JP5278318B2 - Crth2拮抗剤および抗アレルギー剤として有用な多環酸化合物 - Google Patents
Crth2拮抗剤および抗アレルギー剤として有用な多環酸化合物 Download PDFInfo
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- JP5278318B2 JP5278318B2 JP2009524246A JP2009524246A JP5278318B2 JP 5278318 B2 JP5278318 B2 JP 5278318B2 JP 2009524246 A JP2009524246 A JP 2009524246A JP 2009524246 A JP2009524246 A JP 2009524246A JP 5278318 B2 JP5278318 B2 JP 5278318B2
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- HTFUDYLVWNBYMN-UHFFFAOYSA-N C(C1)c(cccc2)c2N1c1c(cc[n]2-c3cccc4c3nc[nH]4)c2ccc1 Chemical compound C(C1)c(cccc2)c2N1c1c(cc[n]2-c3cccc4c3nc[nH]4)c2ccc1 HTFUDYLVWNBYMN-UHFFFAOYSA-N 0.000 description 1
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
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- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US87001406P | 2006-12-14 | 2006-12-14 | |
| US60/870,014 | 2006-12-14 | ||
| PCT/JP2007/074475 WO2008072784A1 (en) | 2006-12-14 | 2007-12-13 | Polycyclic acid compounds useful as crth2 antagonists and antiallergic agents |
Publications (3)
| Publication Number | Publication Date |
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| JP2010513224A JP2010513224A (ja) | 2010-04-30 |
| JP2010513224A5 JP2010513224A5 (enExample) | 2011-01-20 |
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| JP2009524246A Expired - Fee Related JP5278318B2 (ja) | 2006-12-14 | 2007-12-13 | Crth2拮抗剤および抗アレルギー剤として有用な多環酸化合物 |
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| EP (1) | EP2094662B1 (enExample) |
| JP (1) | JP5278318B2 (enExample) |
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| AU2008219166B2 (en) * | 2007-02-16 | 2013-05-16 | Amgen Inc. | Nitrogen-containing heterocyclyl ketones and their use as c-Met inhibitors |
| US8304413B2 (en) | 2008-06-03 | 2012-11-06 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
| MX2011012155A (es) | 2009-05-13 | 2012-02-28 | Enanta Pharm Inc | Compuestos macrociclicos como inhibidores del virus de hepatitis c. |
| EP2590944B1 (en) | 2010-07-05 | 2015-09-30 | Actelion Pharmaceuticals Ltd. | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators |
| US9255090B2 (en) | 2011-12-21 | 2016-02-09 | Actelion Pharmaceuticals Ltd. | Heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators |
| MX2014015156A (es) | 2012-06-12 | 2015-08-06 | Abbvie Inc | Derivados de piridinona y piridazinona. |
| US9169270B2 (en) | 2012-07-05 | 2015-10-27 | Actelion Pharmaceuticals Ltd. | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators |
| WO2014047427A2 (en) | 2012-09-21 | 2014-03-27 | Vanderbilt University | Substituted benzofuran, benzothiophene and indole mcl-1 inhibitors |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| WO2014080290A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Cyclic amines as bromodomain inhibitors |
| WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
| AU2013365926B9 (en) * | 2012-12-21 | 2019-01-17 | Zenith Epigenetics Ltd. | Novel heterocyclic compounds as bromodomain inhibitors |
| ES2661437T3 (es) | 2013-06-21 | 2018-04-02 | Zenith Epigenetics Corp. | Nuevos compuestos bicíclicos sustituidos como inhibidores de bromodominio |
| SI3010503T1 (sl) | 2013-06-21 | 2020-07-31 | Zenith Epigenetics Ltd. | Novi biciklični inhibitorji bromodomene |
| CN105593224B (zh) | 2013-07-31 | 2021-05-25 | 恒元生物医药科技(苏州)有限公司 | 作为溴结构域抑制剂的新型喹唑啉酮类化合物 |
| US10005728B2 (en) | 2013-08-28 | 2018-06-26 | Vanderbilt University | Substituted indole Mcl-1 inhibitors |
| CA2943815C (en) | 2014-03-27 | 2023-04-04 | Vanderbilt University | Substituted indole mcl-1 inhibitors |
| KR102373700B1 (ko) | 2014-04-02 | 2022-03-11 | 인터뮨, 인크. | 항섬유성 피리디논 |
| US9949965B2 (en) | 2014-10-17 | 2018-04-24 | Vanderbilt University | Tricyclic indole Mcl-1 inhibitors and uses thereof |
| US10710992B2 (en) | 2014-12-01 | 2020-07-14 | Zenith Epigenetics Ltd. | Substituted pyridinones as bromodomain inhibitors |
| EP3227280B1 (en) | 2014-12-01 | 2019-04-24 | Zenith Epigenetics Ltd. | Substituted pyridines as bromodomain inhibitors |
| US10292968B2 (en) | 2014-12-11 | 2019-05-21 | Zenith Epigenetics Ltd. | Substituted heterocycles as bromodomain inhibitors |
| CA2966450A1 (en) | 2014-12-17 | 2016-06-23 | Olesya KHARENKO | Inhibitors of bromodomains |
| CN105353095B (zh) * | 2015-11-16 | 2017-10-20 | 华南农业大学 | 一种西地那非及其结构类似物的免疫检测方法 |
| WO2017104728A1 (ja) * | 2015-12-16 | 2017-06-22 | 国立大学法人東京大学 | 食物アレルギー治療薬 |
| WO2017126635A1 (ja) * | 2016-01-22 | 2017-07-27 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| EP4292662A3 (en) | 2016-03-04 | 2024-02-21 | Vanderbilt University | Substituted indole mcl-1 inhibitors |
| US11608320B2 (en) | 2020-02-02 | 2023-03-21 | Kuwait University | Oxazolidinone hydroxamic acid derivatives |
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| JP3245864B2 (ja) | 1994-03-10 | 2002-01-15 | 藤沢薬品工業株式会社 | プロスタグランジンi2アゴニストとしてのナフタレン誘導体 |
| AU3387895A (en) * | 1994-09-10 | 1996-03-27 | Basf Aktiengesellschaft | Phenylacetic acid alkyl esters |
| AU691673B2 (en) | 1994-11-14 | 1998-05-21 | Dow Agrosciences Llc | Pyridazinones and their use as fungicides |
| DE19514568A1 (de) * | 1995-04-20 | 1996-10-24 | Merck Patent Gmbh | Arylalkyl-pyridazinone |
| KR20020014797A (ko) * | 1999-05-17 | 2002-02-25 | 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 | 글루카곤 길항제/역 아고니스트 |
| CA2437932A1 (en) * | 2001-02-12 | 2002-09-19 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Use of type 4 phosphodiesterase inhibitors in myocardial diseases |
| TW200400930A (en) * | 2002-06-26 | 2004-01-16 | Ono Pharmaceutical Co | Therapeutic agent for chronic disease |
| US7820682B2 (en) * | 2002-10-03 | 2010-10-26 | Ono Pharmaceutical Co., Ltd. | LPA receptor antagonist |
| EP2336113A1 (en) | 2004-05-29 | 2011-06-22 | 7TM Pharma A/S | CRTH2 Receptor Ligands for Medical Use |
| DE102005057924A1 (de) | 2005-12-05 | 2007-06-06 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102006037478A1 (de) * | 2006-08-10 | 2008-02-14 | Merck Patent Gmbh | 2-(Heterocyclylbenzyl)-pyridazinonderivate |
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- 2007-12-13 WO PCT/JP2007/074475 patent/WO2008072784A1/en not_active Ceased
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- 2007-12-13 ES ES07859872T patent/ES2383239T3/es active Active
- 2007-12-13 TW TW096147687A patent/TW200848036A/zh unknown
- 2007-12-13 EP EP07859872A patent/EP2094662B1/en not_active Not-in-force
- 2007-12-13 MX MX2009006312A patent/MX2009006312A/es active IP Right Grant
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- 2007-12-13 CN CN200780046458A patent/CN101636386A/zh active Pending
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- 2007-12-13 JP JP2009524246A patent/JP5278318B2/ja not_active Expired - Fee Related
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| MX2009006312A (es) | 2009-08-07 |
| JP2010513224A (ja) | 2010-04-30 |
| US20100009991A1 (en) | 2010-01-14 |
| PL2094662T3 (pl) | 2012-09-28 |
| CA2672601A1 (en) | 2008-06-19 |
| ES2383239T3 (es) | 2012-06-19 |
| CN102442941A (zh) | 2012-05-09 |
| PT2094662E (pt) | 2012-07-02 |
| EP2094662A1 (en) | 2009-09-02 |
| AR064346A1 (es) | 2009-04-01 |
| CN101636386A (zh) | 2010-01-27 |
| TW200848036A (en) | 2008-12-16 |
| ATE553084T1 (de) | 2012-04-15 |
| WO2008072784A1 (en) | 2008-06-19 |
| US8273745B2 (en) | 2012-09-25 |
| KR20090096690A (ko) | 2009-09-14 |
| EP2094662B1 (en) | 2012-04-11 |
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