JP5439183B2 - 哺乳動物の細胞の電気穿孔のための電気穿孔装置および該電気穿孔装置を使用する方法 - Google Patents

哺乳動物の細胞の電気穿孔のための電気穿孔装置および該電気穿孔装置を使用する方法 Download PDF

Info

Publication number
JP5439183B2
JP5439183B2 JP2009533358A JP2009533358A JP5439183B2 JP 5439183 B2 JP5439183 B2 JP 5439183B2 JP 2009533358 A JP2009533358 A JP 2009533358A JP 2009533358 A JP2009533358 A JP 2009533358A JP 5439183 B2 JP5439183 B2 JP 5439183B2
Authority
JP
Japan
Prior art keywords
skin
electroporation
pulse
electrode
current
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2009533358A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010506660A (ja
JP2010506660A5 (enExample
Inventor
ドラギア−アクリ,ルクサンドラ
カン,アミール,エス.
ポープ,メリッサ,エー.
ブラウン,パトリシア,エー.
Original Assignee
ヴィージーエックス ファーマシューティカルズ,インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ヴィージーエックス ファーマシューティカルズ,インコーポレイテッド filed Critical ヴィージーエックス ファーマシューティカルズ,インコーポレイテッド
Publication of JP2010506660A publication Critical patent/JP2010506660A/ja
Publication of JP2010506660A5 publication Critical patent/JP2010506660A5/ja
Application granted granted Critical
Publication of JP5439183B2 publication Critical patent/JP5439183B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Electrotherapy Devices (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
JP2009533358A 2006-10-17 2007-10-17 哺乳動物の細胞の電気穿孔のための電気穿孔装置および該電気穿孔装置を使用する方法 Active JP5439183B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US85214906P 2006-10-17 2006-10-17
US60/852,149 2006-10-17
US97898207P 2007-10-10 2007-10-10
US60/978,982 2007-10-10
PCT/US2007/022139 WO2008048632A1 (en) 2006-10-17 2007-10-17 Electroporation devices and methods of using same for electroporation of cells in mammals

Publications (3)

Publication Number Publication Date
JP2010506660A JP2010506660A (ja) 2010-03-04
JP2010506660A5 JP2010506660A5 (enExample) 2010-12-02
JP5439183B2 true JP5439183B2 (ja) 2014-03-12

Family

ID=38935920

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009533358A Active JP5439183B2 (ja) 2006-10-17 2007-10-17 哺乳動物の細胞の電気穿孔のための電気穿孔装置および該電気穿孔装置を使用する方法

Country Status (16)

Country Link
US (1) US9452285B2 (enExample)
EP (4) EP3524316B1 (enExample)
JP (1) JP5439183B2 (enExample)
KR (1) KR101421760B1 (enExample)
CN (1) CN105457157B (enExample)
AU (1) AU2007313203B2 (enExample)
CA (1) CA2666501C (enExample)
DK (2) DK2066399T3 (enExample)
ES (2) ES2993941T3 (enExample)
FI (1) FI3524316T3 (enExample)
HU (2) HUE069139T2 (enExample)
LT (1) LT3524316T (enExample)
PL (2) PL2409727T3 (enExample)
PT (2) PT2066399T (enExample)
SG (1) SG175627A1 (enExample)
WO (1) WO2008048632A1 (enExample)

Families Citing this family (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9037230B2 (en) * 2006-03-03 2015-05-19 Oncosec Medical Incorporated Method and device for treating microscopic tumors remaining in tissues following surgical resection
US7687267B2 (en) * 2006-09-30 2010-03-30 Rational Biotechnology Inc. High-throughput cell transfection device and methods of using thereof
US9592285B2 (en) 2007-11-12 2017-03-14 The Trustees Of The University Of Pennsylvania Vaccines against multiple subtypes of influenza virus
WO2009065032A1 (en) * 2007-11-14 2009-05-22 Vgx Pharmaceuticals, Inc. Antibody production elicited by a dna vaccine delivered by electroporation
EP2265715B1 (en) 2008-04-04 2016-12-28 The Trustees Of The University Of Pennsylvania Vaccines and immunotherapeutics using il-28 and compositions and methods of using the same
EP2274442B1 (en) * 2008-04-04 2016-06-29 The Trustees Of The University Of Pennsylvania Consensus sequences of chikungunya viral proteins, nucleic acid molecules encoding the same, and compositions and methods for using the same
ITCO20080016A1 (it) * 2008-04-22 2009-10-23 Giuseppe Caccia Manipolo per elettroporazione di prodotti farmacologici e/o naturali e/o estetici su strati cutanei a spessore contenuto
JP5753090B2 (ja) 2008-10-29 2015-07-22 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 改良型hcvワクチンおよびその使用方法
US8921536B2 (en) 2008-10-29 2014-12-30 The Trustees Of The University Of Pennsylvania HCV vaccines and methods for using the same
CA3001374A1 (en) * 2008-11-17 2010-05-20 Vgx Pharmaceuticals, Llc Antigens that elicit immune response against flavivirus and methods of using same
US8632534B2 (en) 2009-04-03 2014-01-21 Angiodynamics, Inc. Irreversible electroporation (IRE) for congestive obstructive pulmonary disease (COPD)
KR102309963B1 (ko) * 2009-04-16 2021-10-08 이노비오 파마수티컬즈, 인크. 비접촉식 전기천공 전극 및 방법
US8903488B2 (en) 2009-05-28 2014-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
US20120244593A1 (en) * 2009-10-19 2012-09-27 Yong Huang Method, device and apparatus for inducing self-adjusting cell electroporation
US8298820B2 (en) 2010-01-26 2012-10-30 The Trustees Of The University Of Pennsylvania Influenza nucleic acid molecules and vaccines made therefrom
ES2549190T3 (es) * 2010-03-01 2015-10-23 Inovio Pharmaceuticals, Inc. Aplicador y dispositivo de electroporación de múltiples capas de tejido
WO2012051433A2 (en) 2010-10-13 2012-04-19 Angiodynamics, Inc. System and method for electrically ablating tissue of a patient
US9561051B2 (en) 2011-01-28 2017-02-07 The General Hospital Corporation Method and apparatus for discontinuous dermabrasion
EP4349211A3 (en) 2011-01-28 2024-06-12 The General Hospital Corporation Method and appratus for skin resurfacing
EP2667805B1 (en) 2011-01-28 2023-04-05 The General Hospital Corporation Apparatus and method for tissue biopsy
CA2826199A1 (en) 2011-01-31 2012-08-09 The Trustees Of The University Of Pennsylvania Nucleic acid molecules encoding novel herpes antigens, vaccine comprising the same, and methods of use thereof
KR101363000B1 (ko) * 2011-03-03 2014-02-24 라종주 피부 미용방법, 미용기 및 미용 시스템
ITTO20110374A1 (it) * 2011-04-29 2012-10-30 Igea S P A Metodo di controllo di un dispositivo di elettro-porazione
KR20140068000A (ko) 2011-06-15 2014-06-05 크론테크 파마 아베 주사 바늘 및 장치
AU2015203882C1 (en) * 2011-06-28 2017-09-21 Inovio Pharmaceuticals, Inc. A minimally invasive dermal electroporation device
DK3473296T3 (da) * 2011-06-28 2020-11-09 Inovio Pharmaceuticals Inc Minimalt invasiv dermal elektroporeringsenhed
BR112014001248B1 (pt) 2011-07-21 2020-12-08 The General Hospital Corporation aparelho e método para afetar o tecido adiposo subcutâneo
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
US9414881B2 (en) 2012-02-08 2016-08-16 Angiodynamics, Inc. System and method for increasing a target zone for electrical ablation
CN102680526B (zh) * 2012-05-16 2014-07-02 清华大学 单细胞阵列微芯片及其制造、电测量和电穿孔方法
KR101979746B1 (ko) * 2012-09-13 2019-05-17 (주)아모레퍼시픽 전기 천공 장치
US20140171957A1 (en) * 2012-12-19 2014-06-19 Alcon Research, Ltd. Control of Automated Intraocular Lens Injectors
CN105025979B (zh) * 2012-12-24 2017-08-25 电子运动医疗有限公司 胃肠道刺激装置和方法
US10543127B2 (en) 2013-02-20 2020-01-28 Cytrellis Biosystems, Inc. Methods and devices for skin tightening
US10555754B2 (en) 2013-08-09 2020-02-11 Cytrellis Biosystems, Inc. Methods and apparatuses for skin treatment using non-thermal tissue ablation
US10953143B2 (en) 2013-12-19 2021-03-23 Cytrellis Biosystems, Inc. Methods and devices for manipulating subdermal fat
US11260137B2 (en) * 2014-04-06 2022-03-01 Emily Chen Tang Electroporation apparatuses and their method of use
US12114911B2 (en) * 2014-08-28 2024-10-15 Angiodynamics, Inc. System and method for ablating a tissue site by electroporation with real-time pulse monitoring
BR112017009805A2 (pt) 2014-11-14 2017-12-26 Cytrellis Biosystems Inc dispositivos e métodos para ablação da pele
WO2016161113A1 (en) 2015-03-31 2016-10-06 University Of South Florida System and method for electroporation controlled by electrical impedance measurements
DK3277368T3 (da) * 2015-03-31 2020-07-27 Oncosec Medical Inc Systemer til forbedret vævsregistreringsbaseret elektroporering
US11027071B2 (en) 2015-12-28 2021-06-08 Inovio Pharmaceuticals, Inc. Intradermal jet injection electroporation device
ITUB20159819A1 (it) * 2015-12-31 2017-07-01 Biopulse S R L Elettroporatore teranostico ad onda bifasica per la diagnosi delle aree patologiche ed il trasferimento terapeutico di molecole e relativo procedimento
AU2017214656B2 (en) 2016-02-05 2022-08-25 Inovio Pharmaceuticals, Inc. Cancer vaccines and methods of treatment using the same
KR20230117470A (ko) 2016-03-29 2023-08-08 사이트렐리스 바이오시스템즈, 인크. 미용 피부 리설페이싱용 디바이스 및 방법
JP7250520B2 (ja) 2016-04-13 2023-04-03 ヤンセン ファーマシューティカルズ,インコーポレーテッド 組換えアルテリウイルスレプリコン系およびその使用
WO2018057630A1 (en) 2016-09-21 2018-03-29 Cytrellis Biosystems, Inc. Devices and methods for cosmetic skin resurfacing
ES2993107T3 (en) 2016-10-17 2024-12-23 Janssen Pharmaceuticals Inc Recombinant virus replicon systems and uses thereof
JP7158820B2 (ja) 2016-10-26 2022-10-24 ロレアル エレクトロポレーションデバイスおよびエレクトロポレーションデバイスを制御するための方法
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
JP7788787B2 (ja) 2016-12-05 2025-12-19 ヤンセン ファーマシューティカルズ,インコーポレーテッド 遺伝子発現増強のための組成物および方法
KR20180123312A (ko) * 2017-05-08 2018-11-16 (주)오스힐 미세전류 조절 수단을 구비한 스킨 부스터
JP6518971B2 (ja) * 2017-05-12 2019-05-29 株式会社ベックス エレクトロポレーター用電源
CN107126628A (zh) * 2017-06-14 2017-09-05 重庆百国智科技发展有限公司 一种人体电位差细胞补水及生物电信号修复的装置及其方法
DE102017116305A1 (de) * 2017-07-19 2019-01-24 Cinogy Gmbh Plasma-Behandlungsgerät
SE541651C2 (en) 2017-07-28 2019-11-19 Scandinavian Chemotech Ab An electrode device and a needle electrode for use in delivery of electrical pulses to a desired tissue of a mammal
CN111479583A (zh) 2017-12-13 2020-07-31 艾诺奥医药品有限公司 靶向存活素的癌症疫苗和其用途
CA3084135C (en) 2017-12-13 2024-03-05 Inovio Pharmaceuticals, Inc. Cancer vaccines targeting muc16 and uses thereof
RU2759681C1 (ru) 2017-12-13 2021-11-16 Иновио Фармасьютикалз, Инк. Противораковые вакцины, нацеленные на boris, и способы их применения
CN111479590A (zh) 2017-12-13 2020-07-31 艾诺奥医药品有限公司 靶向间皮素的癌症疫苗及其使用
MA51311A (fr) 2017-12-19 2020-10-28 Janssen Sciences Ireland Unlimited Co Vaccins contre le virus de l'hépatite b (vhb) et utilisations associées
EA202091516A1 (ru) 2017-12-19 2020-11-03 Янссен Сайенсиз Айрлэнд Анлимитед Компани Способы и композиции для индукции иммунного ответа против вируса гепатита b (hbv)
JP2021506300A (ja) 2017-12-19 2021-02-22 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー B型肝炎ウイルス(hbv)に対する免疫応答を誘導するための方法および組成物
EA202091517A1 (ru) 2017-12-19 2020-11-03 Янссен Сайенсиз Айрлэнд Анлимитед Компани Способы и устройство для доставки вакцин против вируса гепатита b (hbv)
EA202091513A1 (ru) 2017-12-19 2020-09-09 Янссен Сайенсиз Айрлэнд Анлимитед Компани Вакцины против вируса гепатита b (hbv) и их применение
KR20200111729A (ko) 2018-01-19 2020-09-29 얀센 파마슈티칼즈, 인코포레이티드 재조합 레플리콘 시스템을 이용한 면역 반응 유도 및 증진
KR102132370B1 (ko) * 2018-03-13 2020-08-05 주식회사 지씨에스 피부관리장치, 피부관리장치의 구동방법 및 컴퓨터 판독가능 기록매체
JP7594298B2 (ja) * 2018-08-01 2024-12-04 オハイオ・ステイト・イノベーション・ファウンデーション 皮膚をインスリン産生組織にリプログラミングするための組成物および方法
EP3864027A1 (en) 2018-10-08 2021-08-18 Janssen Pharmaceuticals, Inc. Alphavirus-based replicons for administration of biotherapeutics
EP3673846A1 (en) * 2018-12-27 2020-07-01 Bogdan Ionescu Device for an electrophysiology procedure
CN113613711B (zh) * 2019-02-04 2024-09-17 新泽西州立罗格斯大学 使用微电极进行组织电转移的装置
US11071860B2 (en) * 2019-02-06 2021-07-27 Oncosec Medical Incorporated Systems and methods for detecting fault conditions in electroporation therapy
US20220241402A1 (en) 2019-06-18 2022-08-04 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and quinazoline derivatives
WO2020255042A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and a pyrimidine derivative
US20220305116A1 (en) 2019-06-18 2022-09-29 Janssen Sciences lreland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and capsid assembly modulators being sulfonamide derivatives
WO2020255010A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of recombinant interleukin 12 construct and hepatitis b virus (hbv) vaccines
WO2020255016A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators
WO2020255022A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and aminopyridine derivatives as hpk1 inhibitors
WO2020255019A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and a quinazoline derivative
US20220233526A1 (en) 2019-06-18 2022-07-28 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators
CA3140690A1 (en) 2019-06-18 2020-12-24 Helen Horton Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators
US20220233684A1 (en) 2019-06-18 2022-07-28 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and pd-l1 inhibitors
WO2020255038A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and pyridopyrimidine derivatives
WO2020254876A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Virus-like particle delivery of hepatitis b virus (hbv) vaccines
CA3141238A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Hepatitis b virus (hbv) vaccines and uses thereof
JP2022536945A (ja) 2019-06-18 2022-08-22 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー B型肝炎ウイルス(HBV)ワクチンおよびHBVを標的化するRNAiの組合せ
WO2020255013A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and capsid assembly modulators being amide derivatives
CA3140588A1 (en) 2019-06-18 2020-12-24 Helen Horton Combination of hepatitis b virus (hbv) vaccines and small molecule pdl1 or pd1 inhibitor
WO2020255035A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and pyrimidine derivatives
EP3986915A1 (en) 2019-06-18 2022-04-27 Janssen Sciences Ireland Unlimited Company Recombinant interleukin 12 construct and uses thereof
WO2020255008A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND HBV-TARGETING RNAi
CA3143634A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and anti-pd-1 antibody
CN114630675A (zh) 2019-06-18 2022-06-14 爱尔兰詹森科学公司 乙型肝炎病毒(hbv)疫苗和抗pd-1或抗pd-l1抗体的组合
CA3143627A1 (en) 2019-06-20 2020-12-24 Janssen Sciences Ireland Unlimited Company Carbohydrate nanocarrier delivery of hepatitis b virus (hbv) vaccines
EP3986563A1 (en) 2019-06-20 2022-04-27 Janssen Sciences Ireland Unlimited Company Lipid nanoparticle or liposome delivery of hepatitis b virus (hbv) vaccines
US20220290183A1 (en) * 2019-08-30 2022-09-15 Virginia Tech Intellectual Properties, Inc. Method for intracellular delivery of compounds using cell force and shape with electric fields
EP4121161A4 (en) 2020-03-20 2024-10-16 Inovio Pharmaceuticals, Inc. VACUUM-ASSISTED ELECTROPORATION DEVICES AND CORRESPONDING SYSTEMS AND METHODS
CN111581642A (zh) * 2020-05-03 2020-08-25 付贵龙 一种互联网安全防护系统
JP2023533174A (ja) 2020-06-12 2023-08-02 ユニバーシティ オブ ロチェスター ACE-tRNAのコード化及び発現
TWI757205B (zh) 2020-06-30 2022-03-01 財團法人工業技術研究院 微針電轉染裝置
IL299571A (en) 2020-07-08 2023-02-01 Janssen Sciences Ireland Unlimited Co Rna replicon vaccines against hbv
US12006507B2 (en) 2020-07-22 2024-06-11 Nantcell, Inc. Electroporation with active compensation
US12076071B2 (en) 2020-08-14 2024-09-03 Kardium Inc. Systems and methods for treating tissue with pulsed field ablation
US20220071692A1 (en) * 2020-09-08 2022-03-10 Biosense Webster (Israel) Ltd. Impedance based irreversible-electroporation (ire)
TW202245809A (zh) 2020-12-18 2022-12-01 美商詹森藥物公司 用於治療b型肝炎病毒感染之組合療法
AU2021412833A1 (en) 2020-12-28 2023-07-06 Arcturus Therapeutics, Inc. Transcription activator-like effector nucleases (talens) targeting hbv
AU2023215397A1 (en) 2022-02-07 2024-08-22 University Of Rochester Optimized sequences for enhanced trna expression or/and nonsense mutation suppression.
AR128609A1 (es) * 2022-02-25 2024-05-29 Inovio Pharmaceuticals Inc Dispositivos de electroporación portátiles, y sistemas y métodos relacionados
US20250352790A1 (en) * 2022-05-05 2025-11-20 Renbio, Inc. Device related to therapeutic dna delivery
WO2023233290A1 (en) 2022-05-31 2023-12-07 Janssen Sciences Ireland Unlimited Company Rnai agents targeting pd-l1
WO2024129459A1 (en) 2022-12-16 2024-06-20 University Of Rochester Repairmen! of barrier dysfunction in esophagus
WO2025101685A1 (en) 2023-11-09 2025-05-15 University Of Rochester Suppression of nonsense mutations using anticodon engineered (ace)-trnas
WO2026030209A1 (en) 2024-07-29 2026-02-05 University Of Rochester Use of decoding trnas to boost protein expression or function
CN120436779B (zh) * 2025-07-01 2025-09-30 北京航空航天大学青岛研究院 十二指肠粘膜表面置换与电转染一体化设备及基于参数反馈运行的方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68925030T2 (de) * 1988-01-21 1996-07-25 Massachusetts Inst Technology Molekültransport durch gewebe mit der verwendung von elektroporation.
US5545130A (en) 1992-04-08 1996-08-13 Genetronics, Inc. Flow through electroporation method
US5439440A (en) * 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5702359A (en) 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US5869326A (en) 1996-09-09 1999-02-09 Genetronics, Inc. Electroporation employing user-configured pulsing scheme
US6216034B1 (en) 1997-08-01 2001-04-10 Genetronics, Inc. Method of programming an array of needle electrodes for electroporation therapy of tissue
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US6241701B1 (en) 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US6120493A (en) * 1998-01-27 2000-09-19 Genetronics, Inc. Method for the introduction of therapeutic agents utilizing an electroporation apparatus
US6208893B1 (en) 1998-01-27 2001-03-27 Genetronics, Inc. Electroporation apparatus with connective electrode template
US6302874B1 (en) 1998-07-13 2001-10-16 Genetronics, Inc. Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications
EP2428250A1 (en) * 1998-07-13 2012-03-14 Genetronics, Inc. Skin and muscle-targeted gene therapy by pulsed electrical field
US6972013B1 (en) * 1998-07-13 2005-12-06 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
US6192270B1 (en) 1998-08-14 2001-02-20 Genetronics, Inc. Apparatus and method for the delivery of drugs and genes into tissue
US6150148A (en) 1998-10-21 2000-11-21 Genetronics, Inc. Electroporation apparatus for control of temperature during the process
US6148232A (en) * 1998-11-09 2000-11-14 Elecsys Ltd. Transdermal drug delivery and analyte extraction
US7171264B1 (en) * 1999-05-10 2007-01-30 Genetronics, Inc. Intradermal delivery of active agents by needle-free injection and electroporation
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6300108B1 (en) * 1999-07-21 2001-10-09 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes
WO2001089455A2 (en) * 2000-05-22 2001-11-29 Merck & Company, Inc. System and method for assessing the performance of a pharmaceutical agent delivery system
CN1345610A (zh) * 2000-09-30 2002-04-24 杭州泰士生物科技有限公司 一种活体组织电穿孔用的波形及波形发生器
JP3543326B2 (ja) 2001-08-30 2004-07-14 ソニー株式会社 情報処理装置および方法、情報処理システム、情報配信装置、記録媒体、並びにプログラム
US7245963B2 (en) 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
US8209006B2 (en) * 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
US20080269153A1 (en) * 2002-05-28 2008-10-30 Ruxandra Draghia-Akli Increased stability of a dna formulation by including poly-l-glutamate
US7328064B2 (en) * 2002-07-04 2008-02-05 Inovio As Electroporation device and injection apparatus
US20050070841A1 (en) 2002-07-04 2005-03-31 Inovio As Electroporation device and injection apparatus
US7238522B2 (en) 2003-05-30 2007-07-03 Advisys, Inc. Devices and methods for biomaterial production

Also Published As

Publication number Publication date
DK3524316T3 (da) 2024-11-11
DK2066399T3 (en) 2019-01-21
EP4477254A2 (en) 2024-12-18
WO2008048632A8 (en) 2008-10-02
EP4477254A3 (en) 2025-02-19
US9452285B2 (en) 2016-09-27
HUE069139T2 (hu) 2025-02-28
AU2007313203A1 (en) 2008-04-24
JP2010506660A (ja) 2010-03-04
EP2409727B1 (en) 2018-10-03
KR20090107014A (ko) 2009-10-12
ES2993941T3 (en) 2025-01-14
EP3524316B1 (en) 2024-08-07
FI3524316T3 (fi) 2024-11-08
CA2666501A1 (en) 2008-04-24
US20080091135A1 (en) 2008-04-17
EP2066399B1 (en) 2018-10-03
KR101421760B1 (ko) 2014-07-22
PT2066399T (pt) 2019-01-11
CA2666501C (en) 2017-03-21
EP2066399A1 (en) 2009-06-10
ES2703744T3 (es) 2019-03-12
AU2007313203B2 (en) 2012-08-16
PT3524316T (pt) 2024-11-29
CN105457157B (zh) 2020-04-14
EP2409727A1 (en) 2012-01-25
EP3524316A1 (en) 2019-08-14
PL2409727T3 (pl) 2019-03-29
HUE042044T2 (hu) 2019-06-28
WO2008048632A1 (en) 2008-04-24
CN105457157A (zh) 2016-04-06
LT3524316T (lt) 2024-11-25
SG175627A1 (en) 2011-11-28
PL3524316T3 (pl) 2024-12-23

Similar Documents

Publication Publication Date Title
JP2010506660A (ja) 哺乳動物の細胞の電気穿孔のための電気穿孔装置および該電気穿孔装置を使用する方法
Luxembourg et al. Electroporation-based DNA immunisation: translation to the clinic
Heller et al. Gene electrotransfer clinical trials
TWI246930B (en) Electro-kinetic device and electrode disk for electroporation and method for electroporating cells
CN101563132A (zh) 电穿孔装置及用其进行哺乳动物细胞电穿孔的方法
JP2003505114A (ja) パルス電場による皮膚および筋肉を標的とした遺伝子治療
EA025705B1 (ru) Терпимое и минимально инвазивное устройство электропорации кожи
Broderick et al. Enhanced delivery of DNA or RNA vaccines by electroporation
KR20230093536A (ko) 어쥬번트로서 인터류킨-33을 갖는 백신
US20070232984A1 (en) Hand-held electrical stimulation device
Broderick et al. DNA vaccination in skin enhanced by electroporation
US8979818B2 (en) Method and apparatus for the delivery of polynucleotide vaccines to mammalian skin
Tjelle et al. Taking electroporation-based delivery of DNA vaccination into humans: a generic clinical protocol
JP2012521265A (ja) ポリヌクレオチドがんワクチンを哺乳動物の皮膚に送達する方法と装置
KR20240156567A (ko) 마이크로니들 패치를 이용한 물질 전달을 위한 휴대용 전기천공 디바이스 및 이의 용도
JP2005521496A (ja) ポリヌクレオチドのエレクトロポレーションにより増強された送達の際の金属毒性の最小化
HK1131756A (en) Electroporation devices and methods of using same for electroporation of cells in mammals
HK1131756B (en) Electroporation devices and methods of using same for electroporation of cells in mammals
Hannaman et al. Delivery Technology Reenergizes DNA Drug Development
Hannaman Electroporation based TriGrid™ delivery system (TDS) for DNA vaccine administration
HK40028403B (en) Vaccines with interleukin-33 as an adjuvant
JP2011504173A (ja) 電気穿孔により送達されるdnaワクチンにより誘導される抗体の産生
Ronchetti et al. Electroporation-Based Gene Transfer
Heller et al. Electrically Mediated Gene Delivery to the Skin

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101015

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20101015

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120911

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20121203

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20121210

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130205

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130213

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130307

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130702

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130930

RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20131004

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20131007

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20131009

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20131029

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20131119

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20131216

R150 Certificate of patent or registration of utility model

Ref document number: 5439183

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250