JP4881875B2 - 抗腫瘍剤としてのピラゾロピリミジン化合物 - Google Patents

抗腫瘍剤としてのピラゾロピリミジン化合物 Download PDF

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Publication number
JP4881875B2
JP4881875B2 JP2007546165A JP2007546165A JP4881875B2 JP 4881875 B2 JP4881875 B2 JP 4881875B2 JP 2007546165 A JP2007546165 A JP 2007546165A JP 2007546165 A JP2007546165 A JP 2007546165A JP 4881875 B2 JP4881875 B2 JP 4881875B2
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JP
Japan
Prior art keywords
alkyl
pyrazolo
oxy
amino
phenyl
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Expired - Fee Related
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Japanese (ja)
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JP2008523134A (ja
JP2008523134A5 (enExample
Inventor
バーラーム，ベルナール・クリストフ
デュクレ，リシャール
ケトル，ジェイソン・グラント
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AstraZeneca AB
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AstraZeneca AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2007546165A 2004-12-14 2005-12-12 抗腫瘍剤としてのピラゾロピリミジン化合物 Expired - Fee Related JP4881875B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP04292982 2004-12-14
EP04292982.8 2004-12-14
EP05291158.3 2005-05-30
EP05291158 2005-05-30
PCT/GB2005/004770 WO2006064196A1 (en) 2004-12-14 2005-12-12 Pyrazolopyrimidine compounds as antitumor agents

Publications (3)

Publication Number Publication Date
JP2008523134A JP2008523134A (ja) 2008-07-03
JP2008523134A5 JP2008523134A5 (enExample) 2011-12-22
JP4881875B2 true JP4881875B2 (ja) 2012-02-22

Family

ID=35826513

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007546165A Expired - Fee Related JP4881875B2 (ja) 2004-12-14 2005-12-12 抗腫瘍剤としてのピラゾロピリミジン化合物

Country Status (7)

Country Link
US (1) US7947676B2 (enExample)
EP (1) EP1838712B8 (enExample)
JP (1) JP4881875B2 (enExample)
CN (1) CN101124228B (enExample)
AT (1) ATE501148T1 (enExample)
DE (1) DE602005026865D1 (enExample)
WO (1) WO2006064196A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7569577B2 (en) 2003-09-16 2009-08-04 Astrazeneca Ab Quinazoline derivatives as tyrosine kinase inhibitors
GB0322409D0 (en) * 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
GB0326459D0 (en) 2003-11-13 2003-12-17 Astrazeneca Ab Quinazoline derivatives
ATE413389T1 (de) 2004-02-03 2008-11-15 Astrazeneca Ab Chinazolinderivate
JP2008231004A (ja) * 2007-03-19 2008-10-02 Sumitomo Seika Chem Co Ltd アルコキシ−２−メルカプトベンゾチアゾールの製造方法
CA2889572C (en) 2012-11-08 2019-03-05 Pfizer Inc. Heteroaromatic compounds as dopamine d1 ligands
US20160318897A1 (en) 2013-12-18 2016-11-03 Basf Se Azole compounds carrying an imine-derived substituent
US9616063B2 (en) * 2014-12-01 2017-04-11 Astrazeneca Ab 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase
EP3445768A4 (en) * 2016-04-19 2019-12-18 The Regents of The University of California HERITAGE INHIBITORS AND USES THEREOF

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BRPI0413066A (pt) * 2003-07-29 2006-10-17 Astrazeneca Ab derivado de quinazolina, ou um sal farmaceuticamente aceitável, ou um éster farmaceuticamente aceitável do mesmo, da fórmula i, uso e processo para a preparação do mesmo, composto, composição farmacêutica, e, métodos para a produção de um efeito antiproliferativo em um animal de sangue quente, para a prevenção ou tratamento de um tumor, para prover um efeito inibitório de tirosina quinase de egfr seletivo, e para tratar um cáncer em um animal de sangue quente
GB0317665D0 (en) * 2003-07-29 2003-09-03 Astrazeneca Ab Qinazoline derivatives
EP1664030A1 (en) * 2003-09-16 2006-06-07 AstraZeneca AB Quinazoline derivatives
GB0321648D0 (en) * 2003-09-16 2003-10-15 Astrazeneca Ab Quinazoline derivatives
BRPI0414488A (pt) * 2003-09-16 2006-11-14 Astrazeneca Ab derivado de quinazolina, composição farmacêutica, uso de um derivado de quinazolina, métodos para produzir um efeito anti - proliferativo em um animal de sangue quente, para prevenção ou tratamento de tumores em um aminal de sangue quente, para fornecer um efeito inibidor da tirosina quinase de egfr seletivo em um animal de sangue quente e para tratar um cáncer em um animal de sangue quente e, processo para a preparação de um derivado de quinazolina
AU2004272350A1 (en) * 2003-09-16 2005-03-24 Astrazeneca Ab Quinazoline derivatives as tyrosine kinase inhibitors
US7569577B2 (en) * 2003-09-16 2009-08-04 Astrazeneca Ab Quinazoline derivatives as tyrosine kinase inhibitors
JP4036885B2 (ja) * 2003-09-19 2008-01-23 アストラゼネカ アクチボラグ キナゾリン誘導体
DE602004004811T2 (de) * 2003-09-19 2007-11-22 Astrazeneca Ab Chinazolinderivate
GB0322409D0 (en) * 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
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GB0326459D0 (en) * 2003-11-13 2003-12-17 Astrazeneca Ab Quinazoline derivatives
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Also Published As

Publication number Publication date
EP1838712A1 (en) 2007-10-03
JP2008523134A (ja) 2008-07-03
WO2006064196A1 (en) 2006-06-22
ATE501148T1 (de) 2011-03-15
HK1112462A1 (en) 2008-09-05
US20080108613A1 (en) 2008-05-08
CN101124228A (zh) 2008-02-13
EP1838712B8 (en) 2011-10-12
EP1838712B1 (en) 2011-03-09
DE602005026865D1 (de) 2011-04-21
US7947676B2 (en) 2011-05-24
CN101124228B (zh) 2011-06-15

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