JP5270366B2 - 球状メントール粒子 - Google Patents

球状メントール粒子 Download PDF

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Publication number
JP5270366B2
JP5270366B2 JP2008546323A JP2008546323A JP5270366B2 JP 5270366 B2 JP5270366 B2 JP 5270366B2 JP 2008546323 A JP2008546323 A JP 2008546323A JP 2008546323 A JP2008546323 A JP 2008546323A JP 5270366 B2 JP5270366 B2 JP 5270366B2
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Japan
Prior art keywords
menthol
water
particles
spherical
container
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JP2008546323A
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English (en)
Japanese (ja)
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JP2009519992A5 (enExample
JP2009519992A (ja
Inventor
ハインツ ディーター ラインレンダー
ヨルグ ニーケルケン
Original Assignee
シムライズ アーゲー
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
    • C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
    • C07C29/86—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by liquid-liquid treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cosmetics (AREA)
  • Fats And Perfumes (AREA)
  • Medicinal Preparation (AREA)
  • Confectionery (AREA)
JP2008546323A 2005-12-20 2006-11-21 球状メントール粒子 Active JP5270366B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75162905P 2005-12-20 2005-12-20
US60/751,629 2005-12-20
PCT/EP2006/068700 WO2007071512A1 (en) 2005-12-20 2006-11-21 Spherical menthol particles

Publications (3)

Publication Number Publication Date
JP2009519992A JP2009519992A (ja) 2009-05-21
JP2009519992A5 JP2009519992A5 (enExample) 2012-08-02
JP5270366B2 true JP5270366B2 (ja) 2013-08-21

Family

ID=37810171

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008546323A Active JP5270366B2 (ja) 2005-12-20 2006-11-21 球状メントール粒子

Country Status (4)

Country Link
US (1) US20090011238A1 (enExample)
EP (1) EP1968926B1 (enExample)
JP (1) JP5270366B2 (enExample)
WO (1) WO2007071512A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2155638B1 (de) * 2007-06-12 2014-11-26 Basf Se Mentholschuppen und verfahren zu deren herstellung
EP2225192B1 (de) 2007-11-30 2017-05-03 Basf Se Verfahren zur herstellung von optisch aktivem und racemischem menthol
CN101390830B (zh) * 2008-11-12 2011-05-18 常州市第四制药厂有限公司 一种盐酸赛庚啶乳膏剂及其制备方法
WO2010095034A1 (en) 2009-02-17 2010-08-26 Nagaoka & Co., Ltd. Methods and apparatus for production of natural l-menthol
EP2550877B1 (en) * 2010-03-26 2020-06-17 Japan Tobacco Inc. Cigarette with increased volatile-flavor delivery
GB201113776D0 (en) 2011-08-10 2011-09-21 British American Tobacco Co Capsule formation
GB201113775D0 (en) 2011-08-10 2011-09-21 British American Tobacco Co Capsule formation
EP2979751B1 (de) * 2014-07-29 2020-10-28 Symrise AG Verfahren zur herstellung von festen kühlstoffen
DE102014217603A1 (de) * 2014-09-03 2016-03-03 Sandvik Materials Technology Deutschland Gmbh Verfahren und Vorrichtung zum Herstellen von L-Menthol in fester Form
US10492522B2 (en) 2017-05-03 2019-12-03 R.J. Reynolds Tobacco Company Flavored menthol-containing objects for application to smoking article components
JP7608326B2 (ja) * 2018-08-16 2025-01-06 ビーエーエスエフ ソシエタス・ヨーロピア ケーキングに対して安定化されたメントール粒子を製造する方法並びに保存安定性メントール粒子及びその使用
CN110002959B (zh) * 2019-03-08 2022-03-01 天津大学 一种l-薄荷醇球形晶体的制备方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE518090C (de) 1927-12-14 1931-02-12 I G Farbenindustrie Akt Ges Verfahren zur UEberfuehrung von Salzen, insbesondere Duengemitteln, in kugelige Gebilde oder Koerper aehnlicher Form durch Eintropfenlassen des geschmolzenen Materials in eine bewegte Fluessigkeit
US2570423A (en) * 1948-03-20 1951-10-09 F G Findley Co Apparatus for pelleting solids
DE932246C (de) 1950-09-23 1955-08-29 Ruhrchemie Ag Verfahren und Vorrichtung zur Granulierung chemischer Stoffe, insbesondere von Duengemitteln
US3064311A (en) * 1960-01-26 1962-11-20 Glidden Co Flaking of menthol
BE604783A (enExample) 1961-04-28
GB1115071A (en) 1964-03-26 1968-05-22 Fisons Ltd Granulation process
GB1136901A (en) 1964-09-17 1968-12-18 Elliott Assoc Dev Improvements in or relating to the treatment of sulphur
US3637351A (en) * 1969-07-30 1972-01-25 Union Oil Co Porous particulate sulfur and means and method for its preparation
DE2530481C3 (de) 1975-07-09 1980-10-09 Haarmann & Reimer Gmbh, 3450 Holzminden Vorrichtung zum Kristallisieren von Substanzen
DE3116914A1 (de) 1981-04-29 1982-11-18 Chemische Werke Hüls AG, 4370 Marl Verbesserung des prillverfahrens fuer schmelzbare stoffe unter vorlage einer kuehlfluessigkeit
KR910000142B1 (ko) * 1987-05-29 1991-01-21 니혼 다바고 상교오 가부시기가이샤 담배용 필터
JP2709077B2 (ja) * 1987-05-29 1998-02-04 日本たばこ産業株式会社 煙草用フィルター
JP3667791B2 (ja) 1994-07-04 2005-07-06 高砂香料工業株式会社 Ｌ−メントール含有粉体
JP3247277B2 (ja) * 1994-07-29 2002-01-15 高砂香料工業株式会社 液状ｌ−ｎ−メントール組成物及びその調製法
FR2737668B1 (fr) * 1995-08-08 1997-10-31 Rocher Yves Biolog Vegetale Billes a base de substances lipophiles, leur procede de fabrication et leurs applications
WO1998001204A1 (de) 1996-07-05 1998-01-15 Bayer Aktiengesellschaft Kristallisationsvorrichtung und -verfahren
JP3447042B2 (ja) * 1997-07-23 2003-09-16 フロイント産業株式会社 単一物質球形粒の製造方法
DK1064990T3 (da) * 1999-06-29 2004-05-24 Aeromatic Fielder Ag Fremgangsmåde til granulering af et partikelformet materiale
DE10224087A1 (de) * 2002-05-31 2003-12-11 Symrise Gmbh & Co Kg Kompaktiertes Menthol
ATE340566T1 (de) 2002-12-05 2006-10-15 Symrise Gmbh & Co Kg Nahtlose gefüllte kapseln
EP1861172B1 (en) * 2005-03-16 2009-12-23 Symrise GmbH & Co. KG Menthol-containing solids composition

Also Published As

Publication number Publication date
WO2007071512A1 (en) 2007-06-28
US20090011238A1 (en) 2009-01-08
EP1968926B1 (en) 2020-09-02
EP1968926A1 (en) 2008-09-17
JP2009519992A (ja) 2009-05-21

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