BRPI0418309A - géis coesos a partir de hialuronano e/ou hilano reticulados, sua preparação e uso - Google Patents
géis coesos a partir de hialuronano e/ou hilano reticulados, sua preparação e usoInfo
- Publication number
- BRPI0418309A BRPI0418309A BRPI0418309-6A BRPI0418309A BRPI0418309A BR PI0418309 A BRPI0418309 A BR PI0418309A BR PI0418309 A BRPI0418309 A BR PI0418309A BR PI0418309 A BRPI0418309 A BR PI0418309A
- Authority
- BR
- Brazil
- Prior art keywords
- hilane
- relates
- preparation
- cohesive
- gels
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
Abstract
GéIS COESOS A PARTIR DE HIALURONANO E/OU HILANO RETICULADOS, SUA PREPARAçãO E USO. A presente invenção refere-se a feis altamente resilientes e coesos, formados pela reticulação de hialuronano ou hilano, seus sais ou derivados, usando divinil-sulfona (DVS) como agente reticulante. A invenção refere-se também a fluidos viscoeláticos que contêm grupos alquil-sulfona ligados de forma covalente à cadeia principal do polímero, formados pela monofuncionalização do monómero reticulante dvs com hialuronano e/ou hilano. As propriedades mecânicas, tais como dureza e coesão, são especificadas pelas propriedades reológicas dos géis. A invenção refere-se também a métodos para a preparação de tais produtos. Eles têm uso em muitas aplicações como dispositivos injetáveis e/ou implantáveis e como sistemas de distribuição de fármacos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53342903P | 2003-12-30 | 2003-12-30 | |
PCT/US2004/043811 WO2005066215A1 (en) | 2003-12-30 | 2004-12-30 | Cohesive gels form cross-linked hyaluronan and/or hylan, their preparation and use |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0418309A true BRPI0418309A (pt) | 2007-05-02 |
BRPI0418309B1 BRPI0418309B1 (pt) | 2016-08-02 |
BRPI0418309B8 BRPI0418309B8 (pt) | 2021-05-25 |
Family
ID=34748900
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0418309A BRPI0418309B8 (pt) | 2003-12-30 | 2004-12-30 | "géis coesos de hialuronado e/ou hilano reticulados, processo para a preparação dos mesmos, bem como composições e dispositivos compreendendo os referidos géis". |
Country Status (10)
Country | Link |
---|---|
US (1) | US20050142152A1 (pt) |
EP (1) | EP1701981B1 (pt) |
JP (2) | JP5016926B2 (pt) |
CN (1) | CN100537606C (pt) |
AU (1) | AU2004312532B2 (pt) |
BR (1) | BRPI0418309B8 (pt) |
CA (1) | CA2550718C (pt) |
IL (1) | IL176465A (pt) |
MX (1) | MXPA06007556A (pt) |
WO (1) | WO2005066215A1 (pt) |
Families Citing this family (82)
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FR2861734B1 (fr) | 2003-04-10 | 2006-04-14 | Corneal Ind | Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus |
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WO2017119198A1 (ja) * | 2016-01-05 | 2017-07-13 | デンカ株式会社 | 半月板変性治療用組成物 |
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-
2004
- 2004-12-30 WO PCT/US2004/043811 patent/WO2005066215A1/en active Application Filing
- 2004-12-30 EP EP04815811.7A patent/EP1701981B1/en active Active
- 2004-12-30 JP JP2006547530A patent/JP5016926B2/ja active Active
- 2004-12-30 MX MXPA06007556A patent/MXPA06007556A/es active IP Right Grant
- 2004-12-30 US US11/026,388 patent/US20050142152A1/en not_active Abandoned
- 2004-12-30 CN CNB2004800391832A patent/CN100537606C/zh active Active
- 2004-12-30 CA CA2550718A patent/CA2550718C/en active Active
- 2004-12-30 BR BRPI0418309A patent/BRPI0418309B8/pt active IP Right Grant
- 2004-12-30 AU AU2004312532A patent/AU2004312532B2/en active Active
-
2006
- 2006-06-21 IL IL176465A patent/IL176465A/en active IP Right Grant
-
2011
- 2011-08-03 JP JP2011169777A patent/JP5680501B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
US20050142152A1 (en) | 2005-06-30 |
WO2005066215A1 (en) | 2005-07-21 |
AU2004312532B2 (en) | 2010-05-20 |
CA2550718A1 (en) | 2005-07-21 |
JP2012025955A (ja) | 2012-02-09 |
IL176465A (en) | 2013-07-31 |
CN100537606C (zh) | 2009-09-09 |
EP1701981A1 (en) | 2006-09-20 |
CN1902232A (zh) | 2007-01-24 |
CA2550718C (en) | 2013-11-05 |
BRPI0418309B1 (pt) | 2016-08-02 |
AU2004312532A1 (en) | 2005-07-21 |
BRPI0418309B8 (pt) | 2021-05-25 |
MXPA06007556A (es) | 2006-08-31 |
EP1701981B1 (en) | 2017-06-07 |
JP2007519779A (ja) | 2007-07-19 |
IL176465A0 (en) | 2006-10-05 |
JP5680501B2 (ja) | 2015-03-04 |
JP5016926B2 (ja) | 2012-09-05 |
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