ZA200900992B - 2-methylmorpholine pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mTOR inhibitors - Google Patents

2-methylmorpholine pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mTOR inhibitors

Info

Publication number
ZA200900992B
ZA200900992B ZA200900992A ZA200900992A ZA200900992B ZA 200900992 B ZA200900992 B ZA 200900992B ZA 200900992 A ZA200900992 A ZA 200900992A ZA 200900992 A ZA200900992 A ZA 200900992A ZA 200900992 B ZA200900992 B ZA 200900992B
Authority
ZA
South Africa
Prior art keywords
pyrazo
pyrimido
pyrido
methylmorpholine
pyrimidine derivatives
Prior art date
Application number
ZA200900992A
Inventor
Heather Mary Ellen Duggan
Frederic Georges Marie Leroux
Karine Malagu
Niall Morrisson Barr Martin
Keith Allan Menear
Graeme Cameron Murray Smith
Original Assignee
Kudos Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kudos Pharm Ltd filed Critical Kudos Pharm Ltd
Publication of ZA200900992B publication Critical patent/ZA200900992B/en

Links

ZA200900992A 2006-08-23 2009-02-11 2-methylmorpholine pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mTOR inhibitors ZA200900992B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82331106P 2006-08-23 2006-08-23

Publications (1)

Publication Number Publication Date
ZA200900992B true ZA200900992B (en) 2010-07-28

Family

ID=41175600

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200900992A ZA200900992B (en) 2006-08-23 2009-02-11 2-methylmorpholine pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mTOR inhibitors

Country Status (3)

Country Link
CN (1) CN101558067B (en)
UA (1) UA96304C2 (en)
ZA (1) ZA200900992B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102887895B (en) * 2011-07-22 2016-08-24 山东轩竹医药科技有限公司 Pyridopyrimidine class mTOR inhibitors
CN103588792B (en) * 2013-03-04 2016-03-23 中国科学院上海药物研究所 Pyridopyrimidine or pyrimido-pyrimidine compounds, its preparation method, medical composition and its use
CN104557913B (en) * 2013-10-28 2017-02-08 上海汇伦生命科技有限公司 Pyridopyrimidine compounds as well as preparation method and application thereof
CN103908452A (en) * 2014-02-18 2014-07-09 广州金域医学检验中心有限公司 Composite drug and medicinal preparation for inhibiting lung cancer cell metastasis and detection method for lung cancer cell metastasis
CN106008559B (en) * 2015-03-25 2020-10-16 中国科学院上海药物研究所 Synthesis process of substituted pyridopyrimidine compounds
JP7340519B2 (en) * 2017-11-06 2023-09-07 メッドシャイン ディスカバリー インコーポレイテッド Pyridopyrimidine compounds as mTORC1/2 dual inhibitors
CN110407833B (en) * 2018-04-28 2021-03-09 海创药业股份有限公司 Deuterated Vissturtib compound and application thereof
WO2020147842A1 (en) * 2019-01-18 2020-07-23 南京明德新药研发有限公司 Use of pyridopyrimidine compounds in preparation of drug for treating nasopharyngeal carcinoma
WO2020224585A1 (en) * 2019-05-06 2020-11-12 南京明德新药研发有限公司 Salt and crystal form of mtorc1/2 dual kinase activity inhibitor and preparation method therefor
CN111892529A (en) * 2020-08-19 2020-11-06 南通大学 6-chloro-5-hydroxyisoindole-1-one and synthesis method thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5990117A (en) * 1998-04-15 1999-11-23 Cell Pathways, Inc. Method for inhibiting neoplastic cells and related conditions by exposure to quinazoline derivatives
WO2001083456A1 (en) * 2000-04-27 2001-11-08 Yamanouchi Pharmaceutical Co., Ltd. Condensed heteroaryl derivatives
JP5161102B2 (en) * 2005-11-22 2013-03-13 クドス ファーマシューティカルズ リミテッド Pyridopyrimidine, pyrazopyrimidine and pyrimidopyrimidine derivatives as mTOR inhibitors

Also Published As

Publication number Publication date
CN101558067B (en) 2014-05-28
CN101558067A (en) 2009-10-14
UA96304C2 (en) 2011-10-25

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