JP5090423B2 - モルホリノプリン誘導体 - Google Patents

モルホリノプリン誘導体 Download PDF

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Publication number
JP5090423B2
JP5090423B2 JP2009236444A JP2009236444A JP5090423B2 JP 5090423 B2 JP5090423 B2 JP 5090423B2 JP 2009236444 A JP2009236444 A JP 2009236444A JP 2009236444 A JP2009236444 A JP 2009236444A JP 5090423 B2 JP5090423 B2 JP 5090423B2
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JP
Japan
Prior art keywords
group
substituents selected
alkylamino
mmol
compound
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Expired - Fee Related
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JP2009236444A
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English (en)
Japanese (ja)
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JP2011001339A (ja
JP2011001339A5 (https=
Inventor
清 中山
和幸 杉田
正樹 瀬戸口
裕一 冨永
正規 齋藤
高志 小田桐
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Daiichi Sankyo Co Ltd
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Daiichi Sankyo Co Ltd
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Priority to JP2009236444A priority Critical patent/JP5090423B2/ja
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Publication of JP2011001339A5 publication Critical patent/JP2011001339A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2009236444A 2008-10-14 2009-10-13 モルホリノプリン誘導体 Expired - Fee Related JP5090423B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009236444A JP5090423B2 (ja) 2008-10-14 2009-10-13 モルホリノプリン誘導体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2008264797 2008-10-14
JP2008264797 2008-10-14
JP2009121690 2009-05-20
JP2009121690 2009-05-20
JP2009236444A JP5090423B2 (ja) 2008-10-14 2009-10-13 モルホリノプリン誘導体

Publications (3)

Publication Number Publication Date
JP2011001339A JP2011001339A (ja) 2011-01-06
JP2011001339A5 JP2011001339A5 (https=) 2012-09-20
JP5090423B2 true JP5090423B2 (ja) 2012-12-05

Family

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Family Applications (1)

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JP2009236444A Expired - Fee Related JP5090423B2 (ja) 2008-10-14 2009-10-13 モルホリノプリン誘導体

Country Status (21)

Country Link
US (2) US8097622B2 (https=)
EP (1) EP2336132B1 (https=)
JP (1) JP5090423B2 (https=)
KR (1) KR101614976B1 (https=)
CN (1) CN102245607B (https=)
AU (1) AU2009304789B2 (https=)
BR (1) BRPI0920199A2 (https=)
CA (1) CA2740471C (https=)
CO (1) CO6362009A2 (https=)
DK (1) DK2336132T3 (https=)
ES (1) ES2452541T3 (https=)
IL (1) IL212278A (https=)
MX (1) MX2011003490A (https=)
MY (1) MY156456A (https=)
NZ (1) NZ592761A (https=)
PL (1) PL2336132T3 (https=)
PT (1) PT2336132E (https=)
RU (1) RU2490269C2 (https=)
TW (1) TWI378933B (https=)
WO (1) WO2010044401A1 (https=)
ZA (1) ZA201102449B (https=)

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TWI837231B (zh) 2018-11-29 2024-04-01 日商第一三共股份有限公司 含有ｅｚｈ１／２雙重抑制劑之醫藥組合及其用途
CN113368114B (zh) * 2020-03-10 2022-04-22 四川大学 一种吗啉嘧啶类化合物的抗肿瘤应用
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Also Published As

Publication number Publication date
US20100130492A1 (en) 2010-05-27
US8309546B2 (en) 2012-11-13
EP2336132A4 (en) 2012-03-21
JP2011001339A (ja) 2011-01-06
KR20110067038A (ko) 2011-06-20
CA2740471C (en) 2013-09-17
RU2011119525A (ru) 2012-11-27
NZ592761A (en) 2012-05-25
CN102245607A (zh) 2011-11-16
IL212278A (en) 2016-07-31
PL2336132T3 (pl) 2014-06-30
CA2740471A1 (en) 2010-04-22
ZA201102449B (en) 2011-12-28
PT2336132E (pt) 2014-04-02
BRPI0920199A2 (pt) 2019-09-24
EP2336132B1 (en) 2014-01-01
MY156456A (en) 2016-02-26
DK2336132T3 (da) 2014-04-07
RU2490269C2 (ru) 2013-08-20
CO6362009A2 (es) 2012-01-20
TW201018690A (en) 2010-05-16
IL212278A0 (en) 2011-06-30
US20120071476A1 (en) 2012-03-22
MX2011003490A (es) 2011-04-21
HK1158189A1 (en) 2012-07-13
AU2009304789B2 (en) 2012-04-05
ES2452541T3 (es) 2014-04-01
WO2010044401A1 (ja) 2010-04-22
EP2336132A1 (en) 2011-06-22
US8097622B2 (en) 2012-01-17
KR101614976B1 (ko) 2016-04-22
CN102245607B (zh) 2014-07-02
AU2009304789A1 (en) 2010-04-22
TWI378933B (en) 2012-12-11

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