281491 A AU 2009281491A AU 2009281491 A AU2009281491 A AU 2009281491A AU 2009281491 B2 AU2009281491 B2 AU 2009281491B2
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AU
Australia
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denotes
tautomer
stereoisomer
nhet
hal
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Ceased
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AU2009281491A
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English (en)
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AU2009281491A1 (en
Inventor
Andree Blaukat
Dieter Dorsch
Oliver Schadt
Frank Stieber
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Merck Patent GmbH
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Merck Patent GmbH
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Publication of AU2009281491A1 publication Critical patent/AU2009281491A1/en
Application granted granted Critical
Publication of AU2009281491B2 publication Critical patent/AU2009281491B2/en
Ceased legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2009281491A 2008-08-14 2009-07-16 Bicyclic triazole derivatives for treating tumors Ceased AU2009281491B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102008037790A DE102008037790A1 (de) 2008-08-14 2008-08-14 Bicyclische Triazolderivate
DE102008037790.2 2008-08-14
PCT/EP2009/005172 WO2010017870A1 (de) 2008-08-14 2009-07-16 Bicyclische triazolderivate zur behandlung von tumoren

Publications (2)

Publication Number Publication Date
AU2009281491A1 AU2009281491A1 (en) 2010-02-18
AU2009281491B2 true AU2009281491B2 (en) 2014-02-20

Family

ID=41138729

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009281491A Ceased AU2009281491B2 (en) 2008-08-14 2009-07-16 Bicyclic triazole derivatives for treating tumors

Country Status (16)

Country Link
US (1) US8435986B2 (enExample)
EP (1) EP2310013B1 (enExample)
JP (1) JP5475778B2 (enExample)
KR (1) KR20110051243A (enExample)
CN (1) CN102123710B (enExample)
AR (1) AR073055A1 (enExample)
AU (1) AU2009281491B2 (enExample)
BR (1) BRPI0914555A2 (enExample)
CA (1) CA2733941C (enExample)
DE (1) DE102008037790A1 (enExample)
EA (1) EA201100334A1 (enExample)
ES (1) ES2648233T3 (enExample)
IL (1) IL211193A0 (enExample)
MX (1) MX2011001511A (enExample)
WO (1) WO2010017870A1 (enExample)
ZA (1) ZA201101899B (enExample)

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EA201300389A1 (ru) * 2010-09-23 2013-09-30 Бёрингер Ингельхайм Интернациональ Гмбх Оксадиазольные ингибиторы продуцирования лейкотриена
AU2013402175B2 (en) * 2013-09-30 2017-09-07 Handok Inc. Novel triazolopyrazine derivative and use thereof
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WO2015050871A2 (en) 2013-10-04 2015-04-09 Novartis Ag Organic compounds to treat hepatitis b virus
GB201321740D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
KR102379517B1 (ko) * 2013-12-30 2022-03-25 제넨테크, 인크. 세린/트레오닌 키나아제 억제제
US9815850B2 (en) 2016-02-05 2017-11-14 Denali Therapeutics Inc. Compounds, compositions and methods
LT3552017T (lt) 2016-12-09 2022-05-10 Denali Therapeutics Inc. Junginiai, naudotini kaip ripk1 inhibitoriai
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CN108570053A (zh) * 2017-03-13 2018-09-25 中国科学院上海药物研究所 五元并六元杂环化合物、制备方法、中间体、组合和应用
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WO2019160882A1 (en) 2018-02-13 2019-08-22 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
KR102591947B1 (ko) 2018-04-19 2023-10-25 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
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Also Published As

Publication number Publication date
MX2011001511A (es) 2011-03-15
CA2733941C (en) 2016-10-04
AU2009281491A1 (en) 2010-02-18
JP2011530545A (ja) 2011-12-22
IL211193A0 (en) 2011-04-28
CN102123710A (zh) 2011-07-13
BRPI0914555A2 (pt) 2015-12-15
DE102008037790A1 (de) 2010-02-18
JP5475778B2 (ja) 2014-04-16
AR073055A1 (es) 2010-10-13
US8435986B2 (en) 2013-05-07
ZA201101899B (en) 2011-11-30
HK1159989A1 (en) 2012-08-10
EP2310013A1 (de) 2011-04-20
US20110135600A1 (en) 2011-06-09
ES2648233T3 (es) 2017-12-29
KR20110051243A (ko) 2011-05-17
CN102123710B (zh) 2012-11-07
EA201100334A1 (ru) 2011-08-30
CA2733941A1 (en) 2010-02-18
EP2310013B1 (de) 2017-08-23
WO2010017870A1 (de) 2010-02-18

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired