JP5122441B2 - ヒト化抗ｃｄ７０結合剤およびその使用 - Google Patents
ヒト化抗ｃｄ７０結合剤およびその使用 Download PDFInfo
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- JP5122441B2 JP5122441B2 JP2008507926A JP2008507926A JP5122441B2 JP 5122441 B2 JP5122441 B2 JP 5122441B2 JP 2008507926 A JP2008507926 A JP 2008507926A JP 2008507926 A JP2008507926 A JP 2008507926A JP 5122441 B2 JP5122441 B2 JP 5122441B2
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- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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| EP2100619B1 (en) | 2003-02-20 | 2014-02-12 | Seattle Genetics, Inc. | Anti-CD70 antibody-drug conjugates and their use for the treatment of immune disorders |
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| US7491390B2 (en) | 2004-10-15 | 2009-02-17 | Seattle Genetics, Inc. | Anti-CD70 antibody and its use for the treatment and prevention of cancer and immune disorders |
| US8337838B2 (en) * | 2004-10-15 | 2012-12-25 | Seattle Genetics, Inc. | Anti-CD70 antibody and its use for the treatment and prevention of cancer and immune disorders |
| CA2623236A1 (en) | 2005-09-26 | 2007-04-05 | Medarex, Inc. | Human monoclonal antibodies to cd70 |
| US7750116B1 (en) * | 2006-02-18 | 2010-07-06 | Seattle Genetics, Inc. | Antibody drug conjugate metabolites |
| WO2008025020A2 (en) * | 2006-08-25 | 2008-02-28 | Seattle Genetics, Inc. | Cd30 binding agents and uses thereof |
| EP2609932B1 (en) * | 2006-12-01 | 2022-02-02 | Seagen Inc. | Variant target binding agents and uses thereof |
| NZ578354A (en) * | 2006-12-14 | 2012-01-12 | Medarex Inc | Antibody-partner molecule conjugates that bind cd70 and uses thereof |
| JP2010235447A (ja) * | 2007-07-30 | 2010-10-21 | Igaku Seibutsugaku Kenkyusho:Kk | 炎症性サイトカインの抑制剤 |
| US7981415B2 (en) | 2007-09-07 | 2011-07-19 | Cisthera, Inc. | Humanized PAI-1 antibodies |
| US7771720B2 (en) | 2007-09-07 | 2010-08-10 | Cisthera, Inc. | Humanized PAI-1 antibodies |
| JP5224325B2 (ja) * | 2007-10-15 | 2013-07-03 | 国立大学法人 岡山大学 | Ｂ細胞悪性リンパ腫治療薬 |
| EP2090320A1 (en) | 2008-02-15 | 2009-08-19 | Helmholtz-Zentrum für Infektionsforschung GmbH | Ligands of the Natural Killer (NK) cell surface marker CD27 and therapeutic uses thereof |
| ES2523033T3 (es) | 2008-03-18 | 2014-11-20 | Seattle Genetics, Inc. | Conjugados enlazadores del fármaco auriestatina |
| JP5752592B2 (ja) * | 2008-04-11 | 2015-07-22 | シアトル ジェネティックス， インコーポレイテッド | 膵臓癌、卵巣癌、および他の癌の検出および処置 |
| EP2282773B2 (en) | 2008-05-02 | 2025-03-05 | Seagen Inc. | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation |
| EP2391652A4 (en) * | 2009-01-29 | 2013-01-02 | Abbott Lab | IL-1 BINDING PROTEINS |
| CN102821600B (zh) | 2009-12-25 | 2016-01-20 | 中外制药株式会社 | 使用移植了nog确立癌细胞株的非人动物模型进行的抗癌药靶探索以及筛选方法 |
| EP2558475A1 (en) | 2010-04-15 | 2013-02-20 | Spirogen Sàrl | Pyrrolobenzodiazepines used to treat proliferative diseases |
| CN103068405A (zh) | 2010-04-15 | 2013-04-24 | 西雅图基因公司 | 靶向吡咯并苯并二氮杂卓结合物 |
| US9504702B2 (en) | 2010-08-05 | 2016-11-29 | Seattle Genetics, Inc. | Methods of inhibition of protein fucosylation in vivo using fucose analogs |
| EP2626414B1 (en) | 2010-10-06 | 2020-07-15 | Chugai Seiyaku Kabushiki Kaisha | Cancer stem cell mass and process for production thereof |
| TWI545134B (zh) | 2010-10-22 | 2016-08-11 | 西雅圖遺傳學公司 | 以奧裡斯他汀（ＡＵＲＩＳＴＡＴＩＮ）為主之抗體藥物結合物及ＰＩ３Ｋ－ＡＫＴ ｍＴＯＲ路徑抑制劑間的協同功效 |
| JOP20210044A1 (ar) | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
| EP2686347B1 (en) * | 2011-03-16 | 2018-05-02 | argenx BVBA | Antibodies to cd70 |
| KR101529810B1 (ko) | 2011-04-01 | 2015-06-26 | 와이어쓰 엘엘씨 | 항체-약물 접합체 |
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| CN103987718A (zh) | 2011-09-20 | 2014-08-13 | 斯皮罗根有限公司 | 作为非对称二聚体pbd化合物用于内含在靶向结合物中的吡咯并苯并二氮杂卓 |
| AP2014007588A0 (en) * | 2011-09-22 | 2014-04-30 | Amgen Inc | CD27L antigen binding proteins |
| BR112014008981A2 (pt) | 2011-10-14 | 2017-05-02 | Spirogen Sàrl | pirrolobenzodiazepinas |
| JP6399930B2 (ja) | 2011-10-14 | 2018-10-03 | シアトル ジェネティクス，インコーポレーテッド | ピロロベンゾジアゼピンおよび標的コンジュゲート |
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| JP6170497B2 (ja) | 2011-10-14 | 2017-07-26 | メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ | ピロロベンゾジアゼピン |
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| US8067546B2 (en) | 2011-11-29 |
| WO2006113909A2 (en) | 2006-10-26 |
| US20210002380A1 (en) | 2021-01-07 |
| US8562987B2 (en) | 2013-10-22 |
| US20240190981A1 (en) | 2024-06-13 |
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| EP1871418A2 (en) | 2008-01-02 |
| US9701752B2 (en) | 2017-07-11 |
| US20120045436A1 (en) | 2012-02-23 |
| WO2006113909A3 (en) | 2008-01-31 |
| AU2006236225B2 (en) | 2012-05-10 |
| AU2006236225A1 (en) | 2006-10-26 |
| AU2006236225C1 (en) | 2013-05-02 |
| US20090148942A1 (en) | 2009-06-11 |
| US9428585B2 (en) | 2016-08-30 |
| CA2605507C (en) | 2016-06-28 |
| EP2511299A1 (en) | 2012-10-17 |
| ES2477765T3 (es) | 2014-07-17 |
| JP2012205596A (ja) | 2012-10-25 |
| EP1871418A4 (en) | 2010-01-06 |
| CA2605507A1 (en) | 2006-10-26 |
| US20170342157A1 (en) | 2017-11-30 |
| CN101203241A (zh) | 2008-06-18 |
| US20170022282A1 (en) | 2017-01-26 |
| JP2008538292A (ja) | 2008-10-23 |
| CN101203241B (zh) | 2012-02-22 |
| US20140178936A1 (en) | 2014-06-26 |
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