JP5382952B2 - 糖尿病の治療のためのオキサジアゾアントラセン化合物 - Google Patents

糖尿病の治療のためのオキサジアゾアントラセン化合物 Download PDF

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Publication number
JP5382952B2
JP5382952B2 JP2010549910A JP2010549910A JP5382952B2 JP 5382952 B2 JP5382952 B2 JP 5382952B2 JP 2010549910 A JP2010549910 A JP 2010549910A JP 2010549910 A JP2010549910 A JP 2010549910A JP 5382952 B2 JP5382952 B2 JP 5382952B2
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phenyl
oxo
diaza
hexahydro
oxa
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JP2011513431A5 (enExample
JP2011513431A (ja
Inventor
ムジャリ，アドナン・エム・エム
ポリセッティ，ダルマ・ラオ
ヨクム，トーマス・スコット
サントシュ，カルパシィ
グゼル，ムスタファ
ベーメ，クリストファー
ディヴィス，スティーブン・トーマス
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vTv Therapeutics LLC
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vTvx Holdings I LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2010549910A 2008-03-07 2009-03-06 糖尿病の治療のためのオキサジアゾアントラセン化合物 Active JP5382952B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3459908P 2008-03-07 2008-03-07
US61/034,599 2008-03-07
PCT/US2009/036333 WO2009111700A2 (en) 2008-03-07 2009-03-06 Oxadiazoanthracene compounds for the treatment of diabetes

Publications (3)

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JP2011513431A JP2011513431A (ja) 2011-04-28
JP2011513431A5 JP2011513431A5 (enExample) 2013-02-14
JP5382952B2 true JP5382952B2 (ja) 2014-01-08

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Country Link
US (7) US7727983B2 (enExample)
EP (1) EP2262364B1 (enExample)
JP (1) JP5382952B2 (enExample)
KR (1) KR101616737B1 (enExample)
CN (1) CN101959405B (enExample)
AU (1) AU2009221722B2 (enExample)
BR (1) BRPI0910282A2 (enExample)
CA (1) CA2716664C (enExample)
DK (1) DK2262364T3 (enExample)
EA (1) EA018225B1 (enExample)
ES (1) ES2567451T3 (enExample)
IL (1) IL207570A (enExample)
MA (1) MA32175B1 (enExample)
MX (1) MX2010009752A (enExample)
NZ (1) NZ587343A (enExample)
WO (1) WO2009111700A2 (enExample)
ZA (1) ZA201006367B (enExample)

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WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
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US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
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TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
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EA202191432A1 (ru) 2018-11-22 2021-10-14 Цилу Регор Терапьютикс Инк. Агонисты glp-1r и их применения
WO2020207474A1 (en) * 2019-04-12 2020-10-15 Qilu Regor Therapeutics Inc. Glp-1r agonists and uses thereof
CN115315426B (zh) 2020-04-01 2023-12-12 杭州中美华东制药有限公司 Glp-1受体激动剂游离碱的药学上可接受的酸式盐及其制备方法
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TW202210461A (zh) * 2020-05-28 2022-03-16 中國大陸商杭州中美華東製藥有限公司 一種（ｓ）—２—胺基—３—（４—（２，３—二甲基吡啶—４—基）苯基）丙酸甲酯二酸鹽的製備方法
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Also Published As

Publication number Publication date
EA018225B1 (ru) 2013-06-28
KR20100131455A (ko) 2010-12-15
ES2567451T3 (es) 2016-04-22
CA2716664A1 (en) 2009-09-11
US7727983B2 (en) 2010-06-01
CA2716664C (en) 2016-10-11
CN101959405A (zh) 2011-01-26
US20110039837A1 (en) 2011-02-17
MX2010009752A (es) 2010-09-30
US20130317015A1 (en) 2013-11-28
NZ587343A (en) 2012-05-25
EP2262364A2 (en) 2010-12-22
US8703766B2 (en) 2014-04-22
US9120813B2 (en) 2015-09-01
US20140187769A1 (en) 2014-07-03
BRPI0910282A2 (pt) 2015-09-01
US20090306063A1 (en) 2009-12-10
CN101959405B (zh) 2014-07-02
WO2009111700A2 (en) 2009-09-11
MA32175B1 (fr) 2011-03-01
US20100197677A1 (en) 2010-08-05
WO2009111700A3 (en) 2010-03-04
US20150087640A1 (en) 2015-03-26
US20100324033A1 (en) 2010-12-23
ZA201006367B (en) 2011-05-25
EA201071045A1 (ru) 2011-02-28
US7906507B2 (en) 2011-03-15
AU2009221722B2 (en) 2014-12-18
IL207570A (en) 2014-03-31
EP2262364A4 (en) 2012-04-04
HK1148435A1 (en) 2011-09-09
IL207570A0 (en) 2010-12-30
KR101616737B1 (ko) 2016-05-02
DK2262364T3 (en) 2016-03-21
AU2009221722A1 (en) 2009-09-11
US7790714B2 (en) 2010-09-07
US8933222B2 (en) 2015-01-13
EP2262364B1 (en) 2016-03-02
US8524708B2 (en) 2013-09-03
JP2011513431A (ja) 2011-04-28

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