JP5042859B2 - 蛍光ベースの応用で使用される磁性ミクロスフェア - Google Patents

蛍光ベースの応用で使用される磁性ミクロスフェア Download PDF

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JP5042859B2
JP5042859B2 JP2007552333A JP2007552333A JP5042859B2 JP 5042859 B2 JP5042859 B2 JP 5042859B2 JP 2007552333 A JP2007552333 A JP 2007552333A JP 2007552333 A JP2007552333 A JP 2007552333A JP 5042859 B2 JP5042859 B2 JP 5042859B2
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microsphere
microspheres
magnetic material
core
polymer layer
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JP2008528973A (ja
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チャンドラー，ドン・ジェイ
ベドレ，ジェイソン
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ルミネックス コーポレーション
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent materials, e.g. electroluminescent or chemiluminescent
    • C09K11/02—Use of particular materials as binders, particle coatings or suspension media therefor
    • C09K11/025—Use of particular materials as binders, particle coatings or suspension media therefor non-luminescent particle coatings or suspension media
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent materials, e.g. electroluminescent or chemiluminescent
    • C09K11/06—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/0036—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/01—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials
    • H01F1/03—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity
    • H01F1/0302—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity characterised by unspecified or heterogeneous hardness or specially adapted for magnetic hardness transitions
    • H01F1/0311—Compounds
    • H01F1/0313—Oxidic compounds
    • H01F1/0315—Ferrites
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/01—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials
    • H01F1/03—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity
    • H01F1/032—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials
    • H01F1/04—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials metals or alloys
    • H01F1/06—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials metals or alloys in the form of particles, e.g. powder
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/01—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials
    • H01F1/03—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity
    • H01F1/032—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials
    • H01F1/04—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials metals or alloys
    • H01F1/06—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials metals or alloys in the form of particles, e.g. powder
    • H01F1/063—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials metals or alloys in the form of particles, e.g. powder with a non magnetic core
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/01—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials
    • H01F1/03—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity
    • H01F1/032—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials
    • H01F1/10—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials non-metallic substances, e.g. ferrites, e.g. [(Ba,Sr)O(Fe2O3)6] ferrites with hexagonal structure
    • H01F1/11—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials non-metallic substances, e.g. ferrites, e.g. [(Ba,Sr)O(Fe2O3)6] ferrites with hexagonal structure in the form of particles
    • H01F1/111—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials non-metallic substances, e.g. ferrites, e.g. [(Ba,Sr)O(Fe2O3)6] ferrites with hexagonal structure in the form of particles with a non-magnetic core
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/0018—Diamagnetic or paramagnetic materials, i.e. materials with low susceptibility and no hysteresis
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/01—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials
    • H01F1/03—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity
    • H01F1/12—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of soft-magnetic materials
    • H01F1/34—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of soft-magnetic materials non-metallic substances, e.g. ferrites
    • H01F1/36—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of soft-magnetic materials non-metallic substances, e.g. ferrites in the form of particles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
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    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
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    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
    • Y10T428/2995—Silane, siloxane or silicone coating
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
    • Y10T428/2996—Glass particles or spheres
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2998—Coated including synthetic resin or polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/32—Composite [nonstructural laminate] of inorganic material having metal-compound-containing layer and having defined magnetic layer

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
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  • Urology & Nephrology (AREA)
  • Nanotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Luminescent Compositions (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
JP2007552333A 2005-01-20 2006-01-19 蛍光ベースの応用で使用される磁性ミクロスフェア Expired - Lifetime JP5042859B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64554905P 2005-01-20 2005-01-20
US60/645,549 2005-01-20
PCT/US2006/002257 WO2006079016A1 (en) 2005-01-20 2006-01-19 Magnetic microspheres for use in fluorescence-based applications

Publications (2)

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JP2008528973A JP2008528973A (ja) 2008-07-31
JP5042859B2 true JP5042859B2 (ja) 2012-10-03

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Country Link
US (6) US7718262B2 (en:Method)
EP (2) EP1842211B1 (en:Method)
JP (1) JP5042859B2 (en:Method)
KR (1) KR101253265B1 (en:Method)
CN (2) CN100541677C (en:Method)
AT (1) ATE476744T1 (en:Method)
CA (1) CA2595292C (en:Method)
DE (1) DE602006015908D1 (en:Method)
DK (1) DK2244270T3 (en:Method)
ES (1) ES2391529T3 (en:Method)
WO (1) WO2006079016A1 (en:Method)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006079016A1 (en) * 2005-01-20 2006-07-27 Luminex Corporation Magnetic microspheres for use in fluorescence-based applications
US8296088B2 (en) 2006-06-02 2012-10-23 Luminex Corporation Systems and methods for performing measurements of one or more materials
CN101479603B (zh) * 2006-06-02 2012-11-21 卢米尼克斯股份有限公司 包括使用磁粒子和应用磁场的用于执行一种或多种分析物的测量系统和方法
EP2246702B1 (en) * 2007-12-03 2015-10-07 Tamagawa Seiki Co., Ltd. Biosensing method using coated magnetic microparticles and biosensing device to be used in the method
WO2009091643A1 (en) 2008-01-07 2009-07-23 Luminex Corporation Isolation and enumeration of cells from a complex sample matrix
CA2711564A1 (en) * 2008-01-07 2009-07-16 Luminex Corporation Immunomagnetic capture and imaging of biological targets
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CN102084241B (zh) 2008-03-21 2015-02-18 艾博特健康公司 使用荧光淬灭和/或漂白分析个体细胞或微粒的方法及设备
CA2718992C (en) 2008-03-21 2013-04-30 Abbott Point Of Care, Inc. Method and apparatus for determining the hematocrit of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells
CA2718995C (en) * 2008-03-21 2014-08-19 Abbott Point Of Care, Inc. Method and apparatus for determining red blood cell indices of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells
US8045165B2 (en) * 2008-03-21 2011-10-25 Abbott Point Of Care, Inc. Method and apparatus for determining a focal position of an imaging device adapted to image a biologic sample
EP2274613B1 (en) 2008-04-02 2014-06-04 Abbott Point Of Care, Inc. Method for serologic agglutination assays performed in a thin film fluid sample
CA2720077C (en) * 2008-04-09 2014-08-05 Abbott Point Of Care, Inc. Method for measuring the area of a sample disposed within an analysis chamber
JP5301894B2 (ja) * 2008-06-27 2013-09-25 富士フイルム株式会社 検出方法
WO2010029739A1 (ja) * 2008-09-11 2010-03-18 国立大学法人東京工業大学 蛍光分子を含有するポリマー粒子およびその製造方法
US20100255605A1 (en) * 2009-04-02 2010-10-07 Abbott Point Of Care, Inc. Method and device for transferring biologic fluid samples
JP5620154B2 (ja) * 2009-10-15 2014-11-05 公益財団法人神奈川科学技術アカデミー 中空微小体およびその作製方法
JP5678565B2 (ja) * 2009-12-08 2015-03-04 Jnc株式会社 磁性微粒子およびその製造方法
EP2519820B1 (en) * 2009-12-31 2013-11-06 Abbott Point Of Care, Inc. Method and apparatus for determining mean cell volume of red blood cells
US9500644B2 (en) 2010-02-23 2016-11-22 Luminex Corporation Particle populations and assays having varying amounts of magnetic material and particle concentrations among different subsets of particles and methods for processing assays having such particle populations
DK2539450T3 (da) 2010-02-25 2016-05-30 Advanced Liquid Logic Inc Fremgangsmåde til fremstilling af nukleinsyrebiblioteker
US8472693B2 (en) 2010-03-18 2013-06-25 Abbott Point Of Care, Inc. Method for determining at least one hemoglobin related parameter of a whole blood sample
JP2013527428A (ja) * 2010-06-04 2013-06-27 富士レビオ株式会社 磁気蛍光性微小粒子における光学的キャビティモード励起
US20130293246A1 (en) 2010-11-17 2013-11-07 Advanced Liquid Logic Inc. Capacitance Detection in a Droplet Actuator
CN103562729A (zh) 2011-05-02 2014-02-05 先进流体逻辑公司 分子诊断平台
EP2711079B1 (en) 2011-05-09 2018-12-19 Advanced Liquid Logic, Inc. Microfluidic Feedback Using Impedance Detection
WO2012154794A2 (en) 2011-05-10 2012-11-15 Advanced Liquid Logic, Inc. Enzyme concentration and assays
CN102343240B (zh) * 2011-06-27 2013-07-10 苏州科技学院 荧光磁性双功能树状分子微球及其制备方法
US10731199B2 (en) 2011-11-21 2020-08-04 Advanced Liquid Logic, Inc. Glucose-6-phosphate dehydrogenase assays
US9803237B2 (en) 2012-04-24 2017-10-31 California Institute Of Technology Slip-induced compartmentalization
US20140072959A1 (en) 2012-09-12 2014-03-13 Force Diagnostics, Inc. Rapid tests for insurance underwriting
WO2014134280A1 (en) * 2013-02-28 2014-09-04 The Terasaki Family Foundation Methods, compositions and kits to recycle internally dyed particles
BR112015023615A2 (pt) 2013-03-15 2017-07-18 Ameriforge Group Inc conjunto de elevação de perfuração
EP2973404B1 (en) * 2013-03-15 2019-02-27 Luminex Corporation Real-time tracking and correlation of microspheres
US9753042B2 (en) 2013-04-23 2017-09-05 Rosalind Franklin University Of Medicine And Science Kits for determining male fertility by measuring levels of a2V-ATPase, G-CSF, MIP 1 alpha, MCP-1, and methods and kits for improving reproductive outcomes in artificial insemination procedures
WO2015010379A1 (zh) 2013-07-26 2015-01-29 清华大学 基于闭合超导线圈组的磁场屏蔽系统及磁场屏蔽设备
CN111957453B (zh) 2013-08-13 2022-08-19 先进流体逻辑公司 使用作为流体输入的接通致动器储液器来提高液滴计量的准确度和精度的方法
KR20160081896A (ko) 2013-08-30 2016-07-08 일루미나, 인코포레이티드 친수성 또는 다양한-친수성 표면 상에서의 액적의 조작
CN103752821B (zh) * 2014-01-24 2016-01-20 云南大学 一种制备金属微粉覆盖表面的导电复合微球材料方法
AU2015249592A1 (en) 2014-04-24 2016-12-15 Immusant, Inc. Use of Interleukin-2 for diagnosis of Celiac disease
CA3060708A1 (en) 2014-04-29 2015-11-05 Illumina, Inc Multiplexed single cell gene expression analysis using template switch and tagmentation
CN104356323B (zh) * 2014-10-13 2017-05-17 北京大学 一种磁性分子印迹纳米颗粒及其制备方法和应用
JP2017539080A (ja) 2014-10-23 2017-12-28 コーニング インコーポレイテッド 高分子被包磁性ナノ粒子
AU2015349728A1 (en) 2014-11-21 2017-07-13 Immusant, Inc. Peptides for use in treatment and diagnosis of type 1 diabetes
CN104559674A (zh) * 2015-01-20 2015-04-29 芜湖县双宝建材有限公司 一种高韧性高去污性能涂料
US10576471B2 (en) 2015-03-20 2020-03-03 Illumina, Inc. Fluidics cartridge for use in the vertical or substantially vertical position
CA2996529A1 (en) 2015-08-24 2017-03-02 Gpb Scientific, Llc Methods and devices for multi-step cell purification and concentration
EP4086357A1 (en) 2015-08-28 2022-11-09 Illumina, Inc. Nucleic acid sequence analysis from single cells
EP3440220B1 (en) 2016-04-07 2020-03-25 Illumina, Inc. Methods and systems for construction of normalized nucleic acid libraries
US10317413B2 (en) 2016-11-14 2019-06-11 The Board Of Regents Of The University Of Texas System Method and kit for detection of anti-zika virus antibodies
US12130290B2 (en) 2016-11-29 2024-10-29 Trustees Of Tufts College Compositions and methods for diagnosing breast cancer
CN110337331B (zh) * 2017-02-08 2022-04-26 贝克顿·迪金森公司 干染料试剂装置以及制造和使用所述干染料试剂装置的方法
ES2937927T3 (es) 2018-01-29 2023-04-03 St Jude Childrens Res Hospital Inc Método para la amplificación de ácidos nucleicos
CN110732296B (zh) * 2018-07-18 2021-09-03 苏州为度生物技术有限公司 具有蓬松壳层的磁性微球的制备方法
CN109158063A (zh) * 2018-07-31 2019-01-08 湖南华腾制药有限公司 一种磁性高分子微球结构及其制备
CN109092219A (zh) * 2018-07-31 2018-12-28 湖南华腾制药有限公司 一种磁性高分子微球结构及其制备
CN109331753A (zh) * 2018-10-18 2019-02-15 中翰盛泰生物技术股份有限公司 一种羧基磁性微球、制备方法及应用
MX2022001324A (es) 2019-07-31 2022-05-19 Bioskryb Genomics Inc Análisis de células individuales.
EP4058763A4 (en) 2019-11-15 2023-11-29 Scintimetrics, Inc. COMPOSITIONS AND METHODS USING DIFFUSION OF FLUOROPHORES
ES2985378T3 (es) 2020-03-30 2024-11-05 Illumina Inc Métodos y composiciones para preparar bibliotecas de ácidos nucleicos
CN111393574B (zh) * 2020-03-31 2022-02-22 中国科学院过程工程研究所 一种表面带有功能基团的磁性微球及其制备方法和用途
JP7638478B2 (ja) * 2020-07-30 2025-03-04 国立研究開発法人産業技術総合研究所 微小構造体と分子検出法
US12379300B1 (en) 2020-11-30 2025-08-05 Leiden Measurement Technology Llc Multiplexed impedance-based detection methods and systems using impedance-encoded particles
DE102020132495B3 (de) * 2020-12-07 2022-05-12 Bundesrepublik Deutschland, Wirtschaft und Energie, Bundesanstalt für Materialforschung und -prüfung (BAM) Partikel, die aus einem organischen Polymerkern, einer ersten anorganischen Oxidschale, die ein magnetisches Material enthält, und einer mesoporösen zweiten anorganischen Schale bestehen
CN112745833B (zh) * 2020-12-18 2024-01-05 华侨大学 一种时间分辨荧光磁性纳米微球的制备方法
CN115127976A (zh) * 2021-03-24 2022-09-30 深圳市帝迈生物技术有限公司 荧光磁珠及其制作方法
CN115127973A (zh) * 2021-03-24 2022-09-30 深圳市帝迈生物技术有限公司 荧光磁珠及其制作方法
CN115127975A (zh) * 2021-03-24 2022-09-30 深圳市帝迈生物技术有限公司 荧光磁珠及其制作方法
CN115127977A (zh) * 2021-03-24 2022-09-30 深圳市帝迈生物技术有限公司 磁珠及其制作方法
CN115127974A (zh) * 2021-03-24 2022-09-30 深圳市帝迈生物技术有限公司 磁珠及其制作方法
CN115127972A (zh) * 2021-03-24 2022-09-30 深圳市帝迈生物技术有限公司 磁珠及其制作方法
CN115127971A (zh) * 2021-03-24 2022-09-30 深圳市帝迈生物技术有限公司 磁珠及其制作方法
CN115127978A (zh) * 2021-03-24 2022-09-30 深圳市帝迈生物技术有限公司 荧光磁珠及其制作方法
CN114152742B (zh) * 2021-11-30 2024-05-28 深圳市易瑞生物技术股份有限公司 包含磁性发光微球的光激化学发光免疫检测的试剂盒及其应用
CN116037017B (zh) * 2023-02-13 2026-01-09 南京艾迪迈科技有限公司 大粒径核-壳型磁性聚合物微球的合成与功能化修饰技术

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2017125B (en) 1978-03-17 1982-07-21 California Inst Of Techn Polyglutaraldehyde synthesis and protein bonding substrates
US5200270A (en) * 1986-02-25 1993-04-06 Toyo Soda Manufacturing Co., Ltd. Carrier for a biologically active component for immunoassay or enzymatic reaction
US6013531A (en) * 1987-10-26 2000-01-11 Dade International Inc. Method to use fluorescent magnetic polymer particles as markers in an immunoassay
US5091206A (en) * 1987-10-26 1992-02-25 Baxter Diagnostics Inc. Process for producing magnetically responsive polymer particles and application thereof
US5032381A (en) * 1988-12-20 1991-07-16 Tropix, Inc. Chemiluminescence-based static and flow cytometry
US5091200A (en) 1989-01-10 1992-02-25 International Flavors & Fragrances Inc. Process for microwave browning uncooked baked goods foodstuffs
DE69029908T2 (de) * 1989-12-14 1997-05-22 Dade International Inc., Deerfield, Ill. Magnetische und fluoreszierende polymerteilchen und ihre anwendung
ES2076773T3 (es) * 1991-06-17 1995-11-01 Dade Int Inc Proceso para producir particulas de polimero magneticamente sensible y aplicacion de las mismas.
US5648124A (en) * 1993-07-09 1997-07-15 Seradyn, Inc. Process for preparing magnetically responsive microparticles
WO1997014028A2 (en) 1995-10-11 1997-04-17 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US5736330A (en) 1995-10-11 1998-04-07 Luminex Corporation Method and compositions for flow cytometric determination of DNA sequences
GB9524393D0 (en) * 1995-11-29 1996-01-31 Mini Agriculture & Fisheries Extraction and labelling of materials
US6449562B1 (en) * 1996-10-10 2002-09-10 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US5948627A (en) * 1997-05-30 1999-09-07 One Lambda Immunobead flow cytometric detection of anti-HLA panel-reactive antibody
US6139800A (en) 1997-06-23 2000-10-31 Luminex Corporation Interlaced lasers for multiple fluorescence measurement
CA2306501C (en) 1997-10-14 2011-03-29 Luminex Corporation Precision fluorescently dyed particles and methods of making and using same
ATE239801T1 (de) 1998-01-22 2003-05-15 Luminex Corp Mikropartikel mit multiplen fluoreszenz-signalen
JP4215397B2 (ja) * 1998-05-14 2009-01-28 ルミネックス コーポレイション 多重分析物診断システム
CA2328408C (en) * 1998-05-14 2005-02-15 Luminex Corporation Zero dead time architecture and method for flow cytometer
US6046807A (en) * 1998-05-14 2000-04-04 Luminex Corporation Diode laser based measurement apparatus
EP1161490A4 (en) * 1999-02-05 2003-04-09 Univ Maryland LUMINESCENT SPECTRAL CHARACTERISTICS OF CdS NANOPARTICLES
US7179660B1 (en) * 2000-03-06 2007-02-20 Dade Behring Marburg Gmbh Carriers coated with polysaccharides, their preparation and use
US6548264B1 (en) * 2000-05-17 2003-04-15 University Of Florida Coated nanoparticles
US20030186465A1 (en) * 2001-11-27 2003-10-02 Kraus Robert H. Apparatus used in identification, sorting and collection methods using magnetic microspheres and magnetic microsphere kits
CN101084429A (zh) * 2004-12-17 2007-12-05 卢米尼克斯股份有限公司 用于增加由荧光团发射的荧光的系统、照明子系统和方法
WO2006079016A1 (en) * 2005-01-20 2006-07-27 Luminex Corporation Magnetic microspheres for use in fluorescence-based applications

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