ES2477765T3 - Agentes de unión al anti-cd70 humanizado y usos de los mismos - Google Patents
Agentes de unión al anti-cd70 humanizado y usos de los mismos Download PDFInfo
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- ES2477765T3 ES2477765T3 ES06751010.7T ES06751010T ES2477765T3 ES 2477765 T3 ES2477765 T3 ES 2477765T3 ES 06751010 T ES06751010 T ES 06751010T ES 2477765 T3 ES2477765 T3 ES 2477765T3
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- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
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- HDZZVAMISRMYHH-LITAXDCLSA-N tubercidin Chemical compound C1=CC=2C(N)=NC=NC=2N1[C@@H]1O[C@@H](CO)[C@H](O)[C@H]1O HDZZVAMISRMYHH-LITAXDCLSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67307005P | 2005-04-19 | 2005-04-19 | |
| US673070P | 2005-04-19 | ||
| PCT/US2006/015145 WO2006113909A2 (en) | 2005-04-19 | 2006-04-19 | Humanized anti-cd70 binding agents and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2477765T3 true ES2477765T3 (es) | 2014-07-17 |
Family
ID=37115968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES06751010.7T Active ES2477765T3 (es) | 2005-04-19 | 2006-04-19 | Agentes de unión al anti-cd70 humanizado y usos de los mismos |
Country Status (9)
| Country | Link |
|---|---|
| US (7) | US8067546B2 (enExample) |
| EP (2) | EP1871418B1 (enExample) |
| JP (2) | JP5122441B2 (enExample) |
| CN (1) | CN101203241B (enExample) |
| AU (1) | AU2006236225C1 (enExample) |
| CA (1) | CA2605507C (enExample) |
| DK (1) | DK1871418T3 (enExample) |
| ES (1) | ES2477765T3 (enExample) |
| WO (1) | WO2006113909A2 (enExample) |
Families Citing this family (158)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58103228A (ja) * | 1981-12-16 | 1983-06-20 | Kaga Tsushin Kogyo Kk | 光スイツチ方法 |
| ATE472338T1 (de) | 2003-02-20 | 2010-07-15 | Seattle Genetics Inc | Anti-cd70 antikörper-arzneimittelkonjugate und ihre verwendung zur behandlung von krebs |
| US20080025989A1 (en) | 2003-02-20 | 2008-01-31 | Seattle Genetics, Inc. | Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders |
| EP1799262A4 (en) * | 2004-10-15 | 2009-10-21 | Seattle Genetics Inc | ANTI-CD70 ANTIBODIES AND ITS USE FOR THE TREATMENT AND PREVENTION OF CANCER DISORDERS AND IMMUNE DISORDERS |
| US8337838B2 (en) * | 2004-10-15 | 2012-12-25 | Seattle Genetics, Inc. | Anti-CD70 antibody and its use for the treatment and prevention of cancer and immune disorders |
| CN101203241B (zh) | 2005-04-19 | 2012-02-22 | 西雅图基因公司 | 人源化抗-cd70结合物和其应用 |
| BRPI0617549A2 (pt) | 2005-09-26 | 2011-07-26 | Medarex Inc | anticorpo monoclonal humano isolado, anticorpo monoclonal humano isolado ou uma porÇço ligante ao antÍgeno do mesmo, composiÇço, imunoconjugado, molÉcula de Ácido nuclÉico isolada, vetor de expressço, cÉlula hospedeira, mÉtodo para preparar um anticorpo anti-cd70, mÉtodo para tratar ou prevenir uma doenÇa, mÉtodo para tratar uma doenÇa autoimune em um indivÍduo, mÉtodo para tratar uma inflamaÇço em um indivÍduo, mÉtodo para tratar uma infecÇço viral em um indivÍduo, anticorpo ou porÇço ligante ao antÍgeno do mesmo e uso de um anticorpo ou de uma porÇço ligante ao antÍgeno do mesmo |
| US7750116B1 (en) * | 2006-02-18 | 2010-07-06 | Seattle Genetics, Inc. | Antibody drug conjugate metabolites |
| US8257706B2 (en) * | 2006-08-25 | 2012-09-04 | Seattle Genetics, Inc. | CD30 binding agents and uses thereof |
| CA2699837C (en) | 2006-12-01 | 2017-06-13 | Seattle Genetics, Inc. | Variant target binding agents and uses thereof |
| EP2097534A4 (en) * | 2006-12-14 | 2010-05-12 | Medarex Inc | HUMAN ANTIBODIES BINDING TO CD70 AND USES THEREOF |
| JP2010235447A (ja) * | 2007-07-30 | 2010-10-21 | Igaku Seibutsugaku Kenkyusho:Kk | 炎症性サイトカインの抑制剤 |
| US7981415B2 (en) | 2007-09-07 | 2011-07-19 | Cisthera, Inc. | Humanized PAI-1 antibodies |
| WO2009033095A2 (en) * | 2007-09-07 | 2009-03-12 | Cisthera, Incorporated | Humanized pai-1 antibodies |
| JP5224325B2 (ja) * | 2007-10-15 | 2013-07-03 | 国立大学法人 岡山大学 | Ｂ細胞悪性リンパ腫治療薬 |
| EP2090320A1 (en) | 2008-02-15 | 2009-08-19 | Helmholtz-Zentrum für Infektionsforschung GmbH | Ligands of the Natural Killer (NK) cell surface marker CD27 and therapeutic uses thereof |
| EP2265283B1 (en) | 2008-03-18 | 2014-09-03 | Seattle Genetics, Inc. | Auristatin drug linker conjugates |
| RU2556129C2 (ru) | 2008-04-11 | 2015-07-10 | Сиэтл Дженетикс, Инк. | Диагностика и лечение злокачественных опухолей поджелудочной железы, яичников и других злокачественных опухолей |
| CA2975228C (en) | 2008-05-02 | 2020-07-21 | Seattle Genetics, Inc. | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation |
| CA2749966A1 (en) * | 2009-01-29 | 2010-08-05 | Abbott Laboratories | Il-1 binding proteins |
| WO2011078301A1 (ja) | 2009-12-25 | 2011-06-30 | ファーマロジカルズ・リサーチ プライベート リミテッド | Nog樹立癌細胞株が移植された非ヒト動物モデルを用いた抗癌剤ターゲット探索及びスクリーニング法 |
| JP5875083B2 (ja) | 2010-04-15 | 2016-03-02 | メディミューン リミテッド | 増殖性疾患治療用ピロロベンゾジアゼピン |
| KR101671360B1 (ko) | 2010-04-15 | 2016-11-01 | 시애틀 지네틱스, 인크. | 표적화된 피롤로벤조디아제핀 접합체 |
| RU2625768C2 (ru) | 2010-08-05 | 2017-07-18 | Сиэтл Дженетикс, Инк. | Способы ингибирования фукозилирования белков in vivo с использованием аналогов фукозы |
| WO2012046797A1 (ja) | 2010-10-06 | 2012-04-12 | ファーマロジカルズ・リサーチ プライベート リミテッド | 癌幹細胞集団及びその作製方法 |
| US9272052B2 (en) | 2010-10-22 | 2016-03-01 | Seattle Genetics, Inc. | Synergistic effects between auristatin-based antibody drug conjugates and inhibitors of the PI3K-AKT mTOR pathway |
| JOP20210044A1 (ar) | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
| CN103596979B (zh) * | 2011-03-16 | 2018-01-26 | 阿尔金-X有限公司 | 针对cd70的抗体 |
| SG193324A1 (en) | 2011-04-01 | 2013-10-30 | Wyeth Llc | Antibody-drug conjugates |
| EP2749641B1 (en) | 2011-09-07 | 2021-06-02 | Chugai Seiyaku Kabushiki Kaisha | Cancer stem cell isolation |
| MX341524B (es) | 2011-09-20 | 2016-08-24 | Medimmune Ltd | Pirrolobenzodiazepinas como compuestos pbd dimericos asimetricos para inclusion en conjugados dirigidos. |
| ES2806146T3 (es) * | 2011-09-22 | 2021-02-16 | Amgen Inc | Proteínas de unión al antígeno CD27L |
| EA027386B1 (ru) | 2011-10-14 | 2017-07-31 | Медимьюн Лимитед | Пирролобензодиазепины |
| US9399073B2 (en) | 2011-10-14 | 2016-07-26 | Seattle Genetics, Inc. | Pyrrolobenzodiazepines |
| WO2013055990A1 (en) | 2011-10-14 | 2013-04-18 | Seattle Genetics, Inc. | Pyrrolobenzodiazepines and targeted conjugates |
| EA026643B1 (ru) | 2011-10-14 | 2017-04-28 | Сиэтл Дженетикс, Инк. | Пирролбензодиазепины и конъюгаты направленного действия |
| JP6291254B2 (ja) * | 2011-10-28 | 2018-03-14 | 中外製薬株式会社 | 癌幹細胞特異的分子 |
| CN104619351B (zh) | 2012-06-19 | 2020-01-21 | Ambrx公司 | 抗cd70抗体药物结合物 |
| CN112587658A (zh) | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| IL302494B2 (en) | 2012-10-11 | 2024-11-01 | Daiichi Sankyo Co Ltd | Antibody-drug conjugates and methods for their preparation |
| NZ707534A (en) | 2012-10-12 | 2018-08-31 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
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| US20170342157A1 (en) | 2017-11-30 |
| WO2006113909A3 (en) | 2008-01-31 |
| AU2006236225A1 (en) | 2006-10-26 |
| CA2605507A1 (en) | 2006-10-26 |
| JP5122441B2 (ja) | 2013-01-16 |
| EP1871418A4 (en) | 2010-01-06 |
| US20210002380A1 (en) | 2021-01-07 |
| CN101203241A (zh) | 2008-06-18 |
| AU2006236225B2 (en) | 2012-05-10 |
| CA2605507C (en) | 2016-06-28 |
| US8067546B2 (en) | 2011-11-29 |
| US20140178936A1 (en) | 2014-06-26 |
| JP2008538292A (ja) | 2008-10-23 |
| US20240190981A1 (en) | 2024-06-13 |
| US20120045436A1 (en) | 2012-02-23 |
| CN101203241B (zh) | 2012-02-22 |
| US20090148942A1 (en) | 2009-06-11 |
| US8562987B2 (en) | 2013-10-22 |
| JP2012205596A (ja) | 2012-10-25 |
| US9428585B2 (en) | 2016-08-30 |
| EP2511299A1 (en) | 2012-10-17 |
| EP1871418B1 (en) | 2014-03-19 |
| US20170022282A1 (en) | 2017-01-26 |
| AU2006236225C1 (en) | 2013-05-02 |
| DK1871418T3 (da) | 2014-06-10 |
| US9701752B2 (en) | 2017-07-11 |
| EP1871418A2 (en) | 2008-01-02 |
| WO2006113909A2 (en) | 2006-10-26 |
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