JP5016926B2 - 架橋したヒアルロナンおよび/またはハイランに由来する粘着性ゲル、その調製および使用法 - Google Patents
架橋したヒアルロナンおよび/またはハイランに由来する粘着性ゲル、その調製および使用法 Download PDFInfo
- Publication number
- JP5016926B2 JP5016926B2 JP2006547530A JP2006547530A JP5016926B2 JP 5016926 B2 JP5016926 B2 JP 5016926B2 JP 2006547530 A JP2006547530 A JP 2006547530A JP 2006547530 A JP2006547530 A JP 2006547530A JP 5016926 B2 JP5016926 B2 JP 5016926B2
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- JP
- Japan
- Prior art keywords
- gel
- solution
- dvs
- polymer
- ipc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 0 CO[C@](C(C1O)O)C(C([*+])=O)O[C@]1O[C@@](C(*)[C@](OC)OC1CO)C1O Chemical compound CO[C@](C(C1O)O)C(C([*+])=O)O[C@]1O[C@@](C(*)[C@](OC)OC1CO)C1O 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53342903P | 2003-12-30 | 2003-12-30 | |
| US60/533,429 | 2003-12-30 | ||
| PCT/US2004/043811 WO2005066215A1 (en) | 2003-12-30 | 2004-12-30 | Cohesive gels form cross-linked hyaluronan and/or hylan, their preparation and use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011169777A Division JP5680501B2 (ja) | 2003-12-30 | 2011-08-03 | 架橋したヒアルロナンおよび/またはハイランに由来する粘着性ゲル、その調製および使用法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007519779A JP2007519779A (ja) | 2007-07-19 |
| JP5016926B2 true JP5016926B2 (ja) | 2012-09-05 |
Family
ID=34748900
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006547530A Expired - Lifetime JP5016926B2 (ja) | 2003-12-30 | 2004-12-30 | 架橋したヒアルロナンおよび/またはハイランに由来する粘着性ゲル、その調製および使用法 |
| JP2011169777A Expired - Lifetime JP5680501B2 (ja) | 2003-12-30 | 2011-08-03 | 架橋したヒアルロナンおよび/またはハイランに由来する粘着性ゲル、その調製および使用法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011169777A Expired - Lifetime JP5680501B2 (ja) | 2003-12-30 | 2011-08-03 | 架橋したヒアルロナンおよび/またはハイランに由来する粘着性ゲル、その調製および使用法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20050142152A1 (enExample) |
| EP (1) | EP1701981B1 (enExample) |
| JP (2) | JP5016926B2 (enExample) |
| CN (1) | CN100537606C (enExample) |
| AU (1) | AU2004312532B2 (enExample) |
| BR (1) | BRPI0418309B8 (enExample) |
| CA (1) | CA2550718C (enExample) |
| IL (1) | IL176465A (enExample) |
| MX (1) | MXPA06007556A (enExample) |
| WO (1) | WO2005066215A1 (enExample) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7338433B2 (en) | 2002-08-13 | 2008-03-04 | Allergan, Inc. | Remotely adjustable gastric banding method |
| EP2181655B1 (en) | 2002-08-28 | 2016-12-07 | Apollo Endosurgery, Inc. | Fatigue-restistant gastric banding device |
| FR2861734B1 (fr) | 2003-04-10 | 2006-04-14 | Corneal Ind | Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus |
| PT2399528E (pt) | 2004-01-23 | 2013-02-26 | Allergan Inc | Banda gástrica regulável de uma só peça, que pode ser fixada de forma amovível |
| ATE444045T1 (de) | 2004-03-08 | 2009-10-15 | Allergan Medical S A | Verschlusssystem für röhrenförmige organe |
| ATE517652T1 (de) | 2004-03-18 | 2011-08-15 | Allergan Inc | Vorrichtung zur volumeneinstellung intragastraler ballons |
| DK1817347T3 (en) * | 2004-11-24 | 2017-08-14 | Albumedix As | Process for Crosslinking Hyaluronic Acid with Divinyl Sulfone |
| ES2537751T3 (es) * | 2004-12-30 | 2015-06-11 | Genzyme Corporation | Regímenes para viscosuplementación intraarticular |
| US8251888B2 (en) | 2005-04-13 | 2012-08-28 | Mitchell Steven Roslin | Artificial gastric valve |
| US20070067045A1 (en) * | 2005-09-19 | 2007-03-22 | Ar2 Partners, Inc. | Systems and methods for skin wrinkle removal |
| US7798954B2 (en) | 2006-01-04 | 2010-09-21 | Allergan, Inc. | Hydraulic gastric band with collapsible reservoir |
| US8043206B2 (en) | 2006-01-04 | 2011-10-25 | Allergan, Inc. | Self-regulating gastric band with pressure data processing |
| BRPI0708128A2 (pt) * | 2006-03-02 | 2011-05-17 | Novozymes Biopolymer As | derivado de ácido hialurÈnico, processo para produção de um derivado de ácido hialurÈnico, composição, artigo cosmético, artigo sanitário, médico ou cirúrgico, cápsula ou microcápsula de medicamento, métodos para realizar procedimentos em oftalmologia, no tratamento de osteoartrite, e no tratamento de cáncer, para realizar administração transdérmica e dérmica de um agente farmacologicamente ativo, e administração dérmica de um cosmético, e para realizar procedimentos no tratamento de perda de cabelo ou calvìcie, métodos oftalmológico, de tratamento de osteoartrite, de uma ferida, e de perda de cabelo ou calvìcie, e, uso de um derivado de ácido hialurÈnico |
| FR2909560B1 (fr) | 2006-12-06 | 2012-12-28 | Fabre Pierre Dermo Cosmetique | Gel d'acide hyaluronique pour injection intradermique |
| AU2008256819A1 (en) * | 2007-05-23 | 2008-12-04 | Allergan, Inc. | Cross-linked collagen and uses thereof |
| US8658148B2 (en) | 2007-06-22 | 2014-02-25 | Genzyme Corporation | Chemically modified dendrimers |
| US8318695B2 (en) * | 2007-07-30 | 2012-11-27 | Allergan, Inc. | Tunably crosslinked polysaccharide compositions |
| US8697044B2 (en) | 2007-10-09 | 2014-04-15 | Allergan, Inc. | Crossed-linked hyaluronic acid and collagen and uses thereof |
| EP2818184B1 (en) | 2007-11-16 | 2018-10-31 | Allergan, Inc. | Compositions and methods for treating Purpura |
| US20090143348A1 (en) * | 2007-11-30 | 2009-06-04 | Ahmet Tezel | Polysaccharide gel compositions and methods for sustained delivery of drugs |
| US8394782B2 (en) | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having increased longevity |
| US8394784B2 (en) | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having multi-stage bioactive agent delivery |
| AU2015252122A1 (en) * | 2008-08-04 | 2015-11-26 | Allergan Industrie Sas | Hyaluronic acid-based gels including anesthetic agents |
| US8450475B2 (en) * | 2008-08-04 | 2013-05-28 | Allergan, Inc. | Hyaluronic acid-based gels including lidocaine |
| AU2009288118B2 (en) | 2008-09-02 | 2014-12-11 | Allergan, Inc. | Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof |
| JP5702723B2 (ja) | 2008-09-04 | 2015-04-15 | ザ ジェネラル ホスピタル コーポレイション | 声帯および軟組織の増強および修復用ヒドロゲル |
| US8317677B2 (en) | 2008-10-06 | 2012-11-27 | Allergan, Inc. | Mechanical gastric band with cushions |
| US20100305397A1 (en) * | 2008-10-06 | 2010-12-02 | Allergan Medical Sarl | Hydraulic-mechanical gastric band |
| US20100185049A1 (en) | 2008-10-22 | 2010-07-22 | Allergan, Inc. | Dome and screw valves for remotely adjustable gastric banding systems |
| FR2938187B1 (fr) * | 2008-11-07 | 2012-08-17 | Anteis Sa | Composition injectable a base d'acide hyaluronique ou l'un de ses sels, de polyols et de lidocaine, sterilisee a la chaleur |
| US8390326B2 (en) * | 2009-05-05 | 2013-03-05 | William Marsh Rice University | Method for fabrication of a semiconductor element and structure thereof |
| FR2945293B1 (fr) | 2009-05-11 | 2011-06-17 | Teoxane | Procede de preparation d'un gel reticule. |
| US8790702B2 (en) * | 2009-07-30 | 2014-07-29 | Carbylan Therapeutics, Inc. | Modified hyaluronic acid polymer compositions and related methods |
| US8273725B2 (en) * | 2009-09-10 | 2012-09-25 | Genzyme Corporation | Stable hyaluronan/steroid formulation |
| US20110172180A1 (en) | 2010-01-13 | 2011-07-14 | Allergan Industrie. Sas | Heat stable hyaluronic acid compositions for dermatological use |
| US20110171311A1 (en) * | 2010-01-13 | 2011-07-14 | Allergan Industrie, Sas | Stable hydrogel compositions including additives |
| US9114188B2 (en) | 2010-01-13 | 2015-08-25 | Allergan, Industrie, S.A.S. | Stable hydrogel compositions including additives |
| US20110171286A1 (en) * | 2010-01-13 | 2011-07-14 | Allergan, Inc. | Hyaluronic acid compositions for dermatological use |
| US8758221B2 (en) | 2010-02-24 | 2014-06-24 | Apollo Endosurgery, Inc. | Source reservoir with potential energy for remotely adjustable gastric banding system |
| US8840541B2 (en) * | 2010-02-25 | 2014-09-23 | Apollo Endosurgery, Inc. | Pressure sensing gastric banding system |
| WO2011109730A2 (en) | 2010-03-04 | 2011-09-09 | The General Hospital Corporation | Methods and systems of matching voice deficits with a tunable mucosal implant to restore and enhance individualized human sound and voice production |
| US8586562B2 (en) | 2010-03-12 | 2013-11-19 | Allergan Industrie, Sas | Fluid compositions for improving skin conditions |
| DK2550027T4 (da) | 2010-03-22 | 2019-05-13 | Allergan Inc | Tværbundne polysaccharid- og protein-polysaccharid-hydrogeler til blødvævsforøgelse |
| US20110270024A1 (en) | 2010-04-29 | 2011-11-03 | Allergan, Inc. | Self-adjusting gastric band having various compliant components |
| US9028394B2 (en) | 2010-04-29 | 2015-05-12 | Apollo Endosurgery, Inc. | Self-adjusting mechanical gastric band |
| US9044298B2 (en) | 2010-04-29 | 2015-06-02 | Apollo Endosurgery, Inc. | Self-adjusting gastric band |
| US20110270025A1 (en) | 2010-04-30 | 2011-11-03 | Allergan, Inc. | Remotely powered remotely adjustable gastric band system |
| US9074095B2 (en) * | 2010-06-03 | 2015-07-07 | Technology Innovation Momentum Fund (Israel) Limited Partnership | Malleable hydrogel hybrids made of self-assembled peptides and biocompatible polymers and uses thereof |
| US8517915B2 (en) | 2010-06-10 | 2013-08-27 | Allergan, Inc. | Remotely adjustable gastric banding system |
| US8716204B2 (en) | 2010-07-27 | 2014-05-06 | Zimmer, Inc. | Synthetic synovial fluid compositions and methods for making the same |
| US9005605B2 (en) | 2010-08-19 | 2015-04-14 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US8889123B2 (en) | 2010-08-19 | 2014-11-18 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US8697057B2 (en) | 2010-08-19 | 2014-04-15 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US8883139B2 (en) | 2010-08-19 | 2014-11-11 | Allergan Inc. | Compositions and soft tissue replacement methods |
| US20120059216A1 (en) | 2010-09-07 | 2012-03-08 | Allergan, Inc. | Remotely adjustable gastric banding system |
| EP4616907A3 (en) | 2010-11-08 | 2025-11-12 | Allergan Industries, SAS | Soft tissue filler |
| US8961393B2 (en) | 2010-11-15 | 2015-02-24 | Apollo Endosurgery, Inc. | Gastric band devices and drive systems |
| US9393263B2 (en) | 2011-06-03 | 2016-07-19 | Allergan, Inc. | Dermal filler compositions including antioxidants |
| ES2738208T3 (es) | 2011-06-03 | 2020-01-20 | Allergan Ind Sas | Composiciones de relleno dérmico que incluyen antioxidantes |
| US20130096081A1 (en) * | 2011-06-03 | 2013-04-18 | Allergan, Inc. | Dermal filler compositions |
| US9408797B2 (en) | 2011-06-03 | 2016-08-09 | Allergan, Inc. | Dermal filler compositions for fine line treatment |
| RS62488B1 (sr) | 2011-08-10 | 2021-11-30 | Glycores 2000 Srl | Unakrsno povezani hijaluronat male molekulske težine, otporan na razgradnju |
| US20130244943A1 (en) | 2011-09-06 | 2013-09-19 | Allergan, Inc. | Hyaluronic acid-collagen matrices for dermal filling and volumizing applications |
| US9662422B2 (en) | 2011-09-06 | 2017-05-30 | Allergan, Inc. | Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation |
| HK1198124A1 (en) * | 2011-09-14 | 2015-03-13 | Sumit Paliwal | Dermal filler compositions for fine line treatment |
| CN102558600A (zh) * | 2011-12-01 | 2012-07-11 | 上海白衣缘生物工程有限公司 | 交联透明质酸海绵及其制备方法 |
| US8876694B2 (en) | 2011-12-07 | 2014-11-04 | Apollo Endosurgery, Inc. | Tube connector with a guiding tip |
| US8961394B2 (en) | 2011-12-20 | 2015-02-24 | Apollo Endosurgery, Inc. | Self-sealing fluid joint for use with a gastric band |
| PL2861626T3 (pl) | 2012-06-15 | 2019-05-31 | Merz Pharma Gmbh & Co Kgaa | Sposób przygotowywania kompozycji na bazie kwasu hialuronowego |
| US9579388B2 (en) | 2012-11-29 | 2017-02-28 | Rene Gauthier | System and method for alleviating the appearance of scars and/or scar tissue |
| US9421198B2 (en) | 2013-07-30 | 2016-08-23 | Teoxane | Composition comprising hyaluronic acid and mepivacaine |
| US20170080120A1 (en) * | 2014-05-16 | 2017-03-23 | Ulstrast, Inc. | Phase-shifting formulations |
| ES2761558T3 (es) | 2014-09-30 | 2020-05-20 | Allergan Ind Sas | Composiciones de hidrogel estables que incluyen aditivos |
| WO2016128783A1 (en) | 2015-02-09 | 2016-08-18 | Allergan Industrie Sas | Compositions and methods for improving skin appearance |
| PL3256179T3 (pl) | 2015-02-13 | 2020-05-18 | Allergan Industrie, Sas | Implanty do kształtowania, uwydatniania lub korygowania cech twarzy takich jak broda |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| JP6706632B2 (ja) * | 2016-01-05 | 2020-06-10 | デンカ株式会社 | 半月板変性治療用組成物 |
| TW201832783A (zh) | 2016-12-02 | 2018-09-16 | 法商賽諾菲公司 | 包含glp-1/胰高血糖素雙重激動劑、連接子和透明質酸的接合物 |
| CN108250457A (zh) * | 2017-05-08 | 2018-07-06 | 上海利康瑞生物工程有限公司 | 一种剪切粘度可控的双相交联透明质酸钠凝胶及其制备方法和制剂 |
| US20190240335A1 (en) * | 2018-02-07 | 2019-08-08 | Promedon S.A. | Biocompatible Hydrogel Compositions |
| CA3108125A1 (en) * | 2018-08-07 | 2020-02-13 | Merz Pharma Gmbh & Co. Kgaa | Method for dynamic filtration of a cross-linked hydrogel |
| WO2022051060A1 (en) * | 2020-09-01 | 2022-03-10 | Orthogenrx, Inc. | Crosslinking of non-animal-derived hyaluronic acid with divinyl sulfone |
| EP4448588A1 (en) | 2022-01-11 | 2024-10-23 | WiQo S.p.A. | New hyaluronic acid derivatives as innovative fillers |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4586865A (en) * | 1982-12-09 | 1986-05-06 | Hansen John C | Rotatable discharge conveyor for a belly-dump trailer |
| SE442820B (sv) * | 1984-06-08 | 1986-02-03 | Pharmacia Ab | Gel av tverbunden hyaluronsyra for anvendning som glaskroppssubstitut |
| US4582865A (en) * | 1984-12-06 | 1986-04-15 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
| US4713448A (en) * | 1985-03-12 | 1987-12-15 | Biomatrix, Inc. | Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues |
| DE3684887D1 (de) * | 1985-11-29 | 1992-05-21 | Biomatrix Inc | Arzneistoffabgabesysteme auf basis von hyaluronan, dessen derivaten und salzen sowie verfahren zu deren herstellung. |
| US4795741A (en) * | 1987-05-06 | 1989-01-03 | Biomatrix, Inc. | Compositions for therapeutic percutaneous embolization and the use thereof |
| AU619760B2 (en) * | 1987-12-10 | 1992-02-06 | Genzyme Biosurgery Corporation | Hylan preparation and method of recovery thereof from animal tissues |
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| US5143724A (en) * | 1990-07-09 | 1992-09-01 | Biomatrix, Inc. | Biocompatible viscoelastic gel slurries, their preparation and use |
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| CA2349168C (en) * | 1998-11-10 | 2009-01-06 | Denki Kagaku Kogyo Kabushiki Kaisha | Hyaluronic acid gel, method of its production and medical material containing it |
| US6521223B1 (en) * | 2000-02-14 | 2003-02-18 | Genzyme Corporation | Single phase gels for the prevention of adhesions |
| DE60120372T2 (de) * | 2000-03-24 | 2007-07-05 | Genentech Inc., San Francisco | Verwendung von insulin zur behandlung von knorpelkrankheiten |
-
2004
- 2004-12-30 MX MXPA06007556A patent/MXPA06007556A/es active IP Right Grant
- 2004-12-30 WO PCT/US2004/043811 patent/WO2005066215A1/en not_active Ceased
- 2004-12-30 BR BRPI0418309A patent/BRPI0418309B8/pt not_active IP Right Cessation
- 2004-12-30 EP EP04815811.7A patent/EP1701981B1/en not_active Expired - Lifetime
- 2004-12-30 CA CA2550718A patent/CA2550718C/en not_active Expired - Lifetime
- 2004-12-30 US US11/026,388 patent/US20050142152A1/en not_active Abandoned
- 2004-12-30 JP JP2006547530A patent/JP5016926B2/ja not_active Expired - Lifetime
- 2004-12-30 CN CNB2004800391832A patent/CN100537606C/zh not_active Expired - Lifetime
- 2004-12-30 AU AU2004312532A patent/AU2004312532B2/en not_active Expired
-
2006
- 2006-06-21 IL IL176465A patent/IL176465A/en active IP Right Grant
-
2011
- 2011-08-03 JP JP2011169777A patent/JP5680501B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007519779A (ja) | 2007-07-19 |
| MXPA06007556A (es) | 2006-08-31 |
| BRPI0418309A (pt) | 2007-05-02 |
| EP1701981B1 (en) | 2017-06-07 |
| BRPI0418309B8 (pt) | 2021-05-25 |
| CA2550718A1 (en) | 2005-07-21 |
| US20050142152A1 (en) | 2005-06-30 |
| WO2005066215A1 (en) | 2005-07-21 |
| AU2004312532A1 (en) | 2005-07-21 |
| BRPI0418309B1 (pt) | 2016-08-02 |
| EP1701981A1 (en) | 2006-09-20 |
| JP2012025955A (ja) | 2012-02-09 |
| CA2550718C (en) | 2013-11-05 |
| IL176465A0 (en) | 2006-10-05 |
| CN100537606C (zh) | 2009-09-09 |
| CN1902232A (zh) | 2007-01-24 |
| IL176465A (en) | 2013-07-31 |
| AU2004312532B2 (en) | 2010-05-20 |
| JP5680501B2 (ja) | 2015-03-04 |
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