JP5395083B2 - フレグランスとしての大環状ラクトン類 - Google Patents
フレグランスとしての大環状ラクトン類 Download PDFInfo
- Publication number
- JP5395083B2 JP5395083B2 JP2010526125A JP2010526125A JP5395083B2 JP 5395083 B2 JP5395083 B2 JP 5395083B2 JP 2010526125 A JP2010526125 A JP 2010526125A JP 2010526125 A JP2010526125 A JP 2010526125A JP 5395083 B2 JP5395083 B2 JP 5395083B2
- Authority
- JP
- Japan
- Prior art keywords
- dien
- mmol
- formula
- configuration
- fragrance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003205 fragrance Substances 0.000 title claims description 32
- 150000002596 lactones Chemical class 0.000 title description 5
- 150000001875 compounds Chemical class 0.000 claims description 35
- 239000000203 mixture Substances 0.000 claims description 29
- JVQRDDMPHDQRCL-UNQQQNFISA-N (4e,9z)-13-methyl-1-oxacyclopentadeca-4,9-dien-2-one Chemical compound CC1CCOC(=O)C\C=C\CCC\C=C/CC1 JVQRDDMPHDQRCL-UNQQQNFISA-N 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 10
- -1 (4E Chemical compound 0.000 claims description 6
- AQGFOGVVHJFBAV-CUKJDEOPSA-N (4e,8z)-12-methyl-1-oxacyclotetradeca-4,8-dien-2-one Chemical compound CC1CCOC(=O)C\C=C\CC\C=C/CC1 AQGFOGVVHJFBAV-CUKJDEOPSA-N 0.000 claims description 5
- HLWZHXVPHLUUHF-MKKAVFGOSA-N (4e,10z)-13-methyl-1-oxacyclopentadeca-4,10-dien-2-one Chemical compound CC1CCOC(=O)C\C=C\CCCC\C=C/C1 HLWZHXVPHLUUHF-MKKAVFGOSA-N 0.000 claims description 3
- VOFLPUAGGRAUAC-ZOEDNYEGSA-N (4e,11z)-15-methyl-1-oxacycloheptadeca-4,11-dien-2-one Chemical compound CC1CCOC(=O)C\C=C\CCCCC\C=C/CC1 VOFLPUAGGRAUAC-ZOEDNYEGSA-N 0.000 claims description 3
- 238000007302 alkyne metathesis reaction Methods 0.000 claims description 3
- 239000002537 cosmetic Substances 0.000 claims description 3
- GNGXWJWZGRGOET-TWDWIPQFSA-N (4e,10z)-15-methyl-1-oxacycloheptadeca-4,10-dien-2-one Chemical compound CC1CCC\C=C/CCCC\C=C\CC(=O)OCC1 GNGXWJWZGRGOET-TWDWIPQFSA-N 0.000 claims description 2
- TUIWZAZQNNSZEW-OPFOWNOESA-N (4e,8z)-13-methyl-1-oxacyclopentadeca-4,8-dien-2-one Chemical compound CC1CCC\C=C/CC\C=C\CC(=O)OCC1 TUIWZAZQNNSZEW-OPFOWNOESA-N 0.000 claims description 2
- KBYSWFPLVNPWFQ-QQOOZTEWSA-N (4e,8z)-14-methyl-1-oxacyclohexadeca-4,8-dien-2-one Chemical compound CC1CCCC\C=C/CC\C=C\CC(=O)OCC1 KBYSWFPLVNPWFQ-QQOOZTEWSA-N 0.000 claims description 2
- QIUKCXVZRQUGBY-CGXWXWIYSA-N (4e,9z)-12-methyl-1-oxacyclotetradeca-4,9-dien-2-one Chemical compound CC1CCOC(=O)C\C=C\CCC\C=C/C1 QIUKCXVZRQUGBY-CGXWXWIYSA-N 0.000 claims description 2
- HZONBUPKKDSJKC-WEZLDLNLSA-N (4e,9z)-14-methyl-1-oxacyclohexadeca-4,9-dien-2-one Chemical compound CC1CCC\C=C/CCC\C=C\CC(=O)OCC1 HZONBUPKKDSJKC-WEZLDLNLSA-N 0.000 claims description 2
- CGADXTFILBOTPI-HWUGADSMSA-N (4e,9z)-15-methyl-1-oxacycloheptadeca-4,9-dien-2-one Chemical compound CC1CCCC\C=C/CCC\C=C\CC(=O)OCC1 CGADXTFILBOTPI-HWUGADSMSA-N 0.000 claims description 2
- 239000004753 textile Substances 0.000 claims description 2
- 239000000047 product Substances 0.000 description 24
- 241000402754 Erythranthe moschata Species 0.000 description 20
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 15
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 14
- 239000002253 acid Substances 0.000 description 13
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 12
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
- 239000000741 silica gel Substances 0.000 description 9
- 229910002027 silica gel Inorganic materials 0.000 description 9
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 8
- 235000009508 confectionery Nutrition 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 239000002304 perfume Substances 0.000 description 8
- 239000011541 reaction mixture Substances 0.000 description 8
- 239000003054 catalyst Substances 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 7
- 238000002156 mixing Methods 0.000 description 7
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 229910052786 argon Inorganic materials 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 description 5
- 125000003118 aryl group Chemical group 0.000 description 5
- JGQFVRIQXUFPAH-UHFFFAOYSA-N beta-citronellol Natural products OCCC(C)CCCC(C)=C JGQFVRIQXUFPAH-UHFFFAOYSA-N 0.000 description 5
- 235000000484 citronellol Nutrition 0.000 description 5
- 239000000284 extract Substances 0.000 description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 241000207840 Jasminum Species 0.000 description 4
- 235000010254 Jasminum officinale Nutrition 0.000 description 4
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 4
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 4
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 4
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 4
- 238000004587 chromatography analysis Methods 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 150000002576 ketones Chemical class 0.000 description 4
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 description 4
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 3
- FKUPPRZPSYCDRS-UHFFFAOYSA-N Cyclopentadecanolide Chemical compound O=C1CCCCCCCCCCCCCCO1 FKUPPRZPSYCDRS-UHFFFAOYSA-N 0.000 description 3
- 240000000513 Santalum album Species 0.000 description 3
- 235000008632 Santalum album Nutrition 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 150000001298 alcohols Chemical class 0.000 description 3
- 239000003599 detergent Substances 0.000 description 3
- 230000008030 elimination Effects 0.000 description 3
- 238000003379 elimination reaction Methods 0.000 description 3
- 150000002678 macrocyclic compounds Chemical class 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- RAIYODFGMLZUDF-UHFFFAOYSA-N piperidin-1-ium;acetate Chemical compound CC([O-])=O.C1CC[NH2+]CC1 RAIYODFGMLZUDF-UHFFFAOYSA-N 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 3
- ORHSGDMSYGKJJY-SAIIYOCFSA-N (1'r,6's)-2,2,4',7',7'-pentamethylspiro[1,3-dioxane-5,5'-bicyclo[4.1.0]heptane] Chemical compound C12([C@H]3[C@H](C3(C)C)CCC2C)COC(C)(C)OC1 ORHSGDMSYGKJJY-SAIIYOCFSA-N 0.000 description 2
- OUHPOYPYIJCIPG-SUTBWYPISA-N (4e,10z)-14-methyl-1-oxacyclohexadeca-4,10-dien-2-one Chemical compound CC1CCOC(=O)C\C=C\CCCC\C=C/CC1 OUHPOYPYIJCIPG-SUTBWYPISA-N 0.000 description 2
- BVDMQAQCEBGIJR-UHFFFAOYSA-N 1-(2,2,6-trimethylcyclohexyl)hexan-3-ol Chemical compound CCCC(O)CCC1C(C)CCCC1(C)C BVDMQAQCEBGIJR-UHFFFAOYSA-N 0.000 description 2
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
- XPCTZQVDEJYUGT-UHFFFAOYSA-N 3-hydroxy-2-methyl-4-pyrone Chemical compound CC=1OC=CC(=O)C=1O XPCTZQVDEJYUGT-UHFFFAOYSA-N 0.000 description 2
- NGYMOTOXXHCHOC-UHFFFAOYSA-N 3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol Chemical compound CC(O)C(C)CCC1CC=C(C)C1(C)C NGYMOTOXXHCHOC-UHFFFAOYSA-N 0.000 description 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 2
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 2
- 238000000023 Kugelrohr distillation Methods 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 2
- 150000001241 acetals Chemical class 0.000 description 2
- 150000001299 aldehydes Chemical class 0.000 description 2
- YPZUZOLGGMJZJO-UHFFFAOYSA-N ambrofix Natural products C1CC2C(C)(C)CCCC2(C)C2C1(C)OCC2 YPZUZOLGGMJZJO-UHFFFAOYSA-N 0.000 description 2
- 239000012298 atmosphere Substances 0.000 description 2
- QUKGYYKBILRGFE-UHFFFAOYSA-N benzyl acetate Chemical compound CC(=O)OCC1=CC=CC=C1 QUKGYYKBILRGFE-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- HQKQRXZEXPXXIG-VJOHVRBBSA-N chembl2333940 Chemical compound C1[C@]23[C@H](C)CC[C@H]3C(C)(C)[C@H]1[C@@](OC(C)=O)(C)CC2 HQKQRXZEXPXXIG-VJOHVRBBSA-N 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 150000002170 ethers Chemical class 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- IFYYFLINQYPWGJ-UHFFFAOYSA-N gamma-decalactone Chemical compound CCCCCCC1CCC(=O)O1 IFYYFLINQYPWGJ-UHFFFAOYSA-N 0.000 description 2
- CATSNJVOTSVZJV-UHFFFAOYSA-N heptan-2-one Chemical compound CCCCCC(C)=O CATSNJVOTSVZJV-UHFFFAOYSA-N 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- 239000002198 insoluble material Substances 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- KVWWIYGFBYDJQC-UHFFFAOYSA-N methyl dihydrojasmonate Chemical compound CCCCCC1C(CC(=O)OC)CCC1=O KVWWIYGFBYDJQC-UHFFFAOYSA-N 0.000 description 2
- 230000011987 methylation Effects 0.000 description 2
- 238000007069 methylation reaction Methods 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- CZCBTSFUTPZVKJ-UHFFFAOYSA-N rose oxide Chemical compound CC1CCOC(C=C(C)C)C1 CZCBTSFUTPZVKJ-UHFFFAOYSA-N 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 235000010288 sodium nitrite Nutrition 0.000 description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 description 2
- 235000011152 sodium sulphate Nutrition 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
- 239000001069 triethyl citrate Substances 0.000 description 2
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 2
- 235000013769 triethyl citrate Nutrition 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- QWRGOHMKGNCVAC-GVEAZXRRSA-N (2E)-5,6,7-trimethylocta-2,5-dien-4-one Chemical compound C\C=C\C(=O)C(C)=C(C)C(C)C QWRGOHMKGNCVAC-GVEAZXRRSA-N 0.000 description 1
- AVJMJMPVWWWELJ-DHZHZOJOSA-N (2e)-1-methoxy-3,7-dimethylocta-2,6-diene Chemical compound COC\C=C(/C)CCC=C(C)C AVJMJMPVWWWELJ-DHZHZOJOSA-N 0.000 description 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
- GTLKSTALFRGBQG-NYYWCZLTSA-N (e)-6-ethyl-3-methyloct-6-en-1-ol Chemical compound CC\C(=C/C)CCC(C)CCO GTLKSTALFRGBQG-NYYWCZLTSA-N 0.000 description 1
- RNLHVODSMDJCBR-VURMDHGXSA-N (z)-3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pent-4-en-2-ol Chemical compound CC(O)C(C)\C=C/C1CC=C(C)C1(C)C RNLHVODSMDJCBR-VURMDHGXSA-N 0.000 description 1
- FVUGZKDGWGKCFE-UHFFFAOYSA-N 1-(2,3,8,8-tetramethyl-1,3,4,5,6,7-hexahydronaphthalen-2-yl)ethanone Chemical compound CC1(C)CCCC2=C1CC(C(C)=O)(C)C(C)C2 FVUGZKDGWGKCFE-UHFFFAOYSA-N 0.000 description 1
- VPKMGDRERYMTJX-CMDGGOBGSA-N 1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-1-penten-3-one Chemical compound CCC(=O)\C=C\C1C(C)=CCCC1(C)C VPKMGDRERYMTJX-CMDGGOBGSA-N 0.000 description 1
- ORHSGDMSYGKJJY-UHFFFAOYSA-N 2,2,4',7',7'-pentamethylspiro[1,3-dioxane-5,5'-bicyclo[4.1.0]heptane] Chemical compound CC1CCC(C2(C)C)C2C11COC(C)(C)OC1 ORHSGDMSYGKJJY-UHFFFAOYSA-N 0.000 description 1
- HMKKIXGYKWDQSV-SDNWHVSQSA-N 2-Pentyl-3-phenyl-2-propenal Chemical compound CCCCC\C(C=O)=C/C1=CC=CC=C1 HMKKIXGYKWDQSV-SDNWHVSQSA-N 0.000 description 1
- DVPFYMGZIGYXSO-UHFFFAOYSA-N 2-[1-(3,3-dimethylcyclohexyl)ethoxy]-2-methylpropan-1-ol;propanoic acid Chemical compound CCC(O)=O.OCC(C)(C)OC(C)C1CCCC(C)(C)C1 DVPFYMGZIGYXSO-UHFFFAOYSA-N 0.000 description 1
- LKTNAAYQZJAXCJ-UHFFFAOYSA-N 2-methylcyclohex-2-en-1-one Chemical compound CC1=CCCCC1=O LKTNAAYQZJAXCJ-UHFFFAOYSA-N 0.000 description 1
- ZHDQGHCZWWDMRS-UHFFFAOYSA-N 3,5-dimethylcyclohex-3-ene-1-carbaldehyde Chemical compound CC1CC(C=O)CC(C)=C1 ZHDQGHCZWWDMRS-UHFFFAOYSA-N 0.000 description 1
- ZFGBKXBPHOUSJX-UHFFFAOYSA-N 3-methylcyclotetradec-5-en-1-one Chemical compound CC1CC=CCCCCCCCCC(=O)C1 ZFGBKXBPHOUSJX-UHFFFAOYSA-N 0.000 description 1
- ICGLPKIVTVWCFT-UHFFFAOYSA-N 4-methylbenzenesulfonohydrazide Chemical compound CC1=CC=C(S(=O)(=O)NN)C=C1 ICGLPKIVTVWCFT-UHFFFAOYSA-N 0.000 description 1
- AUBLFWWZTFFBNU-UHFFFAOYSA-N 6-butan-2-ylquinoline Chemical compound N1=CC=CC2=CC(C(C)CC)=CC=C21 AUBLFWWZTFFBNU-UHFFFAOYSA-N 0.000 description 1
- WTEVFHFQWNTPQP-UHFFFAOYSA-N 6-methyl-7-oxabicyclo[4.1.0]heptan-5-one Chemical group C1CCC(=O)C2(C)C1O2 WTEVFHFQWNTPQP-UHFFFAOYSA-N 0.000 description 1
- AWAHFLZWCBUHMX-UHFFFAOYSA-N 7-(3-methylbutyl)-1,5-benzodioxepin-3-one Chemical compound O1CC(=O)COC2=CC(CCC(C)C)=CC=C21 AWAHFLZWCBUHMX-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- ZZFQBJQIBBEESC-UHFFFAOYSA-N C1C(CC=CCCC=CCCCCCCC1)=O Chemical compound C1C(CC=CCCC=CCCCCCCC1)=O ZZFQBJQIBBEESC-UHFFFAOYSA-N 0.000 description 1
- 240000007436 Cananga odorata Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 1
- 238000006376 Chugaev elimination reaction Methods 0.000 description 1
- 238000005811 Corey-Fuchs synthesis reaction Methods 0.000 description 1
- 238000006952 Enyne metathesis reaction Methods 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 239000005770 Eugenol Substances 0.000 description 1
- 230000005526 G1 to G0 transition Effects 0.000 description 1
- 239000005792 Geraniol Substances 0.000 description 1
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 1
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 1
- 238000006000 Knoevenagel condensation reaction Methods 0.000 description 1
- HYMLWHLQFGRFIY-UHFFFAOYSA-N Maltol Natural products CC1OC=CC(=O)C1=O HYMLWHLQFGRFIY-UHFFFAOYSA-N 0.000 description 1
- 241000581835 Monodora junodii Species 0.000 description 1
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 description 1
- 101100272976 Panax ginseng CYP716A53v2 gene Proteins 0.000 description 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 1
- 235000014443 Pyrus communis Nutrition 0.000 description 1
- 238000010472 Ramberg-Bäcklund reaction Methods 0.000 description 1
- 238000006882 Shapiro reaction Methods 0.000 description 1
- 238000005741 Steglich esterification reaction Methods 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 229940022663 acetate Drugs 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 150000004703 alkoxides Chemical class 0.000 description 1
- WUOACPNHFRMFPN-UHFFFAOYSA-N alpha-terpineol Chemical compound CC1=CCC(C(C)(C)O)CC1 WUOACPNHFRMFPN-UHFFFAOYSA-N 0.000 description 1
- YPZUZOLGGMJZJO-LQKXBSAESA-N ambroxan Chemical compound CC([C@@H]1CC2)(C)CCC[C@]1(C)[C@@H]1[C@]2(C)OCC1 YPZUZOLGGMJZJO-LQKXBSAESA-N 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 229940007550 benzyl acetate Drugs 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- MIZGSAALSYARKU-UHFFFAOYSA-N cashmeran Chemical compound CC1(C)C(C)C(C)(C)C2=C1C(=O)CCC2 MIZGSAALSYARKU-UHFFFAOYSA-N 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000013375 chromatographic separation Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 239000013058 crude material Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000007333 cyanation reaction Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- SQIFACVGCPWBQZ-UHFFFAOYSA-N delta-terpineol Natural products CC(C)(O)C1CCC(=C)CC1 SQIFACVGCPWBQZ-UHFFFAOYSA-N 0.000 description 1
- 230000017858 demethylation Effects 0.000 description 1
- 238000010520 demethylation reaction Methods 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 238000006735 epoxidation reaction Methods 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- 229960002217 eugenol Drugs 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- IFYYFLINQYPWGJ-VIFPVBQESA-N gamma-Decalactone Natural products CCCCCC[C@H]1CCC(=O)O1 IFYYFLINQYPWGJ-VIFPVBQESA-N 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 229940113087 geraniol Drugs 0.000 description 1
- 239000010648 geranium oil Substances 0.000 description 1
- 235000019717 geranium oil Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- DQNOBCJGUXBBBF-UHFFFAOYSA-N hept-5-ynal Chemical compound CC#CCCCC=O DQNOBCJGUXBBBF-UHFFFAOYSA-N 0.000 description 1
- VRLIPUYDFBXWCH-UHFFFAOYSA-N hydridocarbon(.) Chemical compound [CH] VRLIPUYDFBXWCH-UHFFFAOYSA-N 0.000 description 1
- WPFVBOQKRVRMJB-UHFFFAOYSA-N hydroxycitronellal Chemical compound O=CCC(C)CCCC(C)(C)O WPFVBOQKRVRMJB-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000010409 ironing Methods 0.000 description 1
- 125000000654 isopropylidene group Chemical group C(C)(C)=* 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 229940043353 maltol Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000002088 nanocapsule Substances 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229940067107 phenylethyl alcohol Drugs 0.000 description 1
- 239000001738 pogostemon cablin oil Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- QWRGOHMKGNCVAC-KQHSAVHASA-N pomarose Chemical compound C\C=C\C(=O)C(\C)=C(\C)C(C)C QWRGOHMKGNCVAC-KQHSAVHASA-N 0.000 description 1
- 238000002953 preparative HPLC Methods 0.000 description 1
- ZDYVRSLAEXCVBX-UHFFFAOYSA-N pyridinium p-toluenesulfonate Chemical compound C1=CC=[NH+]C=C1.CC1=CC=C(S([O-])(=O)=O)C=C1 ZDYVRSLAEXCVBX-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 125000006413 ring segment Chemical group 0.000 description 1
- 239000010666 rose oil Substances 0.000 description 1
- 235000019719 rose oil Nutrition 0.000 description 1
- 229930007790 rose oxide Natural products 0.000 description 1
- 239000010671 sandalwood oil Substances 0.000 description 1
- 239000001290 saussurea lappa clarke root oil Substances 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000000707 stereoselective effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229940116411 terpineol Drugs 0.000 description 1
- LFSYLMRHJKGLDV-UHFFFAOYSA-N tetradecanolide Natural products O=C1CCCCCCCCCCCCCO1 LFSYLMRHJKGLDV-UHFFFAOYSA-N 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/0069—Heterocyclic compounds
- C11B9/0073—Heterocyclic compounds containing only O or S as heteroatoms
- C11B9/0084—Heterocyclic compounds containing only O or S as heteroatoms the hetero rings containing more than six atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Fats And Perfumes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Pyrane Compounds (AREA)
Description
C−4とC−5との間の二重結合は(E)立体配置にあり、C−(7+n)とC−(8+n)との間の結合は(Z)立体配置にある、
で表される化合物に言及する。
・アルコール類、例えばシトロネロール、Ebanol(登録商標)(3−メチル−5−(2,2,3−トリメチル−3−シクロペンテン−1−イル−4−ペンテン−2−オール)、オイゲノール、ゲラニオール、スーパーミュゲ(Super Muguet)(6−エチル−3−メチル−6−オクテン−1−オール)、リナロール、フェニルエチルアルコール、Sandalore(登録商標)(5−(2,2,3−トリメチル−3−シクロペンテニル)−3−メチルペンタン−2−オール)、テルピネオールまたはTimberol(登録商標)[1−(2,2,6−トリメチルシクロヘキシル)ヘキサン−3−オール);
・エーテル類およびアセタール類、例えばAmbrox(登録商標)(3a,6,6,9a−テトラメチルドデカヒドロナフト[2,1−b]フラン)、ゲラニルメチルエーテル、ローズオキサイドまたはスピランブレン(Spirambrene)(2,2,3’,7’,7’−ペンタメチルスピロ(1,3−ジオキサン−5,2’−ノルカラン));
・大員環、例えばアンブレットリド、エチレンブラシレートまたはExaltolide(登録商標)(オキサシクロヘキサデカン−2−オン);ならびに
・複素環、例えばイソブチルキノリン。
a)式(I)で表される化合物またはその混合物;および
b)消費者製品ベース
を含むフレグランス利用品を提供する。
で表される化合物)のアルキンメタセシスにより、Schrockのカルビン触媒[Me3CC≡W(OtBu)3]または他のアルキンメタセシス触媒の存在下で調製することができる。
オクタ−6−イナールを、J. Yan, J. Zhu, J. J. Matasi, J. W. Herndon, J. Org. Chem. 1990, 55, 786の合成スキームに従って、メチル化段階中にTHP保護を追加して合成した。商業的に入手できるヘキサ−5−イン−1−オール(15.2g、155mmol)を保護し(DHP、PTSA、CH2Cl2、0℃→室温、5時間)、その後メチル化した(1.6MのBuLi、MeI、THF、−78℃→室温、12時間)。THPエーテルの切断(PPTS、MeOH、室温、12時間)により、ヘプタ−5−イン−1−オール(10.6g、61%)が得られ、それをメシル化し(MsCl、Et3N、Et2O、0℃→室温、12時間)、その後シアン化して(KCN、DMF、還流、3.5時間)オクタ−6−インニトリル(7.90g、69%)を提供した。このニトリルの還元により(DIBAL−H、THF、0℃→室温、12時間)、オクタ−6−イナール(6.70g、83%)が得られた。
室温にて、2N水酸化ナトリウム水溶液(7.00mL、14.0mmol)、続いて30%過酸化水素水溶液(11.0mL、112mmol)を、商業的に入手できる2−メチルシクロヘキサ−2−エノン(2.20g、20.0mmol)をメタノール(250mL)に溶解した撹拌した溶液に加え、その際に溶液の発生した赤色は、10分以内に消失した。室温にて24時間撹拌した後、反応混合物を水(200mL)で希釈し、ジクロロメタン(3×150mL)で抽出した。混ぜ合わせた有機抽出物を水(200mL)で洗浄し、硫酸ナトリウムで乾燥した。溶媒を減圧下で除去し、得られた残留物をシリカゲル上のクロマトグラフィー[40g;ペンタン−Et2O(9:1);Rf=0.29]により精製して、1−メチル−7−オキサビシクロ[4.1.0]ヘプタン−2−オン(1.18g、47%)を無色液体として得た。
以下の化合物をまた、例1および2により記載した一般的手順に従って調製することができる:
(4E,8Z)−13−メチルオキサシクロペンタデカ−4,8−ジエン−2−オン、
(4E,8Z)−14−メチルオキサシクロヘキサデカ−4,8−ジエン−2−オン、
(4E,9Z)−12−メチルオキサシクロテトラデカ−4,9−ジエン−2−オン、
(4E,9Z)−14−メチルオキサシクロヘキサデカ−4,9−ジエン−2−オン、
(4E,9Z)−15−メチルオキサシクロヘプタデカ−4,9−ジエン−2−オン、
(4E,10Z)−13−メチルオキサシクロ−ペンタデカ−4,10−ジエン−2−オン、
(4E,10Z)−14−メチルオキサシクロヘキサデカ−4,10−ジエン−2−オン、
(4E,10Z)−15−メチルオキサシクロヘプタデカ−4,10−ジエン−2−オン、
(4E,11Z)−14−メチルオキサシクロヘキサ−デカ−4,11−ジエン−2−オン、および
(4E,11Z)−15−メチルオキサシクロヘプタデカ−4,11−ジエン−2−オン。
Claims (5)
- (4E,8Z)−12−メチルオキサシクロテトラデカ−4,8−ジエン−2−オン、(4E,8Z)−13−メチルオキサシクロペンタデカ−4,8−ジエン−2−オン、(4E,8Z)−14−メチルオキサシクロヘキサデカ−4,8−ジエン−2−オン、(4E,9Z)−12−メチルオキサシクロテトラデカ−4,9−ジエン−2−オン、(4E,9Z)−13−メチルオキサシクロペンタデカ−4,9−ジエン−2−オン、(4E,9Z)−14−メチルオキサシクロヘキサデカ−4,9−ジエン−2−オン、(4E,9Z)−15−メチルオキサシクロヘプタデカ−4,9−ジエン−2−オン、(4E,10Z)−13−メチルオキサシクロ−ペンタデカ−4,10−ジエン−2−オン、(4E,10Z)−14−メチルオキサシクロヘキサデカ−4,10−ジエン−2−オン、(4E,10Z)−15−メチルオキサシクロヘプタデカ−4,10−ジエン−2−オン、(4E,11Z)−14−メチルオキサシクロヘキサ−デカ−4,11−ジエン−2−オンおよび(4E,11Z)−15−メチルオキサシクロヘプタデカ−4,11−ジエン−2−オンから選択される、請求項1に記載の化合物。
- 請求項1において定義した式(I)で表される化合物またはそれらの混合物ならびにファインフレグランス、家庭用品、織物ケア製品、パーソナルケア用品および化粧品からなる群から選択される消費者製品ベースを含む、フレグランス利用品。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0718806.3 | 2007-09-27 | ||
GBGB0718806.3A GB0718806D0 (en) | 2007-09-27 | 2007-09-27 | Organic compounds |
PCT/CH2008/000396 WO2009039675A1 (en) | 2007-09-27 | 2008-09-25 | Macrocyclic lactones as fragrances |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2010540469A JP2010540469A (ja) | 2010-12-24 |
JP2010540469A5 JP2010540469A5 (ja) | 2012-11-15 |
JP5395083B2 true JP5395083B2 (ja) | 2014-01-22 |
Family
ID=38701704
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010526125A Active JP5395083B2 (ja) | 2007-09-27 | 2008-09-25 | フレグランスとしての大環状ラクトン類 |
Country Status (9)
Country | Link |
---|---|
US (1) | US8217185B2 (ja) |
EP (1) | EP2205581B1 (ja) |
JP (1) | JP5395083B2 (ja) |
CN (1) | CN101809011B (ja) |
BR (1) | BRPI0817618B1 (ja) |
ES (1) | ES2392118T3 (ja) |
GB (1) | GB0718806D0 (ja) |
MX (1) | MX2010003192A (ja) |
WO (1) | WO2009039675A1 (ja) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5480508B2 (ja) * | 2009-01-13 | 2014-04-23 | 花王株式会社 | 香料組成物 |
EP2473496A4 (en) * | 2009-09-02 | 2013-02-20 | Takasago Perfumery Co Ltd | 7, 10, 13-CYCLOHEXADECATRIENE-16-OLIDE AND COMPOSITION OF FLAVOR OR FRAGRANCE, FRAGRANCE OR COSMETIC PRODUCT, FOOD OR BEVERAGE OR TOILET PRODUCT COMPRISING SAME |
JP5718674B2 (ja) * | 2011-02-25 | 2015-05-13 | 高砂香料工業株式会社 | 非共役トリエン構造を有する大環状トリエンラクトン類、その製造方法、およびその合成中間体 |
EP2687586B1 (de) | 2012-07-17 | 2016-11-23 | Symrise AG | Verwendung definierter Cyclohexenone als Mittel zum überadditiven Verstärken eines Geruchseindrucks sowie Riech- und/oder Geschmacksstoffkomposition |
JP6129319B2 (ja) * | 2012-09-14 | 2017-05-17 | シムライズ アーゲー | 香気物質としての不飽和ラクトン |
ES2656208T3 (es) * | 2014-01-14 | 2018-02-26 | Firmenich Sa | Macrociclos odorantes almizclados polvorientes |
EP3294347A1 (en) * | 2015-05-13 | 2018-03-21 | Givaudan SA | Improvements in or relating to organic compounds |
JP2017122101A (ja) * | 2017-02-17 | 2017-07-13 | シムライズ アーゲー | 香気物質としての不飽和ラクトン |
US20230131532A1 (en) * | 2021-09-24 | 2023-04-27 | Phyto Tech Corp. | Use of musk compounds in flavors |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5792740A (en) | 1996-03-08 | 1998-08-11 | Firmenich Sa | Fragrant macrocyclic lactones |
US5726328A (en) | 1996-07-09 | 1998-03-10 | V. Mane Fils S.A. | Preparation of cis-isoambrettolides and their use as a fragrance |
EP0841333A1 (en) | 1996-11-08 | 1998-05-13 | Quest International B.V. | 14-Methyl-hexadecenolide and 14-methyl-hexadecanolide |
DE59804713D1 (de) | 1997-10-09 | 2002-08-14 | Givaudan Sa | Macrocyclen |
DE19804673A1 (de) | 1998-02-06 | 1999-08-12 | Studiengesellschaft Kohle Mbh | Verfahren zur Darstellung makrocyclischer Produkte durch ringschliessende Diin-Metathese |
US6284900B1 (en) | 1999-02-16 | 2001-09-04 | Synarome | Cis-isoambrettolide of high degree of isomer purity and use thereof |
DE10152990A1 (de) | 2001-10-26 | 2003-05-08 | Haarmann & Reimer Gmbh | Gemische zur Verwendung als Moschusriechstoff |
GB2423986A (en) | 2004-12-24 | 2006-09-13 | Givaudan Sa | Fragrance Compound |
-
2007
- 2007-09-27 GB GBGB0718806.3A patent/GB0718806D0/en not_active Ceased
-
2008
- 2008-09-25 MX MX2010003192A patent/MX2010003192A/es active IP Right Grant
- 2008-09-25 WO PCT/CH2008/000396 patent/WO2009039675A1/en active Application Filing
- 2008-09-25 JP JP2010526125A patent/JP5395083B2/ja active Active
- 2008-09-25 BR BRPI0817618-3A patent/BRPI0817618B1/pt not_active IP Right Cessation
- 2008-09-25 EP EP08800442A patent/EP2205581B1/en active Active
- 2008-09-25 US US12/679,846 patent/US8217185B2/en active Active
- 2008-09-25 ES ES08800442T patent/ES2392118T3/es active Active
- 2008-09-25 CN CN200880109085XA patent/CN101809011B/zh active Active
Also Published As
Publication number | Publication date |
---|---|
US8217185B2 (en) | 2012-07-10 |
CN101809011B (zh) | 2013-05-29 |
CN101809011A (zh) | 2010-08-18 |
MX2010003192A (es) | 2010-04-12 |
US20100204344A1 (en) | 2010-08-12 |
BRPI0817618A2 (pt) | 2015-03-31 |
EP2205581A1 (en) | 2010-07-14 |
GB0718806D0 (en) | 2007-11-07 |
JP2010540469A (ja) | 2010-12-24 |
EP2205581B1 (en) | 2012-07-25 |
BRPI0817618B1 (pt) | 2018-01-30 |
ES2392118T3 (es) | 2012-12-04 |
WO2009039675A1 (en) | 2009-04-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5395083B2 (ja) | フレグランスとしての大環状ラクトン類 | |
JP5399908B2 (ja) | 有機化合物 | |
US4521331A (en) | Method of imparting a pleasant odor | |
JP5877243B2 (ja) | フレグランス組成物および芳香製品における使用のためのテルペンアルコール | |
JP2007536285A (ja) | 脂環式カルボン酸オキシカルボニルメチルエステル類および着臭剤としてのこれらの使用 | |
KR20070085865A (ko) | 유기 화합물 | |
JP4352002B2 (ja) | エステルおよび香料におけるそれらの使用 | |
JPH0867661A (ja) | カンホレンアルデヒド誘導体、その製法及びそれを含有する芳香付け成分 | |
WO2011033047A1 (en) | Carbinols having olfactory properties reminiscent of patchouli oil | |
JP4518957B2 (ja) | じゃこう特性を有する香料としての脂肪族化合物 | |
US8911716B2 (en) | Saffron odorants | |
JP2011514325A (ja) | 有機化合物 | |
JP2010500421A (ja) | シクロペンタン/シクロペンテンアルデヒド誘導体またはシクロペンタン/シクロペンテンケトン誘導体および香り物質としてのそれらの使用 | |
JP2013519646A (ja) | 7−(アルカ−1’−エニル)−2H−ベンゾ[b][1,4]ジオキセピン−3(4H)−オン類およびフレグランス利用品におけるそれらの使用 | |
JP4859826B2 (ja) | フレグランス組成物の製造に好適な三置換フラン | |
JP4676880B2 (ja) | シクロオクト−(エン−)イル誘導体の香料としての使用 | |
JP6072797B2 (ja) | フレグランス化合物および組成物 | |
EP2411355B1 (en) | Alcohol as sandalwood odorant | |
US8344023B2 (en) | 2,5-di- and 2,2,5-trisubstituted di- and tetrahydrofuran derivatives and their use for the production of perfumes | |
JP6154893B2 (ja) | 有機化合物 | |
US6043210A (en) | Preparation of thiamacrolide compounds | |
JP2007507563A (ja) | 有機化合物 | |
JP2007507434A (ja) | 3−イソプロピル−1−メチルシクロペンチル誘導体およびフレグランス製品におけるその使用 | |
JP2007518743A (ja) | ビシクロ[3.3.1]ノナン類およびビシクロ[3.3.1]ノネン類並びに風味剤または芳香成分としてのこれらの使用 | |
JPH0365330B2 (ja) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110922 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20110922 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120921 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130521 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130821 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20130917 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20131017 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5395083 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: R3D04 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |