IL212278A - Phosphatidylinositol suppressants 3-kinase (p13k) and mammalian rapamycin (mtor) suppressor derivatives morpholinophorin, preparations containing them and their uses - Google Patents
Phosphatidylinositol suppressants 3-kinase (p13k) and mammalian rapamycin (mtor) suppressor derivatives morpholinophorin, preparations containing them and their usesInfo
- Publication number
- IL212278A IL212278A IL212278A IL21227811A IL212278A IL 212278 A IL212278 A IL 212278A IL 212278 A IL212278 A IL 212278A IL 21227811 A IL21227811 A IL 21227811A IL 212278 A IL212278 A IL 212278A
- Authority
- IL
- Israel
- Prior art keywords
- inhibitor
- mtor
- phosphatidylinositol
- rapamycin
- kinase
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 2
- IBVOXEAVUMUIBU-UHFFFAOYSA-N 4-(7h-purin-2-yl)morpholine Chemical class C1COCCN1C1=NC=C(NC=N2)C2=N1 IBVOXEAVUMUIBU-UHFFFAOYSA-N 0.000 title 1
- 101150097381 Mtor gene Proteins 0.000 title 1
- 108091007960 PI3Ks Proteins 0.000 title 1
- 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 title 1
- 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 title 1
- 102000013530 TOR Serine-Threonine Kinases Human genes 0.000 title 1
- 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008264797 | 2008-10-14 | ||
| JP2009121690 | 2009-05-20 | ||
| PCT/JP2009/067738 WO2010044401A1 (ja) | 2008-10-14 | 2009-10-13 | モルホリノプリン誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL212278A0 IL212278A0 (en) | 2011-06-30 |
| IL212278A true IL212278A (en) | 2016-07-31 |
Family
ID=42106564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL212278A IL212278A (en) | 2008-10-14 | 2011-04-12 | Phosphatidylinositol suppressants 3-kinase (p13k) and mammalian rapamycin (mtor) suppressor derivatives morpholinophorin, preparations containing them and their uses |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US8097622B2 (https=) |
| EP (1) | EP2336132B1 (https=) |
| JP (1) | JP5090423B2 (https=) |
| KR (1) | KR101614976B1 (https=) |
| CN (1) | CN102245607B (https=) |
| AU (1) | AU2009304789B2 (https=) |
| BR (1) | BRPI0920199A2 (https=) |
| CA (1) | CA2740471C (https=) |
| CO (1) | CO6362009A2 (https=) |
| DK (1) | DK2336132T3 (https=) |
| ES (1) | ES2452541T3 (https=) |
| IL (1) | IL212278A (https=) |
| MX (1) | MX2011003490A (https=) |
| MY (1) | MY156456A (https=) |
| NZ (1) | NZ592761A (https=) |
| PL (1) | PL2336132T3 (https=) |
| PT (1) | PT2336132E (https=) |
| RU (1) | RU2490269C2 (https=) |
| TW (1) | TWI378933B (https=) |
| WO (1) | WO2010044401A1 (https=) |
| ZA (1) | ZA201102449B (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011521968A (ja) * | 2008-05-30 | 2011-07-28 | ジェネンテック， インコーポレイテッド | プリンｐｉ３ｋ阻害剤化合物および使用方法 |
| TWI378933B (en) * | 2008-10-14 | 2012-12-11 | Daiichi Sankyo Co Ltd | Morpholinopurine derivatives |
| WO2011058027A2 (en) * | 2009-11-12 | 2011-05-19 | F. Hoffmann-La Roche Ag | N-9-substituted purine compounds, compositions and methods of use |
| CN102260263A (zh) | 2010-05-26 | 2011-11-30 | 四川大学 | 一类二苯胺基嘌呤衍生物及制备方法和医药用途 |
| JP5555378B2 (ja) | 2010-07-14 | 2014-07-23 | エフ．ホフマン−ラ ロシュ アーゲー | Ｐｉ３ｋｐ１１０デルタに選択的なプリン化合物とその使用の方法 |
| CN103313989B (zh) | 2010-12-16 | 2016-05-04 | 霍夫曼-拉罗奇有限公司 | 三环pi3k抑制剂化合物和使用方法 |
| CN104039790B (zh) | 2011-10-28 | 2016-04-13 | 诺华股份有限公司 | 嘌呤衍生物及它们在治疗疾病中的应用 |
| CN103012284A (zh) * | 2012-12-26 | 2013-04-03 | 无锡捷化医药科技有限公司 | 一种2-氨基-5-溴嘧啶类化合物的制备方法 |
| TW201521791A (zh) * | 2013-05-13 | 2015-06-16 | Daiichi Sankyo Co Ltd | ５－｛８－［（３ｒ）－４－乙醯基－３－甲基哌－１－基］－６－□啉－４－基－９－（２，２，２－三氟乙基）－９ｈ－嘌呤－２－基｝嘧啶－２－胺、及其藥理容許鹽之新穎結晶、及其製造方法 |
| TW201520215A (zh) * | 2013-05-13 | 2015-06-01 | Daiichi Sankyo Co Ltd | Ｎ－□啉基嘌呤衍生物之製造方法 |
| CN105764501A (zh) | 2013-07-26 | 2016-07-13 | 现代化制药公司 | 改善比生群治疗效益的组合物 |
| ES2721302T3 (es) * | 2013-10-04 | 2019-07-30 | Univ Basel | Inhibidores de PI3k y mTOR conformacionalmente restringidos |
| ES2733505T3 (es) | 2015-03-30 | 2019-11-29 | Daiichi Sankyo Co Ltd | Derivados de 6-morfolinil-2-pirazolil-9H-purina y su uso como inhibidores PI3K |
| US10765681B2 (en) | 2016-02-05 | 2020-09-08 | Academia Sinica | Purine compounds possessing anticancer activity |
| US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
| JP7068186B2 (ja) | 2016-12-02 | 2022-05-16 | 第一三共株式会社 | 新規エンド－β－Ｎ－アセチルグルコサミニダーゼ |
| EP3360865A1 (en) * | 2017-02-13 | 2018-08-15 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Process for the preparation of cyclopropyldiketopiperazines, and of a key intermediate of ds-5272 |
| TWI837231B (zh) | 2018-11-29 | 2024-04-01 | 日商第一三共股份有限公司 | 含有ｅｚｈ１／２雙重抑制劑之醫藥組合及其用途 |
| CN113368114B (zh) * | 2020-03-10 | 2022-04-22 | 四川大学 | 一种吗啉嘧啶类化合物的抗肿瘤应用 |
| AU2022238886A1 (en) * | 2021-03-17 | 2023-09-14 | Medivir Ab | Purine derivatives as anticancer agents |
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-
2009
- 2009-10-12 TW TW098134442A patent/TWI378933B/zh not_active IP Right Cessation
- 2009-10-13 MX MX2011003490A patent/MX2011003490A/es active IP Right Grant
- 2009-10-13 JP JP2009236444A patent/JP5090423B2/ja not_active Expired - Fee Related
- 2009-10-13 AU AU2009304789A patent/AU2009304789B2/en not_active Ceased
- 2009-10-13 DK DK09820579.2T patent/DK2336132T3/da active
- 2009-10-13 BR BRPI0920199A patent/BRPI0920199A2/pt not_active IP Right Cessation
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