DE602005026865D1 - Pyrazolopyrimidinverbindungen als antitumormittel - Google Patents

Pyrazolopyrimidinverbindungen als antitumormittel

Info

Publication number
DE602005026865D1
DE602005026865D1 DE602005026865T DE602005026865T DE602005026865D1 DE 602005026865 D1 DE602005026865 D1 DE 602005026865D1 DE 602005026865 T DE602005026865 T DE 602005026865T DE 602005026865 T DE602005026865 T DE 602005026865T DE 602005026865 D1 DE602005026865 D1 DE 602005026865D1
Authority
DE
Germany
Prior art keywords
antitum
pyrazolopyrimidine compounds
effect
compounds
substituents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602005026865T
Other languages
German (de)
English (en)
Inventor
Bernard Christophe Barlaam
Richard Ducray
Jason Grant Kettle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of DE602005026865D1 publication Critical patent/DE602005026865D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE602005026865T 2004-12-14 2005-12-12 Pyrazolopyrimidinverbindungen als antitumormittel Expired - Lifetime DE602005026865D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04292982 2004-12-14
EP05291158 2005-05-30
PCT/GB2005/004770 WO2006064196A1 (en) 2004-12-14 2005-12-12 Pyrazolopyrimidine compounds as antitumor agents

Publications (1)

Publication Number Publication Date
DE602005026865D1 true DE602005026865D1 (de) 2011-04-21

Family

ID=35826513

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005026865T Expired - Lifetime DE602005026865D1 (de) 2004-12-14 2005-12-12 Pyrazolopyrimidinverbindungen als antitumormittel

Country Status (7)

Country Link
US (1) US7947676B2 (enExample)
EP (1) EP1838712B8 (enExample)
JP (1) JP4881875B2 (enExample)
CN (1) CN101124228B (enExample)
AT (1) ATE501148T1 (enExample)
DE (1) DE602005026865D1 (enExample)
WO (1) WO2006064196A1 (enExample)

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US20160318897A1 (en) 2013-12-18 2016-11-03 Basf Se Azole compounds carrying an imine-derived substituent
US9616063B2 (en) * 2014-12-01 2017-04-11 Astrazeneca Ab 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase
CN109952306A (zh) * 2016-04-19 2019-06-28 加利福尼亚大学董事会 ErbB抑制剂及其用途

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BRPI0413066A (pt) * 2003-07-29 2006-10-17 Astrazeneca Ab derivado de quinazolina, ou um sal farmaceuticamente aceitável, ou um éster farmaceuticamente aceitável do mesmo, da fórmula i, uso e processo para a preparação do mesmo, composto, composição farmacêutica, e, métodos para a produção de um efeito antiproliferativo em um animal de sangue quente, para a prevenção ou tratamento de um tumor, para prover um efeito inibitório de tirosina quinase de egfr seletivo, e para tratar um cáncer em um animal de sangue quente
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ATE395346T1 (de) * 2003-09-16 2008-05-15 Astrazeneca Ab Chinazolinderivate als tyrosinkinaseinhibitoren
BRPI0414488A (pt) * 2003-09-16 2006-11-14 Astrazeneca Ab derivado de quinazolina, composição farmacêutica, uso de um derivado de quinazolina, métodos para produzir um efeito anti - proliferativo em um animal de sangue quente, para prevenção ou tratamento de tumores em um aminal de sangue quente, para fornecer um efeito inibidor da tirosina quinase de egfr seletivo em um animal de sangue quente e para tratar um cáncer em um animal de sangue quente e, processo para a preparação de um derivado de quinazolina
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ATE352550T1 (de) * 2003-09-19 2007-02-15 Astrazeneca Ab Chinazolinderivate
ATE353888T1 (de) * 2003-09-19 2007-03-15 Astrazeneca Ab Chinazolinderivate
GB0322409D0 (en) * 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
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GB0326459D0 (en) * 2003-11-13 2003-12-17 Astrazeneca Ab Quinazoline derivatives
ES2315834T3 (es) * 2004-02-03 2009-04-01 Astrazeneca Ab Derivados de quinazolina.
CA2567832A1 (en) * 2004-06-04 2005-12-15 Astrazeneca Ab Quinazoline derivatives as erbb receptor tyrosine kinases
GB0504475D0 (en) * 2005-03-04 2005-04-13 Astrazeneca Ab Chemical compounds
GB0504474D0 (en) * 2005-03-04 2005-04-13 Astrazeneca Ab Chemical compounds
GB0508715D0 (en) * 2005-04-29 2005-06-08 Astrazeneca Ab Chemical compounds
GB0508717D0 (en) * 2005-04-29 2005-06-08 Astrazeneca Ab Chemical compounds
EP1940825A1 (en) * 2005-09-20 2008-07-09 Astra Zeneca AB Quinazoline derivatives as anticancer agents
DE602006018331D1 (de) * 2005-09-20 2010-12-30 Astrazeneca Ab 4-(1h-indazol-5-ylamino)chinazolinverbindungen als inhibitoren der erbb-rezeptortyrosinkinase zur behandlung von krebs
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Also Published As

Publication number Publication date
EP1838712B1 (en) 2011-03-09
EP1838712A1 (en) 2007-10-03
HK1112462A1 (en) 2008-09-05
US20080108613A1 (en) 2008-05-08
JP2008523134A (ja) 2008-07-03
US7947676B2 (en) 2011-05-24
CN101124228A (zh) 2008-02-13
ATE501148T1 (de) 2011-03-15
WO2006064196A1 (en) 2006-06-22
JP4881875B2 (ja) 2012-02-22
CN101124228B (zh) 2011-06-15
EP1838712B8 (en) 2011-10-12

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