JP5270366B2 - 球状メントール粒子 - Google Patents

球状メントール粒子 Download PDF

Info

Publication number
JP5270366B2
JP5270366B2 JP2008546323A JP2008546323A JP5270366B2 JP 5270366 B2 JP5270366 B2 JP 5270366B2 JP 2008546323 A JP2008546323 A JP 2008546323A JP 2008546323 A JP2008546323 A JP 2008546323A JP 5270366 B2 JP5270366 B2 JP 5270366B2
Authority
JP
Japan
Prior art keywords
menthol
water
particles
spherical
container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2008546323A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009519992A (ja
JP2009519992A5 (enExample
Inventor
ハインツ ディーター ラインレンダー
ヨルグ ニーケルケン
Original Assignee
シムライズ アーゲー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by シムライズ アーゲー filed Critical シムライズ アーゲー
Publication of JP2009519992A publication Critical patent/JP2009519992A/ja
Publication of JP2009519992A5 publication Critical patent/JP2009519992A5/ja
Application granted granted Critical
Publication of JP5270366B2 publication Critical patent/JP5270366B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
    • C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
    • C07C29/86—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by liquid-liquid treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cosmetics (AREA)
  • Fats And Perfumes (AREA)
  • Medicinal Preparation (AREA)
  • Confectionery (AREA)
JP2008546323A 2005-12-20 2006-11-21 球状メントール粒子 Active JP5270366B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75162905P 2005-12-20 2005-12-20
US60/751,629 2005-12-20
PCT/EP2006/068700 WO2007071512A1 (en) 2005-12-20 2006-11-21 Spherical menthol particles

Publications (3)

Publication Number Publication Date
JP2009519992A JP2009519992A (ja) 2009-05-21
JP2009519992A5 JP2009519992A5 (enExample) 2012-08-02
JP5270366B2 true JP5270366B2 (ja) 2013-08-21

Family

ID=37810171

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008546323A Active JP5270366B2 (ja) 2005-12-20 2006-11-21 球状メントール粒子

Country Status (4)

Country Link
US (1) US20090011238A1 (enExample)
EP (1) EP1968926B1 (enExample)
JP (1) JP5270366B2 (enExample)
WO (1) WO2007071512A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2529551T3 (es) * 2007-06-12 2015-02-23 Basf Se Copos de mentol y procedimiento para su preparación
CN104211566A (zh) 2007-11-30 2014-12-17 巴斯夫欧洲公司 生产光学活性、外消旋薄荷醇的方法
CN101390830B (zh) * 2008-11-12 2011-05-18 常州市第四制药厂有限公司 一种盐酸赛庚啶乳膏剂及其制备方法
US8785698B2 (en) 2009-02-17 2014-07-22 Nagaoka & Co., Ltd. Methods and apparatus for production of natural L-menthol
JP5315455B2 (ja) * 2010-03-26 2013-10-16 日本たばこ産業株式会社 揮発性香料デリバリー量を高めたシガレット
GB201113775D0 (en) 2011-08-10 2011-09-21 British American Tobacco Co Capsule formation
GB201113776D0 (en) 2011-08-10 2011-09-21 British American Tobacco Co Capsule formation
EP2979751B1 (de) 2014-07-29 2020-10-28 Symrise AG Verfahren zur herstellung von festen kühlstoffen
DE102014217603A1 (de) * 2014-09-03 2016-03-03 Sandvik Materials Technology Deutschland Gmbh Verfahren und Vorrichtung zum Herstellen von L-Menthol in fester Form
US10492522B2 (en) 2017-05-03 2019-12-03 R.J. Reynolds Tobacco Company Flavored menthol-containing objects for application to smoking article components
US12162822B2 (en) 2018-08-16 2024-12-10 Basf Se Method for producing menthol particles stabilized against caking, and storage-stable menthol particles and use thereof
CN110002959B (zh) * 2019-03-08 2022-03-01 天津大学 一种l-薄荷醇球形晶体的制备方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE518090C (de) 1927-12-14 1931-02-12 I G Farbenindustrie Akt Ges Verfahren zur UEberfuehrung von Salzen, insbesondere Duengemitteln, in kugelige Gebilde oder Koerper aehnlicher Form durch Eintropfenlassen des geschmolzenen Materials in eine bewegte Fluessigkeit
US2570423A (en) * 1948-03-20 1951-10-09 F G Findley Co Apparatus for pelleting solids
DE932246C (de) 1950-09-23 1955-08-29 Ruhrchemie Ag Verfahren und Vorrichtung zur Granulierung chemischer Stoffe, insbesondere von Duengemitteln
US3064311A (en) * 1960-01-26 1962-11-20 Glidden Co Flaking of menthol
US3123855A (en) 1961-04-28 1964-03-10 Apparatus for converting fusible materials
GB1115071A (en) 1964-03-26 1968-05-22 Fisons Ltd Granulation process
GB1136901A (en) 1964-09-17 1968-12-18 Elliott Assoc Dev Improvements in or relating to the treatment of sulphur
US3637351A (en) 1969-07-30 1972-01-25 Union Oil Co Porous particulate sulfur and means and method for its preparation
DE2530481C3 (de) 1975-07-09 1980-10-09 Haarmann & Reimer Gmbh, 3450 Holzminden Vorrichtung zum Kristallisieren von Substanzen
DE3116914A1 (de) 1981-04-29 1982-11-18 Chemische Werke Hüls AG, 4370 Marl Verbesserung des prillverfahrens fuer schmelzbare stoffe unter vorlage einer kuehlfluessigkeit
KR910000142B1 (ko) * 1987-05-29 1991-01-21 니혼 다바고 상교오 가부시기가이샤 담배용 필터
JP2709077B2 (ja) * 1987-05-29 1998-02-04 日本たばこ産業株式会社 煙草用フィルター
JP3667791B2 (ja) 1994-07-04 2005-07-06 高砂香料工業株式会社 Ｌ−メントール含有粉体
JP3247277B2 (ja) * 1994-07-29 2002-01-15 高砂香料工業株式会社 液状ｌ−ｎ−メントール組成物及びその調製法
FR2737668B1 (fr) * 1995-08-08 1997-10-31 Rocher Yves Biolog Vegetale Billes a base de substances lipophiles, leur procede de fabrication et leurs applications
US6315966B1 (en) 1996-07-05 2001-11-13 Haarmann & Reimer Gmbh Crystallization process and device
JP3447042B2 (ja) * 1997-07-23 2003-09-16 フロイント産業株式会社 単一物質球形粒の製造方法
DK1064990T3 (da) * 1999-06-29 2004-05-24 Aeromatic Fielder Ag Fremgangsmåde til granulering af et partikelformet materiale
DE10224087A1 (de) * 2002-05-31 2003-12-11 Symrise Gmbh & Co Kg Kompaktiertes Menthol
DE50208276D1 (de) 2002-12-05 2006-11-09 Symrise Gmbh & Co Kg Nahtlose gefüllte Kapseln
WO2006097427A1 (en) * 2005-03-16 2006-09-21 Symrise Gmbh & Co. Kg Menthol-containing solids composition

Also Published As

Publication number Publication date
WO2007071512A1 (en) 2007-06-28
EP1968926A1 (en) 2008-09-17
JP2009519992A (ja) 2009-05-21
US20090011238A1 (en) 2009-01-08
EP1968926B1 (en) 2020-09-02

Similar Documents

Publication Publication Date Title
US8524257B2 (en) Menthol-containing solids composition
JP5270366B2 (ja) 球状メントール粒子
US4388328A (en) Sorbitol containing mixture encapsulated flavor
US6174466B1 (en) Methods for making seamless capsules
JP2874778B2 (ja) ソルビトール結晶小球
BRPI0618464A2 (pt) processo para preparaÇço de cÁpsulas, e, cÁpsulas
JP2009537322A (ja) １工程噴霧乾燥法
JP2004262774A (ja) シームレスカプセル
JP2882895B2 (ja) 改善された口触りを有する低カロリー圧縮錠剤
KR20010101265A (ko) 캡슐형 향미 및(또는) 방향 제제
US5362483A (en) Flavoring, fragrance, skin texturizing and deodorant materials and method of making same
CA2426018C (en) Methods and apparatus for making seamless capsules
US20080194883A1 (en) Menthol-Containing Solids Composition
JP2012115205A (ja) 粉末香味料及びその製造方法
EP2515680B1 (en) Active ingredient delivery system
CA2215313C (en) Seamless capsules
JP2002065200A (ja) 糖アルコールが被覆されたカプセル、その製造方法およびそれを用いた経口品

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20091104

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120206

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120507

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120514

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120606

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20120606

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20121225

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130305

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A712

Effective date: 20130305

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20130417

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20130509

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

Ref document number: 5270366

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250