JP5457005B2 - 外用鎮痛組成物 - Google Patents
外用鎮痛組成物 Download PDFInfo
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- JP5457005B2 JP5457005B2 JP2008255825A JP2008255825A JP5457005B2 JP 5457005 B2 JP5457005 B2 JP 5457005B2 JP 2008255825 A JP2008255825 A JP 2008255825A JP 2008255825 A JP2008255825 A JP 2008255825A JP 5457005 B2 JP5457005 B2 JP 5457005B2
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Description
(1)組成物100重量%中、清涼化成分6〜11重量%、多価アルコール40〜90重量%を配合し、さらに清涼化成分1重量部に対し、ノナン酸類を0.001〜0.02重量部配合することを特徴とする外用鎮痛組成物。
(2)揮発性低級アルコールを含まないことを特徴とする前記(1)に記載の外用鎮痛組成物。
(3)ゲル剤であることを特徴とする前記(1)又は(2)に記載の外用鎮痛書生物。
(4)塗布用製剤である前記(1)〜(3)のいずれかに記載の外用鎮痛組成物。
本発明の外用鎮痛組成物に配合するノナン酸類は下記の構造を有する血行促進作用を有する化合物である。
ノナン酸類としては、カプサイシン、ジヒドロカプサイシン、ノルカプサイシン、ホモカプサイシン、オクタン酸バニリルアミド、ノナン酸バニリルアミド等が挙げられる。好ましいノナン酸類はカプサイシン、ノナン酸バニリルアミドである。
本発明の外用鎮痛組成物を液剤として調製する場合、通常の液剤の調製方法により調製することができる。例えば、各成分をアルキレングリコール及びポリアルキレングリコールに添加し、必要に応じて加熱し、溶解することによって調製することができる。
外用組成物の調製
下記の表1〜6に示す割合で以下の方法により製剤(実施例1〜29及び比較例1〜10)を調製した。
(1)水、多価アルコールおよび/または無水エタノールにノナン酸類とl−メントールを溶解させる。
(2)溶解させたものにヒドロキシプロピルセルロースを加え、1時間撹拌する。
(3)粉末類を分散させて、撹拌する。
評価者
膝関節に痛みをもつ対象者10名に各例の製剤を適用して、鎮痛効果を評価した。
鎮痛効果の評価
塗布後1時間までの鎮痛効果について、5段階で評価(最高5点、最低1点)し、35点以上を◎、30点以上〜34点未満を○、30点未満を×として評価した。
以下に処方例を示す。
処方例1〜11:液剤
表7に記載の処方例に従い、常法通り調製して液剤を調製した。
表8に記載の処方例に従い、常法通り調製してゲル剤を調製した。
処方例17:軟膏剤
表8に記載の処方例に従い、常法通り調製して軟膏剤を調製した。
Claims (4)
- 組成物100重量%中、清涼化成分6〜11重量%、多価アルコール40〜90重量%を配合し、さらに清涼化成分1重量部に対し、ノナン酸類を0.001〜0.02重量部配合することを特徴とする外用鎮痛組成物であって、清涼化成分が1−メントールであり、ノナン酸類がノナン酸バニリルアミドおよびカプサイシンから選ばれる1以上である、前記組成物。
- 揮発性低級アルコールを含まないことを特徴とする請求項1に記載の外用鎮痛組成物。
- ゲル剤であることを特徴とする請求項1又は2に記載の外用鎮痛組成物。
- 塗布用製剤である請求項1〜3のいずれかに記載の外用鎮痛組成物。
Priority Applications (1)
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