AU2006272571B2 - 8-methoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones and related compounds as anti-infective agents - Google Patents

8-methoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones and related compounds as anti-infective agents Download PDF

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Publication number
AU2006272571B2
AU2006272571B2 AU2006272571A AU2006272571A AU2006272571B2 AU 2006272571 B2 AU2006272571 B2 AU 2006272571B2 AU 2006272571 A AU2006272571 A AU 2006272571A AU 2006272571 A AU2006272571 A AU 2006272571A AU 2006272571 B2 AU2006272571 B2 AU 2006272571B2
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AU
Australia
Prior art keywords
alkyl
cyclopropyl
dione
pyrrolidin
fluoro
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Ceased
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AU2006272571A
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AU2006272571A1 (en
Inventor
Barton James Bradbury
Milind Deshpande
Akihiro Hashimoto
Ha Young Kim
Edlaine Lucien
Godwin Clarence Gilroy Pais
Michael John Pucci
Qiuping Wang
Jason Allan Wiles
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Achillion Pharmaceuticals Inc
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Achillion Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AU2006272571A 2005-07-27 2006-07-27 8-methoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones and related compounds as anti-infective agents Ceased AU2006272571B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70281105P 2005-07-27 2005-07-27
US60/702,811 2005-07-27
PCT/US2006/029302 WO2007014308A1 (en) 2005-07-27 2006-07-27 8-methoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents

Publications (2)

Publication Number Publication Date
AU2006272571A1 AU2006272571A1 (en) 2007-02-01
AU2006272571B2 true AU2006272571B2 (en) 2012-03-08

Family

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AU2006272571A Ceased AU2006272571B2 (en) 2005-07-27 2006-07-27 8-methoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones and related compounds as anti-infective agents

Country Status (19)

Country Link
US (2) US8044204B2 (OSRAM)
EP (1) EP1913004B1 (OSRAM)
JP (1) JP5143000B2 (OSRAM)
KR (1) KR101272263B1 (OSRAM)
CN (1) CN101263146B (OSRAM)
AT (1) ATE482219T1 (OSRAM)
AU (1) AU2006272571B2 (OSRAM)
BR (1) BRPI0614456B8 (OSRAM)
CA (1) CA2616768C (OSRAM)
DE (1) DE602006017082D1 (OSRAM)
DK (1) DK1913004T3 (OSRAM)
EA (1) EA013244B1 (OSRAM)
ES (1) ES2352799T3 (OSRAM)
IL (1) IL189017A (OSRAM)
NO (1) NO343376B1 (OSRAM)
NZ (1) NZ566209A (OSRAM)
PL (1) PL1913004T3 (OSRAM)
PT (1) PT1913004E (OSRAM)
WO (1) WO2007014308A1 (OSRAM)

Families Citing this family (19)

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WO2008021491A2 (en) * 2006-08-16 2008-02-21 Achillion Pharmaceuticals, Inc. Method for synthesis of 8-alkoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones
WO2010115184A2 (en) * 2009-04-03 2010-10-07 Achillion Pharmaceuticals, Inc. Hydroxythienoquinolones and related compounds as anti-infective agents
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
BR112012008759A2 (pt) 2009-10-16 2020-08-25 Rib-X Pharmaceuticals, Inc. compostos antimicrobianos e métodos de fabricação e uso dos mesmos
WO2011047323A2 (en) 2009-10-16 2011-04-21 Rib-X Pharmaceuticals, Inc. Antimicrobial compounds and methods of making and using the same
CN105646370A (zh) * 2009-10-16 2016-06-08 梅琳塔治疗公司 抗微生物化合物和其制备和使用方法
TN2010000566A1 (en) * 2010-12-03 2012-05-24 Rekik Raouf Folic acid - ramipril combination : cell protective neuroprotective and retinoprotective ophtalmologic drugs
CN103819401B (zh) * 2012-11-19 2016-04-13 浙江中欣氟材股份有限公司 1-环丙基-4-氧代-7-氟-8-甲氧基-1,4-二氢喹啉-3-羧酸的合成方法
EP3039025A4 (en) 2013-09-09 2017-05-31 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
MX2016003046A (es) 2013-09-09 2016-09-08 Melinta Therapeutics Inc Compuestos antimicrobianos y métodos de fabricación y utilización de los mismos.
WO2015114317A1 (en) * 2014-01-28 2015-08-06 Redx Pharma Plc 5h-isothiazolo[4,5-c]pyridine-3,4-dione or 5h-pyrazolo[4,3-c]pyridin-3,4-dione as antibacterial compounds
CN107922418A (zh) 2015-03-11 2018-04-17 梅琳塔治疗公司 抗微生物化合物及制备和使用所述化合物的方法
JP2019515041A (ja) 2016-05-06 2019-06-06 メリンタ セラピューティクス、 インコーポレイテッドＭｅｌｉｎｔａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 抗菌剤ならびにそれを作製および使用する方法
EP4483875A3 (en) 2016-05-10 2025-04-02 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
CN109562107A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的杂环降解决定子体
EP3455219A4 (en) 2016-05-10 2019-12-18 C4 Therapeutics, Inc. AMINE-RELATED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
EP3641762B1 (en) 2017-06-20 2026-02-18 C4 Therapeutics, Inc. N/o-linked degrons and degronimers for protein degradation
KR102534570B1 (ko) * 2019-02-01 2023-05-18 에어리 파마슈티컬즈, 인코포레이티드 근시의 치료를 위한 화합물, 조성물 및 방법

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JPH01160985A (ja) 1987-12-17 1989-06-23 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
JPH01193275A (ja) 1988-01-28 1989-08-03 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
JP2681190B2 (ja) 1988-04-13 1997-11-26 塩野義製薬株式会社 ピリドン系抗菌剤
CA2001203C (en) 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
US5328908A (en) 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
JPH02174784A (ja) 1988-12-27 1990-07-06 Hokuriku Seiyaku Co Ltd イソチアゾロキノリン誘導体
JPH02243692A (ja) 1989-03-16 1990-09-27 Dainippon Pharmaceut Co Ltd 三環式化合物
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FR2645862B1 (fr) 1989-04-18 1991-07-12 Esteve Labor Dr Derives d'isothiazolo-pyrydone azetidinyl substitues, leur preparation et leur application en tant que medicaments
JP2787713B2 (ja) 1989-07-28 1998-08-20 富山化学工業株式会社 新規なイソチアゾローナフチリジンおよびイソチアゾローキノリン誘導体並びにそれらの塩
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Also Published As

Publication number Publication date
PT1913004E (pt) 2010-12-09
EA200800444A1 (ru) 2008-06-30
BRPI0614456B8 (pt) 2021-05-25
PL1913004T3 (pl) 2011-03-31
WO2007014308A1 (en) 2007-02-01
US20120040959A1 (en) 2012-02-16
NO343376B1 (no) 2019-02-11
US20070049586A1 (en) 2007-03-01
AU2006272571A1 (en) 2007-02-01
CA2616768C (en) 2014-05-06
EA013244B1 (ru) 2010-04-30
IL189017A (en) 2014-01-30
DE602006017082D1 (de) 2010-11-04
HK1122024A1 (en) 2009-05-08
CA2616768A1 (en) 2007-02-01
JP5143000B2 (ja) 2013-02-13
BRPI0614456B1 (pt) 2019-08-27
ATE482219T1 (de) 2010-10-15
NZ566209A (en) 2011-03-31
EP1913004A1 (en) 2008-04-23
KR101272263B1 (ko) 2013-06-13
KR20080035661A (ko) 2008-04-23
IL189017A0 (en) 2008-08-07
BRPI0614456A2 (pt) 2011-03-29
JP2009502953A (ja) 2009-01-29
DK1913004T3 (da) 2011-01-10
US8044204B2 (en) 2011-10-25
CN101263146A (zh) 2008-09-10
EP1913004B1 (en) 2010-09-22
US8946422B2 (en) 2015-02-03
CN101263146B (zh) 2012-12-05
NO20081005L (no) 2008-04-09
ES2352799T3 (es) 2011-02-23

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Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired