CN100537606C - 源自交联的透明质酸和/或hylan的粘性凝胶、其制备和用途 - Google Patents

源自交联的透明质酸和/或hylan的粘性凝胶、其制备和用途 Download PDF

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Publication number
CN100537606C
CN100537606C CNB2004800391832A CN200480039183A CN100537606C CN 100537606 C CN100537606 C CN 100537606C CN B2004800391832 A CNB2004800391832 A CN B2004800391832A CN 200480039183 A CN200480039183 A CN 200480039183A CN 100537606 C CN100537606 C CN 100537606C
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gel
solution
dvs
polymer
ipc
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Expired - Lifetime
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English (en)
Chinese (zh)
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CN1902232A (zh
Inventor
A·K·莱希纳
P·A·科诺维克
V·瓦西里耶夫
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Genzyme Corp
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Genzyme Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CNB2004800391832A 2003-12-30 2004-12-30 源自交联的透明质酸和/或hylan的粘性凝胶、其制备和用途 Expired - Lifetime CN100537606C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53342903P 2003-12-30 2003-12-30
US60/533,429 2003-12-30

Publications (2)

Publication Number Publication Date
CN1902232A CN1902232A (zh) 2007-01-24
CN100537606C true CN100537606C (zh) 2009-09-09

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CNB2004800391832A Expired - Lifetime CN100537606C (zh) 2003-12-30 2004-12-30 源自交联的透明质酸和/或hylan的粘性凝胶、其制备和用途

Country Status (10)

Country Link
US (1) US20050142152A1 (enExample)
EP (1) EP1701981B1 (enExample)
JP (2) JP5016926B2 (enExample)
CN (1) CN100537606C (enExample)
AU (1) AU2004312532B2 (enExample)
BR (1) BRPI0418309B8 (enExample)
CA (1) CA2550718C (enExample)
IL (1) IL176465A (enExample)
MX (1) MXPA06007556A (enExample)
WO (1) WO2005066215A1 (enExample)

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Publication number Publication date
JP2007519779A (ja) 2007-07-19
JP5016926B2 (ja) 2012-09-05
MXPA06007556A (es) 2006-08-31
BRPI0418309A (pt) 2007-05-02
EP1701981B1 (en) 2017-06-07
BRPI0418309B8 (pt) 2021-05-25
CA2550718A1 (en) 2005-07-21
US20050142152A1 (en) 2005-06-30
WO2005066215A1 (en) 2005-07-21
AU2004312532A1 (en) 2005-07-21
BRPI0418309B1 (pt) 2016-08-02
EP1701981A1 (en) 2006-09-20
JP2012025955A (ja) 2012-02-09
CA2550718C (en) 2013-11-05
IL176465A0 (en) 2006-10-05
CN1902232A (zh) 2007-01-24
IL176465A (en) 2013-07-31
AU2004312532B2 (en) 2010-05-20
JP5680501B2 (ja) 2015-03-04

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Granted publication date: 20090909