JP5143000B2 - 抗感染症薬としての８−メトキシ−９Ｈ−イソチアゾロ［５，４−ｂ］キノリン−３，４−ジオンおよび関連化合物 - Google Patents

抗感染症薬としての８−メトキシ−９Ｈ−イソチアゾロ［５，４−ｂ］キノリン−３，４−ジオンおよび関連化合物 Download PDF

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JP5143000B2
JP5143000B2 JP2008524168A JP2008524168A JP5143000B2 JP 5143000 B2 JP5143000 B2 JP 5143000B2 JP 2008524168 A JP2008524168 A JP 2008524168A JP 2008524168 A JP2008524168 A JP 2008524168A JP 5143000 B2 JP5143000 B2 JP 5143000B2
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alkyl
cyclopropyl
quinoline
dione
amino
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JP2009502953A (ja
JP2009502953A5 (OSRAM
Inventor
バートン ジェームズ ブラッドベリー
ジェイソン アラン ワイルズ
キウピン ワン
彰宏 橋本
エドレーン ルシアン
ゴッドウィン クラレンス ギルロイ パイス
ミリンド デシュパンデ
マイケル ジョン プッチ
ハ ヨン キム
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アキリオン ファーマシューティカルズ，インコーポレーテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP2008524168A 2005-07-27 2006-07-27 抗感染症薬としての８−メトキシ−９Ｈ−イソチアゾロ［５，４−ｂ］キノリン−３，４−ジオンおよび関連化合物 Expired - Fee Related JP5143000B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70281105P 2005-07-27 2005-07-27
US60/702,811 2005-07-27
PCT/US2006/029302 WO2007014308A1 (en) 2005-07-27 2006-07-27 8-methoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents

Publications (3)

Publication Number Publication Date
JP2009502953A JP2009502953A (ja) 2009-01-29
JP2009502953A5 JP2009502953A5 (OSRAM) 2009-09-03
JP5143000B2 true JP5143000B2 (ja) 2013-02-13

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JP2008524168A Expired - Fee Related JP5143000B2 (ja) 2005-07-27 2006-07-27 抗感染症薬としての８−メトキシ−９Ｈ−イソチアゾロ［５，４−ｂ］キノリン−３，４−ジオンおよび関連化合物

Country Status (19)

Country Link
US (2) US8044204B2 (OSRAM)
EP (1) EP1913004B1 (OSRAM)
JP (1) JP5143000B2 (OSRAM)
KR (1) KR101272263B1 (OSRAM)
CN (1) CN101263146B (OSRAM)
AT (1) ATE482219T1 (OSRAM)
AU (1) AU2006272571B2 (OSRAM)
BR (1) BRPI0614456B8 (OSRAM)
CA (1) CA2616768C (OSRAM)
DE (1) DE602006017082D1 (OSRAM)
DK (1) DK1913004T3 (OSRAM)
EA (1) EA013244B1 (OSRAM)
ES (1) ES2352799T3 (OSRAM)
IL (1) IL189017A (OSRAM)
NO (1) NO343376B1 (OSRAM)
NZ (1) NZ566209A (OSRAM)
PL (1) PL1913004T3 (OSRAM)
PT (1) PT1913004E (OSRAM)
WO (1) WO2007014308A1 (OSRAM)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008021491A2 (en) * 2006-08-16 2008-02-21 Achillion Pharmaceuticals, Inc. Method for synthesis of 8-alkoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones
WO2010115184A2 (en) * 2009-04-03 2010-10-07 Achillion Pharmaceuticals, Inc. Hydroxythienoquinolones and related compounds as anti-infective agents
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
BR112012008759A2 (pt) 2009-10-16 2020-08-25 Rib-X Pharmaceuticals, Inc. compostos antimicrobianos e métodos de fabricação e uso dos mesmos
WO2011047323A2 (en) 2009-10-16 2011-04-21 Rib-X Pharmaceuticals, Inc. Antimicrobial compounds and methods of making and using the same
CN105646370A (zh) * 2009-10-16 2016-06-08 梅琳塔治疗公司 抗微生物化合物和其制备和使用方法
TN2010000566A1 (en) * 2010-12-03 2012-05-24 Rekik Raouf Folic acid - ramipril combination : cell protective neuroprotective and retinoprotective ophtalmologic drugs
CN103819401B (zh) * 2012-11-19 2016-04-13 浙江中欣氟材股份有限公司 1-环丙基-4-氧代-7-氟-8-甲氧基-1,4-二氢喹啉-3-羧酸的合成方法
EP3039025A4 (en) 2013-09-09 2017-05-31 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
MX2016003046A (es) 2013-09-09 2016-09-08 Melinta Therapeutics Inc Compuestos antimicrobianos y métodos de fabricación y utilización de los mismos.
WO2015114317A1 (en) * 2014-01-28 2015-08-06 Redx Pharma Plc 5h-isothiazolo[4,5-c]pyridine-3,4-dione or 5h-pyrazolo[4,3-c]pyridin-3,4-dione as antibacterial compounds
CN107922418A (zh) 2015-03-11 2018-04-17 梅琳塔治疗公司 抗微生物化合物及制备和使用所述化合物的方法
JP2019515041A (ja) 2016-05-06 2019-06-06 メリンタ セラピューティクス、 インコーポレイテッドＭｅｌｉｎｔａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 抗菌剤ならびにそれを作製および使用する方法
EP4483875A3 (en) 2016-05-10 2025-04-02 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
CN109562107A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的杂环降解决定子体
EP3455219A4 (en) 2016-05-10 2019-12-18 C4 Therapeutics, Inc. AMINE-RELATED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
EP3641762B1 (en) 2017-06-20 2026-02-18 C4 Therapeutics, Inc. N/o-linked degrons and degronimers for protein degradation
KR102534570B1 (ko) * 2019-02-01 2023-05-18 에어리 파마슈티컬즈, 인코포레이티드 근시의 치료를 위한 화합물, 조성물 및 방법

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4767762A (en) 1985-12-23 1988-08-30 Abbott Laboratories Tricyclic quinoline and naphthyride antibacterials
JPH01160985A (ja) 1987-12-17 1989-06-23 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
JPH01193275A (ja) 1988-01-28 1989-08-03 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
JP2681190B2 (ja) 1988-04-13 1997-11-26 塩野義製薬株式会社 ピリドン系抗菌剤
CA2001203C (en) 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
US5328908A (en) 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
JPH02174784A (ja) 1988-12-27 1990-07-06 Hokuriku Seiyaku Co Ltd イソチアゾロキノリン誘導体
JPH02243692A (ja) 1989-03-16 1990-09-27 Dainippon Pharmaceut Co Ltd 三環式化合物
JPH02255687A (ja) 1989-03-27 1990-10-16 Dainippon Pharmaceut Co Ltd 三環式化合物
FR2645862B1 (fr) 1989-04-18 1991-07-12 Esteve Labor Dr Derives d'isothiazolo-pyrydone azetidinyl substitues, leur preparation et leur application en tant que medicaments
JP2787713B2 (ja) 1989-07-28 1998-08-20 富山化学工業株式会社 新規なイソチアゾローナフチリジンおよびイソチアゾローキノリン誘導体並びにそれらの塩
US5071848A (en) 1989-10-23 1991-12-10 Abbott Laboratories Tricyclic quinoline antineoplastic agents
JP2939280B2 (ja) 1990-01-10 1999-08-25 三共株式会社 フッ素置換メトキシキノロンカルボン酸誘導体
US5580872A (en) 1990-05-02 1996-12-03 Abbott Laboratories Quinolizinone type compounds
NO304832B1 (no) 1992-05-27 1999-02-22 Ube Industries Aminokinolonderivater samt middel mot HIV
US5646163A (en) 1992-10-30 1997-07-08 The Procter & Gamble Company Quinolone 5-(N-heterosubstituted amino) antimicrobials
HUP9901642A3 (en) 1996-01-31 2000-07-28 Ube Ind Ltd Ube Shi Remedies or preventives for aids
JP3616454B2 (ja) 1996-04-19 2005-02-02 栄研化学株式会社 生体成分測定用試薬
JPH10130149A (ja) 1996-07-12 1998-05-19 Sankyo Co Ltd Ｔｎｆ産生抑制剤
DE19652219A1 (de) 1996-12-16 1998-06-18 Bayer Ag Verwendung von 7-(1-Aminomethyl-2-oxa-7-azabicyclo[3.3.0]oct-7-yl)-chinolon- und naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen
NZ525571A (en) * 2000-12-14 2004-09-24 Procter & Gamble Antimicrobial quinolones
AU2004267052B2 (en) * 2003-08-12 2009-02-05 Achillion Pharmaceuticals, Inc. Isothiazoloquinolones and related compounds as anti-infective agents
ATE445623T1 (de) * 2004-11-11 2009-10-15 Achillion Pharmaceuticals Inc 8a, 9-dihydro-4a-h-isothiazoloä5,4-bü chinolin-3, 4-dione und verwandte verbindungen als infektionsschutzmittel
EP1848723B1 (en) * 2005-02-16 2010-12-15 Achillion Pharmaceuticals, Inc. New isothiazoloquinolones and related compounds as anti-infective agents
WO2010115184A2 (en) 2009-04-03 2010-10-07 Achillion Pharmaceuticals, Inc. Hydroxythienoquinolones and related compounds as anti-infective agents

Also Published As

Publication number Publication date
PT1913004E (pt) 2010-12-09
EA200800444A1 (ru) 2008-06-30
AU2006272571B2 (en) 2012-03-08
BRPI0614456B8 (pt) 2021-05-25
PL1913004T3 (pl) 2011-03-31
WO2007014308A1 (en) 2007-02-01
US20120040959A1 (en) 2012-02-16
NO343376B1 (no) 2019-02-11
US20070049586A1 (en) 2007-03-01
AU2006272571A1 (en) 2007-02-01
CA2616768C (en) 2014-05-06
EA013244B1 (ru) 2010-04-30
IL189017A (en) 2014-01-30
DE602006017082D1 (de) 2010-11-04
HK1122024A1 (en) 2009-05-08
CA2616768A1 (en) 2007-02-01
BRPI0614456B1 (pt) 2019-08-27
ATE482219T1 (de) 2010-10-15
NZ566209A (en) 2011-03-31
EP1913004A1 (en) 2008-04-23
KR101272263B1 (ko) 2013-06-13
KR20080035661A (ko) 2008-04-23
IL189017A0 (en) 2008-08-07
BRPI0614456A2 (pt) 2011-03-29
JP2009502953A (ja) 2009-01-29
DK1913004T3 (da) 2011-01-10
US8044204B2 (en) 2011-10-25
CN101263146A (zh) 2008-09-10
EP1913004B1 (en) 2010-09-22
US8946422B2 (en) 2015-02-03
CN101263146B (zh) 2012-12-05
NO20081005L (no) 2008-04-09
ES2352799T3 (es) 2011-02-23

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