JP5237970B2 - 乳癌を治療または予防するためのアクチビンActRIIaアンタゴニストおよび使用 - Google Patents

乳癌を治療または予防するためのアクチビンActRIIaアンタゴニストおよび使用 Download PDF

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JP5237970B2
JP5237970B2 JP2009548327A JP2009548327A JP5237970B2 JP 5237970 B2 JP5237970 B2 JP 5237970B2 JP 2009548327 A JP2009548327 A JP 2009548327A JP 2009548327 A JP2009548327 A JP 2009548327A JP 5237970 B2 JP5237970 B2 JP 5237970B2
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actriia
amino acid
composition
fusion protein
activin
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ジョン クノッフ,
ジャスビール シーラ,
ラビンドラ クマー,
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アクセルロン ファーマ, インコーポレイテッド
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
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    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1796Receptors; Cell surface antigens; Cell surface determinants for hormones
    • AHUMAN NECESSITIES
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    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A61P35/00Antineoplastic agents
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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    • C12Y207/00Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11Protein-serine/threonine kinases (2.7.11)
    • C12Y207/1103Receptor protein serine/threonine kinase (2.7.11.30)
    • GPHYSICS
    • G01MEASURING; TESTING
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    • G01N33/5011Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/32Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/912Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205Phosphotransferases in general

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JP2009548327A 2007-02-01 2008-02-01 乳癌を治療または予防するためのアクチビンActRIIaアンタゴニストおよび使用 Active JP5237970B2 (ja)

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Application Number Priority Date Filing Date Title
US89907007P 2007-02-01 2007-02-01
US60/899,070 2007-02-01
US54007P 2007-10-25 2007-10-25
US61/000,540 2007-10-25
PCT/US2008/001429 WO2008094708A2 (en) 2007-02-01 2008-02-01 Activin-actriia antagonists and uses for treating or preventing breast cancer

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JP2013073352A Division JP6243133B2 (ja) 2007-02-01 2013-03-29 乳癌を治療または予防するためのアクチビンActRIIaアンタゴニストおよび使用

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JP2010518006A JP2010518006A (ja) 2010-05-27
JP2010518006A5 JP2010518006A5 (cg-RX-API-DMAC7.html) 2012-03-15
JP5237970B2 true JP5237970B2 (ja) 2013-07-17

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JP2009548327A Active JP5237970B2 (ja) 2007-02-01 2008-02-01 乳癌を治療または予防するためのアクチビンActRIIaアンタゴニストおよび使用
JP2013073352A Active JP6243133B2 (ja) 2007-02-01 2013-03-29 乳癌を治療または予防するためのアクチビンActRIIaアンタゴニストおよび使用
JP2014209681A Withdrawn JP2015025005A (ja) 2007-02-01 2014-10-14 乳癌を治療または予防するためのアクチビンActRIIaアンタゴニストおよび使用
JP2016215914A Pending JP2017031217A (ja) 2007-02-01 2016-11-04 乳癌を治療または予防するためのアクチビンActRIIaアンタゴニストおよび使用

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JP2014209681A Withdrawn JP2015025005A (ja) 2007-02-01 2014-10-14 乳癌を治療または予防するためのアクチビンActRIIaアンタゴニストおよび使用
JP2016215914A Pending JP2017031217A (ja) 2007-02-01 2016-11-04 乳癌を治療または予防するためのアクチビンActRIIaアンタゴニストおよび使用

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US (2) US9526759B2 (cg-RX-API-DMAC7.html)
EP (2) EP2599495A1 (cg-RX-API-DMAC7.html)
JP (4) JP5237970B2 (cg-RX-API-DMAC7.html)
KR (2) KR101526613B1 (cg-RX-API-DMAC7.html)
CN (3) CN101835485B (cg-RX-API-DMAC7.html)
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