CN102123710B - 用于治疗肿瘤的二环三唑衍生物 - Google Patents

用于治疗肿瘤的二环三唑衍生物 Download PDF

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Publication number
CN102123710B
CN102123710B CN2009801314380A CN200980131438A CN102123710B CN 102123710 B CN102123710 B CN 102123710B CN 2009801314380 A CN2009801314380 A CN 2009801314380A CN 200980131438 A CN200980131438 A CN 200980131438A CN 102123710 B CN102123710 B CN 102123710B
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China
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formula
compounds
mmol
expression
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Expired - Fee Related
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CN2009801314380A
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English (en)
Chinese (zh)
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CN102123710A (zh
Inventor
F·施蒂贝尔
O·沙特
D·多施
A·布劳卡特
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Merck Patent GmbH
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Merck Patent GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2009801314380A 2008-08-14 2009-07-16 用于治疗肿瘤的二环三唑衍生物 Expired - Fee Related CN102123710B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102008037790.2 2008-08-14
DE102008037790A DE102008037790A1 (de) 2008-08-14 2008-08-14 Bicyclische Triazolderivate
PCT/EP2009/005172 WO2010017870A1 (de) 2008-08-14 2009-07-16 Bicyclische triazolderivate zur behandlung von tumoren

Publications (2)

Publication Number Publication Date
CN102123710A CN102123710A (zh) 2011-07-13
CN102123710B true CN102123710B (zh) 2012-11-07

Family

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CN2009801314380A Expired - Fee Related CN102123710B (zh) 2008-08-14 2009-07-16 用于治疗肿瘤的二环三唑衍生物

Country Status (16)

Country Link
US (1) US8435986B2 (enExample)
EP (1) EP2310013B1 (enExample)
JP (1) JP5475778B2 (enExample)
KR (1) KR20110051243A (enExample)
CN (1) CN102123710B (enExample)
AR (1) AR073055A1 (enExample)
AU (1) AU2009281491B2 (enExample)
BR (1) BRPI0914555A2 (enExample)
CA (1) CA2733941C (enExample)
DE (1) DE102008037790A1 (enExample)
EA (1) EA201100334A1 (enExample)
ES (1) ES2648233T3 (enExample)
IL (1) IL211193A0 (enExample)
MX (1) MX2011001511A (enExample)
WO (1) WO2010017870A1 (enExample)
ZA (1) ZA201101899B (enExample)

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JP6546161B2 (ja) 2013-10-04 2019-07-17 ノバルティス アーゲー Ｂ型肝炎ウイルスを治療するための有機化合物
KR102298475B1 (ko) * 2013-10-04 2021-09-06 노파르티스 아게 ＲＮＡ 간섭에 사용하기 위한 ＲＮＡｉ 작용제를 위한 3' 말단 캡
GB201321740D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
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WO2018107060A1 (en) 2016-12-09 2018-06-14 Denali Therapeutics Inc. Compounds, compositions and methods
KR20180092096A (ko) 2017-02-08 2018-08-17 에이비온 주식회사 트리아졸로 피라진 유도체의 신규한 다형체 및 이의 제조 방법
CN108570053A (zh) * 2017-03-13 2018-09-25 中国科学院上海药物研究所 五元并六元杂环化合物、制备方法、中间体、组合和应用
SI3752501T1 (sl) 2018-02-13 2023-08-31 Gilead Sciences, Inc. Inhibitorji pd-1/pd-l1
CA3093130C (en) 2018-04-19 2023-10-17 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
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JP7158577B2 (ja) 2018-10-24 2022-10-21 ギリアード サイエンシーズ， インコーポレイテッド Ｐｄ－１／ｐｄ－ｌ１阻害剤
EP4463229A1 (en) 2022-01-12 2024-11-20 Denali Therapeutics Inc. Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide

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Also Published As

Publication number Publication date
BRPI0914555A2 (pt) 2015-12-15
CA2733941A1 (en) 2010-02-18
EA201100334A1 (ru) 2011-08-30
JP2011530545A (ja) 2011-12-22
CN102123710A (zh) 2011-07-13
AU2009281491B2 (en) 2014-02-20
US20110135600A1 (en) 2011-06-09
HK1159989A1 (en) 2012-08-10
DE102008037790A1 (de) 2010-02-18
ES2648233T3 (es) 2017-12-29
ZA201101899B (en) 2011-11-30
AR073055A1 (es) 2010-10-13
JP5475778B2 (ja) 2014-04-16
CA2733941C (en) 2016-10-04
EP2310013B1 (de) 2017-08-23
AU2009281491A1 (en) 2010-02-18
KR20110051243A (ko) 2011-05-17
MX2011001511A (es) 2011-03-15
EP2310013A1 (de) 2011-04-20
US8435986B2 (en) 2013-05-07
IL211193A0 (en) 2011-04-28
WO2010017870A1 (de) 2010-02-18

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