JP4939229B2 - Cxc−ケモカインレセプターリガンドおよびcc−ケモカインレセプターリガンドとしてのチアジアゾール - Google Patents
Cxc−ケモカインレセプターリガンドおよびcc−ケモカインレセプターリガンドとしてのチアジアゾール Download PDFInfo
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- JP4939229B2 JP4939229B2 JP2006545364A JP2006545364A JP4939229B2 JP 4939229 B2 JP4939229 B2 JP 4939229B2 JP 2006545364 A JP2006545364 A JP 2006545364A JP 2006545364 A JP2006545364 A JP 2006545364A JP 4939229 B2 JP4939229 B2 JP 4939229B2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
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Applications Claiming Priority (5)
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| US53131103P | 2003-12-19 | 2003-12-19 | |
| US60/531,311 | 2003-12-19 | ||
| US53171303P | 2003-12-22 | 2003-12-22 | |
| US60/531,713 | 2003-12-22 | ||
| PCT/US2004/042060 WO2005066147A1 (en) | 2003-12-19 | 2004-12-16 | Thiadiazoles as cxc- and cc- chemokine receptor ligands |
Related Child Applications (1)
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| JP2007514746A JP2007514746A (ja) | 2007-06-07 |
| JP2007514746A5 JP2007514746A5 (cg-RX-API-DMAC7.html) | 2008-02-07 |
| JP4939229B2 true JP4939229B2 (ja) | 2012-05-23 |
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| JP2011030301A Withdrawn JP2011093943A (ja) | 2003-12-19 | 2011-02-15 | Cxc−ケモカインレセプターリガンドおよびcc−ケモカインレセプターリガンドとしてのチアジアゾール |
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| JP2011030301A Withdrawn JP2011093943A (ja) | 2003-12-19 | 2011-02-15 | Cxc−ケモカインレセプターリガンドおよびcc−ケモカインレセプターリガンドとしてのチアジアゾール |
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| TW (1) | TW200528450A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005066147A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60326080D1 (en) * | 2002-10-09 | 2009-03-19 | Schering Corp | Thiadiazoldioxide und thiadiazoloxide als cxc- und cc-chemokinrezeptor liganden |
| TW200530231A (en) * | 2003-12-22 | 2005-09-16 | Schering Corp | Isothiazole dioxides as CXC-and CC-chemokine receptor ligands |
| US7326729B2 (en) * | 2004-05-12 | 2008-02-05 | Schering Corporation | CXCR1 and CXCR2 chemokine antagonists |
| CA2613607A1 (en) * | 2005-06-29 | 2007-01-04 | Schering Corporation | Di-substituted oxadiazoles as cxc-chemokine receptor ligands |
| ES2353401T3 (es) * | 2005-06-29 | 2011-03-01 | Schering Corporation | Oxidiazolopirazinas y tiadiazolopirazinas 5,6-di-sustituidas como ligandos del receptor de cxc-quimiocina. |
| SI2455382T1 (sl) | 2005-12-13 | 2017-03-31 | Incyte Holdings Corporation | S heteroarilom substituirani pirolo(2,3b)piridini in pirolo(2,3-b)pirimidini kot zaviralci janus kinaze |
| ES2467665T5 (es) | 2007-06-13 | 2022-11-03 | Incyte Holdings Corp | Sales del inhibidor de cinasas Janus (R)-3-(4-(7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-il)-3-ciclopentilpropanonitrilo |
| WO2009019167A1 (en) | 2007-08-08 | 2009-02-12 | Merck Serono S.A. | 6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (s1p) receptor for the treatment of multiple sclerosis |
| EP2116618A1 (en) | 2008-05-09 | 2009-11-11 | Agency for Science, Technology And Research | Diagnosis and treatment of Kawasaki disease |
| CL2009001884A1 (es) * | 2008-10-02 | 2010-05-14 | Incyte Holdings Corp | Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco. |
| WO2010050445A1 (ja) * | 2008-10-27 | 2010-05-06 | 武田薬品工業株式会社 | 二環性化合物 |
| MY156727A (en) | 2009-05-22 | 2016-03-15 | Incyte Corp | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| PT2432472T (pt) | 2009-05-22 | 2019-12-09 | Incyte Holdings Corp | 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]octano- ou heptano-nitrilo como inibidores de jak |
| WO2011028685A1 (en) | 2009-09-01 | 2011-03-10 | Incyte Corporation | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| CA2783699C (en) | 2009-12-08 | 2019-01-15 | Case Western Reserve University | Primary amine compounds for treating ocular disorders |
| US20130085133A1 (en) * | 2010-02-08 | 2013-04-04 | Sourthern Research Institute Office of Commercialization and Intellectual Prop. | Anti-viral treatment and assay to screenfor anti-viral agent |
| MX354212B (es) | 2010-03-10 | 2018-02-19 | Incyte Corp | Derivados de piperidin-4-il azetidina como inhibidores de janus cinasa 1 (jak1). |
| US20110288107A1 (en) | 2010-05-21 | 2011-11-24 | Bhavnish Parikh | Topical formulation for a jak inhibitor |
| CA2818542A1 (en) | 2010-11-19 | 2012-05-24 | Incyte Corporation | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors |
| EP2640725B1 (en) | 2010-11-19 | 2015-01-07 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors |
| WO2012177606A1 (en) | 2011-06-20 | 2012-12-27 | Incyte Corporation | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors |
| TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為jak抑制劑之環己基氮雜環丁烷衍生物 |
| UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
| WO2013173720A1 (en) | 2012-05-18 | 2013-11-21 | Incyte Corporation | Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors |
| US8865723B2 (en) | 2012-10-25 | 2014-10-21 | Tetra Discovery Partners Llc | Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury |
| ES2880814T3 (es) | 2012-11-15 | 2021-11-25 | Incyte Holdings Corp | Formas de dosificación de liberación sostenida de ruxolitinib |
| EP3489239B1 (en) | 2013-03-06 | 2021-09-15 | Incyte Holdings Corporation | Processes and intermediates for making a jak inhibitor |
| TWI789516B (zh) | 2013-08-07 | 2023-01-11 | 美商英塞特公司 | Jak1抑制劑之持續釋放劑型 |
| US9763992B2 (en) | 2014-02-13 | 2017-09-19 | Father Flanagan's Boys' Home | Treatment of noise induced hearing loss |
| WO2015184305A1 (en) | 2014-05-30 | 2015-12-03 | Incyte Corporation | TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 |
| AR113922A1 (es) | 2017-12-08 | 2020-07-01 | Incyte Corp | Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas |
| HRP20220510T1 (hr) | 2018-01-30 | 2022-05-27 | Incyte Corporation | Postupci za pripravu (1-(3-fluoro-2-(trifluorometil)izonikotinil) piperidin-4-ona) |
| HUE067471T2 (hu) | 2018-03-30 | 2024-10-28 | Incyte Corp | Gennyes verejtékmirigy-gyulladás kezelése jak inhibitorok alkalmazásával |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002076926A1 (en) * | 2001-02-02 | 2002-10-03 | Schering Corporation | 3,4-di-substituted cyclobutene-1, 2-diones as cxc chemokine receptor antagonists |
| JP2003512349A (ja) * | 1999-10-15 | 2003-04-02 | デュポン ファーマシューティカルズ カンパニー | ケモカイン受容体活性のモジュレーターとしてのベンジルシクロアルキルアミン |
| WO2003031440A1 (en) * | 2001-10-12 | 2003-04-17 | Schering Corporation | 3,4-di-substituted maleimide compounds as cxc-chemokine receptor antagonists |
| WO2003057676A1 (en) * | 2002-01-04 | 2003-07-17 | Schering Corporation | 3,4-di-substituted pyridazinediones as cxc chemokine receptor antagonists |
| JP2003525242A (ja) * | 2000-03-01 | 2003-08-26 | スミスクライン・ビーチャム・コーポレイション | Il−8受容体アンタゴニスト |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3115496A (en) | 1963-05-13 | 1963-12-24 | Upjohn Co | Certain 3, 4-disubstituted-1, 2, 5-thiadiazole-1, 1-dioxides and their preparation |
| US3115495A (en) | 1963-05-13 | 1963-12-24 | Upjohn Co | Certain 3, 4-diaryl-delta2-1, 2, 5-thiadiazoline-1, 1-dioxides and their preparation |
| BE698156A (cg-RX-API-DMAC7.html) | 1966-05-11 | 1967-10-16 | ||
| DE1669798A1 (de) | 1966-07-28 | 1971-08-26 | Huels Chemische Werke Ag | Verfahren zum Stabilisieren markomolekularer Polyacetale |
| CS214745B2 (en) | 1976-08-28 | 1982-05-28 | Huels Chemische Werke Ag | Shaped and non-shaped products from plastic materials |
| FI76795C (fi) | 1979-09-04 | 1988-12-12 | Bristol Myers Co | Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider samt nya mellanprodukter. |
| DE3175201D1 (en) | 1980-04-30 | 1986-10-02 | Merck & Co Inc | Aminothiadiazoles as gastric secretion inhibitors |
| US4394508A (en) | 1980-06-07 | 1983-07-19 | Bristol-Myers Company | Chemical compounds |
| US4510309A (en) | 1981-03-03 | 1985-04-09 | Bristol-Myers Company | Histamine H2 -antagonists |
| IE53068B1 (en) | 1981-06-15 | 1988-05-25 | Merck & Co Inc | Diamino isothiazole-1-oxides and -1,1-dioxides as gastic secretion inhibitors |
| GB2124622A (en) | 1982-07-08 | 1984-02-22 | Glaxo Group Ltd | Thiadiazole derivatives |
| FI832519L (fi) * | 1982-07-12 | 1984-01-13 | Bristol Myers Co | Farmaceutiska foerfaranden och sammansaettningar |
| AU2222083A (en) | 1982-12-14 | 1984-06-21 | Smith Kline & French Laboratories Limited | Pyridine derivatives |
| US4863936A (en) | 1982-12-14 | 1989-09-05 | Smith Kline & French Laboratories Limited | 3,5-Substituted-2-pyridyl-alkylaminocyclobutenediones having histamine h1 -antagonist activity |
| JO1279B1 (en) | 1982-12-23 | 1985-04-20 | جون ايف روبرت | Pyridine derivatives |
| DE3309655A1 (de) | 1983-03-17 | 1984-09-20 | Bayer Ag, 5090 Leverkusen | 1,2,5-thiadiazol-1-oxide und 1,1-dioxide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4497810A (en) | 1983-10-14 | 1985-02-05 | Merck & Co., Inc. | Thiatriazine dioxides as gastric anti-secretory agents |
| US4562184A (en) | 1984-04-02 | 1985-12-31 | Merck & Co., Inc. | Substituted-aminohydroxypropoxy-thiadiazoles, β-blocking compositions and use |
| JPS60255756A (ja) | 1984-06-01 | 1985-12-17 | Ikeda Mohandou:Kk | アミノアルキルフエノキシ誘導体 |
| GB8501535D0 (en) | 1985-01-22 | 1985-02-20 | Smith Kline French Lab | Chemical compounds |
| US4978665A (en) | 1987-01-20 | 1990-12-18 | Nissan Chemical Industries Ltd. | 3(2H)pyridazinone, and antagonistic agent against SRS-A containing it |
| JPH02256668A (ja) | 1988-12-20 | 1990-10-17 | Nissan Chem Ind Ltd | ピリダジノン誘導体 |
| US5206252A (en) | 1992-05-08 | 1993-04-27 | American Home Products Corporation | Thiadiazolyl-amino derivatives of benzopyrans and indanes |
| GB9312210D0 (en) | 1993-06-14 | 1993-07-28 | Smithkline Beecham Plc | Chemical compounds |
| US5354763A (en) | 1993-11-17 | 1994-10-11 | American Home Products Corporation | Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-diones |
| US5506252A (en) | 1993-11-17 | 1996-04-09 | American Home Products Corporation | Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-diones |
| DE69435133D1 (de) * | 1993-12-10 | 2008-10-09 | Ricoh Kk | Bildextrahierungsverfahren und Gerät, und Bilderkennungsverfahren und Gerät, zum Extrahieren und Erkennen eines bestimmten Bildes aus einem Bildeingabesignal |
| US5550139A (en) | 1994-01-03 | 1996-08-27 | The Wichita State University | Serine protease inhibitors |
| US5466712A (en) | 1994-11-04 | 1995-11-14 | American Home Products Corporation | Substituted n-aryl-1,2-diaminocyclobutene-3,4-diones |
| JPH10509145A (ja) | 1994-11-16 | 1998-09-08 | アメリカン・ホーム・プロダクツ・コーポレイション | ジアミノシクロブテン−3,4−ジオン |
| US5494925A (en) | 1994-12-02 | 1996-02-27 | Sterling Winthrop Inc. | 2-heterocyclyloxymethyl and 2-heterocyclylthiomethyl-1,2,5-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof |
| US5958957A (en) | 1996-04-19 | 1999-09-28 | Novo Nordisk A/S | Modulators of molecules with phosphotyrosine recognition units |
| US5962535A (en) * | 1997-01-17 | 1999-10-05 | Takeda Chemical Industries, Ltd. | Composition for alzheimer's disease |
| IL131004A0 (en) | 1997-01-23 | 2001-01-28 | Smithkline Beecham Corp | Il-8 receptor antagonists |
| US5840764A (en) | 1997-01-30 | 1998-11-24 | American Home Products Corporation | Substituted hydroxy-anilino derivatives of cyclobutene-3,4-diones |
| AU6250298A (en) | 1997-01-30 | 1998-08-25 | American Home Products Corporation | Substituted hydroxy-anilino derivatives of cyclobutene-3,4-diones |
| AR015425A1 (es) | 1997-09-05 | 2001-05-02 | Smithkline Beecham Corp | Compuestos de benzotiazol, composicion farmaceutica que los contiene, su uso en la manufactura de un medicamento, procedimiento para su preparacion,compuestos intermediarios y procedimiento para su preparacion |
| EP1117633B1 (en) | 1998-10-02 | 2002-09-18 | Neurosearch A/S | Diaminocyclobutene-3,4-dione derivatives, their preparation and use |
| ATE284387T1 (de) | 1998-10-08 | 2004-12-15 | Smithkline Beecham Plc | 3-(3-chloro-4-hydroxyphenylamino)-4-(2- nitrophenyl)-1h-pyrrol-2,5-dion als glykogen synthase kinase-3 inhibitor (gsk-3) |
| US6376555B1 (en) | 1998-12-04 | 2002-04-23 | American Home Products Corporation | 4-substituted-3-substituted-amino-cyclobut-3-ene-1,2-diones and analogs thereof as novel potassium channel openers |
| WO2000035855A1 (en) | 1998-12-14 | 2000-06-22 | American Home Products Corporation | 3,4-diamino-3-cyclobutene-1,2-dione derivatives which inhibit leukocyte adhesion mediated by vla-4 |
| US6420396B1 (en) | 1998-12-16 | 2002-07-16 | Beiersdorf Ag | Biphenyl and biphenyl-analogous compounds as integrin antagonists |
| NZ512339A (en) | 1998-12-16 | 2003-03-28 | Bayer Ag | New biphenyl and biphenyl-analogous compounds as integrin antagonists |
| US6498161B1 (en) * | 1999-04-06 | 2002-12-24 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
| US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
| CO5190696A1 (es) | 1999-06-16 | 2002-08-29 | Smithkline Beecham Corp | Antagonistas de los receptores il-8 |
| US6586446B1 (en) | 1999-10-15 | 2003-07-01 | Bristol-Myers Squibb Company | Bicyclic and tricyclic amines as modulators of chemokine receptor activity |
| AU2001243351A1 (en) | 2000-03-01 | 2001-09-12 | Smith Kline Beecham Corporation | Il-8 receptor antagonists |
| AU2001245724A1 (en) | 2000-03-14 | 2001-09-24 | Smith Kline Beecham Corporation | Il-8 receptor antagonists |
| HUP0302382A3 (en) | 2000-05-30 | 2004-09-28 | Smithkline Beecham Corp | Il-8 receptor antagonists and pharmaceutical compositions containing them |
| ATE346043T1 (de) | 2001-01-16 | 2006-12-15 | Smithkline Beecham Corp | Il-8-rezeptorantagonisten |
| ATE419845T1 (de) | 2001-01-16 | 2009-01-15 | Smithkline Beecham Corp | Il-8-rezeptor-antagonisten |
| US20030204085A1 (en) | 2001-02-02 | 2003-10-30 | Taveras Arthur G. | 3, 4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor antagonists |
| DK1381590T3 (da) | 2001-04-16 | 2007-10-22 | Schering Corp | 3,4-disubstituerede cyclobuten-1,2-dioner som CXC-kemokinreceptorligander |
| US7132445B2 (en) | 2001-04-16 | 2006-11-07 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| WO2003080053A1 (en) | 2002-03-18 | 2003-10-02 | Schering Corporation | Combination treatments for chemokine-mediated diseases |
| DE60326080D1 (en) | 2002-10-09 | 2009-03-19 | Schering Corp | Thiadiazoldioxide und thiadiazoloxide als cxc- und cc-chemokinrezeptor liganden |
| TW200530231A (en) | 2003-12-22 | 2005-09-16 | Schering Corp | Isothiazole dioxides as CXC-and CC-chemokine receptor ligands |
| CA2613607A1 (en) * | 2005-06-29 | 2007-01-04 | Schering Corporation | Di-substituted oxadiazoles as cxc-chemokine receptor ligands |
-
2004
- 2004-12-16 AT AT04814266T patent/ATE406356T1/de not_active IP Right Cessation
- 2004-12-16 WO PCT/US2004/042060 patent/WO2005066147A1/en not_active Ceased
- 2004-12-16 DE DE602004016211T patent/DE602004016211D1/de not_active Expired - Lifetime
- 2004-12-16 US US11/013,753 patent/US7338968B2/en not_active Expired - Fee Related
- 2004-12-16 CA CA002550189A patent/CA2550189A1/en not_active Abandoned
- 2004-12-16 CN CN2004800416952A patent/CN1918138B/zh not_active Expired - Fee Related
- 2004-12-16 ES ES04814266T patent/ES2308299T3/es not_active Expired - Lifetime
- 2004-12-16 EP EP04814266A patent/EP1694659B8/en not_active Expired - Lifetime
- 2004-12-16 TW TW093139212A patent/TW200528450A/zh unknown
- 2004-12-16 JP JP2006545364A patent/JP4939229B2/ja not_active Expired - Fee Related
- 2004-12-16 MX MXPA06007076A patent/MXPA06007076A/es active IP Right Grant
- 2004-12-16 MY MYPI20045183A patent/MY139808A/en unknown
- 2004-12-17 AR ARP040104753A patent/AR046791A1/es not_active Application Discontinuation
-
2007
- 2007-09-26 US US11/861,870 patent/US7786149B2/en not_active Expired - Fee Related
-
2011
- 2011-02-15 JP JP2011030301A patent/JP2011093943A/ja not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003512349A (ja) * | 1999-10-15 | 2003-04-02 | デュポン ファーマシューティカルズ カンパニー | ケモカイン受容体活性のモジュレーターとしてのベンジルシクロアルキルアミン |
| JP2003525242A (ja) * | 2000-03-01 | 2003-08-26 | スミスクライン・ビーチャム・コーポレイション | Il−8受容体アンタゴニスト |
| WO2002076926A1 (en) * | 2001-02-02 | 2002-10-03 | Schering Corporation | 3,4-di-substituted cyclobutene-1, 2-diones as cxc chemokine receptor antagonists |
| WO2003031440A1 (en) * | 2001-10-12 | 2003-04-17 | Schering Corporation | 3,4-di-substituted maleimide compounds as cxc-chemokine receptor antagonists |
| WO2003057676A1 (en) * | 2002-01-04 | 2003-07-17 | Schering Corporation | 3,4-di-substituted pyridazinediones as cxc chemokine receptor antagonists |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2308299T3 (es) | 2008-12-01 |
| ATE406356T1 (de) | 2008-09-15 |
| AR046791A1 (es) | 2005-12-21 |
| EP1694659A1 (en) | 2006-08-30 |
| US7338968B2 (en) | 2008-03-04 |
| MXPA06007076A (es) | 2006-08-31 |
| DE602004016211D1 (en) | 2008-10-09 |
| US7786149B2 (en) | 2010-08-31 |
| EP1694659B8 (en) | 2008-10-08 |
| MY139808A (en) | 2009-10-30 |
| US20060223864A1 (en) | 2006-10-05 |
| WO2005066147A1 (en) | 2005-07-21 |
| CA2550189A1 (en) | 2005-07-21 |
| JP2007514746A (ja) | 2007-06-07 |
| HK1087711A1 (en) | 2006-10-20 |
| CN1918138A (zh) | 2007-02-21 |
| JP2011093943A (ja) | 2011-05-12 |
| TW200528450A (en) | 2005-09-01 |
| EP1694659B1 (en) | 2008-08-27 |
| CN1918138B (zh) | 2011-05-04 |
| US20080090823A1 (en) | 2008-04-17 |
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