JP5016778B2 - ビオチンまたはビオチン誘導体との少なくとも一つの共有結合を含み抗血栓活性を有するポリサッカライド - Google Patents

ビオチンまたはビオチン誘導体との少なくとも一つの共有結合を含み抗血栓活性を有するポリサッカライド Download PDF

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JP5016778B2
JP5016778B2 JP2002529162A JP2002529162A JP5016778B2 JP 5016778 B2 JP5016778 B2 JP 5016778B2 JP 2002529162 A JP2002529162 A JP 2002529162A JP 2002529162 A JP2002529162 A JP 2002529162A JP 5016778 B2 JP5016778 B2 JP 5016778B2
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methyl
glucopyranosyl
tri
sulfonate
group
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JP2004509902A5 (show.php
JP2004509902A (ja
Inventor
デュチョソワ，フィリップ
エルベール，ジャン−マルク
ペティトゥ，モリス
サヴィ，ピエール
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Sanofi SA
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Sanofi SA
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
JP2002529162A 2000-09-22 2001-09-20 ビオチンまたはビオチン誘導体との少なくとも一つの共有結合を含み抗血栓活性を有するポリサッカライド Expired - Fee Related JP5016778B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR00/12094 2000-09-22
FR0012094A FR2814463B1 (fr) 2000-09-22 2000-09-22 Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine
PCT/FR2001/002918 WO2002024754A1 (fr) 2000-09-22 2001-09-20 Polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012027377A Division JP2012131809A (ja) 2000-09-22 2012-02-10 ビオチンまたはビオチン誘導体との少なくとも一つの共有結合を含み抗血栓活性を有するポリサッカライド

Publications (3)

Publication Number Publication Date
JP2004509902A JP2004509902A (ja) 2004-04-02
JP2004509902A5 JP2004509902A5 (show.php) 2012-03-29
JP5016778B2 true JP5016778B2 (ja) 2012-09-05

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Application Number Title Priority Date Filing Date
JP2002529162A Expired - Fee Related JP5016778B2 (ja) 2000-09-22 2001-09-20 ビオチンまたはビオチン誘導体との少なくとも一つの共有結合を含み抗血栓活性を有するポリサッカライド
JP2012027377A Pending JP2012131809A (ja) 2000-09-22 2012-02-10 ビオチンまたはビオチン誘導体との少なくとも一つの共有結合を含み抗血栓活性を有するポリサッカライド

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JP2012027377A Pending JP2012131809A (ja) 2000-09-22 2012-02-10 ビオチンまたはビオチン誘導体との少なくとも一つの共有結合を含み抗血栓活性を有するポリサッカライド

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US (3) US6844329B2 (show.php)
EP (1) EP1322673B1 (show.php)
JP (2) JP5016778B2 (show.php)
KR (2) KR20080049139A (show.php)
CN (1) CN1235914C (show.php)
AR (1) AR030774A1 (show.php)
AT (1) ATE374215T1 (show.php)
AU (2) AU9196001A (show.php)
BG (1) BG66191B1 (show.php)
BR (1) BR0114007A (show.php)
CA (1) CA2418815C (show.php)
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DK (1) DK1322673T3 (show.php)
EA (1) EA005133B1 (show.php)
EC (1) ECSP034514A (show.php)
EE (1) EE05202B1 (show.php)
ES (1) ES2292625T3 (show.php)
FR (1) FR2814463B1 (show.php)
GE (1) GEP20053616B (show.php)
HR (1) HRP20030219B1 (show.php)
HU (2) HU1400034D0 (show.php)
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PL (1) PL206727B1 (show.php)
PT (1) PT1322673E (show.php)
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SK (2) SK287054B6 (show.php)
TW (1) TWI308153B (show.php)
UA (1) UA79736C2 (show.php)
WO (1) WO2002024754A1 (show.php)
ZA (1) ZA200301692B (show.php)

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FR2814463B1 (fr) * 2000-09-22 2002-11-15 Sanofi Synthelabo Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine
FR2874924B1 (fr) 2004-09-09 2006-12-01 Sanofi Aventis Sa Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique
TWI403334B (zh) * 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
TWI376234B (en) * 2005-02-01 2012-11-11 Msd Oss Bv Conjugates of a polypeptide and an oligosaccharide
CN101312747B (zh) * 2005-10-10 2013-03-20 Msd欧斯股份有限公司 包括生物素标记的抗血栓形成双重抑制剂
CA2624588C (en) * 2005-10-10 2014-05-20 N.V. Organon Anticoagulant antithrombotic dual inhibitors comprising a biotin label
CN1317035C (zh) * 2005-10-24 2007-05-23 天津大学 基于酰肼基的微粒表面多重生物功能因子组装方法
EP1886696A1 (en) * 2006-08-03 2008-02-13 Endotis Pharma Conjugates of antithrombin binding oligosaccharide derivatives and therapeutic proteins
FR2912409B1 (fr) * 2007-02-14 2012-08-24 Sanofi Aventis Heparines de bas poids moleculaire comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine leur procede de preparation,leur utilisation
EP2145624A1 (en) 2008-07-18 2010-01-20 Sanofi-Aventis Use of idrabiotaparinux for decreasing the incidence of bleedings during an antithrombotic treatment
EP2233143A1 (en) 2009-03-24 2010-09-29 Sanofi-Aventis Use of idrabiotaparinux for decreasing the incidence of bleedings during an antithrombotic treatment
TW201006479A (en) * 2008-07-18 2010-02-16 Sanofi Aventis Use of idrabiotaparinux for decreasing the incidence of bleedings during an antithrombotic treatment
FR2935386B1 (fr) * 2008-08-26 2010-09-10 Sanofi Aventis Nouveaux polysaccharides a activite antithrombotique comprenant une liaion covalente avec une chaine amine
CA2735983A1 (en) * 2008-09-10 2010-03-18 Transpharma Medical Ltd. Transdermal delivery of oligosaccharides
EP2367544A4 (en) 2008-12-19 2016-06-08 Supernus Pharmaceuticals Inc PROCESS FOR TREATING AGGRESSION
FR2952935B1 (fr) * 2009-11-20 2011-12-02 Sanofi Aventis Procede de preparation du n-biotinyl-6-aminocaproate de n succinimidyle
CN102892411B (zh) 2009-12-18 2015-01-21 恩多提斯药业公司 含有合成的低聚糖的药物口服剂型
CZ302510B6 (cs) * 2010-03-29 2011-06-22 Univerzita Palackého v Olomouci Efektivní zpusob biotinylace sloucenin s karboxylovou skupinou pomocí syntézy na pevné fázi pro potreby afinitní chromatografie
CZ302669B6 (cs) * 2010-03-29 2011-08-24 Univerzita Palackého v Olomouci Efektivní zpusob biotinylace aminosloucenin pomocí syntézy na pevné fázi pro potreby afinitní chromatografie
ES2852899T3 (es) 2010-03-31 2021-09-14 Supernus Pharmaceuticals Inc Formulaciones estabilizadas de molindona
WO2012042123A1 (fr) 2010-09-10 2012-04-05 Sanofi Polysaccharides biotinyles a activite antithrombotique et presentant une stabilite metabolique amelioree
FR2964660B1 (fr) * 2010-09-10 2012-09-28 Sanofi Aventis Nouveaux polysaccharides biotinyles a activite antithrombotique et presentant une stabilite metabolique amelioree
EP2484366A1 (en) 2011-02-07 2012-08-08 Sanofi Idrabiotaparinux for the treatment of pulmonary embolism and for the secondary prevention of venous thromboembolic events
JP6051211B2 (ja) * 2011-06-17 2016-12-27 カルボミメティクス 半減期が短く活性が高い合成五糖類
MX2015005937A (es) * 2012-11-13 2015-09-08 Supernus Pharmaceuticals Inc Metodo de tratamiento de la agresion.
WO2015195404A1 (en) 2014-06-20 2015-12-23 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods for detection of an analyte by movement of tethered microparticles
WO2016205239A1 (en) 2015-06-15 2016-12-22 The United States Of America, As Represented By The Secretary Department Of Health And Human Services Non-hormonal mammalian sperm decoy contraception based on the n-terminus of the zp2 protein
CN110234600B (zh) 2016-10-21 2023-03-21 美国政府(由卫生和人类服务部的部长所代表) 分子纳米标签
CN108976318B (zh) * 2017-06-01 2021-03-30 首都医科大学 单-6-(生物素酰胺基)-6-脱氧-β-环糊精及其制备方法和应用
WO2019133727A1 (en) 2017-12-29 2019-07-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Universal influenza virus probe set for enrichment of any influenza virus nucleic acid
WO2021007429A1 (en) 2019-07-09 2021-01-14 Optimvia Llc Methods for synthesizing anticoagulant polysaccharides
CN114556685B (zh) * 2019-10-17 2024-04-02 株式会社自动网络技术研究所 布线模块
WO2022056078A1 (en) 2020-09-11 2022-03-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Rnase h-assisted detection assay for rna (radar)
WO2024191684A1 (en) 2023-03-10 2024-09-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Detection of hepatitis c virus ribonucleic acid from whole blood using reverse transcription loop-mediated isothermal amplification

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US3960884A (en) * 1974-04-24 1976-06-01 Sergei Ivanovich Zavyalov Method of preparing racemic biotin
AU563351C (en) * 1982-01-15 2003-06-19 Glaxo Group Limited Synthesis of oligosaccharides
IL102758A (en) * 1991-08-23 1997-03-18 Akzo Nv Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them
WO2000002050A1 (en) * 1998-07-07 2000-01-13 Department Of Radiation Oncology, University Of Washington Trifunctional reagent for conjugation to a biomolecule
US20010023288A1 (en) * 1999-07-07 2001-09-20 Wilbur D. Scott Trifunctional reagent for conjugation to a biomolecule
FR2751334B1 (fr) * 1996-07-19 1998-10-16 Sanofi Sa Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2773801B1 (fr) * 1998-01-19 2000-05-12 Sanofi Sa Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant
FR2773804B1 (fr) * 1998-01-19 2000-02-18 Sanofi Sa Polysaccharides de synthese, procede pour leur preparation et compositions pharmaceutiques le contenant
GB2335490B (en) * 1998-03-20 2003-05-14 Ortho Clinical Diagnostics An assay surface that permits an analyte releasiing step
EP1022289B1 (en) 1998-07-31 2004-07-07 Seikagaku Corporation Novel glycosaminoglycan and drug compositions containing the same
FR2814463B1 (fr) * 2000-09-22 2002-11-15 Sanofi Synthelabo Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine

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Publication number Publication date
FR2814463A1 (fr) 2002-03-29
NZ524472A (en) 2004-10-29
US8318696B2 (en) 2012-11-27
US20040024197A1 (en) 2004-02-05
US7943595B2 (en) 2011-05-17
EP1322673A1 (fr) 2003-07-02
KR100891388B1 (ko) 2009-04-02
SK287218B6 (sk) 2010-03-08
NO332905B1 (no) 2013-01-28
ECSP034514A (es) 2003-04-25
TWI308153B (en) 2009-04-01
AU9196001A (en) 2002-04-02
AU2001291960C1 (en) 2009-10-08
CZ2003814A3 (cs) 2003-06-18
SK3562003A3 (en) 2003-11-04
AU2001291960B2 (en) 2007-03-01
IS6733A (is) 2003-02-28
CZ300856B6 (cs) 2009-08-26
PE20020471A1 (es) 2002-06-01
KR20030055269A (ko) 2003-07-02
IL154848A (en) 2010-11-30
JP2012131809A (ja) 2012-07-12
NO20110401L (no) 2003-05-22
IL154848A0 (en) 2003-10-31
PT1322673E (pt) 2007-12-03
SI1322673T1 (sl) 2008-02-29
EE200300114A (et) 2005-02-15
BG107650A (bg) 2003-11-28
CY1108076T1 (el) 2014-02-12
WO2002024754A1 (fr) 2002-03-28
CA2418815C (en) 2011-05-10
EP1322673B1 (fr) 2007-09-26
NO20031295D0 (no) 2003-03-20
HRP20030219B1 (hr) 2011-10-31
HU1400034D0 (hu) 2004-03-01
CN1466594A (zh) 2004-01-07
HUP0303551A3 (en) 2004-03-29
HRP20030219A2 (en) 2003-06-30
US20110144042A1 (en) 2011-06-16
WO2002024754A8 (fr) 2003-07-03
ME00080B (me) 2010-10-10
FR2814463B1 (fr) 2002-11-15
EA005133B1 (ru) 2004-12-30
RS50730B (sr) 2010-08-31
HK1053316A1 (zh) 2003-10-17
JP2004509902A (ja) 2004-04-02
BR0114007A (pt) 2003-08-12
ES2292625T3 (es) 2008-03-16
DE60130669D1 (de) 2007-11-08
UA79736C2 (uk) 2007-07-25
AR030774A1 (es) 2003-09-03
ZA200301692B (en) 2004-03-01
HUP0303551A2 (hu) 2004-03-01
DE60130669T2 (de) 2008-07-17
SK287054B6 (sk) 2009-10-07
ATE374215T1 (de) 2007-10-15
DK1322673T3 (da) 2008-01-14
IS2550B (is) 2009-10-15
GEP20053616B (en) 2005-09-26
BG66191B1 (bg) 2011-12-30
CA2418815A1 (en) 2002-03-28
PL363368A1 (en) 2004-11-15
NO20031295L (no) 2003-05-22
MEP23608A (bs) 2010-06-10
PL206727B1 (pl) 2010-09-30
EE05202B1 (et) 2009-08-17
CN1235914C (zh) 2006-01-11
EA200300237A1 (ru) 2003-08-28
MXPA03002483A (es) 2004-05-24
KR20080049139A (ko) 2008-06-03
US20060160768A1 (en) 2006-07-20
US6844329B2 (en) 2005-01-18
YU19703A (sh) 2006-05-25

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