JP4881558B2 - サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン - Google Patents

サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン Download PDF

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JP4881558B2
JP4881558B2 JP2004534487A JP2004534487A JP4881558B2 JP 4881558 B2 JP4881558 B2 JP 4881558B2 JP 2004534487 A JP2004534487 A JP 2004534487A JP 2004534487 A JP2004534487 A JP 2004534487A JP 4881558 B2 JP4881558 B2 JP 4881558B2
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JP2006502163A5 (https=
JP2006502163A (ja
Inventor
ティモシー ジェイ． グジ，
カミル パルチ，
マイケル ピー． ドワイヤー，
ロナルド ジェイ． ドール，
ヴィヨール ムーピル ギリジャバルラブハン，
アラン マラムス，
カーメン エス． アルヴァレツ，
カーティック エム． キールティカー，
ジョセリン リヴェラ，
ティン−ヤウ チャン，
ヴィンセント マディソン，
シーリー オー． フィッシュマン，
ローレンス ダブリュー． ジルラルド，
ヴィン ディー． トラン，
ツェン ミン ヘ，
レイ アンソニー ジェームス，
ヘーンスーン パーク，
ヴィジャドハール エム． パードカー，
ダグラス ウォルシュ ホッブス，
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Merck Sharp and Dohme LLC
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Schering Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2004534487A 2002-09-04 2003-09-03 サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン Expired - Lifetime JP4881558B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US40802702P 2002-09-04 2002-09-04
US60/408,027 2002-09-04
US42195902P 2002-10-29 2002-10-29
US60/421,959 2002-10-29
PCT/US2003/027555 WO2004022561A1 (en) 2002-09-04 2003-09-03 Pyrazolopyrimidines as cyclin-dependent kinase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010088210A Division JP2010180234A (ja) 2002-09-04 2010-04-06 サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン

Publications (3)

Publication Number Publication Date
JP2006502163A JP2006502163A (ja) 2006-01-19
JP2006502163A5 JP2006502163A5 (https=) 2010-05-27
JP4881558B2 true JP4881558B2 (ja) 2012-02-22

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JP2004534487A Expired - Lifetime JP4881558B2 (ja) 2002-09-04 2003-09-03 サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン

Country Status (13)

Country Link
EP (1) EP1537116B1 (https=)
JP (1) JP4881558B2 (https=)
KR (1) KR101088922B1 (https=)
AT (1) ATE469903T1 (https=)
AU (1) AU2003263071B2 (https=)
BR (1) BRPI0314001B8 (https=)
CA (1) CA2497440C (https=)
DK (1) DK1537116T3 (https=)
IL (1) IL167086A (https=)
MX (1) MXPA05002571A (https=)
NO (1) NO20051647L (https=)
NZ (1) NZ539165A (https=)
WO (1) WO2004022561A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
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JP2010215675A (ja) * 2004-02-11 2010-09-30 Schering Corp サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン誘導体

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